Category: 14062-80-7

Reference of 14062-80-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 14062-80-7, name is 4-Chloro-N,N-dimethylbenzamide, This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE I 2-p-Chlorobenzoylpyrrole A mixture of 183 g (1 mole) of p-chloro-N,N-dimethylbenzamide and 153g (1 mole) of phophorous oxychloride in 300 ml of 1,2-dichloroethane is heated under reflux for 30 minutes, after which a solution of 67g (1 mole) of pyrrole in 300 ml of dichloroethane is added drop-wise. It is cooled and a solution of 408g (3 moles) of sodium acetate trihydrate in 1600 ml of water is added dropwise for 45 minutes, after which the mixture is again heated under reflux for 30 minutes. The resulting mixture is poured onto ice, the organic layer is separated, and the aqueous layer is washed with chloroform. The combined organic solutions are washed with sodium bicarbonate and brine and dried over magnesium sulfate. Evaporation of the solvent in vacuo gives a dark oil, which is distilled in vacuo through a heated Vigreaux column to give a white solid; mp 106-9 C. It is recrystallized from cyclohexane to give 2-p-chlorobenzoylpyrrole as white needles; m.p. 110-113 C.

The chemical industry reduces the impact on the environment during synthesis 4-Chloro-N,N-dimethylbenzamide. I believe this compound will play a more active role in future production and life.

Reference:
Patent; McNeil Laboratories, Inc.; US4002643; (1977); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Some common heterocyclic compound, 14062-80-7, name is 4-Chloro-N,N-dimethylbenzamide, molecular formula is C9H10ClNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C9H10ClNO

General procedure: To a mixture of 1a (0.6g, 4.8 mmol, 1equiv), imidazolium chloride (0.25g, 2.4 mmol,0.5equiv) and N,N-dimethylbenzamide (1.43g, 9.6 mmol, 2 equiv) was added. Themixture was stirred at 160C for 10h. after completion of the reaction. 15ml water was added and the resulting mixture was extracted with 20ml EA thrice, and the combined organic layers were dried over anhydrous Na2SO4 and concentrated. The residue was purified by column chromatography on silica gel using PE/EA as eluent to obtain thepure desired product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 14062-80-7, its application will become more common.

Reference:
Article; Tian, Qingqiang; Luo, Wen; Gan, Zongjie; Li, Dan; Dai, Zeshu; Wang, Huajun; Wang, Xuetong; Yuan, Jianyong; Molecules; vol. 24; 1; (2019);,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application of 14062-80-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 14062-80-7, name is 4-Chloro-N,N-dimethylbenzamide, This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE I 2-p-Chlorobenzoylpyrrole A mixture of 183 g (1 mole) of p-chloro-N,N-dimethylbenzamide and 153g (1 mole) of phophorous oxychloride in 300 ml of 1,2-dichloroethane is heated under reflux for 30 minutes, after which a solution of 67g (1 mole) of pyrrole in 300 ml of dichloroethane is added drop-wise. It is cooled and a solution of 408g (3 moles) of sodium acetate trihydrate in 1600 ml of water is added dropwise for 45 minutes, after which the mixture is again heated under reflux for 30 minutes. The resulting mixture is poured onto ice, the organic layer is separated, and the aqueous layer is washed with chloroform. The combined organic solutions are washed with sodium bicarbonate and brine and dried over magnesium sulfate. Evaporation of the solvent in vacuo gives a dark oil, which is distilled in vacuo through a heated Vigreaux column to give a white solid; mp 106-9 C. It is recrystallized from cyclohexane to give 2-p-chlorobenzoylpyrrole as white needles; m.p. 110-113 C.

The chemical industry reduces the impact on the environment during synthesis 4-Chloro-N,N-dimethylbenzamide. I believe this compound will play a more active role in future production and life.

Reference:
Patent; McNeil Laboratories, Inc.; US4002643; (1977); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of 14062-80-7,Some common heterocyclic compound, 14062-80-7, name is 4-Chloro-N,N-dimethylbenzamide, molecular formula is C9H10ClNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

N’-cyanobenzimidamide (16.8 g, 115 mmol),Compound A-2 (21 g, 115 mmol) andPhosphorus oxychloride (12 mL, 128 mmol) was added to a solution ofAnd the mixture was added to 500 mL of acetonitrile, followed by stirring and refluxing for 1 hour. After cooling to room temperature, the resulting solid was filtered, washed with water and ethanol, and dried to give Compound A (27.6 g, yield 80%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Chloro-N,N-dimethylbenzamide, its application will become more common.

Reference:
Patent; LG Chem, Ltd.; Kang Min-yeong; Park Tae-yun; Cho Seong-mi; Moon Jeong-uk; Jeong Min-u; Lee Jeong-ha; Chae Mi-yeong; (30 pag.)KR2019/9211; (2019); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 14062-80-7,Some common heterocyclic compound, 14062-80-7, name is 4-Chloro-N,N-dimethylbenzamide, molecular formula is C9H10ClNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

N’-cyanobenzimidamide (16.8 g, 115 mmol),Compound A-2 (21 g, 115 mmol) and phosphorous oxychloride(12 mL, 128 mmol) was added to 500 mL of acetonitrile, followed by stirring and refluxing for 1 hour.After cooling to room temperature, the resulting solid was filtered,Washed with water and ethanol, and then dried to obtain CompoundA (27.6 g, yield 80%).

The synthetic route of 14062-80-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LG Chem, Ltd.; Kang Min-yeong; Park Tae-yun; Cho Seong-mi; Moon Jeong-uk; Jeong Min-u; Lee Jeong-ha; (29 pag.)KR2019/6353; (2019); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics