Category: 142733-64-0

Application of 142733-64-0, These common heterocyclic compound, 142733-64-0, name is tert-Butyl (cis-3-(hydroxymethyl)cyclobutyl)carbamate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under nitrogen protection,Compound 3-Boc aminocyclobutylmethanol (83f) (350.0 mg, 1.7 mmol)And triethylamine (528.0 mg, 5.2 mmol) was dissolved in 10 mL of dichloromethane.Under ice water bath, methylsulfonyl chloride (219.0 mg, 1.9 mmol) was added dropwise.Stir at room temperature for 3 h.Dichloromethane and 0.2 N of dilute hydrochloric acid were added and extracted.The organic layer was washed twice with brine, dried and dried.The compound 3-((tert-butoxycarbonyl)amino)cyclobutyl)methyl methanesulfonate (83 g) (330.0 mg, 1.2 mmol)The next reaction was directly administered, and the yield was 67.9%.

The synthetic route of 142733-64-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chengdu Haichuang Pharmaceutical Co., Ltd.; Du Wu; Wen Kun; Ai Chaowu; He Jinyun; Li Xinghai; Chen Yuanwei; (28 pag.)CN109988120; (2019); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 142733-64-0,Some common heterocyclic compound, 142733-64-0, name is tert-Butyl (cis-3-(hydroxymethyl)cyclobutyl)carbamate, molecular formula is C10H19NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of II-29-1 (200 mg, 1.0 mmol) and Et3N (202 mg, 2.0 mmol) in CH2C12(10 mL) was added MsCl (172 mg, 1.5 mmol) at 0 C. The reaction mixture was stirred at room temperature overnight before water was added to the reaction. The solution mixture was extracted with CH2C123 times. The organic layer was washed with brine and dried over Na2S04. The solution was filtered and concentrated to give II-29-2 as a white solid (250 mg, yield: 90%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route tert-Butyl (cis-3-(hydroxymethyl)cyclobutyl)carbamate, its application will become more common.

Reference:
Patent; KURA ONCOLOGY, INC.; BURROWS, Francis; KESSLER, Linda V.; LI, Liansheng; REN, Pingda; WANG, Yi; WU, Tao; ZHANG, Jingchuan; (355 pag.)WO2018/175746; (2018); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics