Synthetic Route of 141761-83-3,Some common heterocyclic compound, 141761-83-3, name is Methyl 6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxylate, molecular formula is C11H10ClNO4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
500ml three bottles,After adding 150 ml of water and 12 g (0.3 mol) of sodium hydroxide, the mixture was stirred until the solid was completely dissolved, and 100 ml of ethanol was further added thereto. The temperature was lowered to 20C, 6-chloro-4-methyl-3,4-dihydro- (0.1 mol) of methyl 2,4-benzoxazin-8-carboxylate was added and stirred for 3 h. After the reaction was completed, the reaction mixture was cooled to 10 C or less, diluted hydrochloric acid was adjusted to pH 2, filtered and dried to give 4-methyl-3,4-dihydro-3-oxo-2H-1,4-benzoxazine-8-carboxylic acid as an off-white solid, 21.9 g, 91% yield.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxylate, its application will become more common.
Reference:
Patent; Yangtze River Pharmaceutical Group Sichuan Hairong Pharmaceutical Co., Ltd; Li, Yuanbo; Xie, Yipeng; Cao, Kangping; Wang, Qiang; Wu, Puhua; Wang, Ying; Zhou, Xinyu; (9 pag.)CN104557907; (2016); B;,
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