Category: 123-39-7

Wang, Lu published the artcileDirect C-H Arylation of Aldehydes by Merging Photocatalyzed Hydrogen Atom Transfer with Palladium Catalysis, Synthetic Route of 123-39-7, the main research area is aldehyde direct arylation photocatalyzed hydrogen atom transfer palladium catalysis.

Herein, we report that merging palladium catalysis with hydrogen atom transfer (HAT) photocatalysis enabled direct arylations and alkenylations of aldehyde C-H bonds, facilitating visible light-catalyzed construction of a variety of ketones. Tetrabutylammonium decatungstate and anthraquinone were found to act as synergistic HAT photocatalysts. D. functional theory calculations suggested a Pd0-PdII-PdIII-PdI-Pd0 pathway and revealed that regeneration of the Pd0 catalyst and the photocatalyst occurs simultaneously in the presence of KHCO3. This regeneration features a low energy barrier, promoting efficient coupling of the palladium catalytic cycle with the photocatalytic cycle. The work reported herein suggests great promise for further applications of HAT photocatalysis in palladium-catalyzed cross-coupling and C-H functionalization reactions to be successful.

ACS Catalysis published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Synthetic Route of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Devi, E. Sankari published the artcileN-Heterocyclic Carbene Catalyzed Synthesis of Trisubstituted Epoxides via Tandem Amidation/Epoxidation Sequence, Name: N-Methylformamide, the main research area is chalcone preparation formamide TBHP NHC catalyst tandem amidation epoxidation; benzoyl aryloxiranyl carboxamide diastereoselective preparation green chem.

A tandem amidation/epoxidation sequence between various substituted chalcones and N,N-dimethylformamide (DMF) for the synthesis of trisubstituted epoxides employing N-heterocyclic carbene catalysis was developed. This reaction was performed under metal-free conditions in the presence of tert-Bu hydroperoxide (TBHP) as the oxidant. Trisubstituted epoxides bearing a ketone and an amide functionality (N,N-di-Me formyl group) were synthesized starting from a wide range of chalcones in moderate to good yields with excellent diastereoselectivity.

Organic Letters published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Name: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Xu, Hong-Hui published the artcileThioamidation of Arylpropyne Derivatives with Sulfur and Formamides for the Synthesis of Aryl Propanethioamides, Computed Properties of 123-39-7, the main research area is aryl propanethioamide preparation; arylpropyne sulfur formamide three component cascade thioamidation.

An efficient synthesis of aryl propanethioamides ArCH2CH2C(S)NRR1 [R = H, Me; R1 = Me, Et; RR1 = (CH2)4, (CH2)2O(CH2)2] by a three-component reaction of arylpropynes, elemental sulfur and formamides was developed. The cascade thioamidation proceeded smoothly through the hydrolysis of the C-C triple bond and formamides, the formation of C-N bond and C-S double bond in one-pot reaction.

Asian Journal of Organic Chemistry published new progress about Alkynes, aryl Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Computed Properties of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chen, Jing published the artcileSelectfluor-promoted Synthesis of 2,4- and 2,6-Diarylpyridines Through Annulation of Aromatic Ketones with an Ammonium Source in DMF, Computed Properties of 123-39-7, the main research area is diarylpyridine preparation regioselective; aromatic ketone ammonium acetate DMF condensation cyclization Selectfluor.

An efficient one-pot four-component condensation and cyclization of ketones with DMF and ammonium acetate for the synthesis of 2,4-diarylsubstituted pyridines promoted by Selectfluor has been achieved. Sym. pyridines were obtained selectively when non-Me ketones were used as the starting materials. Two C-C and C-N bonds are formed during the oxidative cyclization process.

ChemistrySelect published new progress about Aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Computed Properties of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Su, Lebin published the artcileCu(I)-Catalyzed 6-endo-dig Cyclization of Terminal Alkynes, 2-Bromoaryl Ketones, and Amides toward 1-Naphthylamines: Applications and Photophysical Properties, Recommanded Product: N-Methylformamide, the main research area is copper catalyzed endo dig cyclization alkyne bromoaryl ketone amide; naphthylamine preparation.

Functional group substituted 1-naphthylamines, especially N-methylated ones, play important roles in numerous chem. and biol. processes. However, these compounds’ general and step-economic syntheses are highly limited, which seriously restricts efforts to improve the properties and develop new functions for this kind of compound In this report, we describe the development of an efficient, convenient, and general method for the synthesis of valuable functionalized 1-naphthylamines directly from readily available terminal alkynes, 2-bromoaryl ketones, and amides via Cu(I)-catalyzed benzannulation in a green solvent (i.e., water) under Pd- and ligand-free conditions. A total of 82 functionalized 1-naphthylamines, especially synthetically and biol. useful N-methylated compounds, are synthesized in isolated yields up to 95%. Some unique features of the reaction are as follows: (1) exclusive 6-endo-dig selectivity, (2) ready incorporation of a broad range of functional groups directly from easily available substrates, and (3) amides that can be used as aminating agents and that are excellent alternatives to toxic and/or odorous amines. Due to facile tuning of functional groups for the reaction, the products possess good electronic donor-acceptor structures and exhibit intriguing photophys. properties, such as tunable and polarity-sensitive fluorescence emission and large Stokes shifts (up to 258 nm). Utilizing the products’ unique polarity-sensitive fluorescence response, we successfully applied the 1-naphthylamine derivatives, such as compound 91, to image lipid droplets (LDs) and monitor cellular LDs growth. The previously mentioned advantages of this methodol., along with the mild conditions, simple operation, and scalable synthesis, may allow this novel reaction to be extended to varied applications in chem., biol., and materials science.

Journal of the American Chemical Society published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Recommanded Product: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Kumar, Vishal published the artcileCu-catalysed transamidation of unactivated aliphatic amides, Computed Properties of 123-39-7, the main research area is amino phenyl alkylamide copper catalyst tranamidation; phenyl amide preparation.

Direct transamidation was gaining prominence as a ground-breaking technique that generates a wide variety of amides without the requirement of acid-amine coupling or other intermediate steps. However, transamidation of unactivated aliphatic amides, on the other hand, was a long-standing issue in comparison to transamidation of activated amides. Herein, a transamidation approach of an unactivated aliphatic amide using a copper catalyst and chlorotrimethylsilane as an additive was reprted. In addition, used transamidation as a tool for selective N-C(O) cleavage and O-C(O) formation to synthesize 2-substituted benzoxazoles and benzothiazoles. The reactions were carried out without using any solvents and offered wide substitution scope.

Organic & Biomolecular Chemistry published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Computed Properties of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Cheng, Hai-Hsuan published the artcileEffects of copper on biological treatment of NMF- and MDG-containing wastewater from TFT-LCD industry, SDS of cas: 123-39-7, the main research area is wastewater copper methylformamide methyl diglycol; Copper inhibition; Copper-to-biomass ratio; Nitrification.

This study aimed to evaluate the effects of copper on N-methylformamide (NMF)- and Me diglycol (MDG)-containing wastewater treatment using batch experiments and a lab-scale anoxic-oxic (A/O) sequencing batch reactor (SBR). Batch exptl. results indicated that aerobic degradation of NMF followed Monod-type kinetics. Copper inhibition on nitrification also followed Monod-type inhibition kinetics with copper-to-biomass ratio instead of copper concentration Specific degradation rates of NMF and MDG under both aerobic and anoxic conditions decreased in the matrix of full-scale wastewater, and high copper dosage would further reduce the degradation rates. In the long-term presence of 0.5 mg/L copper, the A/O SBR could maintain stable and complete degradations of NMF and MDG, 95% of COD removal, and more than 50% of total nitrogen (TN) removal. High concentrations of copper spikes, including 40 mg/L and 110 mg/L, slowed down degradation rates for both NMF and MDG, but did not affect COD and TN removal efficiencies in the full 24 h-cycle operation. The long-term A/O SBR operation revealed that daily dosage of 0.5 mg/L copper was not detrimental to NMF/MDG degradations due to regularly wasting sludge, but 110 mg/L of copper spike obviously reduced NMF/MDG degradation rate although it could be recovered later by regularly wasting sludge and maintaining SRT at 20 days.

Chemosphere published new progress about Biological wastewater treatment, biological sequencing batch reactor. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, SDS of cas: 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Fan, Pei published the artcileNickel/Photo-Cocatalyzed C(sp2)-H Allylation of Aldehydes and Formamides, Formula: C2H5NO, the main research area is unsaturated ketone amide preparation stereoselective; aldehyde formamide allyl acetate alc allylation nickel photocatalyst.

Herein, a nickel/photo-cocatalyzed C(sp2)-H allylation of aldehydes and formamides wherein both allyl acetates and allyl alcs. can be used as the allylating agents is reported. In this reaction, radical-type umpolung of the formyl moiety is enabled by tetrabutylammonium decatungstate as a hydrogen-atom-transfer photocatalyst, whereas nickel serves to cleave the C-O bond of allyl acetates or allyl alcs. The synergistic effect of these two catalysts provides new access to various β,γ-unsaturated ketones and amides with high selectivities.

Organic Letters published new progress about Acetates Role: RCT (Reactant), RACT (Reactant or Reagent) (allyl). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Formula: C2H5NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Vala, Manoj Kumar published the artcileThe synthesis of phenyl carbamates catalyzed by iron(II) bromide: An oxidative approach for cross-coupling of phenols with formamides, Application In Synthesis of 123-39-7, the main research area is phenyl carbamate preparation green chem; phenol formamide cross coupling iron bromide catalyst.

The carbamate group is a key structural motif in many approved drugs and pro-drugs. There is increasing use of carbamates in the medicinal chem. and agrochem. industry. The authors present reagents and chem. methodologies for the synthesis of carbamates and recent applications. The direct coupling of simple phenols with mono- and di-alkyl formamides provided the phenylcarbamate products.

Synthetic Communications published new progress about Carbamates Role: SPN (Synthetic Preparation), PREP (Preparation). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Application In Synthesis of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Khachatrian, Artashes A. published the artcileEffect of cation structure on the formation of hydrogen bond between ionic liquids and solute molecules, Formula: C2H5NO, the main research area is cation structure formation hydrogen bond ionic liquid solute mol.

In this work, we have studied the thermochem. of the hydrogen bond formation between ionic liquids and solute mols. The solution enthalpies of several organic compounds (benzene, acetone, 3-picoline dimethylsulfoxide, formamide, N-methylformamide, acetamide, N-methylacetamide) in the series of ionic liquids with common anion bis(trifluoromethanesulfonyl)imide and different cations (1-butyl-3-methylimidazolium [BMIM][NTf2], 1-butyl-1-methylpyrrolidinium [BMPYR][NTf2], 1-butylpyridinium [BPY][NTf2], 1-butyl-1-methylpiperidinium [BMPIP][NTf2], trimethylpropylammonium [TMPAm][NTf2]) were measured by solution calorimetry at infinite dilution The enthalpies of hydrogen bond between solutes and ionic liquids were determined by the previously proposed approach. The hydrogen bond enthalpies were correlated with the proton acceptor ability of ionic liquids from the Kamlet-Abboud-Taft equation and the proton donor ability of amides from the Abraham model. The proton donor ability and hydrogen bond reorganization of studied ionic liquids was analyzed. The formation of the hydrogen bond complexes of linear amides with ionic liquids with different compositions was shown. The effect of the ionic liquid structure on the strength of the hydrogen bond of linear amides with ionic liquids has been established.

Journal of Molecular Liquids published new progress about Amides Role: PEP (Physical, Engineering or Chemical Process), PROC (Process). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Formula: C2H5NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics