Synthetic Route of 13621-50-6, The chemical industry reduces the impact on the environment during synthesis 13621-50-6, name is Ethyl 3-amino-3-thioxopropanoate, I believe this compound will play a more active role in future production and life.
Ethyl 2-amino-4-isopropyl-6-thio-5-cyano-1,4-dihydropyridine-3-carboxylate (IV). 1.0 g (10 mmol)of cyanothioacetamide II and a solution of sodiumethylate prepared from 0.23 g (10 mmol) of sodiumand 15 mL of anhydrous ethanol were added to a solution of 0.91 mL (10 mmol) of isobutyral Ia in15 mL of anhydrous ethanol at 20C. The reactionmixture was stirred during 5 min, then 1.5 g (10 mmol)of CH-acid III was added, and the mixture was stirredduring 30 min and incubated during 48 h. Next, themixture was diluted with 10% hydrochloric acid to pH5 upon stirring and incubated at room temperatureduring 48 h. The formed precipitate was filtered offand washed sequentially with water, ethanol, andhexane (Tables 1 and 2). Mass spectrum, m/z (Irel, %):266 (100) [M – 1]+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 3-amino-3-thioxopropanoate, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Dyachenko; Karpov; Dyachenko; Russian Journal of General Chemistry; vol. 85; 5; (2015); p. 1063 – 1068; Russian Journal of General Chemistry; vol. 85; 5; (2015); p. 1063 – 1068,6;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics