Application of 1314538-55-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1314538-55-0 as follows.
[01253] A mixture of 4-chloro-2-cyclopropyl-6-(trifluoromethyl)pyrimidine (500 mg, 2.25 mmol, 1.00 equiv), potassium tert-butyl N-[(trifluoroboranuidyl)methyl]carbamate (600 mg, 2.53 mmol, 1.13 equiv), Pd(PPh3)2C12 (150 mg, 0.21 mmol, 0.01 equiv), and sodium carbonate (750 mg, 7.07 mmol, 3.15 equiv) in ethanol (20 mL)/water(2 mL) was stirred for 3 hours at 80C under nitrogen. The resulting mixture was concentrated under vacuum. The residue was purified by a silica gel colunm eluting with ethyl acetate/petroleum ether (1/4) to afford the title compound (250 mg, 35%) as greenish oil. LCMS [M+H] 318.
According to the analysis of related databases, 1314538-55-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; ESTRADA, Anthony; VOLGRAF, Matthew; CHEN, Huifen; KOLESNIKOV, Aleksandr; VILLEMURE, Elisia; VERMA, Vishal; WANG, Lan; SHORE, Daniel; DO, Steven; YUEN, Po-wai; HU, Baihua; WU, Guosheng; LIN, Xingyu; LU, Aijun; (537 pag.)WO2016/128529; (2016); A1;,
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