Application of 128263-66-1,Some common heterocyclic compound, 128263-66-1, name is N-(4-(Aminomethyl)phenyl)methanesulfonamide hydrochloride, molecular formula is C8H13ClN2O2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example I N-[4-[[2-Hydroxy-3-(3-methylphenoxy)propyl]aminomethyl]phenyl]methanesulfonamide hydrochloride Heat a mixture of N-[4-(aminomethyl)phenyl]methanesulfonamide hydrochloride(15.0 g, 63.4 mmol) and 1,2-epoxy-3-phenoxypropane (10.41 g, 63.4 mmol) in 63.4 mL of 1 N KOH in methanol and 10 mL of water for about 3.5 h. Remove the solvent to afford crystals of the title compound. NMR (DMSO-d6): delta=2.27(s,3), 2.85-3.15(m,2), 3.02 (s,3), 3.93(s,2), 4.14(s,2), 4.23(br s,1), 5.90(br s,1), 6.74(m,3), 7.19(m,1), 7.24(d,2), 7.53(d,2), ca. 9.35 (br s,2) and 9.97(s,1) ppm.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route N-(4-(Aminomethyl)phenyl)methanesulfonamide hydrochloride, its application will become more common.
Reference:
Patent; Schering AG; US5051423; (1991); A;,
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