Category: 146140-95-6

Guillier, F. published the artcileSynthesis of 4,5-disubstituted benzo[c][2,7]naphthyridines by combined metalation-palladium-catalyzed cross-coupling strategies. Preparation of 8H-pyrido[4,3,2-mn]acridone as a model of cystodytin alkaloids, Related Products of amides-buliding-blocks, the publication is Synthetic Communications (1996), 26(23), 4421-4436, database is CAplus.

A short and efficient synthesis of 8H-pyrido[4,3,2-mn]acridone (I) was achieved. The strategy involves the preparation of 4-chloro-5-methylbenzo[c][2,7]naphtyridine (II), as key intermediate, by metalation and palladium catalyzed cross-coupling reaction. A second cross-coupling reaction and subsequent oxidation by SeO₂ led to I.

Synthetic Communications published new progress about 146140-95-6. 146140-95-6 belongs to amides-buliding-blocks, auxiliary class Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (2-Pivalamidophenyl)boronic acid, and the molecular formula is C11H16BNO3, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Guillier, F. published the artcileAn original one-pot synthesis of 5-(4-pyridyl)-benzo[c]-2,7-naphthyridine as key intermediate in the synthesis of amphimedine by metalation connected with cross-coupling reaction, Computed Properties of 146140-95-6, the publication is Tetrahedron Letters (1994), 35(35), 6489-92, database is CAplus.

A short new route to 4,5-disubstituted-benzo[c]-2,7-naphthyridines has been developed. The strategy involves directed ortho metalation of pyridines following by an halogen dance reaction and biaryl cross-coupling as key steps. A concise and efficient one-pot synthesis of 4-chloro-5-(4-pyridyl)-benzo[c]-2,7-naphthyridine (I), as a key intermediate in the synthesis of amphimedine is described.

Tetrahedron Letters published new progress about 146140-95-6. 146140-95-6 belongs to amides-buliding-blocks, auxiliary class Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (2-Pivalamidophenyl)boronic acid, and the molecular formula is C11H16BNO3, Computed Properties of 146140-95-6.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Guillier, F. published the artcileCombined Metalation-Palladium-Catalyzed Cross Coupling Strategies. A Formal Synthesis of the Marine Alkaloid Amphimedine, Name: (2-Pivalamidophenyl)boronic acid, the publication is Journal of Organic Chemistry (1995), 60(2), 292-6, database is CAplus.

The synthesis of 5-(4-pyridyl)benzo[c][2,7]naphthyridin-4-one (I), an intermediate previously employed in a total synthesis of the marine alkaloid, amphimedine (II), is reported. The route comprises the Pd-catalyzed Suzuki cross coupling of a pyridylborane with 2-iodoaniline to give the azabiaryl III, which upon LDA-mediated cyclization and triflation leads to benzonaphthyridine IV. Stille cross coupling of IV with a pyridylstannane affords the pyridylbenzonaphthyridine, which upon BBr₃ treatment leads to I.

Journal of Organic Chemistry published new progress about 146140-95-6. 146140-95-6 belongs to amides-buliding-blocks, auxiliary class Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (2-Pivalamidophenyl)boronic acid, and the molecular formula is C11H16BNO3, Name: (2-Pivalamidophenyl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Duvey, G. published the artcileReactivity of 4-chlorobenzo[c][2,7]naphthyridines towards Pd(0) catalyzed coupling reactions and nucleophilic substitutions. Aroylation by nucleophilic substitution with analogues of acyl anions, Computed Properties of 146140-95-6, the publication is Journal of Heterocyclic Chemistry (2001), 38(5), 1039-1044, database is CAplus.

Various 4-substituted benzo[c][2,7]naphthyridines were prepared from the corresponding 4-chloro derivative by Pd(0) coupling reaction or nucleophilic substitution. More particularly, 4-aroylbenzo[c][2,7]naphthyridines were synthesized by aroylation with arenecarboxaldehydes in the presence of 1,3-dimethylimidazolium iodide.

Journal of Heterocyclic Chemistry published new progress about 146140-95-6. 146140-95-6 belongs to amides-buliding-blocks, auxiliary class Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (2-Pivalamidophenyl)boronic acid, and the molecular formula is C11H16BNO3, Computed Properties of 146140-95-6.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Nakahara, Shinsuke published the artcileSynthesis of neoamphimedine, Recommanded Product: (2-Pivalamidophenyl)boronic acid, the publication is Heterocycles (2012), 85(4), 933-940, database is CAplus.

The synthesis of neoamphimedine {(I), from Xestospongia sp.}, which is a potent antitumor agent both in vitro and in vivo, also can induce topoisomerase II-mediated catenation of plasmid DNA in vitro. The synthesis was achieved in twelve steps from 2,5-dimethoxyphenethylamine in 6% overall yield.

Heterocycles published new progress about 146140-95-6. 146140-95-6 belongs to amides-buliding-blocks, auxiliary class Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (2-Pivalamidophenyl)boronic acid, and the molecular formula is C11H16BNO3, Recommanded Product: (2-Pivalamidophenyl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Riedl, Zsuzsanna published the artcileSynthesis of novel 1-methyl-1H-pyridazino[3,4-b]indoles, Quality Control of 146140-95-6, the publication is Tetrahedron (2006), 62(1), 121-129, database is CAplus.

New synthetic pathways have been elaborated to 1-methyl-1H-pyridazino[3,4-b]indoles starting from halopyridazin-3(2H)-ones. Suzuki cross-coupling reaction of chloro, iodo, dichloro, and dibromo substituted pyridazin-3(2H)-ones with 2-pivaloylaminophenylboronic acid followed by hydrolysis of the amide and subsequent ring closure via condensation gave fused indoles. Some of these compounds showed biol. activity as antitrypanosomal agents.

Tetrahedron published new progress about 146140-95-6. 146140-95-6 belongs to amides-buliding-blocks, auxiliary class Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (2-Pivalamidophenyl)boronic acid, and the molecular formula is C11H16BNO3, Quality Control of 146140-95-6.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Trecourt, Francois published the artcileSynthesis of 7H-pyrido[2,3-c]carbazoles from 5-bromo-8-methoxyquinolines via coupling and azide cyclization reactions, Quality Control of 146140-95-6, the publication is Journal of Heterocyclic Chemistry (1995), 32(4), 1261-7, database is CAplus.

A new strategy for the synthesis of substituted 7H-pyrido[2,3-c]carbazoles has been developed from substituted 5-bromoquinolines by using cross-coupling reaction with (2-aminophenyl)boric acids, followed by a regioselective azide cyclization.

Journal of Heterocyclic Chemistry published new progress about 146140-95-6. 146140-95-6 belongs to amides-buliding-blocks, auxiliary class Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (2-Pivalamidophenyl)boronic acid, and the molecular formula is C8H15ClN2, Quality Control of 146140-95-6.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Rebstock, Anne-Sophie published the artcileSynthesis and deprotonation of 2-(pyridyl)phenols and 2-(pyridyl)anilines, SDS of cas: 146140-95-6, the publication is Organic & Biomolecular Chemistry (2003), 1(17), 3064-3068, database is CAplus and MEDLINE.

2-(2- And 3-Pyridyl)anilines, 2,2-dimethyl-N-[2-(2- and 3-pyridyl)phenyl]propanamides, and 2-, 3- and 4-(2-methoxyphenyl)pyridines are readily synthesized using cross-coupling reactions. Whereas 2-(3-pyridinyl)benzenamine and 2-(2-pyridinyl)benzenamine undergo side reactions, the corresponding 2,2-dimethyl-N-[2-(2-pyridinyl)phenyl]propanamide and 2,2-dimethyl-N-[2-(3-pyridinyl)phenyl]propanamide (amides) are deprotonated with lithium 2,2,6,6-tetramethylpiperidide. When 2-(2-methoxyphenyl)pyridine (ether) is subjected to the same reagent, lithiation occurs at C6′.

Organic & Biomolecular Chemistry published new progress about 146140-95-6. 146140-95-6 belongs to amides-buliding-blocks, auxiliary class Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (2-Pivalamidophenyl)boronic acid, and the molecular formula is C11H16BNO3, SDS of cas: 146140-95-6.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Van Baelen, Gitte published the artcileSynthesis of 6-methyl-6H-indolo[3,2-c]isoquinoline and 6-methyl-6H-indolo[2,3-c]isoquinoline: two new unnatural isoquinoline isomers of the cryptolepine series, Safety of (2-Pivalamidophenyl)boronic acid, the publication is Tetrahedron (2008), 64(51), 11802-11809, database is CAplus.

11H-indolo[3,2-c]isoquinoline has been synthesized in two steps starting from 4-bromoisoquinoline and 2-bromoaniline via a selective Buchwald-Hartwig reaction followed by a Pd-catalyzed intramol. direct arylation involving C(sp²)-H activation. The synthesis of 7H-indolo[2,3-c]isoquinoline was achieved by a combination of a Suzuki reaction with an intramol. nitrene insertion reaction starting from 4-bromoisoquinoline and {2-[(2,2-dimethylpropanoyl)amino]phenyl}boronic acid. Selective methylation of the tetracyclic skeletons yielded the title compounds 6-methyl-6H-indolo[3,2-c]isoquinoline and 6-methyl-6H-indolo[2,3-c]isoquinoline, which have never been described in the literature before. The antiprotozoal activity and cytotoxicity of the title compounds was tested.

Tetrahedron published new progress about 146140-95-6. 146140-95-6 belongs to amides-buliding-blocks, auxiliary class Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (2-Pivalamidophenyl)boronic acid, and the molecular formula is C3H8N2S, Safety of (2-Pivalamidophenyl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Krajsovszky, Gabor published the artcileNew synthetic approach to pyridazino[4,5-b]indoles by Pd(0)-catalyzed cross-coupling reaction, HPLC of Formula: 146140-95-6, the publication is Heterocycles (2001), 55(6), 1105-1111, database is CAplus.

5-Iodo-2-methylpyridazin-3(2H)-one readily underwent Suzuki coupling with protected anilinoboronic acids I (X = H, Cl) to yield the corresponding arylpyridazinones which proved to be suitable starting compounds to a ring closure – a 4 step pathway – to pyridazino[4,5-b]indoles II.

Heterocycles published new progress about 146140-95-6. 146140-95-6 belongs to amides-buliding-blocks, auxiliary class Boronic acid and ester,Amine,Benzene,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (2-Pivalamidophenyl)boronic acid, and the molecular formula is C11H16BNO3, HPLC of Formula: 146140-95-6.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics