Category: 123-39-7

Li, Ming-Jun published the artcileThe deleterious effects of N,N-dimethylformamide on liver: A mini-review, COA of Formula: C2H5NO, the main research area is review liver cell proliferation differentiation apoptosis DMF; Cytochrome P4502E1; Hepatotoxicity; N,N-dimethylformamide; N-methylformamide; Occupational exposure limit; Oxidative stress.

N,N-dimethylformamide (DMF) is a versatile solvent with wide industrial applications. Evidences from animal studies and occupational poisoning cases have clearly demonstrated that DMF exposure can lead to different degrees of liver damage. It is noteworthy that DMF below the threshold limit value (TLV) may also cause liver injury in some sensitive populations. Unfortunately, the underlying mechanisms by which DMF induces hepatotoxicity remain largely unknown, despite considerable attention has been drawn to the hepatotoxic effects of DMF. Although some pilot studies have provided some evidences supporting the involvement of oxidative stress, the disturbance of gut microbiota and calcium homeostasis, etc, the causal roles of these factors on the onset of DMF-induced hepatotoxicity need to be confirmed. This article reviews the current knowledge about the deleterious effects of DMF on the liver.

Chemico-Biological Interactions published new progress about Apoptosis. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, COA of Formula: C2H5NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Hermes, Robert published the artcileFirst cryopreservation of phyllostomid bat sperm, HPLC of Formula: 123-39-7, the main research area is Carollia cryopreservation media sperm motility artificial insemination; Assisted reproduction technology; Methylformamide; Species conservation; Yangochiroptera.

Bats, the second-largest mammalian order, are widely distributed and provide crucial ecosystem services. Their reproductive biol. comprises noteworthy characteristics, such as long-term sperm storage, delayed implantation or even delayed fetal development. The understanding of these mechanisms remains limited. Research in reproductive biol. may become crucial for the conservation of endangered bat species. Indeed, the IUCN Red List of Threatened Species currently lists 76 bat species as endangered or critically endangered, for which conservation measures should be taken. The development of assisted reproductive technologies (ART) in bats would thus open new perspectives. In this context we here describe the first successful cryopreservation of bat sperm in the Seba′s short-tailed bat (Carollia perspicillata). Epididymal sperm of 30 males was pooled in 6 sample sets and diluted using four different cryo-diluents: Canifreeze, modified Canifreeze, BotuCrio and Test egg yolk extender. Glycerol and a mixture of glycerol and methylformamide were used as cryoprotectants. Best post-thaw results were achieved when sperm was diluted in Test egg yolk extender containing a mixture of glycerol and methylformamide as cryoprotectant. Post-thaw sperm motility, progressive motility and acrosome integrity of 42.0 ± 3.4%, 28.3 ± 6.3% and 87.7 ± 1.7%, resp. were superior to all other variants tested. It remains to be determined if the post-thaw quality of cryopreserved bat spermatozoa achieved in this study is sufficient for the use in artificial inseminations and produces acceptable pregnancy rates. Successful cryopreservation of spermatozoa in C. perspicillata may serve as the first model to establish gamete rescue programs and develop ART in other, critically endangered bat species.

Theriogenology published new progress about Acrosome. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, HPLC of Formula: 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Soni, Yogesh published the artcileEffects of different concentration and combinations of cryoprotectants on sperm quality, functional integrity in three Indian horse breeds, Quality Control of 123-39-7, the main research area is glycerol dimethyl formamide toxicity cryoprotectant horse sperm breed; Acrosome integrity; Cryopreservation; Cryoprotectant; DMF; Glycerol.

Traditionally Glycerol (Gly) is being used as major cryoprotectant and its toxicity could be a reason for the variation on stallion sperm freezability and fertility. In an effort to minimize Gly toxicity alternative cryoprotective agents like DMF (DMF) have been investigated. The effect of the cryoprotectant and dose of cryoprotective agent varies from breed to breed and also from stallion to stallion within the same breed. Considering these factors a study was designed to study the effects of Gly and DMF at different concentrations and combinations on the plasma membrane, acrosome and DNA integrity as well as other post thaw seminal characteristics of semen of three Indigenous stallion breeds. In the current study, semen was collected from apparently healthy 4-6 years old 3 Marwari, 3 Manipuri and 3 Zanskari breed stallions. After semen collection and evaluation of fresh semen, each semen sample was extended with semen extender containing different concentrations and combinations of Gly and DMF cryoprotectants (i.e. 5% Gly, 5% DMF, 2% Gly, 2% DMF, 2.5% Gly +2.5% DMF and 1% Gly +1% DMF) and frozen. Post thaw semen evaluation was done on the basis of post thaw motility, live sperm count, hypo osmotic swelling test, acrosomal integrity and DNA integrity. Frozen thawed semen showed that the values of plasma membrane integrity, acrosome integrity and DNA integrity parameters were significantly higher (P < 0.05) with 5% DMF than the other cryoprotectants levels and combinations of Gly and DMF. From the present study, it was inferred that the combination of cryoprotectants at different concentrations (Gly and DMF @ 2.5 and 1%) also could not show better enhancement compared to the single cryoprotectant i.e DMF @5% in various post thaw seminal characteristics of Indigenous stallion semen. DMF at 5% concentration gave better protection to the plasma membrane and retained the acrosome and DNA integrity of the spermatozoa. Hence it can be concluded that DMF at 5% can be used for the cryopreservation of the Indigenous stallion with better preservation of the seminal quality. Cryobiology published new progress about Acrosome. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Quality Control of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ramya, Kunchanapalli published the artcileRoom-temperature cost-effective in-situ grown MAPbBr3 crystals and their characterization towards optoelectronic devices, Related Products of amides-buliding-blocks, the main research area is room temperature methylammonium lead bromidecrystal optoelectronic device.

We report the in-situ, room-temperature synthesis of methylammonium lead bromide CH3NH3PbBr3 crystals using N-Me formamide as a source of methylammonium (MA+) ions during the crystallization process to explore the structural, dielec., and electronic properties of CH3NH3PbBr3 crystals for optoelectronic applications. Optical absorption and radio-luminescence measurements affirm the direct bandgap nature of the crystals. Impedance spectroscopy measurements with various applied AC voltages within the 20 Hz-10 MHz frequency range depict the influence of ionic motions on elec. transport across crystal planes. We have extracted elec. transport parameters in CH3NH3PbBr3 crystals from the Nyquist plots, which we found to be distinctly varied wherein two different AC voltage amplitude regimes, broadly for 10-50 mV and 100-500 mV AC voltage range.

Materials Science & Engineering, B: Advanced Functional Solid-State Materials published new progress about Band gap. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Related Products of amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Waghorne, W. Earle published the artcileA Study of Kamlet-Taft β and π* Scales of Solvent Basicity and Polarity/Polarizability Using Computationally Derived Molecular Properties, Product Details of C2H5NO, the main research area is solvent basicity polarity polarizability molicualr property.

The Kamlet and Taft solvent basicity parameter, β, and solvent polarity/polarizability parameter, π*, were analyzed in terms of properties of the solvent mols. derived from computational chem. The anal. of β, using a larger data set, confirms earlier conclusions that, for aprotic solvents, the basicity is determined by the partial charge on the most neg. atom of the solvent mol. and by the energy of the highest energy MO associated with the donor site. For alcs. and nitrogen bases containing N-H moieties, the β values deviate systematically from those for the non-hydrogen bonding solvents. Anal. of the polarity/polarizability parameter, π*, shows that it depends directly on the dipole moment, and quadrupolar amplitude of the solvent and on the energy of the HOMO, but decreases linearly with increasing solvent polarizability.

Journal of Solution Chemistry published new progress about Basicity. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Product Details of C2H5NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhou, Jing published the artcileFructus Gardeniae-induced gastrointestinal injury was associated with the inflammatory response mediated by the disturbance of vitamin B6, phenylalanine, arachidonic acid, taurine and hypotaurine metabolism, Computed Properties of 123-39-7, the main research area is vitamin B phenylalanine arachidonic acid taurine hypotaurine metabolism; Fructus Gardeniae; Gastrointestinal injury; HPLC-TOF-MS/MS; Metabolomics.

Fructus Gardenia (FG) is a widely used bitter and cold herb for clearing heat and detoxicating. Currently, toxicity of FG and its relative formula has been reported in many clin. and animal studies. However, no systematic research has been carried out on FG-related gastrointestinal (GI) injury which has been emphasized in China since the Ming Dynasty. The purpose of this article is to investigate whether FG could damage GI and explore the mechanisms involved. FG was given to male mice by 7-day intragastric administration at average doses of 0.90 g (L group), 1.50 g (M group), and 3.00 g (H group) crude drug/kg FG. Comprehensive understanding of changes in weight, diarrhea degree, stool routine, histomorphol. and inflammatory factors of stomach, small intestine, and colon for evaluating the effect of different doses of FG on GI injury. Moreover, metabolomics-based mechanisms exploration of FG on GI injury was carried out via HPLC-Q-TOF/MS anal. on mice urine. High dose FG caused GI injury with serious diarrhea, decreased weight, abnormal stool routine, sever alteration in histomorphol. of small intestine and colon (mild change in stomach), and significant change in inflammatory factors. The results of metabolomics suggested that 55 endogenous metabolites dispersed in 21 significantly altered metabolic pathways in 3.00 g/kg crude FG treated mice. The hub metabolites of GI injury were mainly related with vitamin B6 metabolism, phenylalanine metabolism, arachidonic acid metabolism, and taurine and hypotaurine metabolism via correlated network anal. FG affected the normal functions of GI via the regulating a variety of metabolic pathways to an abnormal state, and our results provided a research paradigm for the GI-injury of the relative bitter and cold traditional Chinese medicines.

Journal of Ethnopharmacology published new progress about Biomarkers. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Computed Properties of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zuo, Chenpeng published the artcileA theoretical study of hydrogen-bonded molecular clusters of sulfuric acid and organic acids with amides, Quality Control of 123-39-7, the main research area is hydrogen bond mol cluster sulfuric acid organic amide; Amides; Hydrogen bond; Nucleation; Organic acids; Sulfuric acid.

Amides, a series of significant atm. nitrogen-containing volatile organic compounds (VOCs), can participate in new particle formation (NPF) through interacting with sulfuric acid (SA) and organic acids. In this study, we investigated the mol. interactions of formamide (FA), acetamide (AA), N-methylformamide (MF), propanamide (PA), N-methylacetamide (MA), and N, N-dimethylformamide (DMF) with SA, acetic acid (HAC), propanoic acid (PAC), oxalic acid (OA), and malonic acid (MOA). Global min. of clusters were obtained through the association of the artificial bee colony (ABC) algorithm and d. functional theory (DFT) calculations The conformational anal., thermochem. anal., frequency anal., and topol. anal. were conducted to determine the interactions of hydrogen-bonded mol. clusters. The heterodimers formed a hepta or octa membered ring through four different types of hydrogen bonds, and the strength of the bonds are ranked in the following order: SO-HO > CO-HO > N-HO > C-HO. We also evaluated the stability of the clusters and found that the stabilization effect of amides with SA is weaker than that of amines with SA but stronger than that of ammonia (NH3) with SA in the dimer formation of nucleation process. Addnl., the nucleation capacity of SA with amides is greater than that of organic acids with amides.

Journal of Environmental Sciences (Beijing, China) published new progress about Bond angle. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Quality Control of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhao, Jian-Qiang published the artcileLead chlorine cluster assembled one-dimensional halide with highly efficient broadband white-light emission, Name: N-Methylformamide, the main research area is lead chlorine cluster halide broadband white light emission.

One new type of hybrid lead halide of [DTHPE]2Pb3Cl10 has been synthesized and characterized containing a one-dimensional (1D) wavelike [Pb3Cl10]4- chain based on a corner-shared [Pb3Cl11] cluster. Remarkably, this cluster-based 1D chain displays intrinsic broadband white light emission with a high quantum efficiency of 19.45% exceeding those of previously reported typical two-dimensional perovskites.

Chemical Communications (Cambridge, United Kingdom) published new progress about Bond angle. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Name: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Yang, Hongxing published the artcilePigmentiphaga sp. strain D-2 uses a novel amidase to initiate the catabolism of the neonicotinoid insecticide acetamiprid, Application In Synthesis of 123-39-7, the main research area is Pigmentiphaga amidase neonicotinoid acetamiprid catabolism; AceAB; IM 1-4; Pigmentiphaga sp. strain D-2; acetamiprid; amidase; initial hydrolysis.

Acetamiprid, a chloronicotinyl neonicotinoid insecticide, is among the most commonly used insecticides worldwide, and its environmental fate has caused considerable concern. The compound 1-(6-chloropyridin-3-yl)-N-methylmethanamine (IM 1-4) has been reported to be the main intermediate during acetamiprid catabolism in microorganisms, honeybees, and spinach. However, the mol. mechanism underlying the hydrolysis of acetamiprid to IM 1-4 has not yet been elucidated. In this study, a novel amidase (AceAB) that initially hydrolyzes the C-N bond of acetamiprid to generate IM 1-4 was purified and characterized from the acetamiprid-degrading strain Pigmentiphaga sp. strain D-2. Based on peptide profiling of the purified AceAB and the draft genome sequence of strain D-2, aceA (372 bp) and aceB (2,295 bp), encoding the α and β subunits of AceAB, resp., were cloned and found to be necessary for acetamiprid hydrolysis in strain D-2. The characteristics of AceAB were also systematically investigated. Though AceA and AceB showed 35% to 56% identity to the α and β subunits of the N,N-dimethylformamidase from Paracoccus aminophilus, AceAB was specific for the hydrolysis of acetamiprid and showed no activities to N,N-dimethylformamide or its structural analogs.

Applied and Environmental Microbiology published new progress about Catabolism. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Application In Synthesis of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Silva, Murilo O. published the artcileEffect of single and double methylation on the position of the π* shape resonance of formamide and acetamide, Quality Control of 123-39-7, the main research area is formamide acetamide methylation ground state.

In this work we report calculated integral and differential cross sections for elastic electron collision with formamide, acetamide and their resp. methylated derivatives, for impact energies up to 6 eV. Our calculations were performed with the Schwinger multichannel method with pseudopotentials, in the static-exchange and static-exchange plus polarization approximations The aim of this work is to investigate the methylation effect on the π* shape resonance, which is present in the A’spm symmetry of all studied systems. Our results were compared with existent data from the literature and showed good agreement. Stabilization or destabilization of the π* resonance due to methylation occur, but there is no clear tendency on stabilization or destabilization among the methylated derivatives Changes in the widths of the resonance due to the Me group were also observed

Chemical Physics published new progress about Conformers. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Quality Control of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics