Category: 144-80-9

Cengiz, Gokhan; Algin Yapar, Evren; Kara, Bilge Ahsen; Sindhu, Rakesh K. published an article in 2021, the title of the article was Comparison and evaluation of pharmacopoeial methods for the assessment of potency of antibiotics.COA of Formula: C8H10N2O3S And the article contains the following content:

The detection and assessment of potency of antibiotics are crucial for the pharmaceutics. The valid methods for microbiol. assays in pharmacopoeias are mainly based on statistical comparison of the data obtained by measuring the cidal activity resulting from the treatment of the antibiotic active ingredient in the composition of the pharmaceutics with the target microorganism. However, it was seen that there is no validated microbiol. method for some active ingredients. Due to microbiol. assays are indispensable methods for determining the potency of some active ingredient groups, the calculation of the potency is performed logarithmically. In either turbidimetric or chromatog. methods, the statistical evaluation of the sample is compared with the standard reference material. Anal. data obtained by chromatog. and chem. methods are linear peak areas and spectrophotometer readings. In microbiol. methods, the data obtained from the analyzes performed to determine the potency of antibiotics are the inhibition zone diameters or turbidimetric turbidity data. In this study, above-mentioned microbiol. assays are compared in the context of the main pharmacopoeias EP, USP, CP, IP and BP, and evaluated in terms of the chromatog. method and classical microbiol. method. It has been observed that chromatog. and chem. methods are not available to determine the potency of some pharmaceutical products containing antibiotics. The examinations made reveal the difficulty of analyzing some active ingredient groups according to chem. and chromatog. methods. For this reason, the importance of method validation studies is increasing in order to analyze active substances that do not have alternative anal. methods with microbiol. and chem. methods. In this study, all validated microbiol. methods were investigated, and it was aimed to determine alternative methods to chromatog. and chem. methods. It was concluded that the realization of new microbiol. methods to be validated by evaluating the methods in all differences would facilitate the study. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).COA of Formula: C8H10N2O3S

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Hussein, Ag; Sakr, Hm; Mansour, Am; Ayyad, Rr published an article in 2021, the title of the article was Ulcer index and anti-inflammatory testing of some benzimidazole derivatives.Related Products of 144-80-9 And the article contains the following content:

In this work, we carry out the testing of some Benzimidazole derivatives as anti-inflammatory using Indomethacin 10mg/Kg, diclofenac sodium 7mg/Kg, celecoxib 100mg/Kg and tested compounds of 200mg/Kg. The tested compounds showed anti-inflammatory activity in comparison with the standard reference drugs. In addnl., carrying out the testing of ulcer index for some testing compounds 600mg/Kg comparing with indomethacin 100mg/Kg, the testing revealed indomethacin causes ulcer in stomach of the testing animals, while the testing compounds no ulcerated the stomach of the testing animal. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Related Products of 144-80-9

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Li, Xiaoqin; Fang, Zhijuan; He, Xinye; Zhang, Shuqin; Ding, Hongliu; Ye, Hu published an article in 2021, the title of the article was Optimization of 204 veterinary drug residues method and establishing their mass spectrum library.Reference of N-((4-Aminophenyl)sulfonyl)acetamide And the article contains the following content:

A multi-class multi-residue anal. method was validated in this paper for simultaneously identifying 204 veterinary drugs in pork by UPLC-QTRAP MS/MS, including sulfonamides, quinolones, 尾-agonists, and nitroimidazoles. MRM-IDA-EPI mode of QTRAP was used to establish a secondary mass spectrum library of these 204 veterinary drugs, which could enhance the qual. anal. of suspect substances. The separation of substances was performed on a C18 column, with a gradient elution of 0.1% formic acid solution in water and methanol. Electrospray ionization (ESI), fast polarity switching, and scheduled MRM mode were used to collect the characterization results. Factors that affected the recovery were delicately optimized, such as solvent proportion, formic acid content, and purification method. We finally determined the extracting method with formic acid-acetonitrile-water (0.1:90:10, v:v:v) and purifying method with Cleanert LipoNo as a package for dispersive solid-phase extraction Matrix effects on the quant. results were also investigated. Some compounds had strong matrix inhibition or enhancement, and the matrix matching external standard method was used to quantify the compounds accurately. The correlation coefficient R2 was over 0.99 within the calibration linearity range for the detected 204 veterinary drugs. The limit of quantification (LOQ) was 0.5 鈭?5 渭g/kg. The recoveries ranged from 61.4% to 118.8% with RSDs of 3.1% to 19.2% (n = 6). The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Reference of N-((4-Aminophenyl)sulfonyl)acetamide

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Saluti, Giorgio; Colagrande, Maria Novella; Castellani, Federica; Ricci, Matteo; Diletti, Gianfranco; Scortichini, Giampiero published an article in 2021, the title of the article was Survey on Antibiotic Residues in Egg Samples in Italy.Electric Literature of 144-80-9 And the article contains the following content:

The presence of antibiotic residue in eggs is a current issue due to the increasingly important phenomenon of antibiotic resistance. A multiclass, confirmatory method for the determination of seventy-three antimicrobial agents (amphenicols, cephalosporins, diaminopyrimidines, lincosamides, macrolides, penicillins, pleuromutilins, quinolones, sulfonamides, and tetracyclines) with liquid chromatog. high-resolution mass spectrometry was applied to 200 egg samples collected from 119 Italian farms during the years 2018-2021. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Electric Literature of 144-80-9

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On February 28, 2022, Varani, Tania; Abdouss, Majid; Azerang, Parisa; Tahghighi, Azar published an article.Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide The title of the article was Acetylenic Sulfones and Acetylenic Sulfonamide Analogs: A Novel and Preferable Antimicrobial Drugs Based on Computational Strategies. And the article contained the following:

This study was done to report virtual screening and mol. docking studies of sulfacetamide derivatives as new antimicrobial drugs, belonging to the pharmacol. class of sulfonamides. For this purpose, sulfonamide functional groups from a library of chem. structures were converted into acetylenic sulfone and acetylenic sulfonamide functional groups to introduce a new class of antimicrobial drugs with mechanisms of action of dihydropteroate synthase inhibitors (DHPS). Initially, a library of compounds containing approx. 170 acetylenic sulfone ligands was created by similarity search method, and a library containing 170 acetylenic sulfonamide ligands was designed to be administered as new inhibitors. After designing, their mol. docking energies were calculated by three software programs including Arguslab4.0.1, AutoDock Vina and Molegro Virtual Docker and the results were compared in terms of binding energy. Although acetylenic sulfonamide compounds showed better results, acceptable results were observed in both groups of compounds Adsorption, distribution, metabolism and excretion (ADME) properties of acetylenic sulfones/acetylenic sulfonamide analogs were also analyzed using the admetSAR program. These new derivatives can be used in drug improvement processes for the treatment of antibacterial infections after performing further studies. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide

The Article related to cetylenic sulfonamide antimicrobial drug computational strategy, Placeholder for records without volume info and other aspects.Quality Control of N-((4-Aminophenyl)sulfonyl)acetamide

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Tam, Nguyen Minh; Pham, Minh Quan; Nguyen, Huy Truong; Hong, Nam Dao; Hien, Nguyen Khoa; Quang, Duong Tuan; Thu Phung, Huong Thi; Ngo, Son Tung published an article in 2021, the title of the article was Potential inhibitors for SARS-CoV-2 Mpro from marine compounds.Related Products of 144-80-9 And the article contains the following content:

Preventing the biol. activity of SARS-CoV-2 main protease using natural compounds is of great interest. In this context, using a combination of AutoDock Vina and fast pulling of ligand simulations, eleven marine fungi compounds were identified that probably play as highly potent inhibitors for preventing viral replication. In particular, four compounds including M15 (3-O-(6-O-伪-L-arabinopyranosyl)-尾-D-glucopyranosyl-1,4-dimethoxyxanthone), M8 (wailupemycins H), M11 (cottoquinazolines B), and M9 (wailupemycins I) adopted the predicted ligand-binding free energy of -9.87, -9.82, -9.62, and -9.35 kcal mol-1, resp., whereas the other adopted predicted ligand-binding free energies in the range from -8.54 to -8.94 kcal mol-1. The results were obtained using a combination of Vina and FPL simulations. Notably, although, AutoDock4 adopted higher accurate results in comparison with Vina, Vina is proven to be a more suitable technique for rapidly screening ligand-binding affinity with a large database of compounds since it requires much smaller computing resources. Furthermore, FPL is better than Vina to classify inhibitors upon ROC-AUC anal. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Related Products of 144-80-9

The Article related to mpro inhibitors marine compound mol docking covid19 antiviral, Placeholder for records without volume info and other aspects.Related Products of 144-80-9

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On February 15, 2022, Kumar Bishoyi, Ajit; Mahapatra, Monalisa; Sahoo, Chita Ranjan; Kumar Paidesetty, Sudhir; Nath Padhy, Rabindra published an article.Computed Properties of 144-80-9 The title of the article was Design, molecular docking and antimicrobial assessment of newly synthesized p-cuminal-sulfonamide Schiff base derivatives. And the article contained the following:

Antibiotic resistance of bacteria and fungi has been brewing for decades and has now surfaced as a potential public health emergency, globally. Thus, newer potent drug candidates are needed urgently to overcome antibiotic-resistant episodes. As an attempt to overcome the antimicrobial multi-drug resistance problems, a new series of p-cuminal sulfonamide Schiff base congeners 3a-3h were designed, synthesized, and their structures confirmed by several spectral studies. The antimicrobial activities assessment of obtained products was carried out against pathogenic bacteria Staphylococcus aureus, Streptococcus pyogenes, Methicillin-resistant Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and against pathogenic fungi Candida tropicalis and Trichophyton rubrum. Among them, 3b exhibited significant inhibition of all the strains of bacteria with MIC as 3.12渭g/mL and the compound 3e exhibited the most promising control against both C. tropicalis and T. rubrum (MIC 6.25渭g/mL) in comparison to Ketoconazole as well as good inhibition against both S. aureus and MRSA at MIC 6.25 渭g/mL The presence of sulfamoyl and azomethine groups and some of heteroaryl rings in individual mols. could have increased the antibacterial actions, while the antifungal action could be attributed to the presence of guanyl and acetyl groups in the mol. structure. Furthermore, in silico investigation and drug-likeness have been ascertained with biol. targets. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Computed Properties of 144-80-9

The Article related to cuminal schiff base reaction sulfanilamide antimicrobial sars, Placeholder for records without volume info and other aspects.Computed Properties of 144-80-9

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On August 1, 2022, Dou, Shuzhen; Lu, Jiaxin; Chen, Qiye; Chen, Chunning; Lu, Nan published an article.HPLC of Formula: 144-80-9 The title of the article was High-density Si nanopillars modified with Ag nanoislands: Sensitive SALDI-MS chip for sulfonamides. And the article contained the following:

In recent years, the abuse of antibiotics has brought adverse effects on water environment and food safety, to monitor the antibiotic content in water and foodstuffs is imperative for environmental protection and human health. In this work, a chip, composed of high-d. Si nanopillars and Ag nanoislands, is prepared for sensitive detection of sulfonamides with surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS). In this chip, the high-d. Si nanopillars can absorb laser energy efficiently and promote electron transfer as antennas; the Ag nanoislands can enhance the thermal effect; the formation of the Schottky barrier and the conductive nanolayer between Si/Ag can extend the lifetime of electrons and promote electron tunneling effect. Therefore, the heterostructure presents high detection sensitivity (the limit of detection of sulfamethazine is as low as 3 amol); in addition, the satisfactory coefficients of determination (> 0.99) show that the chip is applicable for rapid quantification of sulfonamides. Further, the sulfacetamides spiked in milk and lake water can be sensitively identified and rapidly quantified. The prepared chip presents a considerable potential for food and environment monitoring. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).HPLC of Formula: 144-80-9

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On April 30, 2022, Hu, Jingrun; Qi, Dianqing; Chen, Qian; Sun, Weiling published an article.Product Details of 144-80-9 The title of the article was Comparison and prioritization of antibiotics in a reservoir and its inflow rivers of Beijing, China. And the article contained the following:

The occurrence of antibiotics in drinking water resources, like reservoirs, is of considerable concern due to their potential risks to ecosystem, human health, and antimicrobial resistance development. Here, we quantified 83 antibiotics in water and sediments of wet and dry seasons from the Miyun reservoir and its inflow rivers in Beijing, China. Twenty-four antibiotics were detected in water with concentrations of ND-11.6 ng/L and 19 antibiotics were observed in sediments with concentrations of ND-6.50 ng/g. Sulfonamides (SAs) were the dominated antibiotics in water in two seasons. SAs and quinolones (QNs) in wet season and macrolides (MLs) and QNs in dry season predominated in sediments. The reservoir and inflow rivers showed significant differences in antibiotic concentrations and compositions in water and sediments. As an important input source of reservoir, the river water showed significantly higher total antibiotic concentrations than those in the reservoir. In contrast, the reservoir sediments are the sink of antibiotics, and had higher total antibiotic concentrations compared with rivers. A prioritization approach based on the overall risk scores and detection frequencies of antibiotics was developed, and 3 (sulfaguanidine, anhydroerythromycin, and sulfamethoxazole) and 5 (doxycycline, sulfadiazine, clarithromycin, roxithromycin, and flumequine) antibiotics with high and moderate priority, resp., were screened. The study provides a comprehensive insight of antibiotics in the Miyun Reservoir and its inflow rivers, and is significant for future monitoring and pollution mitigation of antibiotics. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Product Details of 144-80-9

The Article related to antibiotic inflow river pollution beijing china, antibiotics, comparison, prioritization, reservoir, inflow rivers, Placeholder for records without volume info and other aspects.Product Details of 144-80-9

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Yan, Ni; Long, Shengxing; Xiong, Kangning; Zhang, Ting published an article in 2022, the title of the article was Antibiotic bioaccumulation in zooplankton from the Yelang Lake Reservoir of Anshun City, Southwest China.Application of 144-80-9 And the article contains the following content:

Antibiotic (蟽sulfonamide, 蟽fluoroquinolone, 蟽tetracycline and 蟽macrolide) contamination in aquatic systems has remained a global concern in recent years. In this study, fourteen antibiotics, sulfadiazine (SDZ), sulphapyridine (SPD), sulfacetamide (SCT), sulfamethoxazole (SMX), sulfamethazine (SMZ), trimethoprim (TMP), ofloxacin (OFX), lomefloxacin (LFX), ciprofloxacin (CFX), norfloxacin (NFX), oxytetracycline (OTC), tetracycline (TC), dehydroerythromycin (ETM-H2O) and roxithromycin (RTM), were analyzed in zooplankton collected from the Yelang Lake Reservoir between May 2016 and Mar. 2017. Our results demonstrated that the antibiotic TC (mean 95.80 ng g-1), OTC (mean 167.0 ng g-1) and RTM (mean 151.80 ng g-1) concentrations were significantly higher in zooplankton than the other antibiotics. TC, OTC and RTM accumulated intensively in zooplankton, and the BAFs of OTC, RTM and TC were significantly higher, with mean BAF values of 78.43, 108.4 and 110.1, resp. Antibiotic concentrations were strongly correlated with zooplankton phytoplankton biomass, OTC, RTM and SMX concentrations in zooplankton were significantly pos. correlated with bacillariophyte biomass, and SDZ and SMZ concentrations in zooplankton were significantly pos. correlated with T. brevifurcatus, T. mongolicus, and D. pulex biomass. SPD with P. tunguidus, C. cornuta, TMP, ETM and OFX with P. tunguidus, C. cornuta, M. leuckarti, C. vicinus vicinus, CFX with D. pulex, LFX with T. brevifurcatus, T. mongolicus, Bosmina longirostris, and D. dubium were significantly pos. correlated. These results show that bioaccumulation or scavenging of antibiotics across trophic levels is a fundamental and complex component of antibiotic cycling in aquatic environments. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Application of 144-80-9

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