Category: 14719-21-2

14719-21-2, name is 2,2,2-Trifluoro-N-(prop-2-yn-1-yl)acetamide, belongs to amides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 14719-21-2

B. PREPARATION OF 5-(3-TRIFLUOROACETAMIDO1-PROPYNYL)2′-DEOXYCYTIDINE (56) Iodide 55 (353.1 mg, 1.00 mmol) was coupled for 4 h to N-propargyltrifluoroacetamide following the general procedure given in EXAMPLE 1C. Chomatography of the crude product with a 0-20% methanol in dichloromethane gradient afforded 3.84 g, (102%) of white powder after vacuum drying overnight. This material was homogeneous by TLC, but tenaciously retained solvent. Recrystallization of this powder from boiling isopropanol (10 mL) and cooling to -20 afforded 299.6 mg (74%) alkynylamino nucleoside 56 as white needles (mp 168-170). NMR showed that the recrystallized product was homogeneous and that the crystals contained 0.5 molecules of isopropanol per molecule of product 56.

The synthetic route of 14719-21-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; E. I. Du Pont de Nemours and Company; US5047519; (1991); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application of 14719-21-2, The chemical industry reduces the impact on the environment during synthesis 14719-21-2, name is 2,2,2-Trifluoro-N-(prop-2-yn-1-yl)acetamide, I believe this compound will play a more active role in future production and life.

A solution of compound 57 (50 mg, 0.08 mmol), N-propargyltrifluoroacetylamide (117 mg, 0.8 mmol), tetrakis(triphenylphosphine)-palladium(0) (18 mg, 0.02 mmol), Cul (5.9 mg, 0.03 mmol), and Et3N (48 mu?, 0.34 mmol) in anhydrous DMF (3.0 mL) was stirred at 50 C for 12 hours. The mixture was concentrated in vacuo and the residue was purified by silica gel column chromatography to yield 7-{(5)-l-[5-methoxy-4-(3-trifluoroacetamido-l-propynyl)-2-nitrophenyl]-2,2-dimethyl-propyloxy}methyl-7-deaza-2′-deoxyguanosine 58 (50 mg, 96%). 1H NMR (400 MHz, MeOH-d4): delta 7.87 (s, 1 H, Ph-H), 7.26 (s, 1 H, Ph-H), 6.84 (s, 1 H, H-8), 6.20 (m, 1 H, H-l ‘), 5.25 (s, 1 H, Ph-CH), 4.67 (d, 1 H, J = 12.0 Hz, 7-CH2a), 4.54 (d, 1 H, J = 12.0 Hz, 7-CH2b), 4.43 (m, 1 H, H-3 ‘), 4.33 (s, 2 H, CH2), 3.95 (s, 3 H, OCH3), 3.89 (m, 1 H, H-4′), 3.70 (m, 2 H, H-5’), 2.46 (m, 1 H, H-2’a), 2.18 (m, 1 H, H-2’b), 0.86 (s, 9 H, (CH3)3).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,2,2-Trifluoro-N-(prop-2-yn-1-yl)acetamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; LASERGEN, INC.; STUPI, Brian, Philip; LI, Hong; WU, Weidong; HERSH, Megan, N.; HERTZOG, David; MORRIS, Sidney, E.; METZKER, Michael, L.; WO2013/40257; (2013); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 14719-21-2 as follows. category: amides-buliding-blocks

Vl.j .dN-[3-(6-Benzyloxy-pyridazin-3-yl)-prop-2-vnyl1-2,2,2-trifluoro-acetamide; 16.7 g (50.0 mmol) Trifluoro-methanesulfonic acid 6-benzyloxy-pyridazin-3-yl ester and 15.1 g (100.0 mmol) 2,2,2-trifluoro-N-prop-2-ynyl-acetamide are dissolved in 150 ml THF and 75 ml triethyl amine. 1.4 g (2.0 mmol) bis-(triphenylphosphine)palladiumdichloride and 1.40 g (7.35 mmol) copper-(l)-iodide are added at -5C. The mixture is stirred for 20 hours at RT. After that time the solvent is evaporated. The residue is taken up in ethyl acetate and washed with water. The organic phase is dried over sodium sulphate, the solvent is evaporated. The product is washed with tert-butyl methyl ether and dried at 80C. Yield: 9.50 g (57% of theory),Rf value: 0.50 (silica gel, methylene chloride/ethyl acetate = 5:1 ) M. p. 163-166C C-IeH-I2FsNsO2

According to the analysis of related databases, 14719-21-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2007/48802; (2007); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of 14719-21-2, The chemical industry reduces the impact on the environment during synthesis 14719-21-2, name is 2,2,2-Trifluoro-N-(prop-2-yn-1-yl)acetamide, I believe this compound will play a more active role in future production and life.

A solution of compound 57 (50 mg, 0.08 mmol), N-propargyltrifluoroacetylamide (117 mg, 0.8 mmol), tetrakis(triphenylphosphine)-palladium(0) (18 mg, 0.02 mmol), Cul (5.9 mg, 0.03 mmol), and Et3N (48 mu?, 0.34 mmol) in anhydrous DMF (3.0 mL) was stirred at 50 C for 12 hours. The mixture was concentrated in vacuo and the residue was purified by silica gel column chromatography to yield 7-{(5)-l-[5-methoxy-4-(3-trifluoroacetamido-l-propynyl)-2-nitrophenyl]-2,2-dimethyl-propyloxy}methyl-7-deaza-2′-deoxyguanosine 58 (50 mg, 96%). 1H NMR (400 MHz, MeOH-d4): delta 7.87 (s, 1 H, Ph-H), 7.26 (s, 1 H, Ph-H), 6.84 (s, 1 H, H-8), 6.20 (m, 1 H, H-l ‘), 5.25 (s, 1 H, Ph-CH), 4.67 (d, 1 H, J = 12.0 Hz, 7-CH2a), 4.54 (d, 1 H, J = 12.0 Hz, 7-CH2b), 4.43 (m, 1 H, H-3 ‘), 4.33 (s, 2 H, CH2), 3.95 (s, 3 H, OCH3), 3.89 (m, 1 H, H-4′), 3.70 (m, 2 H, H-5’), 2.46 (m, 1 H, H-2’a), 2.18 (m, 1 H, H-2’b), 0.86 (s, 9 H, (CH3)3).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,2,2-Trifluoro-N-(prop-2-yn-1-yl)acetamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; LASERGEN, INC.; STUPI, Brian, Philip; LI, Hong; WU, Weidong; HERSH, Megan, N.; HERTZOG, David; MORRIS, Sidney, E.; METZKER, Michael, L.; WO2013/40257; (2013); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 14719-21-2, name is 2,2,2-Trifluoro-N-(prop-2-yn-1-yl)acetamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14719-21-2, category: amides-buliding-blocks

To a mixture of 45 (1.96 g, 5.20 mmol), Cul (103 mg, 0.54 mmol) and tetrakis[triphenylphosphine]palladium[0] (317 mg, 0.276 mmol) in 10 ml of anhydrous DMF was added anhydrous triethylamine (1.1 ml) followed by propargyl trifluoroacetimide (1.50 g, 9.88 mmol). The reaction mixture was stirred under argon for 4 h. The solvent DMF was removed by evaporation and the residual oil was purified by silica gel chromatography eluting with 7% methanol in ethyl acetate. The product fractions were pooled and evaporated affording a foam: 2.16 g (99%) yield.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,2,2-Trifluoro-N-(prop-2-yn-1-yl)acetamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Epoch Biosciences, Inc.; US6699975; (2004); B2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application of 14719-21-2, A common heterocyclic compound, 14719-21-2, name is 2,2,2-Trifluoro-N-(prop-2-yn-1-yl)acetamide, molecular formula is C5H4F3NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of compound 61 (80 mg, 0.13 mmol), N-propargyltrifluoroacetylamide (196 mg, 1.30 mmol), tetrakis(triphenylphosphine)-palladium(0) (30 mg, 0.026 mmol), Cul (9.9 mg, 0.052 mmol), and Et3N (80 muGamma) in anhydrous DMF (3.0 mL) was stirred at 50C for 12 hours. The mixture was concentrated in vacuo and the residue was purified by silica gel column chromatography to yield 5-{(5)-l-[5-methoxy-4-(3-trifluoroacetamido-l-propynyl)-2-nitrophenyl]-2,2-dimethyl-propyloxy}methyl-2′-deoxyuridine 62 (75 mg, 90%). 1H NMR (400 MHz, MeOD-d4): 5 8.1 1 (s, 1 Eta, Eta-6), 8.08 (s, 1 Eta, Ph-H), 7.36 (s, 1 H, Ph-H), 6.27 (t, 1 H, J = 6.4 Hz, Eta-Gamma), 5.33 (s, 1 H, Ph-CH), 4.47 (m, 1 H, H-3′), 4.44 (s, 2 H, 5-CH2), 4.32 (d, 2 H, J = 2.0 Hz, CH2), 4.08 (s, 3 H, OCH3), 3.99 (m, 1 H, H-4′), 3.87 (m, 1 H, H-5’a), 3.79 (m, 1 H, H-5’b), 2.30 (m, 2 H, H-2), 0.93 (s, 9 H, C(CH3)3).

The synthetic route of 14719-21-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LASERGEN, INC.; STUPI, Brian, Philip; LI, Hong; WU, Weidong; HERSH, Megan, N.; HERTZOG, David; MORRIS, Sidney, E.; METZKER, Michael, L.; WO2013/40257; (2013); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 14719-21-2, name is 2,2,2-Trifluoro-N-(prop-2-yn-1-yl)acetamide, A new synthetic method of this compound is introduced below., name: 2,2,2-Trifluoro-N-(prop-2-yn-1-yl)acetamide

Add dU-I (0.7mmol, 247mg) to a single-mouth bottle, add 9.7mg CuI and 20.3mg Pd(PPh3)4 to the reaction flask, vacuum, protect with nitrogen, wrap with aluminum foil, add 2.3ml DMF, stir and dissolve. 0.2 ml of TEA was added, and trifluoroethylpropynylamine (254 mg, 1.7 mmol) was weighed and dissolved in DMF, and then added to the above reaction flask, stirred at room temperature, and allowed to react overnight. After the reaction is completed, the solvent is evaporated to dryness under reduced pressure, and then directly separated by column chromatography, and dichloromethane and methanol are mixed at a volume ratio of 20:1 as a leaching agent to obtain dU-F3.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Suzhou Bai Yuan Genes Co., Ltd.; Lanzhou Bai Yuan Genes Co., Ltd.; Che Tuanjie; (40 pag.)CN108752406; (2018); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of 14719-21-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 14719-21-2 as follows.

F1 (0.7 mmol, 247 mg) was added to a single-necked flask and 9.7 mg CuI and 20.3 mg Pd (PPh3) 4 (tetrakistriphenylphosphine) palladium were weighed into a reaction flask. The reaction flask was evacuated, purged with nitrogen and wrapped in aluminum foil , 2.3 ml DMF was added,Stirring to dissolve, adding 0.2ml TEA, weighing F2 (254mg, 1.7mmol) dissolved in DMF was added to the above reaction flask, stirred at room temperature, the reaction overnight.TLC plate monitoring, EA as developing solvent, Rf = 0.35 as the raw material F1, Rf = 0.32 for the product F3, two very close position.After the reaction was over, the solvent was evaporated to dryness under reduced pressure and the residue was directly purified by column chromatography. Elution with 20: 1 DCM: MeOH as eluant gave 214 mg, yield 61%.

According to the analysis of related databases, 14719-21-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shanghai Jiao Tong University; Shen Yumei; Gong Bing; Shao Zhifeng; Zhao Xiaodong; Liu Yazhi; Li Xiaowei; Wu Xinyan; Wei Xiaofei; Tang Daonian; (99 pag.)CN104292117; (2016); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Electric Literature of 14719-21-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 14719-21-2, name is 2,2,2-Trifluoro-N-(prop-2-yn-1-yl)acetamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

step 1: A single jar was charged with compound dG-I (0.25 g, 0.4 mmol) Lmmo 1) and Pd (PPh3) 4 (48 mg; 0.04 mmol) were weighed into a reaction vial, Vacuum, nitrogen protection, wrapped in aluminum, add 10ml DMF, Stirring dissolved, TEA (0. 088 g; 0.8 mmol) and trifluoroacetylpropargylamine (0.2 g; 1.2 mmol) were injected, 50 C stirring 13 hours after the end of the reaction, The residue was dissolved in of ethyl acetate, Washed successively with saturated sodium bicarbonate solution and saturated sodium chloride solution, Dried over anhydrous sodium sulfate, concentrated and purified by column chromatography [V (ethyl acetate): V (n-hexane) = 1: 3] To obtain 0.1 g of a white solid, dG (AP3), in a yield of 39%

The synthetic route of 2,2,2-Trifluoro-N-(prop-2-yn-1-yl)acetamide has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shanghai Jiao Tong University; SHEN, YUMEI; SHAO, ZHIFENG; GONG, BING; LIU, YAZHI; ZHAO, XIAODONG; JIANG, MIN; LI, XIAOWEI; TANG, DAONIAN; WU, XINYAN; (19 pag.)CN103601779; (2016); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of 14719-21-2, The chemical industry reduces the impact on the environment during synthesis 14719-21-2, name is 2,2,2-Trifluoro-N-(prop-2-yn-1-yl)acetamide, I believe this compound will play a more active role in future production and life.

The mixture of compound 3 (500 mg, 1.18 mmol), Pd (PPh3)4 (145 mg,0.12 mmol, 0.1 eq), CuI (44.5 mg, 0.25 mmol, 0.2 eq), N-(2-propynyl)-2,2,2-trifluoroacetamide (1.07 g,7.08 mmol, 6.0 eq) and triethylamine (0.5 mL, 3.54 mmol, 3.0 eq) in DMF (20 mL) was stirred at roomtemperature overnight. Upon completion of the reaction as monitored by TLC, the mixture wasconcentrated under reduced pressure. The residue was purified by flash chromatography on a silicagel column to provided 310 mg of product 17 as a white solid in 60% yield with an HPLC purity of95%. Rf = 0.40 (dichloromethane-methanol = 10:1). 1H NMR (DMSO-d6, 400 MHz) 10.16 (s, 1H, NH),7.03 (s, 2H, NH2), 5.95 (d, 1H, J = 4.2 Hz, 10-H), 5.36 (d, 1H, J = 6.0 Hz, 20-OH), 5.10 (d, J = 4.2 Hz, 1H,30-OH), 4.74 (t, J = 5.6 Hz, 1H, 50-OH), 4.44-4.55 (m, 1H, 20-H), 4.07-4.17 (m, 1H, 30-H), 3.96 (s, 3H,CH3), 3.76-3.88 (m, 1H, 40-H), 3.37-3.56 (m, 2H, CH2). ESI-MS m/z: 447.1 [M + H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,2,2-Trifluoro-N-(prop-2-yn-1-yl)acetamide, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ren, Hang; An, Haoyun; Tao, Jingchao; Molecules; vol. 24; 5; (2019);,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics