Category: 146140-95-6

Kim, Byung-Seok published the artcilePd-Catalyzed Sequential C-C and C-N Bond Formations for the Synthesis of N-Heterocycles: Exploiting Protecting Group-Directed C-H Activation under Modified Reaction Conditions, Safety of (2-Pivalamidophenyl)boronic acid, the publication is Chemistry – An Asian Journal (2011), 6(8), 1952-1957, database is CAplus and MEDLINE.

A Pd-catalyzed domino olefination/conjugate addition reaction of N-Ts-2-arylanilines with activated olefins has been achieved at ambient temperature under the newly defined reaction conditions. This process highlighted the directing effect of the N-protecting group in C-H activation, displayed broad substrate scope with wide functional group compatibility; thus rendering a straightforward entry to a wide variety of N-heterocycles such as dihydrophenanthridines.

Chemistry – An Asian Journal published new progress about 146140-95-6. 146140-95-6 belongs to amides-buliding-blocks, auxiliary class Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (2-Pivalamidophenyl)boronic acid, and the molecular formula is C11H16BNO3, Safety of (2-Pivalamidophenyl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Tapolcsanyi, Pal published the artcileSynthesis of some diazino-fused tricyclic systems via Suzuki cross-coupling and regioselective nitrene insertion reactions, Quality Control of 146140-95-6, the publication is Tetrahedron (2002), 58(51), 10137-10143, database is CAplus.

Suzuki coupling of 5-chloro-2-methyl-6-phenylpyridazin-3(2H)-one, 6-chloro-1,3-dimethyluracil and 2-chloropyrazine with protected aminoaryl boronic acids resulted in the corresponding (pivaloylamino)phenyl diazines which were transformed to diazino-fused indole and cinnoline derivatives Suzuki coupling of 5-amino-6-chloro-1,3-dimethyluracil with 2-formylphenyl boronic acid afforded a novel pyrimidoisoquinoline ring system in a one-pot reaction. For example, Suzuki coupling of 5-chloro-2-methyl-6-phenyl-3(2H)-pyridazinone with [2-[(2,2-dimethyl-1-oxopropyl)amino]phenyl]boronic acid gave 2-methyl-6-phenyl-5-[2-(pivaloyl)amino]-3(2H)-pyridazinone which was deprotected to give 5-(2-aminophenyl)-2-methyl-6-phenyl-3(2H)-Pyridazinone (I). Diazotization and sequential azidization of I gave 5-(2-azidophenyl)-2-methyl-6-phenyl-3(2H)-pyridazinone which was cyclized to give 3,5-dihydro-3-methyl-1-phenyl-4H-pyridazino[4,5-b]indol-4-one (II).

Tetrahedron published new progress about 146140-95-6. 146140-95-6 belongs to amides-buliding-blocks, auxiliary class Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (2-Pivalamidophenyl)boronic acid, and the molecular formula is C7H7ClN2S, Quality Control of 146140-95-6.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Krajsovszky, Gabor published the artcileSuzuki-aza-Wittig, Suzuki-condensation and aza-Wittig-electrocyclic ring-closure tandem reactions for synthesis of fused nitrogen-containing ring systems, Recommanded Product: (2-Pivalamidophenyl)boronic acid, the publication is ARKIVOC (Gainesville, FL, United States) (2011), 229-253, database is CAplus.

Tandem combinations of Suzuki-aza-Wittig, Suzuki-condensation, and aza-Wittig-electrocyclic ring closure reactions for the synthesis of new pyridazino[4,5-c]isoquinolinone, pyridazino[4,5-c]quinolinone, and pyrimido[5,4-c]quinoline derivatives were described.

ARKIVOC (Gainesville, FL, United States) published new progress about 146140-95-6. 146140-95-6 belongs to amides-buliding-blocks, auxiliary class Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (2-Pivalamidophenyl)boronic acid, and the molecular formula is C11H16BNO3, Recommanded Product: (2-Pivalamidophenyl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Beletskiy, Evgeny V. published the artcileSelective binding and extraction of aqueous dihydrogen phosphate solutions via three-armed thiourea receptors, Related Products of amides-buliding-blocks, the publication is Organic & Biomolecular Chemistry (2015), 13(38), 9844-9849, database is CAplus and MEDLINE.

A series of neutral anion receptors with one to three thiourea arms were synthesized and their binding to tetrabutylammonium chloride, acetate, and dihydrogen phosphate salts in aqueous DMSO mixtures was examined The three-armed thiourea host was found to strongly and selectively bind H₂PO₄^– even in DMSO solutions containing up to 30% water. This enabled the dihydrogen phosphate salt to be extracted from water into chloroform in its dibasic form despite the high heat of the hydration of HPO₄^2-.

Organic & Biomolecular Chemistry published new progress about 146140-95-6. 146140-95-6 belongs to amides-buliding-blocks, auxiliary class Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (2-Pivalamidophenyl)boronic acid, and the molecular formula is C11H16BNO3, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Csanyi, D. published the artcileSynthesis of two new heteroaromatic β-carboline-fused pentacycles. observation of a new intercalating agent, Product Details of C11H16BNO3, the publication is Bioorganic & Medicinal Chemistry Letters (2000), 10(15), 1767-1769, database is CAplus and MEDLINE.

Five-step synthetic routes of two new polyfused heterocycles: indazolo[3,2-a]-ss-carboline (3) and benzo[4′,5′][1,2,3]triazino[6,1-a]-ss-carbolinium salt (10) applying Pd(0)-catalyzed cross-coupling reaction were elaborated.

Bioorganic & Medicinal Chemistry Letters published new progress about 146140-95-6. 146140-95-6 belongs to amides-buliding-blocks, auxiliary class Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (2-Pivalamidophenyl)boronic acid, and the molecular formula is C11H16BNO3, Product Details of C11H16BNO3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Grimes, Kimberly D. published the artcileCopper(II)-catalyzed conversion of aryl/heteroaryl boronic acids, boronates, and trifluoroborates into the corresponding azides: substrate scope and limitations, Safety of (2-Pivalamidophenyl)boronic acid, the publication is Synthesis (2010), 1441-1448, database is CAplus and MEDLINE.

We report the copper(II)-catalyzed conversion of organoboron compounds into the corresponding azide derivatives A systematic series of phenylboronic acid derivatives is evaluated to examine the importance of steric and electronic effects of the substituents on reaction yield as well as functional group compatibility. Heterocyclic substrates are also shown to participate in this mild reaction while compounds incorporating B-C(sp³) bonds are unreactive under the reaction conditions. The copper(II)-catalyzed boronic acid-azide coupling reaction is further extended to both boronate esters and potassium organotrifluoroborate salts. The method described herein complements existing procedures for the preparation of aryl azides from the resp. amino, triazene, and halide derivatives and we expect that it will greatly facilitate copper- and ruthenium-catalyzed azide-alkyne cycloaddition reactions for the preparation of diversely functionalized 1-aryl- or 1-heteroaryl-1,2,3-triazoles derivatives

Synthesis published new progress about 146140-95-6. 146140-95-6 belongs to amides-buliding-blocks, auxiliary class Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (2-Pivalamidophenyl)boronic acid, and the molecular formula is C11H16BNO3, Safety of (2-Pivalamidophenyl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Charifson, Paul S. published the artcileNovel Dual-Targeting Benzimidazole Urea Inhibitors of DNA Gyrase and Topoisomerase IV Possessing Potent Antibacterial Activity: Intelligent Design and Evolution through the Judicious Use of Structure-Guided Design and Structure-Activity Relationships, COA of Formula: C11H16BNO3, the publication is Journal of Medicinal Chemistry (2008), 51(17), 5243-5263, database is CAplus and MEDLINE.

The discovery of new antibacterial agents with novel mechanisms of action is necessary to overcome the problem of bacterial resistance that affects all currently used classes of antibiotics. Bacterial DNA gyrase and topoisomerase IV are well-characterized clin. validated targets of the fluoroquinolone antibiotics which exert their antibacterial activity through inhibition of the catalytic subunits. Inhibition of these targets through interaction with their ATP sites has been less clin. successful. The discovery and characterization of a new class of low mol. weight, synthetic inhibitors of gyrase and topoisomerase IV that bind to the ATP sites are presented. The benzimidazole ureas are dual targeting inhibitors of both enzymes and possess potent antibacterial activity against a wide spectrum of relevant pathogens responsible for hospital- and community-acquired infections. The discovery and optimization of this novel class of antibacterials by the use of structure-guided design, modeling, and structure-activity relationships are described. Data are presented for enzyme inhibition, antibacterial activity, and in vivo efficacy by oral and i.v. administration in two rodent infection models.

Journal of Medicinal Chemistry published new progress about 146140-95-6. 146140-95-6 belongs to amides-buliding-blocks, auxiliary class Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (2-Pivalamidophenyl)boronic acid, and the molecular formula is C11H16BNO3, COA of Formula: C11H16BNO3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Salives, Richard published the artcileSolid-phase syntheses of 6-arylpyridazin-3(2H)-ones, COA of Formula: C11H16BNO3, the publication is Journal of Combinatorial Chemistry (2005), 7(3), 414-420, database is CAplus and MEDLINE.

The 3-chloropyridazine moiety was immobilized on a Wang resin, using two different methodologies. The first of these involved direct nucleophilic substitution of 3,6-dichloropyridazine with the alcoholate of Wang resin. The exptl. conditions were optimized. The second method involved a Mitsunobu reaction between the Wang resin and 6-chloropyridazin-3-ol during which a problem of regioselectivity was observed The so-obtained chloropyridazine-containing resins were subsequently reacted with various arylboronic acids under Suzuki conditions. Acid cleavage yielded 6-arylpyridazin-3(2H)-ones, e.g., I, with high chem. purity.

Journal of Combinatorial Chemistry published new progress about 146140-95-6. 146140-95-6 belongs to amides-buliding-blocks, auxiliary class Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (2-Pivalamidophenyl)boronic acid, and the molecular formula is C11H16BNO3, COA of Formula: C11H16BNO3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Horvath, Daniel Vajk published the artcileRegioexhaustive Functionalization of the Carbocyclic Core of Isoquinoline: Concise Synthesis of Oxoaporphine Core and Ellipticine, Formula: C11H16BNO3, the publication is Synthesis (2018), 50(11), 2181-2190, database is CAplus.

A general and versatile strategy has been developed for the functionalization of the carbocyclic core of the isoquinoline. This regioexhaustive approach employs electrophilic halogenation as a toolbox methodol. and delivers highly decorated intermediates that can be further elaborated toward medicinally relevant building blocks or natural products.

Synthesis published new progress about 146140-95-6. 146140-95-6 belongs to amides-buliding-blocks, auxiliary class Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (2-Pivalamidophenyl)boronic acid, and the molecular formula is C11H16BNO3, Formula: C11H16BNO3.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Appukkuttan, Prasad published the artcileMicrowave-Enhanced Synthesis of N-Shifted Buflavine Analogues via a Suzuki-Ring-Closing Metathesis Protocol, Related Products of amides-buliding-blocks, the publication is Organic Letters (2005), 7(13), 2723-2726, database is CAplus and MEDLINE.

A novel, microwave-enhanced six-step synthesis was devised for the synthesis of N-shifted buflavine analogs, I (R = H, OMe). Microwave-enhanced Suzuki-Miyaura cross-coupling and ring-closing metathesis reactions were used as the key steps. Microwave irradiation was found to enhance the ring-closing metathesis reaction to generate the otherwise difficultly obtainable medium-sized ring system of the target mols.

Organic Letters published new progress about 146140-95-6. 146140-95-6 belongs to amides-buliding-blocks, auxiliary class Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (2-Pivalamidophenyl)boronic acid, and the molecular formula is C11H16BNO3, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics