Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 136927-63-4, name is Pyrrolo[1,2-a]pyrazin-1(2H)-one, A new synthetic method of this compound is introduced below., Quality Control of Pyrrolo[1,2-a]pyrazin-1(2H)-one
PREPARATION 20 1-chloropyrrolo[1,2-a]pyrazine (A compound of formula (BB)) To pyrrolo[1,2-a]pyrazin-1(2H)-one (0.35 g, 2.61 mmol) was added phosphorous oxychloride (4.0 g, 26.1 mmol). The reaction mixture was agitated for approximately 16 hours. The reaction mixture was then made alkaline by the addition of sodium bicarbonate. The reaction mixture was then extracted with hexane, washed with a saturated sodium bicarbonate solution, dried over MgSO4 and evaporated. The product was purified by recrystallization in hexane and cooled with a mixture of dry ice and acetone to give the title compound, 1-chloropyrrolo[1,2-a]pyrazine (71%), m.p. 56-57 C.
The synthetic route of 136927-63-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Syntex (U.S.A.) Inc.; US5041442; (1991); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics