Category: 123-39-7

Reis Conceicao, Nuno published the artcileKnoevenagel condensation reaction in supercritical carbon dioxide medium using a Zn(II) coordination polymer as catalyst, Product Details of C2H5NO, the main research area is zinc coordination polymer catalyst preparation benzaldehyde Knoevenagel condensation reaction.

The replacement of conventional organic solvents by the so-called “”green solvents”” is a usual approach to more sustainable chem. processes. Supercritical carbon dioxide (scCO2) has been successfully regarded as a candidate for such a purpose. Moreover, it possesses moderate critical pressure and temperature conditions and may be easily separated from the catalytic system by a simple depressurization. In the present work, the new Zn(II) coordination polymer [Zn(L1)(NMeF)]n·n(NMeF) (Zn-CP 1) is reported, being prepared by the solvothermal reaction of 5-{(pyren-4-ylmethyl)amino}isophthalic acid (H2L1) with Zn(NO3)2·6H2O in N-methylformamide (NMeF). The SCXRD anal. revealed that Zn-CP 1 has a 1D double chain type of structure. Its potential as catalyst was studied in the Knoevenagel condensation of benzaldehyde and malononitrile as a model reaction under mild conditions, in scCO2 medium. An increasing trend was observed in the reaction yield as we moved from aprotic (THF) to protic (EtOH and H2O) polar co-solvents, reaching the full conversion in the case of water. It was found that scCO2, in the absence of a protic co-solvent, is not the most suitable medium for this reaction. The catalyst can be recycled without a considerable loss of activity; SEM, PXRD, FT-IR and TGA analyzes indicate its high stability throughout the process.

Inorganica Chimica Acta published new progress about Crystal structure. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Product Details of C2H5NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kharaneko, A. O. published the artcileSynthesis and Modification of Hetero-Fused Pyrazoles Derived from Methyl 1-(2-Oxo-2-phenylethyl)-3-phenyl-1H-pyrazole-5-carboxylate, Application In Synthesis of 123-39-7, the main research area is hetero fused pyrazole preparation.

A modified procedure has been proposed for the synthesis of 2,7-diphenyl-5,8-dihydro-4H-pyrazolo[5,1-d][1,2,5]triazepin-4-one, and the possibility of transformation of the latter to the pyrazolo[1,5-a]pyrazine system has been demonstrated. Functionalization of 2,7-diphenyl-5,8-dihydro-4H-pyrazolo[5,1-d][1,2,5]triazepin-4-one at the 4-position and fusion of a tetrazole or triazole ring at the C4-N5 bond have been performed.

Russian Journal of Organic Chemistry published new progress about Heterocyclization. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Application In Synthesis of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Hornink, Milene Macedo published the artcileBiobased Spiroimides from Itaconic Acid and Formamides: Molecular Targets for a Novel Synthetic Application of Renewable Chemicals, Computed Properties of 123-39-7, the main research area is spiro dihydroquinolinone succinimide spiroindolinone glutarimide preparation; dihydroquinolinone indolinone itaconic acid anhydride formamide Fenton photochem flow.

Herein, a novel synthetic application of renewable chems., itaconic acid and formamides, is described. Proper exploitation of the reactivity of itaconic acid and formamide allows for the development of an efficient synthetic approach for the production of several new biobased spiroimides, spiro[dihydroquinolin-2-one-succinimides] I (R1 = H, Me, Cl, etc.; R2 = Me, Ph, Bn; R3 = H, Me) and spiro[indolin-2-one-glutarimides] II (R1 = H, OMe, CF3; R2 = Me, Bn; R3 = H, Me), in excellent overall yields (up to 98%).

Synthesis published new progress about Aromatic amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Computed Properties of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kharaneko, A. O. published the artcileSynthesis of 3-Phenyl-1H-[1,4]oxazino[4,3-a]benzimidazol-1-one and Its Transformation into 4-Phenyl-2,5-dihydro-1H-[1,2,5]triazepino[5,4-a]benzimidazol-1-one, Safety of N-Methylformamide, the main research area is phenyl oxazinobenzimidazolone preparation; dihydrotriazepinobenzimidazolone preparation; phenylpyrazino benzimidazolone preparation; benzimidazole preparation.

A synthetic route was proposed to 3-phenyl-1H-[1,4]oxazino[4,3-a]benzimidazol-1-one I, which was the first representative of a new heterocyclic system. The transformation of the title compound I to 4-phenyl-2,5-dihydro-1H-[1,2,5]triazepino[5,4-a]benzimidazol-1-one II via reaction with hydrazine hydrate was studied.

Russian Journal of Organic Chemistry published new progress about Fused heterocyclic compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Safety of N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhu, Zhentong published the artcileLow-Noise Nanopore Enables In-Situ and Label-Free Tracking of a Trigger-Induced DNA Molecular Machine at the Single-Molecular Level, Synthetic Route of 123-39-7, the main research area is nanopore DNA machine.

Solid-state nanopores have shown special high potential in a label-free mol. assay, structure identification, and target-index at the single-mol. level, even though frustrating elec. baseline noise is still one of the major factors that limit the spatial resolution and signaling reliability of solid-state nanopores, especially in small target detection. Here the authors develop a significant and easy-operating noise-reduction approach via mixing organic solvents with high dielec. constants into a traditional aqueous electrolyte. The strategy is generally effective for pores made of different materials, such as the most commonly used conical glass (CGN) or SiNx. While the mechanism should be multisourced, MD simulations suggest the noise reduction may partially arise from the even ionic distribution caused by the addition of higher dielec. species. Among all solvents exptl. tested, the two with the highest dielec. constants, formamide and methylformamide, exhibit the best noise reduction effect for target detection of CGN. The power spectral d. at the low-frequency limit is reduced by nearly 3 orders with the addition of 20% formamide. The work qualifies the reliability of solid-state nanopores into much subtler scales of detection, such as dsDNAs under 100 bp. As a practical example, bare CGN is innovatively employed to perform in-situ tracking of trigger-responsive DNA machine forming oligomers.

Journal of the American Chemical Society published new progress about Glass Role: ARG (Analytical Reagent Use), BUU (Biological Use, Unclassified), TEM (Technical or Engineered Material Use), ANST (Analytical Study), USES (Uses), BIOL (Biological Study). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Synthetic Route of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zheng, Yong published the artcileNanophase Separation in Immiscible Double Network Elastomers Induces Synergetic Strengthening, Toughening, and Fatigue Resistance, Safety of N-Methylformamide, the main research area is nanophase immiscible network elastomer synergetic strengthening toughening fatigue resistance.

High modulus, toughness, and fatigue resistance are usually difficult to be obtained simultaneously in rubbery materials. Here, we report that by superimposing the nanophase separation structure in double network (DN) elastomers using immiscible polymers, the modulus, fracture energy, and energy release rate of fatigue threshold are enhanced all together by 13, 5, and 5 times, resp. We reveal that the interplay between the DN structure and the nanophase separation structure brings two effects synergistically: (1) formation of nanoclusters overstresses and homogenizes the sacrificial network, thereby remarkably increasing the modulus and yielding stress and (2) the nanoclusters act as viscoelastic nanofillers dissipating energy and pinning the crack propagation, thereby significantly enhancing toughness and fatigue resistance. This work provides a facile approach to superimpose high-order structures in DN materials for excellent mech. performance. The clarified synergetic effects should be universal for DN materials made of immiscible polymers. We believe that this work will facilitate more studies on elastomers and gels along this line.

Chemistry of Materials published new progress about Acrylic rubber, methoxyethyl acrylate-polyethylene glycol diacrylate Role: POF (Polymer in Formulation), PRP (Properties), SPN (Synthetic Preparation), TEM (Technical or Engineered Material Use), USES (Uses), PREP (Preparation). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Safety of N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kohlmeyer, Corinna published the artcileFormamide-Catalyzed Nucleophilic Substitutions: Mechanistic Insight and Rationalization of Catalytic Activity, Recommanded Product: N-Methylformamide, the main research area is formamide catalyzed nucleophilic substitution mechanism.

Herein, detailed mechanistic investigations into formamide-catalyzed nucleophilic substitution (SN) of alcs. are reported. Alkoxyiminium chlorides and hexafluorophosphates were synthesized and characterized as a key intermediate of the catalytic cycle. The determination of reaction orders and control experiments indicated that the nucleophilic attack of the formamide catalyst onto the reagent BzCl is the rate-determining step. Linear free energy relationship revealed a correlation between the quantified Lewis basicity strength of formamides by means of 11B NMR spectroscopy and their catalytic activity in SN-transformations. The observed difference in catalytic ability was attributed to the natural bond order charge, dipole moment, and Sterimol parameter B5. Importantly, this rationalization enables the prediction of the capacity of formamides to promote SN-type transformations in general.

ACS Catalysis published new progress about Allylic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Recommanded Product: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ma, Xin published the artcileProtonated Ground-State Singlet meta-Pyridynes React from an Excited Triplet State, Quality Control of 123-39-7, the main research area is protonated meta pyridyne singlet ground triplet excited state reactivity.

The gaseous 2,6-didehydropyridinium cation and its derivatives transfer a proton to reagents for which the reaction for their singlet ground states is too endothermic to be observed These reactions occur from the lowest-energy excited triplet states, which has not been observed (or reported) for other meta-benzyne analogs. Quantum chem. calculations indicate that the (excited) triplet states are stronger Bronsted acids than their (ground) singlet states, likely due to unfavorable three-center, four-electron interactions in the singlet-state conjugate bases. The cations have substantially smaller (calculated) singlet-triplet (S-T) splittings (ranging from ca. -11 to -17 kcal mol-1) than other related meta-benzyne analogs (e.g., -23.4 kcal mol-1 for the 3,5-isomer). This is rationalized by the destabilization of the singlet states (relative to the triplet states) by reduced (spatial) overlap of the nonbonding MOs due to the presence of the nitrogen atom between the radical sites (making the ring more rigid). Both the singlet and triplet states are believed to be generated upon formation of these biradicals via energetic collisions due to their small S-T splittings. It appears that once the triplet states are formed, the rate of proton transfer is faster than the rate of intersystem crossing unless the biradicals contain heavy atoms.

Journal of Organic Chemistry published new progress about Crystal structure. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Quality Control of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhang, Stephanie J. published the artcilePotentially Prebiotic Activation Chemistry Compatible with Nonenzymatic RNA Copying, SDS of cas: 123-39-7, the main research area is nonenzymic RNA replication life origin primer extension.

The nonenzymic replication of RNA may have enabled the propagation of genetic information during the origin of life. RNA copying can be initiated in the laboratory with chem. activated nucleotides, but continued copying requires a source of chem. energy for in situ nucleotide activation. Recent work has illuminated a potentially prebiotic cyanosulfidic chem. that activates nucleotides, but its application to nonenzymic RNA copying had not been demonstrated. Here, we report a novel pathway that activates RNA nucleotides in a manner compatible with template-directed nonenzymic copying. We show that this pathway, which we refer to as bridge-forming activation, selectively yields the reactive imidazolium-bridged dinucleotide intermediate required for copying. Our results will enable more realistic simulations of RNA propagation based on continuous in situ nucleotide activation.

Journal of the American Chemical Society published new progress about Life, origin. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, SDS of cas: 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of 123-39-7, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 123-39-7, Name is N-Methylformamide, SMILES is O=CNC, belongs to amides-buliding-blocks compound. In a article, author is Hwang, Keum Saem, introduce new discover of the category.

This review covers further applications of the conjugate addition of enantiomerically pure lithium amides as chiral ammonia equivalents in asymmetric synthesis and provides an update since our last review of this area, which was published in 2012. (C) 2017 Published by Elsevier Ltd.

Synthetic Route of 123-39-7, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 123-39-7.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics