Category: 14294-10-1

Hartmann, Horst published the artcileAlkylene-bridged N,N,N’,N’-tetrasubstituted bis(2-amino-5-thiazolyl)methinium salts – a new class of strongly fluorescent dyes, Synthetic Route of 14294-10-1, the publication is Angewandte Chemie, International Edition (2001), 40(3), 552-554, database is CAplus and MEDLINE.

N,N-Disubstituted thioureas were cyclocondensed with 1,5-dibromo-3,3-dimethyl-2,4-pentanedione or 4,6-dibromo-2,2-dimethyl-1,3-cyclohexanedione and the products were converted into the title benzobisthiazole methinium dyes.

Angewandte Chemie, International Edition published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Synthetic Route of 14294-10-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Takahashi, Hitoe published the artcileSelenoureas and thioureas are effective superoxide radical scavengers in vitro, Formula: C5H10N2OS, the publication is Life Sciences (2005), 76(19), 2185-2192, database is CAplus and MEDLINE.

The authors investigated scavenging of superoxide radicals by selenoureas and thioureas using a highly sensitive and quant. chemiluminescence method. At 330 nM, five selenoureas and five thioureas scavenged fractions of superoxide radicals (O^–₂) ranging from 8.4% to 87.6%. Among five N,N-unsubstituted selenoureas and N,N-unsubstituted thioureas, 1-selenocarbamoylpiperidine and 1-thiocarbamoylpyrrolidine were the most effective scavengers. The study showed that selenoureas could be used as new superoxide anion-scavenging substances.

Life Sciences published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C12H20O6, Formula: C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Burger, Klaus published the artcileA surprising access route to α-hetero-substituted methylphosphonate esters, Synthetic Route of 14294-10-1, the publication is Chemiker-Zeitung (1988), 112(3), 108-9, database is CAplus.

A mixture of 2,2-bis(trifluoromethyl)oxazolone I and P(OMe)₃ reacts with thiourea, as well as with N,N-dimethylthiourea, morpholinothioamide, and thioacetamide to give 65% (MeO)₂P(O)CH(SMe)NHCH(CF₃)₂.

Chemiker-Zeitung published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Synthetic Route of 14294-10-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Burger, Klaus published the artcileApplication of hexafluoroacetone as protecting and activating reagent in amino acid and peptide chemistry. N-Substituted glycine derivatives from iminodiacetic acid, Name: Morpholine-4-carbothioamide, the publication is Zeitschrift fuer Naturforschung, B: Chemical Sciences (1993), 48(1), 107-20, database is CAplus.

3-Carboxymethyl-2,2-bis(trifluoromethyl)-5-oxazolidinone, obtained on reaction of HN(CH₂CO₂H)₂ with (CF₃)₂CO, represents a preparatively useful intermediate for the synthesis of unsym. substituted derivatives of HN(CH₂CO₂H)₂. The N-substituted glycine derivatives obtained are interesting candidates for peptide modification.

Zeitschrift fuer Naturforschung, B: Chemical Sciences published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Name: Morpholine-4-carbothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Richter, Adrian published the artcileEfficient Synthesis of Benzothiazinone Analogues with Activity against Intracellular Mycobacterium tuberculosis, SDS of cas: 14294-10-1, the publication is ChemMedChem (2022), 17(6), e202100733, database is CAplus and MEDLINE.

8-Nitrobenzothiazinones (BTZs) were a promising class of antimycobacterial agents currently under investigation in clin. trials. Starting from thiourea derivatives, a new synthetic pathway to BTZs was established. It allows the formation of the thiazinone ring system in one synthetic step and was applicable for preparation of a wide variety of BTZ analogs. The synthetic procedure furthermore facilitates the replacement of the sulfur atom in the thiazinone ring system by oxygen or nitrogen to afford the analogous benzoxazinone and quinazolinone systems. 36 BTZ analogs were prepared and tested in luminescence-based assays for in vitro activity against Mycobacterium tuberculosis (Mtb) using the microdilution broth method and a high-throughput macrophage infection assay.

ChemMedChem published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, SDS of cas: 14294-10-1.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Zubenko, Alexander A. published the artcileThiourea assisted recyclization of 1-(chloromethyl)dihydroisoquinolines: a convenient route to β-(o-thiazolylaryl)ethylamines, Recommanded Product: Morpholine-4-carbothioamide, the publication is Mendeleev Communications (2021), 31(1), 125-127, database is CAplus.

Synthesis of new β-(o-thiazolylaryl)ethylamines such as I [R¹ = H, OMe; R² = H, Me; R³ = H, Ph, 4-BrC₆H₄, etc. R⁴ = H, CH₂CH₂OCH₂CH₂; Hal = Cl, Br; n = 1, 2] was afforded via recyclization of 1-chloromethyl-3,4-dihydroisoquinolines upon treatment with thioureas under acidic conditions.

Mendeleev Communications published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C3H5F3O, Recommanded Product: Morpholine-4-carbothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Spitzner, R. published the artcileKetovinylization of thiocarbamides and thioureas. On the ambidence of the thioamido function, Product Details of C5H10N2OS, the publication is Tetrahedron (1982), 38(7), 927-36, database is CAplus.

Thiocarbamides and thioureas reacted as ambident systems with β-chlorovinyl ketones to give (S)-[(Z)-ketovinyl] salts. E.g., addition reaction of PhCSNH₂ with PhCOCH:CHCl in HCO₂H/HClO₄ for 1-2 h gave 78% (Z)-PhCOCH:CHSCPh:N⁺H₂ ClO₄^–. The ketovinyl salts obtained from monoprotic thiocarbamides and thioureas underwent deprotonation to give (S)-[(Z)-ketovinyl]thioimidate esters or -isothioureas, which isomerized intramolecularly on heating. E.g., deprotonation of (Z)-4-MeOC₆H₄COCH:CHSCPh:N⁺HPh ClO₄^– gave 82% (Z)-4-MeOC₆H₄COCH:CHSCPh:NPh, which on heating in PhMe gave (E)-4-MeOC₆H₄COCH:CHSCPh:NPh. Lithiated monoprotic thiocarbonamides reacted with β-chlorovinyl ketones to give N-[(E)-ketovinyl]thiocarbonamides, whereas lithiated thioureas gave S-[(E)-ketovinyl]isothioureas, which rearranged to the N-[(E)-ketovinyl]thioureas under mild conditions. E.g., lithiation and addition reaction of PhCSNHPh with PhCOCH:CHCl gave 59% (E)-PhCOCH:CHNPhCSPh, whereas similar treatment of Me₂NC(S)NHPh gave (E)-PhCOCH:CHSC(:NPh)NMe₂, which above room temperature gave (E)-PhCOCH:CHNPhC(S)NMe₂.

Tetrahedron published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C7H13NO2, Product Details of C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Funnell, Richard A. published the artcileThree reactions leading to isomeric 2-(N,N-disubstituted amino)thiazol-5-yl ketones, Recommanded Product: Morpholine-4-carbothioamide, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1987), 2311-15, database is CAplus.

N-Imidoyl-N,N-disubstituted thioureas PhNHCR:NCSR¹ (R = CMe₃, Ph, 4-MeOC₆H₄, 4-ClC₆H₄, 2-thienyl, R¹ = NMe₂, NPhMe, pyrrolidino, piperidino, morpholino, hexahydroazepino) react with α-halo ketones R²COCH₂R³ (I, R² = Me, R³ = Cl; R² = Me, CMe₃, Ph, 4-ClC₆H₄, 4-MeOC₆H₄, 4-O₂NC₆H₄, Me₂CH, R³ = Br) in the presence of Et₃N to give the expected 2-(N,N-disubstituted amino)thiazol-5-yl ketones II in high yield. The corresponding reactions of N-acyl-N,N-disubstituted thioureas RCONHCSR¹ with I lead to mixtures of II and III, which arise from rearrangement between cyclic intermediates. Mixtures of II and III are also formed by treating N,N-disubstituted thioureas R¹CSNH₂ with 2-bromo-1,3-diketones RCOCHBrCOR². The mixtures from the second and third routes contain the same products but in significantly different proportions. A mechanistic scheme which accounts for the main findings was developed. Characteristic mass spectral fragmentation patterns were particularly useful in identifying the substituents at positions 4 and 5 of the thiazole ring.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, Recommanded Product: Morpholine-4-carbothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Xiao, Jingbo published the artcileDiscovery, Synthesis, and Biological Evaluation of Novel SMN Protein Modulators, Recommanded Product: Morpholine-4-carbothioamide, the publication is Journal of Medicinal Chemistry (2011), 54(18), 6215-6233, database is CAplus and MEDLINE.

Spinal muscular atrophy (SMA) is an autosomal recessive disorder affecting the expression or function of survival motor neuron protein (SMN) due to the homozygous deletion or rare point mutations in the survival motor neuron gene 1 (SMN1). The human genome includes a second nearly identical gene called SMN2 that is retained in SMA. SMN2 transcripts undergo alternative splicing with reduced levels of SMN. Up-regulation of SMN2 expression, modification of its splicing, or inhibition of proteolysis of the truncated protein derived from SMN2 have been discussed as potential therapeutic strategies for SMA. In this manuscript, the discovery of a series of arylpiperidines as novel modulators of SMN protein is described. Systematic hit-to-lead efforts significantly improved potency and efficacy of the series in the primary and orthogonal assays. Structure-property relationships including microsomal stability, cell permeability, and in vivo pharmacokinetics were also investigated. In consideration to all the aspects including ADME properties, the analogs I (X = NH₂, R = 3-i-PrOC₆H₄; X = OH, R = 3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl) possessed the best combination of potency, efficacy, mouse liver microsomal stability and cell permeability as well as good oral absorption and CNS penetration upon oral gavage administration. These compounds also showed no sign of toxicity or behavioral disturbance in animals.

Journal of Medicinal Chemistry published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C12H10N2O5, Recommanded Product: Morpholine-4-carbothioamide.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics

Mohbiya, Dhanraj R. published the artcileInfluence of acceptors in NLOphoric aacenaphthene and morpholine-thiourea hybrid dyes: Photophysical, viscosity, DFT and Z-Scan study, COA of Formula: C5H10N2OS, the publication is Optical Materials (Amsterdam, Netherlands) (2019), 178-190, database is CAplus.

Three novel fluorescent NLOphoric push-pull fluorophores (2a-c) constituted by different cyano containing acceptors linked to morpholine-thiourea (donor) and acenaphthene (rotor) hybrid were synthesized and characterized. They exhibit pos. absorption and emission solvatochromism. The solvent polarity function based Lippert-Mataga plot provides the validation of charge transfer (CT) characteristics whereas, Rettig plot furnishes an alternative relaxation channel due to twisting around the σ-bonds between donor and acceptor on photoexcitation leading to the twisted intramol. charge transfer (TICT) state in dyes 2a-c. Viscosity induced emission studies show 4.18, 17.61, and 5.30 fold increase in the emission intensity for dyes 2a, 2b, and 2c resp. which recommends these dyes as fluorescent mol. rotors (FMR). D. Functional Theory (DFT) calculations [B3LYP/6-311++G(d,p)] give complete information of structural as well as electronic properties of dyes 2a-c. The difference in dipole moment (ca. 4.86-8.23 D) results in a strong non-linear optical (NLO) properties which increases in the order 2a< 2b < 2c. Z-scan studies reveal that the dyes possesses reverse-saturable i.e. pos. type of absorption non-linearity resulting in a pos. values of β (2c > 2b > 2a). The lower optical limiting threshold values for dyes 2a-c, made them suitable for the use in the application of NLO materials.

Optical Materials (Amsterdam, Netherlands) published new progress about 14294-10-1. 14294-10-1 belongs to amides-buliding-blocks, auxiliary class Morpholine,Thiourea,Amine,Amide, name is Morpholine-4-carbothioamide, and the molecular formula is C5H10N2OS, COA of Formula: C5H10N2OS.

Referemce:
https://en.wikipedia.org/wiki/Amide,
Amide – an overview | ScienceDirect Topics