Category: 123-39-7

Li, Dong-Sheng published the artcileStop-Flow Microtubing Reactor-Assisted Visible Light-Induced Hydrogen-Evolution Cross Coupling of Heteroarenes with C(sp3)-H Bonds, Related Products of amides-buliding-blocks, the main research area is alkyl heteroarene preparation; heteroarene alkane photochem hydrogen evolution cross coupling.

Herein, assisted by stop-flow microtubing reactors, an operationally simple protocol for the visible light-induced hydrogen-evolution cross coupling of heteroarenes Ar-H (Ar = 4-methylquinolin-2-yl, phenanthridin-6-yl, 1,3-benzothiazol-2-yl, etc.) with unactivated C(sp3)-H bonds was developed in a metal- and external oxidant-free manner. A wide range of alkylated heteroarenes ArR1 (R1 = oxan-2-yl, Me, (1R,4S)-bicyclo[2.2.1]heptan-2-yl, etc.) was generated with common feedstock chems., including ethane. Mechanistic studies indicated that photoredox-induced hydrogen atom transfer processes followed by dehydrogenative rearomatization delivered the desired coupling products. The merits of this strategy were further demonstrated by the late-stage functionalization of various complex bioactive mols.

ACS Catalysis published new progress about Alkanes Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Related Products of amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chen, Hao published the artcileEnantioselective Twofold C-H Annulation of Formamides and Alkynes without Built-in Chelating Groups, Recommanded Product: N-Methylformamide, the main research area is ferrocene based formamide preparation nickel catalyzed oxidative annulation alkyne; chiral benzyldiphenyl ferrocenopyridinone preparation crystal structure; mol structure chiral benzyldiphenyl ferrocenopyridinone; aluminum; annulation; ferrocenes; formamides; nickel.

Twofold C-H annulation of readily available formamides and alkynes without built-in chelating groups was achieved. Ni-Al bimetallic catalysis enabled by a bulky BINOL-derived chiral secondary phosphine oxide (SPO) ligand proved to be critical for high reactivity and high selectivity. This reaction uses readily available formamides as starting materials and provides a concise synthetic pathway to a broad range of chiral ferrocenes in 40-98% yield and 93-99% ee.

Angewandte Chemie, International Edition published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Recommanded Product: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wang, Rong-Hua published the artcileSelective C(sp3)-H Cleavage of Enamides for Synthesis of 2-Pyridones via Ligand-enabled Ni-Al Bimetallic Catalysis, Application of N-Methylformamide, the main research area is pyridone preparation regioselective; formyl enamide alkyne cyclization nickel aluminum catalyst.

Herein, a selective C(sp3)-H cleavage of N-formyl enamides R(R1)C=C(CH2(R2))N(CHO)R3 [R = H, Me; R1 = H, propan-2-yl, 4-methoxyphenyl, etc.; R2 = H; R1R2 = -((CH2)2)-, -((CH2)3)-, -(CH2CH(C6H5)CH2)-; R3 = Me, n-Pr, Ph, Bn, 3-methylbut-3-en-1-yl] without backbone modification, providing a series of 2-pyridones I [R4 = Me, Ph, thiophen-2-yl, etc.; R5 = n-Bu, Ph, thiophen-2-yl, etc.] in 58-99% yields was reported. A bifunctional phosphine oxide (PO) ligand-bridging Ni-Al bimetallic catalyst played key role in the reaction.

ACS Catalysis published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Application of N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Molaei Yielzoleh, Fatemeh published the artcileTitanomagnetite functionalized by amino acid-based ionic liquid and cobalt (Fe3-xTixO4-SiO2@TrpBu+3I–Co(II)): A reusable bio-nanocomposite for the synthesis of aryl thioamides, Safety of N-Methylformamide, the main research area is cobalt titanomagnetite ionic liquid nanocomposite functionalized amino acid preparation; reusable bio nanocomposite preparation catalyst aryl thioamide; tributyltryptophanium cobalt titanomagnetite ionic liquid bio nanocomposite preparation catalyst.

An efficient and straightforward three-component reaction of alkynes (terminal and internal), elemental sulfur, and amides using novel bio-nanocomposite is described. The bio-nanostructure obtained from step-by-step coating the titanomagnetite core by silica, N,N,N-tributyltryptophanium iodide ionic liquid, and cobalt resp. The Fe3-xTixO4-SiO2@TrpBu+3I–Co(II) characterized though FT-IR, FESEM, EDAX, XRF, TGA/DTG, VSM, and XPS techniques. Its catalytic efficacy examined successfully in the solvent-free three-component reaction of alkynes (terminal and internal), S8, and amides to prepare the corresponding aryl thioamides via the C-C triple bond cleavage. The reusability examination of the Fe3-xTixO4-SiO2@TrpBu+3I–Co(II) bio-nanocomposite proceeded successfully within two runs. The recovered nanostructure characterized through EDAX and FESEM techniques that demonstrated no significant changes in the morphol. and constitutive elements.

Journal of Molecular Structure published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Safety of N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Magsumov, Timur I. published the artcileDevelopment of Abraham model correlations for enthalpies of solvation of solutes dissolved in N-methylformamide, 2-pyrrolidone and N-methylpyrrolidone, Related Products of amides-buliding-blocks, the main research area is methylformamide pyrrolidone methylpyrrolidone solute solvation enthalpy Abraham model correlation.

Enthalpies of solution at infinite dilution have been determined for 2-propanol, ethylene glycol, 1,3-butanediol, 1,4-butanediol, phenol, 1-naphthol, 3-nitrophenol, 4-nitrophenol, 4-chlorophenol, and formamide dissolved in N-methylformamide, 2-pyrrolidone, and N-methylpyrrolidone at 298.15 K, as well as for N-methylformamide dissolved in 2-pyrrolidone and N-methylpyrrolidone, based on solution calorimetric measurements. Results of our exptl. measurements, combined with published literature data, have been used to derive Abraham model expressions for predicting the enthalpies of solvation of solutes dissolved in the three fore-mentioned amide solvents. Our derived math. expressions back-calculated the observed enthalpy of solvation data to within a standard deviation of 3.1 kJ mol-1 or less.

Journal of Molecular Liquids published new progress about Amides Role: NUU (Other Use, Unclassified), USES (Uses). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Related Products of amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Khaliullin, F. A. published the artcileUnusual Reaction of 8-Bromo-3-methyl-7-(thietan-3-yl)3,7-dihydro-1H-purine-2,6-diones with Trisamine in Dimethylformamide, Related Products of amides-buliding-blocks, the main research area is dimethylamino methylthietanyl dihydropurine dione preparation; bromo methylthietanyl dihydropurine dione DMF nucleophilic substitution reaction.

The reaction of title compounds I (R = H, Et, pentyl, benzyl, etc.; R1 = Br) with trisamine in DMF gave, instead of the expected 8-tris(hydroxymethyl)methylamino-substituted products I (R1 = NHC(CH2OH)3), 8-dimethylamino-substituted products I (R1 = N(CH3)2). The formation of unusual reaction products was explained by the initial reaction of DMF with trisamine to form dimethylamine and subsequent nucleophilic substitution reaction of the latter with the bromine atom.

Russian Journal of Organic Chemistry published new progress about Formamides Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Related Products of amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Bi, Wen-Zhu published the artcileVisible-light-promoted synthesis of secondary and tertiary thiocarbamates from thiosulfonates and N-substituted formamides, Formula: C2H5NO, the main research area is secondary thiocarbamate tertiary preparation; thiosulfonate formamide thiolation rhodamine B photocatalyst.

A general visible-light-promoted metal-free synthesis of secondary and tertiary thiocarbamates RSC(O)NR1R2 [R = Ph, 4-MeC6H4, Bn, etc., R1 = Me, iso-Pr, cyclohexyl, etc., R2 = H, Me, Et, n-Pr, iso-Pr, (CH2)3CH3, R1R2 = (CH2)5, (CH2)2O(CH2)2] starting from thiosulfonates and N-substituted formamides was developed. By employing rhodamine B as a photocatalyst and tert-Bu hydroperoxide (TBHP) as an oxidant, a wide scope of thiocarbamates could be obtained through direct thiolation of acyl C-H bonds under irradiation of blue light at room temperature for 12 h.

Organic & Biomolecular Chemistry published new progress about Formamides Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Formula: C2H5NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wang, Jia-Wang published the artcileCatalytic asymmetric reductive hydroalkylation of enamides and enecarbamates to chiral aliphatic amines, COA of Formula: C2H5NO, the main research area is enamine alkyl halide nickel reductive alkylation regioselective enantioselective diastereoselective; enecarbamate alkyl halide nickel reductive alkylation regioselective enantioselective diastereoselective; chiral aliphatic amine preparation.

A mild and general nickel-catalyzed asym. reductive hydroalkylation effectively converted to enamides and enecarbamates into drug-like α-branched chiral amines was reported. This reaction involved the regio- and stereoselective hydrometallation of an enamide or enecarbamate to generated a catalytic amount of enantioenriched alkylnickel intermediate, followed by C-C bond formation via alkyl electrophiles.

Nature Communications published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, COA of Formula: C2H5NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Prieto, Alexis published the artcileVisible-Light Decatungstate/Disulfide Dual Catalysis for the Hydro-Functionalization of Styrenes, Product Details of C2H5NO, the main research area is alkene tetrabutylammonium decatungstate disulfide photoredox dual catalyst hydrofunctionalization; amide preparation; unsym ketone preparation.

An efficient photoredox system, relied on decatungstate/disulfide catalysts, for the hydrofunctionalization of styrenes was described. In this methodol. the use of disulfide as a cocatalyst was shown to be crucial for the reaction efficiency. This photoredox system was employed for the hydro-carbamoylation, -acylation, -alkylation, and -silylation of styrenes, gave access to a large variety of useful building blocks and high-value mols. such as amides and unsym. ketones from simple starting materials.

Organic Letters published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Product Details of C2H5NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhang, Xiangyu published the artcileDirect synthesis of quinazolinones via the carbon-supported acid-catalyzed cascade reaction of isatoic anhydrides with amides and aldehydes, Related Products of amides-buliding-blocks, the main research area is dihydroquinazoline preparation; quinazolinone preparation green chem phenylsilane selective hydrosilylation ruthenium catalyst; benzoxazindione amide aldehyde amidation cyclization tandem acid catalyst recycling.

A novel catalytic system is reported for the construction of quinazolinones I (R1 = H, 7-Me, 6-OMe, etc.; R2 = Me, Et, cyclopropyl; R3 = Ph, pyridin-3-yl, cyclohexyl, etc.) via the carbon-supported acid-catalyzed cascade coupling of isatoic anhydrides II with amides R2NHCHO and aldehydes R3CHO. Subsequent selective hydrosilylation of the quinazolinones I using a hydrogen-transfer strategy was also explored to provide dihydroquinazolines III with structural diversity. The developed methodol. proceeds with a broad substrate scope and excellent functional group tolerance and utilizes a reusable catalyst and air as a green oxidant.

Tetrahedron Letters published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Related Products of amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics