Category: 14294-10-1

Burger, Klaus published the artcileHexafluoroacetone as protective group and activating reagent in amino acid and peptide chemistry. 10. Synthesis of 3-(thiazol-4-yl)alanine and 3-(selenazol-4-yl)alanine derivatives from aspartic acid, Product Details of C5H10N2OS, the publication is Synthesis (1992), 1145-50, database is CAplus.

3-(Thiazol-4-yl)alanines I (R = Ph, 4-MeC₆H₄, 4-MeOC₆H₄, 2-furyl, NMe₂, 4-FC₆H₄, 2-thienyl, H, Me; R¹ = H, Me) and the 3-(selenazol-4-yl)alanine II were obtained from aspartic acid via 2,2-bis(trifluoromethyl)-4-(3-bromo-2-oxopropyl)-1,3-oxazolidin-5-one in a Hantzsch synthesis, using hexafluoroacetone as protective group.

Synthesis published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Product Details of C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Schweiger, K. published the artcileHeterocycles, 52. Reaction of 3,4,5,6-tetrahydro-6-hydroxy-4,4,6-trimethyl-1,3-thiazine-2-thione with secondary amines, Product Details of C5H10N2OS, the publication is Monatshefte fuer Chemie (1977), 108(1), 243-55, database is CAplus.

The title compound reacted with secondary amines via the dialkylammonium-3-oxoalkyldithiocarbamate, either via isothiocyanates to 4-dialkylaminodihydro-2(1H)-pyridinethiones I (NRR1 = Et2N, piperidino, morpholino, 4-methyl-1-piperazinyl, etc.) or to dialkylammonium dithiocarbamates, depending on the amine used and the reaction conditions. Subsequently, 6-dialkylaminotetrahydro-1,3-thiazine-2-thiones II (NRR1 = morpholino, 4-methyl-1-piperazinyl) or tetrahydro-6-mercapto-1,3-thiazine-2-thione were formed. On being heated to reflux, II gave I and 4-dialkylaminodihydrothiopyranthione III. With secondary amines only dithiocarbamates were formed from tetrahydro-6-hydroxy-3,4,4,6-tetramethyl-1,3-thiazine-2-thione. The reaction of 5,6-dihydro-4,4,6-trimethyl-1,3-thiazine-2-thione with secondary amines gave N,N-dialkylthioureas or dialkylammonium thiocyanates; with dialkylformamides, 4-dialkylaminodihydropyridinethiones I were formed. 5,6-Dihyro-3,4,4,6-tetramethyl-1,3-thiazine-2-thione did not react with secondary amines or with dialkylformamides.

Monatshefte fuer Chemie published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C12H13NO3, Product Details of C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Perova, N. M. published the artcileTransformation of 2-cycloalkylimino-6H-1,3,4-thiadiazines under action of UV-irradiation, Name: Morpholine-4-carbothioamide, the publication is Khimiya Geterotsiklicheskikh Soedinenii (1993), 565-6, database is CAplus.

UV irradiation of thiadiazines I (R¹ = H, R² = morpholino, piperidino, 1-pyrrolidinyl, 1H-azepin-1-yl) gave pyrazoles II and in the case of I (R¹ = H, R² = morpholino) 1-(4-phenyl-2-thiazolyl)morpholine was obtained.

Khimiya Geterotsiklicheskikh Soedinenii published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Name: Morpholine-4-carbothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Kalluraya, Balakrishna published the artcileSynthesis and antibacterial activity of some 2-substituted-4-(5-nitro-2-thienyl)thiazoles, SDS of cas: 14294-10-1, the publication is Revue Roumaine de Chimie (1995), 40(11-12), 1183-1188, database is CAplus.

The preparation of 2-substituted 4-(5-nitro-2-thienyl)thiazoles I (R = Ph, chlorophenyl, phenylamino, etc.) was described. These compounds were tested for their antibacterial activity against both Gram-pos. and Gram-neg. bacteria. The results of the screening indicate that the title compounds carrying chloro substituents in the aryl moiety possess better activity against all the organisms testes.

Revue Roumaine de Chimie published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, SDS of cas: 14294-10-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Dreyer, R. published the artcileSynthesis and characterization of cationic astatine compounds with sulfur-containing ligands stable in aqueous solutions, COA of Formula: C5H10N2OS, the publication is Journal of Radioanalytical and Nuclear Chemistry (1985), 96(3), 333-41, database is CAplus.

The formation of cationic At compounds with thiourea, thiourea derivatives and some N-acylthioureas was studied in aqueous solutions The ion mobilities in free electrolytes were determined for the detection of carrier-free At compounds and their characterization. Information about the stability of this group of compounds could be given after studies in the presence of halide and pseudohalide ions (Cl^–, Br^–, I^–, SCN^–).

Journal of Radioanalytical and Nuclear Chemistry published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, COA of Formula: C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Culbertson, Townley P. published the artcileNew 7-substituted quinolone antibacterial agents. The synthesis of 1-ethyl-1,4-dihydro-4-oxo-7-(2-thiazolyl and 4-thiazolyl)-3-quinolinecarboxylic acids, Related Products of amides-buliding-blocks, the publication is Journal of Heterocyclic Chemistry (1987), 24(6), 1509-20, database is CAplus.

A series of 1-ethyl-1,4-dihydro-4-oxo-7-(4-thiazolyl)-3-quinolinecarboxylic acids e.g. I (R = NH₂, MeNH, AcNCH₂, Me₂N, 3-pyridyl, morpholino, etc.; R¹,R² = H, F), and 1-ethyl-1,4-dihydro-4-oxo-7-(2-thiazolyl)-3-quinolinecarboxylic acids were prepared Also prepared was 10-[2-(aminomethyl)-4-thiazolyl]-9-fluoro-2,3-dihydro-3-methyl-7–oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid (II). Analogs with basic amine substituents on the thiazole moiety were found to have antibacterial activity.

Journal of Heterocyclic Chemistry published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Henry, Ronald A. published the artcileMiscellaneous derivatives of morpholine, Product Details of C5H10N2OS, the publication is Journal of the American Chemical Society (1950), 2806, database is CAplus.

Molar proportions of Ph₂NCOCl and morpholine (I) reacted directly. The mixture heated with H₂O and NaHCO₃ precipitated diphenylcarbamyl morpholide, m. 110-11° (from EtOH). I with RNCS gave the following thioureas: Ph, m. 130.5°; o-tolyl, m. 144.5-5.5°; p-tolyl, m. 151-1.5°; allyl, m. 56-7°. I in EtOH refluxed with picryl chloride gave 90% 4-picrylmorpholine (II), m. 147.5-8.5°, resolidified, and m. at 166-6.5° (from EtOH). II with (NH₄)₂S gave 4-picramylmorpholine, decompose 256° (from EtOH). A solution of I.HCl and KCNS evaporated to dryness, then extracted with absolute EtOH, gave (4-morpholinyl)thiocarbonamide, m. 111.5-12.5°. [O(CH₂.CH₂)₂NCS]₂S₂ (III) and KCN in 40% EtOH refluxed 30 min., then diluted with 50 ml. H₂O, precipitated [O(CH₂.CH₂)₂NCS]₂S, m. 126-6.5° (from EtOH). III and I heated at 120° for 4 hrs., then extracted with H₂O gave [O(CH₂.CH₂)₂N]₂CS.H₂O, m. 89.5-90° (from H₂O).

Journal of the American Chemical Society published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Product Details of C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Arya, V. P. published the artcilePsychoactive agents: part VIII. Isothiazoles: part VIII. Synthesis and biological activity of 4-(2-amino-4-thiazolyl)isothiazoles, Product Details of C5H10N2OS, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1978), 16B(5), 402-4, database is CAplus.

RR¹NH (NRR¹ = morpholino, hexahydro-1-azepinyl, octahydro-1-azocinyl, 3-azabicyclo[3.2.2]nonan-3-yl, 4-(4-fluorophenyl)piperazin-1-yl) were treated with tert-BuNCS to give RR¹NCSNHCMe₃, which ws debutylated to give RR¹NCSNH₂. This and R²CSNH² (R² = NH₂, NHMe, NHBu, NHCH₂CH:CH₂, NHCH₂Ph, etc.) were cyclized with I (R³ = H, Me, Et) to give the corresponding II. Among II, 4-(2-amino-4-thiazolyl)-3,5-dimethylisothiazole showed the highest analgesic activity and 4-(2-amino-4-thiazolyl)-3-methylisothiazole had the highest antiinflammatory activity.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Product Details of C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Mameli, Efisio published the artcileAminolysis of ethylxanthogenamide. III, Quality Control of 14294-10-1, the publication is Annali di Chimica (Rome, Italy) (1956), 545-62, database is CAplus.

cf. C.A. 51, 3458d. EtOCSNH₂ (I) reacts with 2 moles RNH₂ at room temperature to give RNHCSNH₂ (II); the rate of reaction and yield are greatly increased by addition of 0.3 mole KOH. Yields of II obtained without and with KOH, resp., are: from MeNH₂, 61, 79; EtNH₂, 57, 61; PrNH₂, 39, 79; iso-PrNH₂, 42, 45; BuNH₂, 22, 71; PhCH₂NH₂, about 16, 61; cyclohexylamine, 12, 36. Reaction times are up to 50 days. No byproducts (except SCN^–) are found when KOH is used; the following are detected in experiments without KOH: (MeNH)₂C:NH, (EtNH)₂C:NH, BuNHCSOEt, [(PhCH₂NH)₂C:NH]₂.H₂S₂O₃ (III), C₆H₁₁NHCSOEt. Reaction between 2.1 g. I and 2 moles 33% aqueous PhCH₂NH₂ in 6 cc. EtOH gives first a precipitate of II, then (after exposure of the filtrate to air) an oil, from which III is obtained by crystallization from Me₂CO. III, m. 168-9°, is identified by conversion to (PhCH₂NH)₂C:NH and its hydrochloride; its infrared spectrum is given. Me₂NH reacts with I in aqueous EtOH to give 7% Me₂NCSOEt and 10% [Me₂NC(:NH)NH₂]₂.H₂S₂O₃, but in the presence of KOH gives 67% Me₂NCSNH₂. Et₂NH and iso-Bu₂NH fail to react. Pyrrolidine after 4 days with I in aqueous EtOH gives 30% 1-(thiocarbamyl)pyrrolidine, m. 193-7° (dependent on the rate of heating), which isomerizes to the corresponding thiocyanate above the m.p.; the same product (84%) is obtained in 1 day when KOH is added. Piperidine and I without KOH give only traces of 1-(thiocarbethoxy)piperidine and 1-(thiocarbamyl)piperidine; with KOH 27% of the latter is formed. Piperidine, I, and 1 mole 30% NH₃ in aqueous solution evaporated after 30 days give 7% 1-guanylpiperidine hyposulfite, m. 246-7° (variable). Morpholine gives approx. 20% N-(ethoxythiocarbonyl)morpholine and 15% N-guanylmorpholine hyposulfite, m. 263-5° (variable); addition of 1 mole NH₃ increases these yields to about 30% each, but addition of 0.3 mole KOH changes the reaction completely, the only product being N-(thiocarbamyl)morpholine (50%). In general, increase in KOH concentration or temperature only leads to increased decomposition of I. Attempts to make I react with (HOCH₂CH₂)₂NH or with aromatic amines at room temperature or above were unsuccessful. Formation of hyposulfites is ascribed to spontaneous oxidation of S^—, but yields are not improved by aeration or addition of H₂O₂. The variety of products obtained from I is ascribed to the possibility of tautomerism.

Annali di Chimica (Rome, Italy) published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Quality Control of 14294-10-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Charnley, Adam K. published the artcileCrystal structures of human RIP2 kinase catalytic domain complexed with ATP-competitive inhibitors: Foundations for understanding inhibitor selectivity, Name: Morpholine-4-carbothioamide, the publication is Bioorganic & Medicinal Chemistry (2015), 23(21), 7000-7006, database is CAplus and MEDLINE.

Receptor interacting protein 2 (RIP2) is an intracellular kinase and key signaling partner for the pattern recognition receptors NOD1 and NOD2 (nucleotide-binding oligomerization domain-containing proteins 1 and 2). As such, RIP2 represents an attractive target to probe the role of these pathways in disease. In an effort to design potent and selective inhibitors of RIP2 we established a crystallog. system and determined the structure of the RIP2 kinase domain in an apo form and also in complex with multiple inhibitors, including AMP-PCP (β,γ-methyleneadenosine 5′-triphosphate, a non-hydrolyzable ATP mimic) and structurally diverse ATP competitive chemotypes identified via a high-throughput screening campaign. These structures represent the first set of diverse RIP2-inhibitor co-crystal structures and demonstrate that the protein possesses the ability to adopt multiple DFG-in as well as DFG-out and C-helix out conformations. These structures reveal key protein-inhibitor structural insights and serve as the foundation for establishing a robust structure-based drug design effort to identify both potent and highly selective inhibitors of RIP2 kinase.

Bioorganic & Medicinal Chemistry published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Name: Morpholine-4-carbothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics