Category: 144-80-9

On September 15, 2021, Zhang, Biao; Qin, Shang; Guan, Xiangyu; Jiang, Kaidi; Jiang, Minhui; Liu, Fei published an article.COA of Formula: C8H10N2O3S The title of the article was Distribution of Antibiotic Resistance Genes in Karst River and Its Ecological Risk. And the article contained the following:

In recent years, karst water has been polluted by emerging pollutants such as antibiotics. In this study, the bacterial communities and antibiotic resistance genes (ARGs) in antibiotics contaminated karst river was studied in summer and winter. The concentration of antibiotics in winter karst river is higher than that in summer, and there are significant differences in structure of bacterial community and ARGs between karst river water samples. Aminoglycoside, beta-lactamase and multidrug are the main types of ARGs, and transposons play an important role in the spread of ARGs. The horizontal gene transfer (HGT) of ARGs between bacteria mediated by mobile genetic elements (MGEs) would cause the spread of ARGs and bring potential ecol. risks. In addition, we found that the risk of antibiotic resistant pathogenic bacteria (ARPB) in winter was possibly higher than that in summer. It was suggested that the discharge of antibiotics, water amount and seasonal occurrence time of human intestinal diseases affect the risks caused by antibiotics contaminants. This study helps us to understand the transmission mechanism of ARGs and their potential seasonal ecol. risks in complex karst water systems. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).COA of Formula: C8H10N2O3S

The Article related to distribution antibiotic resistance gene karst river ecol risk, antibiotic pollution, antibiotic resistance genes, environmental risk, karst river, microbial community, Water: Water Pollution and other aspects.COA of Formula: C8H10N2O3S

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On July 5, 2021, Tirmazi, Syed Azhar Ali Shah; Qadir, Muhammad Abdul; Ahmed, Mahmood; Imran, Muhammad; Hussain, Riaz; Sharif, Mehwish; Yousaf, Muhammad; Muddassar, Muhammad published an article.Synthetic Route of 144-80-9 The title of the article was Levofloxacin and sulfa drugs linked via Schiff bases: Exploring their urease inhibition, enzyme kinetics and in silico studies. And the article contained the following:

Involvement of urease in various pathol. conditions specifically in gastric and peptic ulcers make it an important therapeutic target. In the present study urease inhibition was investigated by newly designed Schiff bases of levofloxacin. Structure elucidation of these compounds were done by spectral studies such as IR, 1H NMR and 13C NMR and elemental anal. In vitro urease enzyme inhibition assay revealed the compounds LS01, LS06 and LS07 were found to be the most potent and showed comparable IC50 values 0.58±0.11, 0.45±0.21μM and 0.52±0.28μM resp. The compound LS06 was competitive inhibitor with Ki value 1.13μM while the compounds LS01 and LS07 were mixed type of inhibitors with Ki values 3.40 and 6.03μM resp. Plausible binding mode of competitive inhibitor was predicted using mol. docking studies. Ancillary to synthetic studies, d. functional theory (DFT) at B3LYP/6-31G(d,p) basis sets in ground state is utilized in order to gain optimized geometries of LS01-LS09 mols. Different geometric parameters like mol. electrostatic potential anal., alignment of HOMO and LUMO levels, natural bonding orbital (NBO) anal. and global descriptor of reactivity were performed in support of exptl. findings. All DFT based computed results showed best agreement with exptl. finding and suggest that all synthesized compounds are chem. stable. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Synthetic Route of 144-80-9

The Article related to urease levofloxacin schiff bases enzyme kinetics inhibition, Pharmacology: Methods and other aspects.Synthetic Route of 144-80-9

Referemce:
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On June 30, 2021, Wang, Linfang; Li, Hua; Dang, Jinhua; Guo, Hong; Zhu, Yu’en; Han, Wenhui published an article.HPLC of Formula: 144-80-9 The title of the article was Occurrence, distribution, and partitioning of antibiotics in surface water and sediment in a typical tributary of Yellow River, China. And the article contained the following:

The antibiotic distributions, partitioning, and migration pathways in river basins have withdrawn great attention in the past decades. This study investigates 26 antibiotics of five classifications in surface water and sediment samples at 23 sites in Fenhe River, a typical tributary of Yellow River. There are 21 antibiotics found in the water samples at the concentration from 113.8 to 1106.0 ng/L, in the decreasing order of SAs > QNs > MLs > TCs > CAs. Fifteen antibiotics were detected in the sediment at the concentrations from 25.11 to 73.22μg/kg following the decreasing order of SAs > MLs > TCs > QNs > CAs. The antibiotic concentrations vary greatly in surface water, generally lower in upstream and in reservoirs, and reaching highest in the midstream of the Fenhe River after passing Taiyuan and Jinzhong, and then lower again in the downstream. The antibiotic concentrations in sediment have a less variation in the entire river basin, but become high in the downstream. The results show the water-sediment partitioning coefficients of antibiotics generally were lower than those in other areas, having a migration path from the water to suspended solids, and then accumulated in sediment. The water-sediment partitioning coefficients also vary across the basin. The water-sediment partitioning coefficients of sulfacetamide and tetracycline are higher than the water-sediment partitioning coefficients of other antibiotics, with less variation across the basin, the water-sediment partitioning coefficients of azithromycin, enrofloxacin, and roxithromycin are low in the midstream of the river, and high at the river source and downstream. The water-sediment partitioning coefficients are significantly affected by the pH of sediment and the particle size of sediment. The prediction models of water-sediment partitioning coefficients for antibiotics are constructed with the selected effecting factors. The simulation values of antibiotics except chlortetracycline and erythromycin are highly consistent with the observed values, indicating that the prediction model is reliable. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).HPLC of Formula: 144-80-9

The Article related to antibiotic surface water sediment partitioning distribution simulation, antibiotics, partitioning coefficient, spatial distribution, suspended solids, water and sediment, Water: Analysis and other aspects.HPLC of Formula: 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 1, 2022, Wang, Jialin; Zhang, Chong; Xiong, Ling; Song, Guangdong; Liu, Fei published an article.Electric Literature of 144-80-9 The title of the article was Changes of antibiotic occurrence and hydrochemistry in groundwater under the influence of the South-to-North Water Diversion (the Hutuo River, China). And the article contained the following:

The occurrence of antibiotics in groundwater has significant spatial variability, owing to the complexity of pollutant properties, pollution sources and groundwater recharge and discharge conditions. This study aimed to identify the relationship between antibiotic occurrence and hydrochem. in groundwater. Thus, we undertook this study in a characteristic alluvial-diluvial aquifer where groundwater receives unidirectional recharge from surface water. In total, 47 samples were collected from the Hutuo River before and after an artificial replenishment project. We screened up to four classes of antibiotics and detected 28 types. The statistical anal. of antibiotic concentrations, indicated that there were two pollution areas. Next, we discussed the results pertaining to the occurrence and source of antibiotics by comparing them with hydrochem. data. In the study area, a pos. correlation has been found between inorganic compounds, as SO42-and Cl-, and the most mobile antibiotics given that both share the same source. This shows that a previous sound geochem. study may provide evidence of the extend of antibiotic occurrence, as in the Hutuo River aquifer. The relationship between antibiotics and hydrochem. in groundwater is determined by recharge sources (rainwater and surface water contaminated with antibiotics). Antibiotics from wastewater treatment plants enter groundwater indirectly through surface water with high SO42- in lightly polluted areas, while in heavily polluted areas, there are high concentrations of inorganic components in garbage leachate and wastewater leakage that carry antibiotics directly into groundwater. In summarized, the relationship between antibiotics and hydrochem. observed in this study shows that a previous sound geochem. study may provide evidence of the extend of antibiotic occurrence. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Electric Literature of 144-80-9

The Article related to groundwater antibiotic occurrence hydrochem change hutuo river china, antibiotics, groundwater, hydrochemistry, recharge sources, south-to-north water diversion, Water: Analysis and other aspects.Electric Literature of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 1, 2022, Wang, Linfang; Wang, Yifan; Li, Hua; Zhu, Yuen; Liu, Ruimin published an article.Formula: C8H10N2O3S The title of the article was Occurrence, source apportionment and source-specific risk assessment of antibiotics in a typical tributary of the Yellow River basin. And the article contained the following:

The spatial distributions, sources, and source-specific risk apportionments of 26 antibiotics (5 categories) in the Fenhe river basin were determined based on sample data. The results showed that antibiotics were widely distributed in the surface water. There were significant differences between the different types of antibiotics, and the highest mean concentration was that of the sulfonamide category (33.74 ng/L), accounting for 36% of the total antibiotic concentration Spatially, all antibiotics were mainly detected in the middle and downstream areas. The ecol. risk assessment results showed that the significant risk rate of antibiotics accounted for 70% and was mainly distributed in the downstream area; however, the risks differed between the 5 categories. Quinolone antibiotics exhibited the highest significant risk rate, reaching 100%. The ecol. risk associated with sulfamethoxazole was the highest among all detected antibiotics. The following five main factors influenced the antibiotic concentrations: aquaculture, pharmaceutical wastewater, livestock discharges, domestic sewage, and sewage treatment plants. Among these, pharmaceutical wastewater sources contributed the most (35%) to the total antibiotic concentration, and were distributed throughout the river. Although livestock discharges were not the main reason for the high level of ecol. risk, these discharges were highest at certain sites in the midstream region. Different pollution sources posed different levels of ecol. risk to the Fenhe river basin, the highest of which was pharmaceutical wastewater with a significant risk rate of 58%. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Formula: C8H10N2O3S

The Article related to antibiotic risk assessment sewage treatment yellow river basin, antibiotics, fenhe river, positive matrix factorization, source-specific risk, surface water, Water: Analysis and other aspects.Formula: C8H10N2O3S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 15, 2022, Dong, Jianwei; Shang, Meiqi; Feng, Ranran; Song, Xin; Yan, Dandan; Xie, Hui published an article.Category: amides-buliding-blocks The title of the article was Export and risk from antibiotic remobilization from surrounding water to lake in the extreme 2020 Yangtze River basin flooding. And the article contained the following:

Global climate change increased the frequency of extreme rainfall events, leading to higher flood risk. In addition to the personal and property losses, another important consequence of a flood disaster was release and exposure risks from emerging contaminants, which was usually overlooked. The remobilization and fate of the antibiotics induced by floods remain unclear. We captured antibiotic concentrations around the Chaohu Lake after an unprecedented flood with a range of 5.0-317 ng/L. Higher concentrations in polder waters than their receiving rivers were attributed to the antibiotic release from soil particles and the sharp increase of water: soil ratio by flood storage. Source apportionment anal. of antibiotics implied that diffuse pollution by manure application and aquaculture activity was the predominant sources. Commonalities of spatial variations of antibiotics in polders were related to the condition of waterlogging and pollution source. The total antibiotic storage for all submerged polders was estimated at 27.9 kg. The concentrations and risks from pumping floodwater detained by polders into the lake were much higher than that from discharging flood directly into the lake. The retention-reaction-remobilization process would pose unexpectedly high risks for the lake. This study provided a new sight for constructing ecol. wetland flood storage areas. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Category: amides-buliding-blocks

The Article related to antibiotic remobilization exposure risk lake water, chaohu lake, cluster analysis, environmental risk, principal component analysis, source apportionment, Water: Analysis and other aspects.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 31, 2021, Ye, Chunmeng; Shi, Jiaqi; Zhang, Xuesheng; Qin, Li; Jiang, Zhongguan; Wang, Jinhua; Li, Yucheng; Liu, Bingxiang published an article.SDS of cas: 144-80-9 The title of the article was Occurrence and bioaccumulation of sulfonamide antibiotics in different fish species from Hangbu-Fengle River, Southeast China. And the article contained the following:

As a class of synthetic sulfur drugs, sulfonamides (SAs) have been used to treat diseases and promote organism growth. Different concentrations of SAs have been detected in the water environment, which has threatened the ecol. environment. In this study, the contamination of 9 SAs in water, sediments, and 8 fish species from the Hangbu-Fengle River, China, were analyzed using UPLC-MS/MS. The total SA concentrations in surface water, sediments, and fish were ND-5.064 ng/L, ND-5.052 ng/g dry weight (d.w.), and ND-1.42 ng/g wet weight (w.w.), resp. The major compounds were sulfadiazine (SDZ), sulfamerazine (SMZ), and sulfamethoxazole (SMX) in water and fish. The SA levels of in fish from different habitat preferences revealed a spatial difference, with the order of demersal species > pelagic species. Moreover, the SA concentrations were affected by trophic guilds, indicating their decrease in the order of piscivorous fish > omnivorous fish > planktivorous fish > herbivorous fish. The obtained bioaccumulation factors showed that SMZ and SMX have strong bioenrichments in Ophiocephalus argus Cantor and Pelteobagrus fulvidraco. The risk assessment indicated that SAs did not pose significant health threats to the organisms. This research is the first report of SA contamination in the Hangbu-Fenle River, which can provide an important scientific basis for their pollution prevention and ecol. risk assessment in the aquatic environment. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).SDS of cas: 144-80-9

The Article related to occurrence bioaccumulation sulfonamide antibiotic fish species southeast china, bioaccumulation, hangbu-fengle river, risk assessment, sulfonamides, Water: Analysis and other aspects.SDS of cas: 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On September 1, 2021, Dong, Jianwei; Xie, Hui; Feng, Ranran; Lai, Xijun; Duan, Hongtao; Xu, Ligang; Xia, Xinghui published an article.Product Details of 144-80-9 The title of the article was Transport and fate of antibiotics in a typical aqua-agricultural catchment explained by rainfall events: Implications for catchment management. And the article contained the following:

Antibiotics receive many concerns since their neg. environmental impacts are being revealed, especially in aqua-agricultural areas. Rainfall events are responsible for transferring excess contaminants to receiving waters. However, the understanding of antibiotics transport and fate responding to rainfall events was constrained by limited event-based data and lacking integrated consideration of dissolved and particulate forms. We developed an intensive monitoring strategy to capture responses of fourteen antibiotics to different types of rainfall events and inter-event low flow periods. Pollutant-rich suspended particles, as high as 1471 ng/g, were found in low flow periods while the very heavy rainfall events and consecutive rainfall events stimulated the release of antibiotics from eroded soil particles to river water. Therefore, these rainfall events drove radical increase of dissolved antibiotic concentration up to 592 ng/L and total flux up to 25.0 g/d. Sulfonamides were particularly sensitive to rainfall events because of their residues in manure-applied agricultural lands. Transport dynamics of most antibiotics were accretion whereas only clarithromycin exhibited a dilution pattern by concentration-discharge relationships. Aquaculture ponds were inferred to significantly contribute tetracycline, oxytetracycline, and clarithromycin. Conventional contaminants were compared to discriminate potential sources of antibiotics and imply effective catchment management. The results provided novel insights into event-based drivers and dynamics of antibiotics and could lead to appropriate management strategy. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Product Details of 144-80-9

The Article related to antibiotics aqua agricultural catchment rainfall events, agriculture, diffuse pollution, emerging contaminants, nutrients, suspended particles, Water: Analysis and other aspects.Product Details of 144-80-9

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 28, 2021, Zhu, Feng; Wang, Siqi; Liu, Yujie; Wu, Minghong; Wang, Hongyong; Xu, Gang published an article.Recommanded Product: N-((4-Aminophenyl)sulfonyl)acetamide The title of the article was Antibiotics in the surface water of Shanghai, China: screening, distribution, and indicator selecting. And the article contained the following:

The widespread existence of antibiotics has caused inevitable influence on ecol. and humans. In this study, we screened the most commonly used antibiotics, and 64 antibiotics were detected in Shanghai, an international metropolis. Most of the target substances were detected in all 46 water samples including main rivers and districts in Shanghai, with concentrations ranging from 0.02 to 502.43 ng L-1. In particular, sulfadiazine (502.43 ng L-1) had the highest maximum concentration Besides, risk quotients based on fish suggested that sulfonamides had a medium risk (0.12) in Shanghai. Correlation studies had shown that most compounds with frequencies exceeding 60% were significantly pos. correlated with the total concentration Based on further anal., sulfadiazine, sulfamerazine, and sulfapyridine were screened as indicators to reflect the pollution status of antibiotics in Shanghai for a long time. The screening conditions for these indicators include detection rate (> 60%), maximum concentration (> 100 ng L-1), RQ (> 0.01), and correlation (> 0). In addition, population d. may be the main factor for antibiotic pollution through regional comparison. In a word, this work can systematically reflect the overall situation of Shanghai antibiotics and provide support for global data comparison in the future. Meanwhile, we provided the potential indicators that can be applied in the long term and economical monitoring of antibiotics. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Recommanded Product: N-((4-Aminophenyl)sulfonyl)acetamide

The Article related to antibiotics surface water screening distribution sewage treatment plant, antibiotics, distribution, rqs, screening, typical indicators, Water: Analysis and other aspects.Recommanded Product: N-((4-Aminophenyl)sulfonyl)acetamide

Referemce:
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Amide – an overview | ScienceDirect Topics

On March 31, 2021, Da Le, Nhu; Hoang, Anh Quoc; Hoang, Thi Thu Ha; Nguyen, Thi Anh Huong; Duong, Thi Thuy; Pham, Thi Mai Huong; Nguyen, Tien Dat; Hoang, Van Chung; Phung, Thi Xuan Binh; Le, Huu Tuyen; Tran, Cao Son; Dang, Thu Hien; Vu, Ngoc Tu; Nguyen, Trong Nghia; Le, Thi Phuong Quynh published an article.Formula: C8H10N2O3S The title of the article was Antibiotic and antiparasitic residues in surface water of urban rivers in the Red River Delta (Hanoi, Vietnam): concentrations, profiles, source estimation, and risk assessment. And the article contained the following:

Antibiotic residues and antimicrobial resistance in surface water are issues of global concern, especially in developing countries. In this study, the occurrence of seven antibiotics and one antiparasitic agent was determined in surface water samples collected from four rivers running through Hanoi urban area in the Red River Delta, northern Vietnam. The pharmaceuticals in water samples were analyzed by solid-phase extraction combined with liquid chromatog.-tandem mass spectrometry method. The concentrations of pharmaceuticals in our samples ranged from 3050 to 16,700 (median 7800) ng/L, which were generally higher than levels found in river water from many other locations in the world. Amoxicillin, oxfendazole, and lincomycin were the most dominant and frequently detected compounds (detection rate 100%), which together accounted for 76 ± 14% of total concentrations Antibiotic concentrations in the water samples were not significantly different between the investigated rivers. Meanwhile, levels of pharmaceuticals in the samples collected in Feb. 2020 were higher than those found in the remaining samples, largely due to the sharp decrease in sulfamethoxazole and azithromycin concentrations of the samples collected in March and Apr. Considerable ecol. risks of antibiotics in surface water were estimated for some compounds such as amoxicillin, ciprofloxacin, and ofloxacin. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Formula: C8H10N2O3S

The Article related to antibiotic antiparasitic residue surface water urban river, antibiotics, hanoi, risk assessment, surface water, urban pollution, Water: Analysis and other aspects.Formula: C8H10N2O3S

Referemce:
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Amide – an overview | ScienceDirect Topics