Category: 14294-10-1

Mokry, Cornelia published the artcilePreparation and properties of 2-(dialkylamino)-5-(haloacetyl)thiazoles and 4-[2-(dialkylamino)-5-thiazolyl]thiazoles, Application In Synthesis of 14294-10-1, the publication is Journal fuer Praktische Chemie/Chemiker-Zeitung (1998), 340(4), 375-380, database is CAplus.

By the reaction of N-acylthioureas with (ClCH₂)₂CO, 2-(dialkylamino)-5-(chloroacetyl)thiazoles are available. These compounds react with thioureas or arylthioamides under heterocyclization to give bis[2-(dialkylamino)-5-thiazolyl]methanones, 2-aryl-4-[2-(dialkylamino)-5-thiazolyl]thiazoles, or 2-(dialkylamino)-4-[2-(dialkylamino)-5-thiazolyl]thiazoles, resp., from which the latter exhibit a high reactivity towards several electrophilic reagents. Thus, deeply colored cyanovinyl-, arylazo-, and arylmethine-substituted bisthiazole dyes formed.

Journal fuer Praktische Chemie/Chemiker-Zeitung published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Application In Synthesis of 14294-10-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Liebscher, Juergen published the artcileNitrile-formamide chloride adducts; VII. A simple route to 6-N-formamidino-1,3-thiazinium salts, SDS of cas: 14294-10-1, the publication is Zeitschrift fuer Chemie (1976), 16(7), 268-70, database is CAplus.

R3R4N+:CHCR:CClN:CHNR1R2 ClO4-(I; R = Ph, CN, CO2Et, 4-ClC6H4, etc; R1, R2, R3, R4 = Me; R1R2N, R3R4N = morpholino) reacted with R5CSNH2 (R5 = Ph, Me2N, morpholino, PhNH, etc.) to give the thiazinium salts II. I were prepared by the reaction of RCH2CN with dialkylformamide chlorides in the presence of HCl.

Zeitschrift fuer Chemie published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, SDS of cas: 14294-10-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Liebscher, Juergen published the artcileNitrile-formamide adducts. 4. Reaction of nitrile-formamide adducts. Synthesis of N-thioacylamide derivatives and aza analogs of thiopyrylium salts, Safety of Morpholine-4-carbothioamide, the publication is Zeitschrift fuer Chemie (1975), 15(11), 438-40, database is CAplus.

4-RC6H4CSN:CHNR1R2 (R = H, Me, OMe; NR1R2 = pyrrolidino, morpholino, NMe2) were obtained by treating 4-RC6H4CONHCH:N+R1R2 ClO4- with P2S5 or by treating 4-RC6H4CCl:NCH:N+R1R2 ClO4- (I) with Na2S or Na2S2O3. 4-RC6H4CSN:CHNR1R2 were hydrolyzed to 4-RC6H4CSNHCHO or condensed with I (R = H, Cl) to the thiazines II. The thiadiazines III were similarly obtained from I and R4NHCSNR1R2 (R4 = Bz, 4-O2NC6H4CO, 3-O2NC6H4CO, H).

Zeitschrift fuer Chemie published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Safety of Morpholine-4-carbothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Liebscher, Juergen published the artcileReaction of 3-chloroprop-2-eniminium salts with alkali rhodanides, SDS of cas: 14294-10-1, the publication is Zeitschrift fuer Chemie (1978), 18(9), 334-5, database is CAplus.

The pyrimidinethiones I (R = Ph, 4-MeC₆H₄, 4-MeOC₆H₄, 4-ClC₆H₄, 2-naphthyl; R¹ = 4-MeOC₆H₄, 2-MeOC₆H₄, 4-MeC₆H₄, 2-naphthyl, 3-MeOC₆H₄) were obtained by treating RCCl:CHCH:N⁺Me₂ ClO₄^– was alkali metal isothiocyanate and treating SCNCR:CHCH:N⁺Me₂ ClO₄^– (II) with R¹NH₂. Treatment of II with R₂²NH (NR₂² = morpholino, pyrrolidino, NMe₂) gave the thiazinium salts III (R³ = H). Reaction of III (R = 4-MeC₆H₄, NR₂² = NMe₂, R³ = H) with PhNMe₂ gave III (R = 4-MeC₆H₄, NR₂² = NMe₂, R³ = 4-Me₂NC₆H₄).

Zeitschrift fuer Chemie published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, SDS of cas: 14294-10-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Flaig, Ronald published the artcileSynthesis of N-substituted 2,4-diaminothiazoles and their salts, Product Details of C5H10N2OS, the publication is Heterocycles (1997), 45(5), 875-888, database is CAplus.

A series of N(2),N(4)-substituted 2,4-diaminothiazoles I (R¹R²N = morpholino, pyrrolidino, piperidino, diethylamino, n-butylamino, phenylamino, di-n-propylamino, R³R⁴N = morpholino, pyrrolidino, piperidino, diphenylamino, diethylamino, n-butylamio) and their corresponding mineral acid salts have been prepared by the reaction of POCl₃ with N-substituted S-(dialkylaminocarbonylmethylene)isothiouronium salts R¹R²NC(:NH₂)SCH₂CONR³R⁴ available from corresponding substituted thioureas R¹R²NC(S)NH₂ (II) and N,N-disubstituted chloroacetamides ClCH₂CONR³R⁴ or by the reaction of primary or secondary amines R³R⁴NH in excess with N(2)-unsubstituted or N(2)-disubstituted 2-amino-4-thiazolinimine hydrochlorides III available by the reaction of corresponding N-substituted thioureas II with chloroacetonitrile.

Heterocycles published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Product Details of C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Czerney, Peter published the artcileHeterocyclic substituted coumarins from β-chloropropeniminium salts, Application of Morpholine-4-carbothioamide, the publication is Journal fuer Praktische Chemie (Leipzig) (1982), 324(2), 255-66, database is CAplus.

The chloropropeniminium salts I (X = N⁺Me₂ ClO₄^–; R = H, 6-Br, 7-OH, 7-OMe, 7-NMe₂, 7-pyrrolidino, 8-OMe, 7-NEt₂, R¹ = H; RR¹ = 5,6-CH:CHCH:CH, 7,8-CH:CHCH:CH) and the aldehydes I (X = O) were prepared by treating 3-acetylcoumarins with DMF-POCl₃ in the presence of HClO₄ or H₂O, resp. I are versatile synthetic intermediates giving I (X = CR²CN, R² = cyano, CO₂Et, 2-benzimidazolyl, 4-O₂NC₆H₄) which were converted to the aminobutadienes. I were also cyclized to pyrylium, thiopyrylium, pyrazolyl, and thiazinyl derivatives

Journal fuer Praktische Chemie (Leipzig) published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Application of Morpholine-4-carbothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Keil, D. published the artcileSynthesis and characterization of 1,3-bis-(2-dialkylamino-5-thiazolyl)-substituted squaraines and their 2-(dialkylamino)thiazole precursors, Product Details of C5H10N2OS, the publication is Liebigs Annalen (1995), 979-84, database is CAplus.

By condensing of squaric acid with 2-(dialkylamino)-substituted thiazoles, a novel type of heterocyclic-substituted squaraines was prepared in moderate yield mostly. The squaraines are sparingly soluble in most organic solvents and exhibit narrow absorption bands in the visible range at ∼ 620-700 nm in solution. In dispersed form, the absorption bands of the squaraines are, however, broadened and shifted into the near IR region at ∼ 900 nm. These unique properties of the new squaraines suggest the use of these dyes as spectral sensitizers for laser-driven data recording or data storage media.

Liebigs Annalen published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Product Details of C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Kagami, Hiroaki published the artcileNucleophilic substitution on dialkoxy disulfides. III. Reaction with thioureas, Category: amides-buliding-blocks, the publication is Bulletin of the Chemical Society of Japan (1980), 53(12), 3658-60, database is CAplus.

Treating RNHC(S)NHR¹ (R = Me₂CH, cyclohexyl, Ph, 2-MeC₆H₄, Et, 2-ClC₆H₄, allyl; R¹ = Me₂CH, cyclohexyl, 2-MeC₆H₄) with (EtOS)₂ in CH₂Cl₂ in the presence of mol. sieves gave 19-66% RN:C:NR¹; whereas upon treatment with (EtOS)₂, (R²)₂NC(S)NH₂ (R² = Et, Pr, Bu, Ph, N(R²)₂ = morpholino) gave 48-75% thiadiazole I.

Bulletin of the Chemical Society of Japan published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Category: amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Certal, Victor published the artcilePreparation and optimization of new 4-(2-(indolin-1-yl)-2-oxoethyl)-2-morpholinothiazole-5-carboxylic acid and amide derivatives as potent and selective PI3Kβ inhibitors, Related Products of amides-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry Letters (2014), 24(6), 1506-1510, database is CAplus and MEDLINE.

In the authors’ continuous efforts to identify and develop novel targeted cancer treatments, a new morpholino-thiazole scaffold active against PI3Kβ was identified. This Letter reports the optimization of this compound class to develop PI3Kβ isoform-selective inhibitors with suitable pharmacol. properties.

Bioorganic & Medicinal Chemistry Letters published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Louvel, Julien published the artcileAgonists for the Adenosine A₁ Receptor with Tunable Residence Time. A Case for Nonribose 4-Amino-6-aryl-5-cyano-2-thiopyrimidines, Formula: C5H10N2OS, the publication is Journal of Medicinal Chemistry (2014), 57(8), 3213-3222, database is CAplus and MEDLINE.

The synthesis and evaluation of previously unreported 4-amino-6-aryl-5-cyano-2-thiopyrimidines as selective human adenosine A₁ receptor (hA₁AR) agonists with tunable binding kinetics, this without affecting their nanomolar affinity for the target receptor were described. They show a very diverse range of kinetic profiles (from 1 min (compound I) to 1 h (compound II)), and their structure-affinity relationships (SAR) and structure-kinetics relationships (SKR) were established. When put in perspective with the increasing importance of binding kinetics in drug discovery, these results bring new evidence of the consequences of affinity-only driven selection of drug candidates, i.e., the potential elimination of slightly less active compounds that may display preferable binding kinetics.

Journal of Medicinal Chemistry published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Formula: C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics