Application of 132414-81-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 132414-81-4, name is 5-Boc-hexahydropyrrolo[3,4-b]pyrrole belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
A mixture of compound 4a (100 mg, 0.47 mmol) and TEA (260 mg,2.56 mmol) in DCM (10 mL) was added compound 9 (97 mg, 0.52 mmol) stirred at r.t. for 3 hrs under N2 atmosphere. The mixture was diluted with water and extracted with EtOAc. The organic combined layers were washed with brine, dried over Na2SO4, filtered, concentrated and purified by Flash column to give compound 6 (150 mg,yield: 88%). MS (ESI): m/z 364.1 [M + H]+
The synthetic route of 5-Boc-hexahydropyrrolo[3,4-b]pyrrole has been constantly updated, and we look forward to future research findings.
Reference:
Article; Wu, Songliang; Sun, Yu; Hu, Yi; Zhang, Hongmei; Hou, Lijuan; Liu, Xing; Li, Yufeng; He, Haiying; Luo, Zhi; Chen, Yuan; Wang, Yuhe; Shi, Weihua; Shen, Liang; Cao, Changqing; Liang, Wei; Xu, Qing; Lv, Qiang; Lan, Jiong; Li, Jian; Chen, Shuhui; Bioorganic and Medicinal Chemistry Letters; vol. 27; 6; (2017); p. 1458 – 1462;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics