Category: 144-80-9

On August 31, 2021, Liu, Yanhua; Chen, Yu; Feng, Mengjuan; Chen, Jianqiu; Shen, Weitao; Zhang, Shenghu published an article.Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide The title of the article was Occurrence of antibiotics and antibiotic resistance genes and their correlations in river-type drinking water source, China. And the article contained the following:

The occurrence and distribution of antibiotics and antibiotic resistance genes (ARGs) in natural water has attracted worldwide attention. Antibiotic and ARG pollution in the surface water of drinking water sources might directly/indirectly affect human health. In this study, the distribution of 38 antibiotics, 10 ARGs, 2 integrons, and 16S r DNA in river-type water sources in a large city of China were monitored in winter, which was a period with high level of antibiotic pollution. The results showed that 20 antibiotics were detected with different detection frequencies. The antibiotic pollution in Dec. 2019 was relatively high, with the total concentrations of antibiotics ranging from 281.95 to 472.42 ng/L, followed by that in Jan. 2020 (191.70-337.29 ng/L) and Nov. 2019 (161.25-309.72 ng/L). Sulfacetamide was dominant in Nov. 2019 (23.52-219.00 ng/L) and in Jan. 2020 (113.18-209 ng/L), while norfloxacin in Dec. 2019 (146.72-290.20 ng/L). All the target antibiotics posed low or medium risk for aquatic organisms, and posed low health risk for mankind. Sul1 and erm36 were the predominant ARGs, and intI1 was the predominant integron in drinking water sources. Only tetA showed pos. correlations with its corresponding antibiotic (tetracycline). The rest of ARGs showed no correlations with antibiotics or pos. / neg. correlations with their non-corresponding antibiotics. Overall, the antibiotics and ARG pollution in these water sources was relatively low. These findings provided some reference data for the distribution of antibiotics and ARGs in river-type drinking water sources of large cities in China. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide

The Article related to antibiotics antibiotic resistance gene drinking water pollution china, antibiotic residues, antibiotic resistance genes, risk assessment, river-type drinking water, yangtze river and other aspects.Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On November 30, 2022, Wang, Pu; Lou, Xiaoyi; Chen, Qianqian; Liu, Yujing; Sun, Xiaohu; Guo, Yaoguang; Zhang, Xiaojiao; Wang, Ruixue; Wang, Zhaohui; Chen, Shuai; Zhang, Li; Zhang, Rui-Qin; Guan, Jie published an article.Application In Synthesis of N-((4-Aminophenyl)sulfonyl)acetamide The title of the article was Spent LiFePO4: An old but vigorous peroxymonosulfate activator for degradation of organic pollutants in water. And the article contained the following:

Iron-based catalysts have been demonstrated to activate peroxymonosulfate (PMS) to generate reactive radicals, which is however limited by their complex preparation process, high costs and inefficiency for practical applications. Herein we obtain spent LiFePO4 (SLFP), with powerful catalytic capacity by a simple one-step treatment of the retired LiFePO4 cathode material, for PMS activation to decontaminate organic pollutants. Lithium defects and oxygen vacancies in SLFP play critical roles for PMS utilization, further confirmed by d. functional theory (DFT) calculations SLFP materials rapidly adsorb PMS, and the surface PMS is activated by Fe(II) to generate radicals, with ·OH playing a major role for the degradation of organics after multi-step reactions. The SLFP/PMS process is finally validated for ability to remove organic contaminants and potential environmental application. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Application In Synthesis of N-((4-Aminophenyl)sulfonyl)acetamide

The Article related to iron lithium phosphate catalyst peroxymonosulfate activator organic pollutant degradation, advanced oxidation processes, catalysis, hydroxyl radical, peroxymonosulfate, quantum chemical calculations and other aspects.Application In Synthesis of N-((4-Aminophenyl)sulfonyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 31, 2021, Zhao, Wentao; Jiang, Rui; Guo, Wenping; Guo, Chao; Li, Shilei; Wang, Juanqiang; Wang, Shouwei; Li, Yingying published an article.Product Details of 144-80-9 The title of the article was Screening and Analysis of Multiclass Veterinary Drug Residues in Animal Source Foods using UPLC-Q-Exactive Orbitrap/MS. And the article contained the following:

A rapid, simple, and sensitive method of detecting veterinary drug residues in animal food sources, including poultry and pork, was developed and validated. The method was optimized for over 155 veterinary drugs of 21 different classes. Sample pretreatment included a simple solid-liquid extraction step with 0.2% formic acid-acetonitrile-water and a purification step with a PRiME HLB (hydrophile-lipophile balance) solid-phase extraction cartridge. Data were collected using ultra-high-performance liquid chromatog. coupled to Quadrupole-Exactive Orbitrap mass spectrometry. The limits of detection of 155 veterinary drugs ranged from 0.1μg/kg to 10μg/kg. The recovery rates were between 79.2 and 118.5% in all matrixes studied, with relative standard deviation values less than 15% (n = 6). The evaluated method allows the reliable screening, quantification, and identification of 155 veterinary drug residues in animal source food and has been successfully applied in authentic samples. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Product Details of 144-80-9

The Article related to veterinary drug residue animal source food uplcqexactive orbitrap ms, animal source foods, qualitative screening, quantitative determination, uplc-q-exactive orbitrap/ms, veterinary drug residues and other aspects.Product Details of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 20, 2021, Zhang, Lili; Zhang, Cheng; Lian, Keting; Ke, Dongfang; Xie, Ting; Liu, Chongxuan published an article.Synthetic Route of 144-80-9 The title of the article was River restoration changes distributions of antibiotics, antibiotic resistance genes, and microbial community. And the article contained the following:

Although river restoration has been increasingly implemented to restore water quality in ecosystems, its effect on the removal of emerging pollutant antibiotics, and their resultant influence on microbial community structure and functions in river water is still unclear. This study investigated the changes of antibiotics, antibiotic resistant genes (ARGs), microbial communities, and their spatial distributions in a megacity river before and after river restoration. Results indicated that although the restoration activities including riverbed dredging, riverbank hardening, sewage and storm water separation and re-pipelining improved water quality such as by decreasing total phosphorus (TP) content from 4.60 mg/L in 2018 to 0.98 mg/L in 2020, the antibiotic concentrations in river water increased. Total antibiotic concentrations in the water samples were higher in 2020 (506.89-6952.50 ng/L) than those in 2018 (137.93-1751.51 ng/L), likely caused by increased usage of antibiotics in 2020 for COVID-19 treatment. The spatial distributions of antibiotics were less varied likely as a result of less retardation and fast mixing during antibiotic transport. The result also found that the abundance of Actinobacteria and Proteobacteria, and their correlations with ARGs increased. The spatial distributions of ARGs and microbial communities became less varied in the river water, consistent with the antibiotic variations before and after river restoration. Physicochem. changes such as decreased TP and dissolved organic carbon content may also be a factor. The results indicated that the current river restoration efforts were not effective in removing antibiotics, and implied that further studies are needed to investigate their subsequent transformation and transport, and to assess their risks to the health of ecosystems. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Synthetic Route of 144-80-9

The Article related to antibiotic resistance gene microorganism maozhou river restoration, antibiotic resistance genes, antibiotics, maozhou river, river contamination, river restoration, riverine microbial community and other aspects.Synthetic Route of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 1, 2022, Han, Yu; Hu, Li-Xin; Liu, Ting; Liu, Jing; Wang, Yu-Qing; Zhao, Jia-Hui; Liu, You-Sheng; Zhao, Jian-Liang; Ying, Guang-Guo published an article.Application of 144-80-9 The title of the article was Non-target, suspect and target screening of chemicals of emerging concern in landfill leachates and groundwater in Guangzhou, South China. And the article contained the following:

Landfill sites have been regarded as a significant source of chems. of emerging concern (CECs) in groundwater. However, our understanding about the compositions of CECs in landfill leachate and adjacent groundwater is still very limited. Here we investigated the CECs in landfill leachates and groundwater of Guangzhou in South China by target, suspect and non-target anal. using high-resolution mass spectrometry (HRMS). A variety of CECs (n = 242), including pharmaceuticals (n = 64), pharmaceutical intermediates (n = 18), personal care products (n = 9), food additives (n = 18), industrial chems. (n = 82, e.g., flame retardants, plasticizers, antioxidants and catalysts), pesticides (n = 26), transformation products (n = 8) and other organic compounds (n = 17) were (tentatively) identified by non-target and suspect screening. 142 CECs were quantitated with target anal., and among them 37, 24 and 27 CECs were detected resp. in the raw leachate (272-1780μg/L), treated leachate (0.25-0.81μg/L) and groundwater (0.10-53.7μg/L). The CECs in the raw leachates were efficiently removed with the removal efficiencies greater than 88.7%. Acesulfame, bisphenol F and ketoprofen were the most abundant compounds in both treated leachate and groundwater. The CECs in groundwater was found most likely to be originated from the landfill sites. Our results highlight the importance of non-target screening in identifying CECs, and reveal the contamination risk of groundwater by landfill leachate. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Application of 144-80-9

The Article related to chem target screening landfill leachates groundwater guangzhou south china, chemicals of emerging concern, groundwater, high-resolution mass spectrometry, landfill leachate, non-target analysis and other aspects.Application of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wang, Yixiao; Li, Jinhua; Ji, Ling; Chen, Lingxin published an article in 2022, the title of the article was Simultaneous Determination of Sulfonamides Antibiotics in Environmental Water and Seafood Samples Using Ultrasonic-Assisted Dispersive Liquid-Liquid Microextraction Coupled with High Performance Liquid Chromatography.Safety of N-((4-Aminophenyl)sulfonyl)acetamide And the article contains the following content:

The residues and abuse of antibiotics have seriously endangered ecol. balance and human health; meanwhile, antibiotics determination is very difficult because of their low levels and multiple categories in complicated matrixes. Appropriate sample pretreatment is usually imperative to enrich (ultra)trace antibiotics and eliminate matrix interference prior to chromatog. anal. Dispersive liquid-liquid microextraction (DLLME) has become an ideal pretreatment technique owing to its simplicity, effectiveness, low-consumption, etc. In this work, an ultrasonic-assisted DLLME (UA-DLLME) was developed for the simultaneous extraction of seven sulfonamides (SAs) antibiotics in environmental water and seafood samples coupled with HPLC-DAD determination Several parameters affecting UA-DLLME efficiency were systematically optimized, and consequently the SAs were separated and detected within 14.5 min. The obtained limits of detection (LODs) and limits of quantification (LOQs) ranged from 0.7-7.8 μg/L and 2.4-26.0 μg/L for three water samples (seawater, aquaculture wastewater and lake water) and two seafood samples (pomfrets and shrimps). High recoveries (80.0-116.0%) with low relative standard deviations (0.1-8.1%) were achieved for all the tested samples at three spiked levels. Notably, sulfadimethoxine was found at 24.49 μg/L in one seawater sample. The facile, robust and benign DLLME-HPLC method demonstrated promising perspectives for multiresidue anal. of antibiotics. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Safety of N-((4-Aminophenyl)sulfonyl)acetamide

The Article related to seafood sulfonamide antibiotic determination uadllme high performance liquid chromatog, dispersive liquid-liquid microextraction, environmental water, seafood samples, sulfonamides antibiotics, ultrasonic-assisted and other aspects.Safety of N-((4-Aminophenyl)sulfonyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 31, 2021, Gouda, Moustafa A.; Barnawi, Ibrahim O. published an article.Related Products of 144-80-9 The title of the article was Synthesis and cytotoxic activity of some new pyrazolo[1,5-a]pyrimidine derivatives. And the article contained the following:

A series of arylazopyrazolones II [R = amino, hydroxy, acetamido, etc] was synthesized through treatment of the 3-aminopyrazolin-5-one with the appropriate diazonium salts, followed by cyclization of the resulted arylazopyrazolones II [R = hydroxy, (4,6-dimethylpyrimidin-2-yl)amino] and I [R = (4,6-dimethylpyrimidin-2-yl)amino] with acetylacetone in boiling acetic acid. Using doxorubicin as the reference drug, the in-vitro cytotoxic activity of the synthetic arylazopyrazoles II [R = amino, hydroxy, acetamido, etc] and I [R = amino, thiazol-2-ylamino, (4,6-dimethylpyrimidin-2-yl)amino] was evaluated on four human cell lines. The results revealed that compounds II [R = amino, hydroxy, acetamido, etc] revealed good cytotoxic activity toward HepG2, HCT-116, MCF-7, and PC3 cell lines, within IC50 5.89±0.4-19.23±1.6; 7.15±0.6-23.15±1.8; 4.93±0.4-24.35±1.9; and 9.14±0.8-32.09±2.0μg/mL. The derivatives II [R = amino, acetamido, guanidino] displayed accurate anticancer activity toward all most cancers cell lines, even as compounds I [R = thiazol-2-ylamino] exhibited moderate activities, while the pyrazolopyrimidine I [R = amino] has lower anticancer activity. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Related Products of 144-80-9

The Article related to aryl diazonium chloride aminopyraxolone coupling reaction, oxo aminopyrzolyl sulfonylphenyl hydrazine preparation acetyl acetone heterocyclization, dimethyl oxo dihydropyrazolopyrimidinyl diazenylbenzenesulfonamide preparation antitumor sar and other aspects.Related Products of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 5, 2021, Hain, Ethan; Adejumo, Hollie; Anger, Bridget; Orenstein, Joseph; Blaney, Lee published an article.HPLC of Formula: 144-80-9 The title of the article was Advances in antimicrobial activity analysis of fluoroquinolone, macrolide, sulfonamide, and tetracycline antibiotics for environmental applications through improved bacteria selection. And the article contained the following:

The widespread use of antibiotics has led to their ubiquitous presence in water and wastewater and raised concerns about antimicrobial resistance. Clin. antibiotic susceptibility assays have been repurposed to measure removal of antimicrobial activity during water and wastewater treatment processes. The corresponding protocols have mainly employed growth inhibition of Escherichia coli. The present work focused on optimizing bacteria selection to improve the sensitivity of residual antimicrobial activity measurements by broth microdilution assays. Thirteen antibiotics from four classes (i.e., fluoroquinolones, macrolides, sulfonamides, tetracyclines) were investigated against three gram-neg. organisms, namely E. coli, Mycoplasma microti, and Pseudomonas fluorescens. The min. inhibitory concentration (MIC) and half-maximal inhibitory concentration (IC50) were calculated for each antibiotic-bacteria pair. P. fluorescens produces a fluorescent siderophore, pyoverdine, that was used to assess sublethal effects and further enhance the sensitivity of antimicrobial activity measurements. The optimal antibiotic-bacteria pairs were as follows: fluoroquinolone-E. coli (growth inhibition); macrolide- and sulfonamide-M. microti (growth inhibition); and, tetracycline-P. fluorescens (pyoverdine inhibition). Compared to E. coli growth inhibition, the sensitivity of antimicrobial activity anal. was improved by up to 728, 19, and 2.7 times for macrolides (tylosin), sulfonamides (sulfamethoxazole), and tetracyclines (chlortetracycline), facilitating application of these bioassays at environmentally-relevant conditions. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).HPLC of Formula: 144-80-9

The Article related to fluoroquinolone macrolide sulfonamide tetracycline antibiotics antimicrobial activity, bioassay, contaminants of emerging concern, half-maximal inhibitory concentration (ic(50)), minimum inhibitory concentration (mic), pharmaceutical and other aspects.HPLC of Formula: 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On January 31, 2022, Wang, Yifan; Wang, Linfang; Liu, Ruimin; Li, Lin; Cao, Leiping; Jiao, Lijun; Xia, Xinghui published an article.Product Details of 144-80-9 The title of the article was Source-specific risk apportionment and critical risk source identification of antibiotic resistance in Fenhe River basin, China. And the article contained the following:

A comprehensive understanding of the sources and distribution of antibiotic resistance risk is essential for controlling antibiotic pollution and resistance. Based on surface water samples collected from the Fenhe River basin in the flood season, using the pos. matrix factorization (PMF) model, the risk quotient (RQ) method and the multiple attribute decision making (MADM) method, the resistance risk and source-specific resistance risk of antibiotics were analyzed in this study. The results showed that sulfonamides (SAs) were the dominant antibiotics with a mean concentration of 118.30 ng/L, whereas tetracyclines (TCs) and macrolides (MLs) had the highest detection frequencies (100%). The significant resistance risk rate of antibiotics in the entire river basin was 48%, but no high risk occurred. The significant resistance risk rate of quinolones (QNs) was the highest (100%), followed by that of MLs and TCs. Owing to human activities, the most serious resistance risk occurred in the midstream of the river basin. The resistance risk was the lowest upstream. The antibiotics were mainly contributed by six sources. Pharmaceutical wastewater was the main source, accounting for 30%, followed by livestock discharge (22%). The resistance risk from the six sources showed clear differences, but none of the sources caused a high risk of antibiotic resistance. Pharmaceutical wastewater poses the greatest risk of antibiotic resistance in the Fenhe River basin and is widely distributed. The second greatest source was livestock discharge, which was mainly concentrated in the upstream and midstream areas. The critical sources upstream, midstream, and downstream were all pharmaceutical wastewater, whereas the sequences of other sources were different because different areas were affected by different human activities. The proposed method might provide an important reference for the identification the key source of antibiotics and management of antibiotic pollution, as well as help for the management of antibiotics in Fenhe and Shanxi Province. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Product Details of 144-80-9

The Article related to antibiotic resistance risk apportionment source identification river basin china, antibiotics, critical risk source identification, fenhe river basin, positive matrix factorization, resistance risk, source-specific risk apportionment and other aspects.Product Details of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 15, 2022, Cunat, Alejandro; Alvarez-Ruiz, Rodrigo; Morales Suarez-Varela, Maria M.; Pico, Yolanda published an article.Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide The title of the article was Suspected-screening assessment of the occurrence of organic compounds in sewage sludge. And the article contained the following:

The profiling of emerging organic pollutants present in sludge and generated during wastewater treatment is much more limited than in water. This is mainly due to the difficulty of sludge anal. because of its high content of organic matter and interfering compounds In this study, a generic extraction method using a mixture of buffered water (pH 4.1) and solid phase extraction (SPE) clean-up was applied to samples of sludge obtained in different treatment plants. This extraction was followed by determination of the contaminants by ultra-high performance liquid chromatog. coupled to high resolution mass spectrometry (UHPLC-HRMS), using suspected screening to detect the most relevant organic compounds that access the environment through sludge application. This screening (including >3000 substances, such as, pharmaceuticals, pesticides, metabolites and industrial chems.) tentatively identified 122 compound and assigned most probable structure to 39. The set of compounds assigned to a probable structure was increased in 14 compounds by searching in a free database of metabolites. Fifteen compounds were unequivocally confirmed against the anal. standard Pharmaceuticals and personal care products (PPCPs), with 31 substances identified and 8 confirmed were the main group of compounds Compounds frequently detected in all sludge samples include nucleotides such as ATP, amino acids such as phenylalanine, or peptides such as leu-phe. Altogether, the results of this work highlight the interest of HRMS to draw the profile of organic compounds in complex matrixes. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide

The Article related to suspected screening assessment occurrence organic compound sewage sludge, contaminants, emerging contaminants, high resolution mass spectrometry (hrms), pharmaceuticals, tentative identification, wastewater treatment plants (wwtp) and other aspects.Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics