《Sterically Congested 2,6-Disubstituted Anilines from Direct C-N Bond Formation at an Iodine(III) Center》 was published in Angewandte Chemie, International Edition in 2016. These research results belong to Lucchetti, Nicola; Scalone, Michelangelo; Fantasia, Serena; Muniz, Kilian. Name: 5-Oxopyrrolidine-3-carboxamide The article mentions the following:
2,6-Disubstituted anilines are readily prepared from the direct reaction between amides and diaryliodonium salts. As demonstrated for 24 different examples, the reaction is of unusually broad scope with respect to the sterically congested arene and the nitrogen source, occurs without the requirement for any addnl. promoter, and proceeds through a direct reductive elimination at the iodine(III) center. The efficiency of the coupling procedure is further demonstrated within the short synthesis of a chemerin binding inhibitor. The results came from multiple reactions, including the reaction of 5-Oxopyrrolidine-3-carboxamide(cas: 14466-21-8Name: 5-Oxopyrrolidine-3-carboxamide)
5-Oxopyrrolidine-3-carboxamide(cas: 14466-21-8) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Name: 5-Oxopyrrolidine-3-carboxamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics