Category: 13255-50-0

Tf₂O-Mediated Intermolecular Coupling of Secondary Amides with Enamines or Ketones: A Versatile and Direct Access to β-Enaminones was written by Liu, Yong-Peng;Zhu, Cheng-Jie;Yu, Cun-Cun;Wang, Ai-E.;Huang, Pei-Qiang. And the article was included in European Journal of Organic Chemistry in 2019.Safety of 4-Formyl-N-isopropylbenzamide This article mentions the following:

Based on the Tf₂O-mediated intermol. reaction of secondary amides with enamines derived from ketones, a novel approach to β-enaminones was developed. The reaction is widely functional group tolerant and highly chemoselective. In the presence of 4 Å mol. sieves, the method can be extended to the one-pot condensation of secondary amides with ketones for NH β-enaminones synthesis. In the experiment, the researchers used many compounds, for example, 4-Formyl-N-isopropylbenzamide (cas: 13255-50-0Safety of 4-Formyl-N-isopropylbenzamide).

4-Formyl-N-isopropylbenzamide (cas: 13255-50-0) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be freed from solvent or water by drying below their melting points. These purifications can also be used for sulfonamides and acid hydrazides.Safety of 4-Formyl-N-isopropylbenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Determination of phytocomponents of twenty-one varieties of smokeless tobacco using gas chromatography-mass spectroscopy (GC-MS) was written by Alhazmi, Hassan A.;Khalid, Asaad;Sultana, Shahnaz;Abdelwahab, Siddig I.;Ahsan, Waquar;Oraiby, Magbool E.;Al Brattya, Mohammad. And the article was included in South African Journal of Chemistry in 2019.Electric Literature of C11H13NO2 This article mentions the following:

Smokeless tobacco (ST) leaves are being consumed by millions in Middle Eastern countries including Saudi Arabia, Sudan and Yemen, where the locally manufactured form is called shammah. We intended to explore and compare the phytocomponents of 21 different varieties of shammah that are commonly available in different cities of Jazan province of Saudi Arabia using gas chromatog.-mass spectroscopy (GC-MS). A total of 61 different constituents were tentatively identified in these samples including both hazardous and non-hazardous compounds Solvents of different polarity, such as petroleum ether, chloroform, ethanol and water were used to prepare the extracts Interestingly, a number of new and unusual constituents were identified in some samples. N-methoxycarbonyl-amphetamine was detected as 6.76%, 4.88% and 2.58% of total compounds in Khadrah, Arishi and Sudani shammah samples, resp. Similarly, the presence of caffeine (0.44-1.41%) in Adani cold from Jazan city and Abu Arish and Adani hot shammah from Abu Arish suggested the possibility of adulteration. Extremely hazardous arsenic and benzopyran derivatives were present in Sudani shammah from Sabya in small but significant amounts Furthermore, carcinogenic components were also detected in significant amounts which indicate a relation between ST amounts used and different types of cancer, especially oral cancer. Chemometric hierarchical cluster anal. (HCA) revealed the existence of sufficient differences between samples from different extracts based on the polarity and dendrograms. In the experiment, the researchers used many compounds, for example, 4-Formyl-N-isopropylbenzamide (cas: 13255-50-0Electric Literature of C11H13NO2).

4-Formyl-N-isopropylbenzamide (cas: 13255-50-0) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Electric Literature of C11H13NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mechanism of the cytostatic action of methylhydrazines. III was written by Weitzel, Guenther;Schneider, Friedhelm;Hirschmann, Wolf D.;Durst, Juergen;Thauer, Rudolf K.;Ochs, Hans Dieter;Kummer, Dieter. And the article was included in Zeitschrift fuer Physiologische Chemie in 1967.SDS of cas: 13255-50-0 This article mentions the following:

Hydrazine acetate (225-750 γ) injected i.v. into mice bearing Ehrlich ascites tumors reduced the incorporation rate of thymidine (I) and leucine (II) into the tumor cells dependent on dose; uridine (III) incorporation was not influenced. I.p. injections of Natulan (IV) (4-[(2-methylhydrazino)methyl]-N-isopropylbenzamide) and Azo-Natulan (4-(methylazomethyl)-N-isopropylbenzamide) (10 mg.) into mice bearing ascites tumors preferentially reduced the incorporation of III and also reduced I and II incorporation. Demethylated IV (4-(hydrazinomethyl)-N-isopropylbenzamide) reduced II and III, but not I incorporation. In the presence of NADPH, liver microsomes split IV to give HCHO. N-Isopropyl-4-formylbenzamide (1-2 × 10-3M) inhibited III and II and, to a lesser extent, I incorporation into ascites cells in vitro and produced similar results when injected at 15 mg. into ascitic mice. The biosynthesis of proteins in a cell-free system was not inhibited by hydrazine acetate, methylhydrazine, formalhydrazine, benzylhydrazine, 1-methyl-2-benzylhydrazine, IV, or demethylated IV. The spontaneous reaction of the IV degradation product, N-isopropyl-4-formylbenzamide, with amino acids produced Schiff bases, which could inhibit II incorporation by removing amino acids from protein synthesis. The synthesis of DNA and RNA was affected in the following manner. Hydrazine acetate (1-2 × 10-3M) inhibited the formation of purine deoxynucleosides. The HCHO resulting from the Me group of methylhydrazine inhibited the formation of deoxynucleoside diphosphates and deoxynucleoside triphosphates. The substituent N-isopropylcarbamide in the para position on the benzene ring inhibited the entrance of nucleosides and purines into the cell, resulting in a general lowering of the intracellular content of nucleosides and purines. In addition to condensation with amino acids, the aldehyde group of the N-isopropyl-4-formylbenzamide inhibited the formation of the nucleoside diphosphates and nucleoside triphosphates. All of these effects could be demonstrated simultaneously for IV and Azo-Natulan. 27 references. In the experiment, the researchers used many compounds, for example, 4-Formyl-N-isopropylbenzamide (cas: 13255-50-0SDS of cas: 13255-50-0).

4-Formyl-N-isopropylbenzamide (cas: 13255-50-0) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.SDS of cas: 13255-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Analysis of procarbazine and metabolites by gas chromatography-mass spectrometry was written by Gorsen, Robert M.;Weiss, A. J.;Manthei, R. W.. And the article was included in Journal of Chromatography, Biomedical Applications in 1980.Product Details of 13255-50-0 This article mentions the following:

Procarbazine-HCl (I) [366-70-1], and several metabolites, and an internal standard were analyzed by gas chromatog.-mass spectrometry on a 3% OV-1 column. Procarbazine and 4 metabolites were derivatized with acetic anhydride. A sensitive, specific and quant. assay was established by selected ion monitoring using a synthetic analog of the drug as an internal standard The limits of detection were approx. 1 ng/mL of plasma while the limits of quantitation were 10 ng/mL of plasma. Studies on the degradation of procarbazine-HCl in 0.05 M phosphate buffer (pH 7.4) were compared to in vivo studies. At 1 h after incubation of procarbazine-HCl in buffer, the azo and aldehyde metabolites were detected in the highest concentrations representing 27.2% and 20.3% of total drug and metabolites. In the in vivo studies, analyses of rat plasmas indicated that 1 h after an oral dose of procarbazine-HCl the aldehyde metabolite [13255-50-0] represented 72% of the total drug and metabolites, and that relatively little of the azo metabolite was present. In the experiment, the researchers used many compounds, for example, 4-Formyl-N-isopropylbenzamide (cas: 13255-50-0Product Details of 13255-50-0).

4-Formyl-N-isopropylbenzamide (cas: 13255-50-0) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Product Details of 13255-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reactions of OH-radicals with procarbazine. A pulse radiolysis and computer simulation study was written by Delipetar-Grudl, A.;Solar, S.;Getoff, N.. And the article was included in Anticancer Research in 2006.Recommanded Product: 13255-50-0 This article mentions the following:

Pulse radiolysis was applied to study the reactivity of ^·OH radicals with procarbazine (PC), a cytostatic agent widely used in radiation- and chemotherapy. An overall rate constant of k(^·OH+PC)=3.7×10⁹ l.mol^-1.s^-1 was determined The thereby formed transients had a strong absorption at 350 nm, ε₃₅₀=4.46×10³ l.mol^-1.cm^-1, and a weak absorption band around 530 nm. Computer simulation studies to elucidate the most probable sites of ^·OH attack on the PC mol. showed that ^·OH radical addition to the aromatic ring had the highest probability. These transients decayed by a first order reaction, k=1.75×10³ s^-1, whereby species having a maximum absorption at 300 nm and broad shoulder at 340-380 nm were formed. Similar absorptions were observed after gamma radiolysis of PC. A reaction mechanism is suggested. For the reaction of H-atoms with PC, a rate constant k(^·H+PC)=6.4×10⁸ l.mol^-1.s^-1 was determined In the experiment, the researchers used many compounds, for example, 4-Formyl-N-isopropylbenzamide (cas: 13255-50-0Recommanded Product: 13255-50-0).

4-Formyl-N-isopropylbenzamide (cas: 13255-50-0) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Recommanded Product: 13255-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Versatile and chemoselective transformation of aliphatic and aromatic secondary amides to nitriles was written by Geng, Hui;Huang, Pei-Qiang. And the article was included in Tetrahedron in 2015.Name: 4-Formyl-N-isopropylbenzamide This article mentions the following:

Triflic anhydride in combination with 2-fluoropyridine effectively dehydrates secondary amides to afford nitriles under mild reaction conditions. The reaction is general in scope and compatible with the use of aliphatic, α,β-unsaturated, aromatic and heteroaromatic amides bearing either secondary, tertiary, or benzylic N-alkyl groups. The reaction also shows good to excellent chemoselectivity for the secondary amide and tolerates several labile functional groups. Under optimized conditions the synthesis of the target compounds was achieved using amides as starting materials, such as N-(isopropyl)benzenebutanamide, N-(isopropyl)benzenepropanamide, adamantanecarboxamide derivatives, N-(tert-butyl)benzamide, 3-(phenyl)-2-propenamide derivatives (unsaturated amides), 1,3-benzodioxole-5-carboxamide, 2-thiophenecarboxamide (thiophene), benzo[b]thiophene-2-carboxamide derivatives, (aminocarbonyl)benzoic acid derivatives In the experiment, the researchers used many compounds, for example, 4-Formyl-N-isopropylbenzamide (cas: 13255-50-0Name: 4-Formyl-N-isopropylbenzamide).

4-Formyl-N-isopropylbenzamide (cas: 13255-50-0) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Name: 4-Formyl-N-isopropylbenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Cross-Coupling of Secondary Amides with Tertiary Amides: The Use of Tertiary Amides as Surrogates of Alkyl Carbanions for Ketone Synthesis was written by Wang, Shu-Ren;Huang, Pei-Qiang. And the article was included in Chinese Journal of Chemistry in 2019.Computed Properties of C11H13NO2 This article mentions the following:

Herein, we reported the cross-coupling of secondary amides with tertiary amides, which provided a synthesis of ketones R¹C(O)R² [R¹ = Et, 2-thienyl, Ph, etc.; R² = i-Pr, i-Bu, cyclohexyl, etc.] under mild conditions and features the use of tertiary amides as surrogates of alkyl carbanions. The method relied on the coupling of enamines, generated from tertiary amides by catalytic partial reduction of tertiary amides with Vaska’s catalyst, with nitrilium ions, formed in-situ from secondary amides via activation with trifluoromethanesulfonic anhydride and on the subsequent deformylation. In the experiment, the researchers used many compounds, for example, 4-Formyl-N-isopropylbenzamide (cas: 13255-50-0Computed Properties of C11H13NO2).

4-Formyl-N-isopropylbenzamide (cas: 13255-50-0) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Computed Properties of C11H13NO2

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics