Adding a certain compound to certain chemical reactions, such as: 1232365-42-2, name is tert-Butyl (3,3-difluoro-1-(hydroxymethyl)cyclobutyl)carbamate, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1232365-42-2, SDS of cas: 1232365-42-2
Tert-Butyl N- [3,3 -difluoro- 1 -(hydroxymethyl)cyclobutyl] carbamate (900 mg, 3.79mmol) was dissolved in 25 mL of 4M HC1/dioxane at r.t. and the resulting mixture was stirredovernight. Upon completion of the reaction (monitored by 1 H NMR), the resulting mixture was concentrated under reduced pressure, the residue was treated with 20 mL of acetonitrile, and filtered. The precipitate was washed with acetonitrile and dried in vacuo to obtain (1-amino-3,3- difluorocyclobutyl)methanol hydrochloride (550.0 mg, 3.17 mmol, 83.5% yield) as whitepowder.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, tert-Butyl (3,3-difluoro-1-(hydroxymethyl)cyclobutyl)carbamate, and friends who are interested can also refer to it.
Reference:
Patent; AICURIS GMBH & CO. KG; DONALD, Alastair; URBAN, Andreas; BONSMANN, Susanne; WEGERT, Anita; GREMMEN, Christiaan; SPRINGER, Jasper; (376 pag.)WO2019/86141; (2019); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics