Category: 14294-10-1

Sugimoto, Hirohiko published the artcileActivation of dithiocarbamate by 2-halothiazolium salts, Synthetic Route of 14294-10-1, the publication is Journal of Organic Chemistry (1988), 53(10), 2263-7, database is CAplus.

Activation of dithiocarbamate salts with 2-halo-3-alkyl-4-phenylthiazolium salts and subsequent 1-pot nucleophilic reactions with N, S, and O nucleophiles gave substituted thioureas, dithiocarbamates, and thiocarbamates or amides, resp., under very mild conditions. A useful thiocarbonyl-transfer reaction that consists of activation of imidazolodithiocarbamate and a subsequent 1-pot nucleophilic reaction is also described. (Thiocarbonyl)diimidazole is generated in situ.

Journal of Organic Chemistry published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C10H11NO4, Synthetic Route of 14294-10-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Mitzner, Elke published the artcileFormylation products of thioamides. V. Synthesis of aminomethylene thioureas from substituted thioureas and formamide chlorides, Related Products of amides-buliding-blocks, the publication is Zeitschrift fuer Chemie (1983), 23(1), 19-20, database is CAplus.

Iminoformylation of R¹R²NC(S)NH₂ [R¹R² = CH₂CH₂OCH₂CH₂, (CH₂)₄, R¹ = Ph, R² = H] with a mixture of HCONR₂³ [R₂³ = (CH₂)₅, Me₂, CH₂CH₂OCH₂CH₂, (CH₂)₄] gave 32-71% (aminomethylene)thioureas R¹R²NC(S)NCHNR₂³. Attempts to prepare PhNMeC(S)N:CHNR₂³ [R₂³ = (CH₂)₄] gave 21% of the hydrolysis product PhNMeN(S)NHCHO. Thiazoles I [R¹R² = CH₂CH₂OCH₂CH₂, R = Br, H; R¹R² = (CH₂)₄, R = Cl] were prepared by cyclizing R¹R²NC(S)N:CHNR₂³ with BrCH₂COC₆H₄R-4.

Zeitschrift fuer Chemie published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Hagelloch, G. published the artcileThe bacteria-inhibiting effectiveness of some compounds with the :NC(:S) group, Application In Synthesis of 14294-10-1, the publication is Zeitschrift fuer Naturforschung (1951), 147-55, database is CAplus.

The predicated ability of :NC(:S) to act as a chelating agent for heavy metals prompted the testing of homologous compounds against staphylococci, coli bacteria, pleuropneumonia-like organisms, and tubercle bacteria. The following related groups were tested on nutrient and serum agar: dithiocarbamates and derivatives, thioamides, thioöxamide and derivatives, NCS in heterocyclic compounds, thioureas, and thiobiurets and derivatives The majority of the substances investigated were completely effective in concentrations of less than 10 mg.%.

Zeitschrift fuer Naturforschung published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Application In Synthesis of 14294-10-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Tisler, M. published the artcileSyntheses of some N-substituted thiocarbamylpiperidines and thiocarbamylmerpholines, Recommanded Product: Morpholine-4-carbothioamide, the publication is Croatica Chemica Acta (1957), 409-11, database is CAplus.

RCNS (0.02 mole) in 10 ml. Et₂O added to an ice-cold solution of 0.02 mole piperidine or morpholine in 10 ml. Et₂O, kept 15 min., the solution filtered and the precipitate crystallized (EtOH or aqueous EtOH) gave 82-90% XCSNHR [R, m.p., and EtOH-H₂O ratio for crystallization given]: (Χ = piperidino) 2,3-Me₂C₆H₃, 138°, 3:1; 2,4-Me₂C₆H₃, 119°, 1:1; 2,5-Me₂C₆H₃, 118°, 2:1; 2-MeOC₆H₄, 61°, 2:1; 4-MeOC₆H₄, 146°, 3:1; 3-ClC₆H₄, 135°, 1:0; 4-Me₂NC₆H₄ (I), 129°, 1:1; C₆H₁₂, 133°, 3:1; Ph, 99°, -; 2-MeC₆H₄, 98°, -; 3-MeC₆H₄, 102°, -; 4-MeC₆H₄, 134°, -; 4-ClC₆H₄, 153°, -; 4-BrC₆H₄, 166°, -; PhCH₂, 88°, -; 1-C₁₀H₇, 125°, -; Me, 131°, -; (Χ = morpholino) Ph, 134°, 1:0; 2-MeC₆H₄, 144°, 1:0; 2-MeOC₆H₄, 91°, 1:1; 2,3-Me₂C₆H₃, 147°, 1:0; 2,4-Me₂C₆H₃, 148°, 1:0; 2,5-Me₂C₆H₃, 156°, 1:0; 3-ClC₆H₄, 162°, 1:0; 4-Me₂NC₆H₄, 170°, 1:0; PhCH₂, 100°, 3:1; C₆H₁₂, 136°, 2:1. Tested against M. tuberculosis H37Rv strain on liquid Sula medium only I showed complete inhibition at 5 γ/ml.

Croatica Chemica Acta published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C7H7N3, Recommanded Product: Morpholine-4-carbothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Scott, Francis L. published the artcileNitrogen systems. VI. Some nucleophilic displacements on 1-carbamoylpyrazoles, SDS of cas: 14294-10-1, the publication is Chemistry & Industry (London, United Kingdom) (1956), 547-8, database is CAplus.

cf. C.A. 49, 15i. ZCSNH₂ (throughout this abstract Z = 3,5-dimethyl-1-pyrazolyl) (I) refluxed in EtOH with RNH₂ [R = Bu] (II), cyclohexyl (III), Ph₂NCONH, H₂O.NH₂, or PhNHNH₂ (IV)], morpholine (V), or piperidine (VI) gave the corresponding monosubstituted thiourea. I with aniline (VII) or benzylamine the sym. disubstituted thiourea. ZC(:NH)NHR [R = Bz (VIII), SO₂C₆H₄Me-p (IX), and CSNHPh (X)] were unaffected by II, III, IV, V, or VI in EtOH, but, in the absence of EtOH, VIII on refluxing with II, III, VI, or VII gave the corresponding Bz derivatives of the mono substituted guanidines and with V gave both 4-(benzoylguanyl)morpholine and BzN:CR₂(R = morpholino). Similarly IX refluxed with II, III, IV, V or VI in the absence of EtOH gave the p-tolylsulfonyl derivatives of the corresponding monosubstituted guanidines. ZC(:NH)NHC(SMe):NR.HI or its 4-Cl or 4-Br derivative (R = Ph) on refluxing in EtOH with amines gives very little reaction, but refluxing with II, III, or V in the absence of EtOH gives RC(:NH)NHC(SMe):NPh (R = the corresponding amino group), α-C₁₀H₇NHCONHC(:NH)Z in EtOH refluxed with II, III, IV, V, or VI gives the corresponding α-naphthyl ureas and ZH. Use of an azide ion gives with ZC(:NH)NHR(R = H or NO₂) 5-amino- and 5-nitraminotetrazoles, resp. Cf. C.A. 47, 6886a, 8670g, 9923c.

Chemistry & Industry (London, United Kingdom) published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C14H21BO2, SDS of cas: 14294-10-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Nair, G. Vijayakumaran published the artcileTert-butyl and tert-amyl isothiocyanates as novel reagents for the preparation of 1-substituted thiocarbamide derivatives, Recommanded Product: Morpholine-4-carbothioamide, the publication is Indian Journal of Chemistry (1966), 4(12), 516-20, database is CAplus.

cf. Neville and McGee, CA 59: 8715f. tert-Butyl (I) and tert-amyl isothiocyanates (II) on treating with amino compounds, aliphatic and aromatic primary and secondary amines, heterocyclic primary amines and imines and cyclic amines, in which the amino group is part of the ring system, afforded the related tertiary alkyl thiocarbamide derivatives [TABLE OMITTED] I was prepared as follows: A mixture of 27.4 g. NH4CNS, 10 g. ZnCl2, 27.8 g. tert-BuCl, and 100 ml. H2O was shaken 96 hrs. at intervals. The upper organic layer was separated, washed with H2O, dried and shaken 1 hr. with 5 g. powd. anhydrous ZnCl2 for 96 hrs. The decanted liquid was washed with H2O and dried with CaCl2 to yield 29.5 g. I, which was used directly for condensation. II was similarly prepared using tert-AmCl. Molar quantities of aliphatic primary and secondary amines and I reacted rapidly at room temperature in petroleum ether solution giving quant. yields of the desired tertiary alkyl thiocarbamide derivatives Aromatic primary and secondary amines, heterocyclic amines, and mono- and diarylguanidines, however, reacted only when the reactants were heated 1.5-5 hrs. in C6H6 solution II also reacted similarly. These derivatives were easily and quant. heterolyzed by treating with concentrated HCl at 90-95° for 2-30 min. to the corresponding thiocarbamides and tertiary alkyl chloride. 1-Substituted-3-tert-butylthiocarbamides (III) prepared are listed in the first table. 1-Substituted-3-tert-amylthiocarbamides (IV) prepared by the reaction of II and amines are listed in the 2nd table. (Ts stands for thiosemicarbazide). [TABLE OMITTED] The reaction of I with N2H4.H2O for 30 min. yielded 90% 4-tert-butylthiosemicarbazide (V), m. 143° (dilute EtOH). Similar reaction with PhNHNH2 yielded 91% 2-phenyl-4-tert-butylthiosemicarbazide (VI), m. 177° (absolute EtOH). Heterolysis of V and VI yielded H2NNHCSNH2, m. 180°, and PhNHNHCSNH2, m. 201°, in 67 and 94% resp. This procedure provides a novel and economic method of wider applicability for the preparation of 1-substituted thiocarbamides.

Indian Journal of Chemistry published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Recommanded Product: Morpholine-4-carbothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Hayat, Waseem published the artcileInsight into the degradation of methomyl in water by peroxymonosulfate, Application In Synthesis of 14294-10-1, the publication is Journal of Environmental Chemical Engineering (2021), 9(4), 105358, database is CAplus.

Methomyl (MET) is a carbamate pesticide frequently used in agriculture, globally. Its high solubility makes it a potential water pollutant. MET can be removed by peroxymonosulfate (PMS)-based advanced oxidation processes. This study explains MET degradation by PMS-Only, pyrite (PyR)-PMS and zero-valent iron (ZVI)-PMS systems. The degradation by PMS-Only, PyR-PMS and ZVI-PMS systems was 85.4%, 94.9% and 87.0%, resp. The generation of reactive oxygen species (ROS) and their role in degradation was elucidated by ESR (EPR) and free-radical quenching analyses, resp. EPR anal. indicated the presence of sulfate (SO•^–₄) and hydroxyl (•OH) radicals. The degradation in PMS-Only and ZVI-PMS systems was not significantly inhibited by tert-Bu alc. (TBA) and methanol (MeOH), which suggests that the degradation in both systems was not majorly carried out by SO•^–₄ and •OH. However, furfuryl acid (FFA) resulted in reduced degradation by applied systems, which showed that singlet oxygen (¹O₂) was mainly responsible for degradation in all systems. These results showed that MET was majorly degraded by non-radical PMS oxidation PMS-Only system resulted in an almost equal degradation, compared with PyR-PMS and ZVI-PMS systems. So, detailed anal. was carried out for PMS-Only system. Hence, experiments were conducted to investigate the effect of PMS concentration, MET concentration, pH and temperature on the degradation by PMS-Only system, which showed that PMS-Only system was efficient from pH 5.0 to pH 9.0, and from 10.0 °C to 40.0 °C. Further, PMS-Only system has a potential for effective degradation in real waters because it resulted in 66.5%, 63.7% and 60.4% degradation in tap water, lake water and sewage water, resp.

Journal of Environmental Chemical Engineering published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Application In Synthesis of 14294-10-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Zhao, Jin-Wu published the artcileGreen synthesis of 1,2,4-thiadizoles from thioamides in water using molecular oxygen as an oxidant, Related Products of amides-buliding-blocks, the publication is Chinese Chemical Letters (2014), 25(11), 1499-1502, database is CAplus.

The authors present here an efficient green process for the synthesis of 1,2,4-thiadiazoles via iodine-catalyzed, oxidative dimerization of thioamides in water using mol. oxygen as a terminal oxidant. Under the optimized reaction conditions, aryl thioamides produced 3,5-diaryl-1,2,4-thiadiazoles in good to excellent yields. Alkyl thioamides and substituted thioureas could also provide corresponding 1,2,4-thiadiazole products.

Chinese Chemical Letters published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C8H17Br, Related Products of amides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Zhao, Jinwu published the artcilePotassium iodide and ammonium nitrate catalyzed aerobic oxidative cyclization of ketones with thioureas in ionic liquid: an access to 2-aminothiazoles, SDS of cas: 14294-10-1, the publication is Tetrahedron (2015), 71(4), 539-543, database is CAplus.

An efficient procedure for the synthesis of 2-aminothiazoles via KI/NH₄NO₃-catalyzed oxidative cyclization of ketones and thioureas using mol. oxygen as a green oxidant is reported. Different ketones and thioureas went through the transformation and gave corresponding 2-aminothiazole heterocycles in satisfactory yields. E.g., in presence of KI/NH₄NO₃, H₂SO₄, and mol. oxygen in [Bmim]OTf/H₂O (4:1), oxidative cyclization of PhCOMe and H₂NCSNH₂ gave 95% 2-aminothiazole derivative (I).

Tetrahedron published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C10H14N2Na4O9, SDS of cas: 14294-10-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Sun, Yadong published the artcileCopper(II)-mediated homocoupling of thioamides for the synthesis of 1,2,4-thiadiazoles, Application of Morpholine-4-carbothioamide, the publication is European Journal of Organic Chemistry (2014), 2014(20), 4239-4243, database is CAplus.

A copper(II)-mediated highly selective oxidative cyclization reaction of thioamides to provide 3,5-disubstituted 1,2,4-thiadiazoles was developed. The copper species played a key role in this transformation and different functional groups were tolerated under the optimal reaction conditions.

European Journal of Organic Chemistry published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C11H22N2O4, Application of Morpholine-4-carbothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics