Category: 144-80-9

On January 31, 2022, Guemues, Mehmet; Babacan, Semsi N.; Demir, Yeliz; Sert, Yusuf; Koca, Irfan; Guelcin, Ilhami published an article.Product Details of 144-80-9 The title of the article was Discovery of sulfadrug-pyrrole conjugates as carbonic anhydrase and acetylcholinesterase inhibitors. And the article contained the following:

Human carbonic anhydrase (hCA) isoenzymes are zinc ion-containing, widespread metalloenzymes and they classically play a role in pH homeostasis maintenance. CA inhibitors suppress the CA activity and their usage has been clin. established as antiglaucoma agents, antiepileptics, diuretics, and in some other disorders. Alzheimer鈥瞫 disease (AD) is a slowly progressive neurodegenerative disorder and a fatal disease of the brain. An advanced method to cure AD includes the strategy to design acetylcholinesterase (AChE) inhibitors. A novel series of pyrrole-3-one derivatives containing sulfa drugs (5a-i) were determined to be highly potent inhibitors for AChE and hCA I and hCA II (inhibitory constant [Ki] values are in the range of 6.50 卤 1.02-37.46 卤 4.12 nM, 1.20 卤 0.19-44.21 卤 1.09 nM, and 8.93 卤 1.58-46.86 卤 8.41 nM for AChE, hCA I, and hCA II, resp.). The designed compounds often show a more effective inhibition than the chems. used as the standard Among these compounds, 5f was the most effective compound against hCA I, and compound 5e was the most effective compound against hCA II. It was determined that compound 5c was the most effective inhibitor for AChE. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Product Details of 144-80-9

The Article related to alzheimer disease carbonic anhydrase acetylcholinesterase inhibitor, acetylcholinesterase, carbonic anhydrase, enzyme inhibition, pyrrole-3-one, sulfa drug, Placeholder for records without volume info and other aspects.Product Details of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 15, 2022, Dou, Shuzhen; Wang, Zhongshun; Chen, Qiye; Lu, Nan published an article.Electric Literature of 144-80-9 The title of the article was One-step fabrication of high-density Si nanotips as SALDI-MS substrate for highly sensitive detection. And the article contained the following:

The high sensitivity of surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) anal. depends on the enhancement of the signal intensity and the reduction of the background. Here, high-d. Si nanotips were prepared as SALDI-MS substrate by taking template-free reactive ion etching for sensitive detection. The high-d. Si nanotips act as tiny antennas to concentrate the laser energy and generate photo-induced electrons on a small area, which promotes desorption and ionization of mol., enhancing the signal intensity. Addnl., the high stability of Si nanotips under laser irradiation ensures low background interference. The applicability of the substrate was demonstrated by the detection of various small mols., e.g., fatty acids, amino acids, environmental pollutants and drugs. In addition, this substrate can be successfully applied for detecting trace small mols. in complex sample, such as 10-9 M verapamil in serum and 10-12 M crystal violet in lake water. Moreover, the banned fungicides left on the fish skin was also detected. The substrate is compatible with imaging, and the endogenous and exogenous substances in fingerprint were visualized by MS imaging. These results demonstrate the easily prepared high-d. Si nanotips SALDI-MS substrate is of high detection sensitivity and great value toward large-scale practical applications. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Electric Literature of 144-80-9

The Article related to silicon nanotip verapamil stearic acid sarcosine saldi ms fabrication, Biochemical Methods: Spectral and Related Methods and other aspects.Electric Literature of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Xue, Weifeng; Zhang, Haiqin; Wang, Mei; Liu, Ying; Liu, Mengyao; Shen, Baozhen published an article in 2022, the title of the article was Metabolomics-based non-targeted screening analysis of 34 PPCPs in bovine and piscine muscles.Application of 144-80-9 And the article contains the following content:

The metabolomics-based anal. strategy has showed superiority on the non-targeted screening of contaminants, especially for unknown and unexpected (U&U) contaminants in the field of food safety, but data anal. is often the bottleneck of the strategy. In this study, a novel metabolomics-based anal. method via searching for marker compounds was developed on the basis of ultrahigh-performance liquid chromatog.-tandem mass spectrometry (UHPLC-MS/MS) results to accurately, rapidly and comprehensively achieve the non-targeted screening of 34 pharmaceutical and personal care products (PPCPs) as U&U contaminants spiked in bovine and piscine muscle matrixes. Three concentration groups (20, 50 and 100 ng mL-1) were intentionally designed to simulate the control and exptl. groups for the discovery of marker compounds, for which multivariate and univariate analyses were adopted. In multivariate anal., each concentration group was fully separated from the other two groups in PCA and OPLS-DA plots, laying a foundation to distinguish marker compounds among groups. The S-plot, permutation and variable importance in projection (VIP) in OPLS-DA were employed to screen and identify marker compounds, which were further verified by pairwise t-test and fold change judgement in univariate anal. The results indicate that 34 PPCPs spiked in two muscle matrixes were all identified as marker compounds, proving the validity and practicability of this novel metabolomics-based non-targeted screening method, which will exhibit great superiority and broad application prospects, especially in the face of massive PPCPs and various animal matrixes in the field of food safety control. In addition, the limits of detection (LODs) for 34 PPCPs were calculated to be 0.2-2.6μg kg-1 and 0.3-2.1μg kg-1 in bovine and piscine muscle matrixes, resp. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Application of 144-80-9

The Article related to muscle pharmaceutical personal care product metabolomics screening, Biochemical Methods: Spectral and Related Methods and other aspects.Application of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 15, 2022, Dou, Shuzhen; Wang, Zhongshun; Chen, Qiye; Lu, Nan published an article.Electric Literature of 144-80-9 The title of the article was One-step fabrication of high-density Si nanotips as SALDI-MS substrate for highly sensitive detection. And the article contained the following:

The high sensitivity of surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) anal. depends on the enhancement of the signal intensity and the reduction of the background. Here, high-d. Si nanotips were prepared as SALDI-MS substrate by taking template-free reactive ion etching for sensitive detection. The high-d. Si nanotips act as tiny antennas to concentrate the laser energy and generate photo-induced electrons on a small area, which promotes desorption and ionization of mol., enhancing the signal intensity. Addnl., the high stability of Si nanotips under laser irradiation ensures low background interference. The applicability of the substrate was demonstrated by the detection of various small mols., e.g., fatty acids, amino acids, environmental pollutants and drugs. In addition, this substrate can be successfully applied for detecting trace small mols. in complex sample, such as 10-9 M verapamil in serum and 10-12 M crystal violet in lake water. Moreover, the banned fungicides left on the fish skin was also detected. The substrate is compatible with imaging, and the endogenous and exogenous substances in fingerprint were visualized by MS imaging. These results demonstrate the easily prepared high-d. Si nanotips SALDI-MS substrate is of high detection sensitivity and great value toward large-scale practical applications. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Electric Literature of 144-80-9

The Article related to silicon nanotip verapamil stearic acid sarcosine saldi ms fabrication, Biochemical Methods: Spectral and Related Methods and other aspects.Electric Literature of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Xue, Weifeng; Zhang, Haiqin; Wang, Mei; Liu, Ying; Liu, Mengyao; Shen, Baozhen published an article in 2022, the title of the article was Metabolomics-based non-targeted screening analysis of 34 PPCPs in bovine and piscine muscles.Application of 144-80-9 And the article contains the following content:

The metabolomics-based anal. strategy has showed superiority on the non-targeted screening of contaminants, especially for unknown and unexpected (U&U) contaminants in the field of food safety, but data anal. is often the bottleneck of the strategy. In this study, a novel metabolomics-based anal. method via searching for marker compounds was developed on the basis of ultrahigh-performance liquid chromatog.-tandem mass spectrometry (UHPLC-MS/MS) results to accurately, rapidly and comprehensively achieve the non-targeted screening of 34 pharmaceutical and personal care products (PPCPs) as U&U contaminants spiked in bovine and piscine muscle matrixes. Three concentration groups (20, 50 and 100 ng mL-1) were intentionally designed to simulate the control and exptl. groups for the discovery of marker compounds, for which multivariate and univariate analyses were adopted. In multivariate anal., each concentration group was fully separated from the other two groups in PCA and OPLS-DA plots, laying a foundation to distinguish marker compounds among groups. The S-plot, permutation and variable importance in projection (VIP) in OPLS-DA were employed to screen and identify marker compounds, which were further verified by pairwise t-test and fold change judgement in univariate anal. The results indicate that 34 PPCPs spiked in two muscle matrixes were all identified as marker compounds, proving the validity and practicability of this novel metabolomics-based non-targeted screening method, which will exhibit great superiority and broad application prospects, especially in the face of massive PPCPs and various animal matrixes in the field of food safety control. In addition, the limits of detection (LODs) for 34 PPCPs were calculated to be 0.2-2.6μg kg-1 and 0.3-2.1μg kg-1 in bovine and piscine muscle matrixes, resp. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Application of 144-80-9

The Article related to muscle pharmaceutical personal care product metabolomics screening, Biochemical Methods: Spectral and Related Methods and other aspects.Application of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On April 30, 2021, Dhumad, Adil M.; Jassem, Ahmed M.; Alharis, Raed A.; Almashal, Faeza A. published an article.Reference of N-((4-Aminophenyl)sulfonyl)acetamide The title of the article was Design, cytotoxic effects on breast cancer cell line (MDA-MB 231), and molecular docking of some maleimide-benzenesulfonamide derivatives. And the article contained the following:

A group of novel maleimide-benzenesulfonamide derivatives 3a-d was designed and synthesized for their evaluation as a potential anti-breast cancer agent. The structures of these derivatives were confirmed by their 1H, 13C NMR, Mass, FT-IR spectral data, and m.ps. The cytotoxic activity (in vitro) of the selected mols. against MDA-MB231 cell line was evaluated by MTT method. Among them, compounds 3a and 3d exhibited a significant cytotoxicity with the IC50 value of 1.61 and 1.26μM, resp., whereas compounds 3b and 3c showed a moderate cytotoxicity with IC50 values of 0.45 and 1.12μM, resp. against MDA-MB231 cells. Docking modeling of the synthesized compounds 3a-d into binding sites of human aromatase protein (PDB ID: 4GL7) was performed to investigate if these derivatives possess analogus binding mode to breast cancer proteins. Docking results showed these compounds have efficient interactions such as hydrogen bonding, Van der Waals interactions, and hydrophobic interactions with the active site residues of the aromatase protein (PDB ID: 4GL7). The low binding energies and a number of hydrogen bonding indicated that the maleimide-benzenesulfonamide derivatives might be considered as a promising anti-breast cancer agent with further developments in drug discovery. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Reference of N-((4-Aminophenyl)sulfonyl)acetamide

The Article related to maleimide benzenesulfonamide derivative mol docking breast cancer cytotoxicity, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.Reference of N-((4-Aminophenyl)sulfonyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 1, 2022, Dabrowska, Aleksandra M.; Mech-Warda, Paulina; Wera, Michal; Domzalska, Marta; Makowski, Mariusz; Chylewska, Agnieszka published an article.Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide The title of the article was Prototropic tautomerism of (E)-N-((4-((2-hydroxy-5-methoxybenzylidene) amino)phenyl)sulfonyl)acetamide and its coordination abilities towards Ru, Rh, and Ir trivalent metal ions. And the article contained the following:

The Schiff base (E)-N-((4-((2-hydroxy-5-methoxybenzylidene)amino)phenyl)sulfonyl) acetamide (ScB-SAM) has been synthesized bytheir condensation at room temperature in ethanol. X-ray crystallog. anal. revealed that the keto-enol tautomerism of its solid state exists as a complex equilibrium system that is stabilized intramol. hydrogen bond. The enol, keto and mixed enol-zwitterionic forms were observed in the crystal structure. The crystallog. results were supported by ATR, and UV-Vis. Phys. properties were determined in different polar and nonpolar solvents and solid state. All above exptl. results were then compared with DFT calculations Addnl., the stabilities of the trivalent: iridium, rhodium and ruthenium ions complexes with ScB-SAM have also been investigated by spectrophotometric titration methods in water. The data showed that the examined coordination compounds were stable in solution based on the values of their stability constants found. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide

The Article related to salicylideneaniline schiff base preparation electronic structure metal coordination stability, Physical Organic Chemistry: Other Reactions, Processes, and Spectra and other aspects.Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 31, 2021, Wang, Guoying; Li, Guoxue; Chang, Jiali; Kong, Yilin; Jiang, Tao; Wang, Jiani; Yuan, Jing published an article.Recommanded Product: 144-80-9 The title of the article was Enrichment of antibiotic resistance genes after sheep manure aerobic heap composting. And the article contained the following:

In this study, physio-chem. properties, 45 antibiotics, 6 heavy metals, 42 antibiotic resistance genes (ARGs), 3 mobile genetic elements, and the bacterial community structure were investigated to analyze the fate of ARGs during sheep manure aerobic heap composting. Results showed that sheep manure heap composting could produce mature compost. The degradation processes reduced the total antibiotics content by 85%. The abundance of ARGs and mobile genetic elements (MGEs) were enriched 9-fold, with the major increases to sul and tet genes (sulI, sulII, tetQ, and tetX). Tetracycline and sulfonamide resistance genes were the most abundant ARGs after composting (more than 88% of all genes). The genes tetA, tetX and sulI were related to the most diverse bacteria that were most able to proliferate during heap composting. Therefore, sulI and tetX are the major ARGs to be controlled, and Actinobacteria and Bacteroidetes may be the major host bacteria. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Recommanded Product: 144-80-9

The Article related to antibiotic resistance gene sheep manure aerobic heap composting, antibiotic, antibiotic resistance genes, bacterial community structures, heap composting, sheep manure, Waste Treatment and Disposal: Physical Treatment Of Aqueous Wastes and other aspects.Recommanded Product: 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 31, 2021, Camargo-Perea, Ana L.; Serna-Galvis, Efraim A.; Lee, Judy; Torres-Palma, Ricardo A. published an article.Application In Synthesis of N-((4-Aminophenyl)sulfonyl)acetamide The title of the article was Understanding the effects of mineral water matrix on degradation of several pharmaceuticals by ultrasound: Influence of chemical structure and concentration of the pollutants. And the article contained the following:

Degradation of seven relevant pharmaceuticals with different chem. structures and properties: acetaminophen (ACE), cloxacillin (CXL), diclofenac (DCF), naproxen (NPX), piroxicam (PXC), sulfacetamide (SAM) and cefadroxil (CDX), in distilled water and mineral water by ultrasound was studied herein. Firstly, proper conditions of frequency and acoustic power were determined based on the degradation ability of the system and the accumulation of sonogenerated hydrogen peroxide (24.4 W and 375 kHz were found as the suitable conditions for the sonochem. treatment of the pharmaceuticals). Under such conditions, the pharmaceuticals degradation order in distilled water was: PXC > DCF ∼ NPX > CXL > ACE > SAM > CDX. In fact, the initial degradation rate showed a good correlation with the Log P parameter, most hydrophobic compounds were eliminated faster than the hydrophilic ones. Interestingly, in mineral water, the degradation of those hydrophilic compounds (i.e., ACE, SAM and CDX) was accelerated, which was attributed to the presence of bicarbonate ions. Afterwards, mineral water containing six different initial concentrations (i.e., 0.331, 0.662, 3.31, 16.55, 33.1, and 331μM) of selected pharmaceuticals was sonicated, the lowest concentration (0.331μM) always gave the highest degradation of the pollutants. This result highlights the great ability of the sonochem. process to treat bicarbonate-rich waters containing pollutants at trace levels, as pharmaceuticals. Finally, the addition of ferrous ions to the sonochem. system to generate a sono-Fenton process resulted in an acceleration of degradation in distilled water but not in mineral water. This was attributed to the scavenging of sonogenerated HO• by bicarbonate anion, which decreases H2O2 accumulation, thus limiting the Fenton reaction. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Application In Synthesis of N-((4-Aminophenyl)sulfonyl)acetamide

The Article related to mineral water pollutant degradation pharmaceutical ultrasound, bicarbonate effect, carbonate radical, mineral water, pharmaceuticals, sonochemistry, Waste Treatment and Disposal: Chemical Treatment Of Aqueous Wastes and other aspects.Application In Synthesis of N-((4-Aminophenyl)sulfonyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 31, 2022, Zhi, Suli; Zhou, Jing; Zhang, Zulin; Zhang, Keqiang published an article.Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide The title of the article was Determination of 38 antibiotics in raw and treated wastewater from swine farms using liquid chromatography-mass spectrometry. And the article contained the following:

The present study firstly aimed at developing a multi-residue method to identify and quantify 38 veterinary antibiotics (belonging to five different classes) not only for raw swine wastewater but also for wastewater differently treated by different units. The proposed method is based on a solid-phase extraction procedure and ultra high performance liquid chromatog. with mass spectrometry. For sample preparation, the optimal loading sample volume was selected as 50 mL, the pH of which was adjusted to approx. 3.0 using formic acid. Then 0.1 g/L EDTA disodium salt was added. The recovery rates for different types of wastewaters were in the range of 35.94-124.51% and the relative standard deviations were in the range of 0.36-14.62%. All the matrix standard curves exhibited high linearity (0.9956-0.9999). The matrix effects for the target antibiotics ranged from -61.73 to +148.75%. To ensure the practicality of the method, we performed the detection of the actually added concentration to determine method detection limits and quantitation limits. The quantitation limits of most of the target antibiotics were 0.04μg/L, except for spiramycin (0.1μg/L) and roxithromycin (0.2μg/L). This optimized and validated method was applied to analyze antibiotic residues in swine water samples from four swine farms. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide

The Article related to swine farms wastewater antibiotic liquid chromatog mass spectrometry, solid-phase extraction, swine wastewater, veterinary antibiotics, Waste Treatment and Disposal: Physical Treatment Of Aqueous Wastes and other aspects.Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics