Category: 123-39-7

Zhang, Bonan published the artcileA Review of Stereotactic Body Radiation Therapy in the Management of Oligometastatic Prostate Cancer., Recommanded Product: N-Methylformamide, the main research area is SBRT; SRT; Stereotactic body radiation therapy; oligometastatic prostate cancer; prostate neoplasm; review.

BACKGROUND/AIM: Management strategies such as surgery and systemic therapy (androgen-deprivation therapy and chemotherapy) are considered a standard of care for patients with oligometastatic prostate cancer and have shown some positive results in many patients. However, they are often accompanied by side-effects that can negatively affect patients. The aim of this study is to review the potential of stereotactic body radiation therapy (SBRT) in the management of oligometastatic prostate cancer and to compare treatment outcomes with SBRT to those under standard of care management regarding progression-free survival (PFS), androgen-deprivation therapy (ADT)-free survival and local control rate (LCR) as well as a comparison of toxicity profiles. MATERIALS AND METHODS: MEDLINE (PubMed), EMBASE, and Clinicaltrials.gov databases were searched to identify prospective randomised controlled trials as well as retrospective studies investigating SBRT and standard of care management for oligometastatic prostate cancer. Data on treatment outcomes and toxicity profiles were extracted. RESULTS: A total of 18 studies were included: 14 reported on the use of SBRT and four reported on the use of standard of care management. For SBRT, median PFS was 7.36-24 months. Median ADT-free survival was 12.3-39.7 months. The LCR varied, with some reports of 100% at 6 months and others of 92% at 5 years. No significant grade 3 toxicity was reported, with only five grade 3 events reported in two studies. For standard of care management, most of the studies reported 3-year PFS of 46.9-58.6%, with one study reporting a median PFS of 38.6 months. No standard of care study reported on LCR and ADT-free survival. Although different toxicity grading systems were used depending on the treatment modality, there were some reports of grade 3 events using standard of care management. CONCLUSION: SBRT appears to be a safe and effective modality for treating oligometastatic prostate cancer, having the potential to defer palliative ADT. Although LCR is excellent compared to conventional therapies, the PFS rate is reportedly inferior to standard of care therapies. No significant grade 3 toxicity was observed with SBRT.

Anticancer research published new progress about SBRT; SRT; Stereotactic body radiation therapy; oligometastatic prostate cancer; prostate neoplasm; review. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Recommanded Product: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Dubouis, Arnaud published the artcileResults of the Surgical Management of Acute Limb Ischemia in the Nonagenarians., Formula: C2H5NO, the main research area is .

BACKGROUND: The aging of the population leads us to treat older patients, in particular presenting with acute limb ischemia (ALI). However, there has been little evaluation of this pathology in the nonagenarians. The objectives of this work are thus to evaluate the 1-month and 1-year mortality of the nonagenarians treated for ALI, which made possible to determine the 1-year survival and to highlight the factors influencing the mortality. METHODS: This is a monocentric retrospective study including all the patients aged 90 years old or more surgically treated for ALI between January 2012 and December 2016. In all the patients, we recorded the 1-month mortality and the 1-year survival and the demographic, clinical, and paraclinical data. RESULTS: We operated 83 nonagenarians, with a majority of women (59, 71.1%), using general anesthesia in 20 patients (16.6%), including 10 cases of upper limb acute ischemia (12.0%). The overall mortality rate at 1 month was 22.9%, and the 1-year survival rate was 43.4%. Major amputation rate was 9.6% at 1 year. The survival of the patients operated for upper or lower limb ischemia was similar (P = 0.82). Univariate analysis showed that the 1-year survival was lower in patients having a history of cerebrovascular problems (P = 0.0003), heart failure (P = 0.0027), dementia (P = 0.0452), or in patients that were institutionalized (P = 0.0125), invalid (P = 0.0001), or presented with a complete acute ischemia (P = 0.0002). In multivariate analysis, 3 risk factors remained statistically significant: a previous history of cerebrovascular accident (hazard ratio [HR] = 3.05 [1.54-6.02]; P = 0.0014), cardiac failure (HR = 2.21 [1.23-3.97]; P = 0.0083), and complete ALI (HR = 3.07 [1.64-5.75]; P = 0.0005). CONCLUSIONS: Our study showed that a history of cerebrovascular accident, cardiac failure, or complete ALI is a poor prognostic factor for the 1-year survival of nonagenarians dealt operated for ALI. These elements should be taken into account when deciding either to operate or not in this precise context.

Annals of vascular surgery published new progress in MEDLINE about 123-39-7, 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Formula: C2H5NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Otlyotov, Arseniy A. published the artcileConformational energies of microsolvated Na+ clusters with protic and aprotic solvents from GFNn-xTB methods, Synthetic Route of 123-39-7, the main research area is sodium methanol water cluster conformational potential correlation function; cluster-continuum theory; conformational analysis; microsolvation; semiempirical methods; sodium cation clusters.

Performance of contemporary tight-binding semiempirical GFNn-xTB methods for the conformational energies of singly charged sodium clusters Na+(S)n (n = 4-8) with 3 protic and 8 aprotic solvents is examined against the reference RI-MP2/CBS method. The median Pearson correlation coefficients of ρ = 0.84 (GFN2-xTB) and ρ = 0.82 (GFN1-xTB) do not give the clear preference to any tested approach. GFN1-xTB method demonstrates more stable performance than its GFN2-xTB successor with the average mean absolute errors (MAEs)/mean signed errors (MSEs) of 1.2/0.2 and 2.3/1.6 kcal mol-1, resp. Conformational energies produced by the computationally efficient DFT functional PBE and double-ζ basis set complemented with -D3(BJ) dispersion correction are suitable for the preliminary sampling (median ρ = 0.93), but should be used with a caution for the calculations of the average ensemble properties (MAE/MSE = 1.7/1.1 kcal mol-1). Higher-ranking PBE0-D3(BJ) and ωB97M-V with triple-ζ basis sets yield significantly lower MAEs/MSEs of 0.55/0.20 and 0.51/0.23 kcal mol-1, resp.

Journal of Computational Chemistry published new progress about Clusters. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Synthetic Route of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Lin, Li-Dan published the artcileDevelopment of a new Lindqvist-like Fe6 cluster secondary building unit for MOFs, Name: N-Methylformamide, the main research area is hydroxymethyl pyridinylpropanediol iron Lindqvist cluster preparation crystal mol structure.

This work demonstrates a new Lindqvist-like [FeIII6(μ6-O)L4Cl6]2- (Fe6, L = 2-(hydroxymethyl)-2-(pyridin-4-yl)-1,3-propanediol) cluster for the construction of a novel class of Fe-cluster organic frameworks. The novel Fe6 cluster can be used to build not only a homometallic MOF, but also a heterometallic MOF by introducing copper halide clusters to the reaction system. In particular, the heterometallic MOF achieved a skillful combination of Fe6 SBU and cuprous-halide clusters for the first time. Our synthesis strategy opens up an effective avenue to novel Fe-cluster-based MOF materials.

Chemical Communications (Cambridge, United Kingdom) published new progress about Clusters. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Name: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Suganthi R., Josephine Usha published the artcileThe growth and characterization techniques of organometallic nonlinear optical crystal – Manganese mercury thiocyanate – Bis (N -methyl formamide), Synthetic Route of 123-39-7, the main research area is manganese mercury thiocyanate methyl formamide optical crystal growth.

Manganese mercury thiocyanate – bis (N -Me formamide) has been prepared to be a novel organometallic nonlinear optical crystal. The cell parameters of the grown crystals were obtained by single-crystal XRD anal. The second harmonic generation and optical transmittance of the grown crystal are studied by Kurtz and Perry powder technique and UV spectroscopic absorbance spectrum. The thermal anal. reveals that MMTN crystal possesses good physicochem. stability. The dielec. responses of the grown crystals are studied as a function of the temperature and the results are discussed.

Materials Today: Proceedings published new progress about Crystals. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Synthetic Route of 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wu, Tsung-Tse published the artcileMeasurements of the dissociation conditions for methane hydrates with various additives of 1,2-epoxybutane, 2,3-dihydrofuran, N-methylformamide, 4-methylmorpholine, or 1-(2-furyl)methylamine, HPLC of Formula: 123-39-7, the main research area is methane hydrate sodium chloride phase equilibrium.

The exptl. phase equilibrium measurements for the dissociation conditions of methane hydrates in the presence of five additives are reported in this study. The isochoric method was employed to measure the three-phase (hydrate + liquid water + vapor, H-Lw-V) dissociation conditions (the three-phase equilibrium temperatures and pressures) under various concentrations of five additive compounds These additives include 1,2-epoxybutane that showed a promotion effect up to 2.6 K at a fixed pressure for the formation of methane hydrate. Other additives of 2,3-dihydrofuran N-methylformamide, 4-methylmorpholine and 1-(2-furyl)methylamine, however, all showed the inhibition effect from 1.3 up to 9 K. The possible structures of methane hydrates with these additives were estimated from the Clausius-Clapeyron equation by using the measured equilibrium temperature and pressure data. It is shown that with the additive of 1,2-epoxybutane, a sII hydrate structure might cause the promotion effect. The other four additives with inhibition effect all showed the possible sI structure. This study reports novel phase equilibrium data and verifies a useful screening method to select the available additives for natural gas production or transportation.

Fluid Phase Equilibria published new progress about Enthalpy. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, HPLC of Formula: 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Anggo Krisbiantoro, Philip published the artcileCatalytic glycolysis of polyethylene terephthalate (PET) by solvent-free mechanochemically synthesized MFe2O4 (M = Co, Ni, Cu and Zn) spinel, Name: N-Methylformamide, the main research area is catalytic glycolysis polyethylene terephthalate spinel catalyst.

In the present study, the solvent-free mechanochem. synthesized MFe2O4 (M = Co, Ni, Cu, and Zn) spinel was used as a catalyst for PET glycolysis. All catalysts were active for PET glycolysis to produce bis(2-hydroxyethyl) terephthalate (BHET) with the order of PET conversion of ZnFe2O4 > CuFe2O4 > CoFe2O4 > NiFe2O4. The catalytic activity was correlated with the Lewis acid strength of the M2+ in MFe2O4, i.e., a catalyst with strong Lewis acid exhibited high catalytic activity. Although CoFe2O4 was the second-best catalyst among the four in terms of yield of BHET, it possessed the highest saturation magnetization, which is a great advantage for magnetic separation of the catalyst. The reaction over CoFe2O4 exhibited apparent activation energy (Ea) of 188 kJ mol-1, and it was reusable for at least five times. Moreover, a simulation using Aspen Plus software showed that scale-up is highly feasible.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about Acidity. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Name: N-Methylformamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Spange, Stefan published the artcileReappraisal of Empirical Solvent Polarity Scales for Organic Solvents, Product Details of C2H5NO, the main research area is organic solvent empirical polarity.

Correlations of Reichardt ‘s ET(30), the Catalan SdP (solvent dipolarity), SP (solvent polarizability), SA (solvent acidity), SB (solvent basicity), Kamlet-Taft π* (dipolarity/polarizability), α (hydrogen bond donating ability) and β (hydrogen bond accepting ability) polarity parameters with the molar concentration of 161 pure organic solvents are presented. Mostly, linear relationships of the polarity parameter as a function of molar concentration are obtained as long as each individual solvent class is considered sep. A phys. different interpretation of the ET(30), Kamlet-Taft π* and α as well as Catalan SA and SB parameters has been proposed. Furthermore, the Hildebrand solubility parameter in combination with the diffraction index is used for the correlation anal. with the above-mentioned solvent parameters. It can be concluded that empirical polarity parameters derived from solvatochromic UV/Vis measurements are inherently a function of the mol. structure of the probe.

Chemistry: Methods published new progress about Acidity. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, Product Details of C2H5NO.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Du, Ming-Xuan published the artcileHydrogen-Bonding Interactions in Polymer-Organic Solvent Mixtures, SDS of cas: 123-39-7, the main research area is hydrogen bonding polymer organic solvent.

Polymer solubility in organic solvents generally is predicted by the Hildebrand solubility parameter (δ) approach based on the “”like dissolves like”” principle. A conspicuous exception is that there exist many soluble pairs that the solubility parameter approach predicts to be insoluble due to the large δ difference between the pair. These cases were attributed to specific attractive interactions (e.g., hydrogen bonding) between the solute and solvent that lead to a neg. enthalpy of mixing to promote the solubility Recently, we find that the polymer solubility in ionic liquids is dominated by hydrogen-bonding interactions (Phys. Chem. Phys.2021,23, 21893-21900). More importantly, three principles based on the Kamlet-Abraham-Taft multiple-polarity scale for dealing with hydrogen-bonding interactions were proposed. Two parameters (α is the hydrogen-bond acidity parameter, and β is the basicity parameter) are required to describe hydrogen-bonding complementarity. The product of ΔαΔβ, where Δ is the difference in parameters between the polymer and solvent, is an indicator of the competition between cross-association and self-association hydrogen bonding. Therefore, an excess interaction parameter χHB, which is proportional to ΔαΔβ, can be introduced to account for the solubility promotion. In this study, these principles were used to test the solubility of polymer/organic solvent mixtures, for which the solubility parameter approach fails. These polymer/organic solvent pairs that consist of 12 polymers and 27 organic small mols. have discrepant solubility parameters (>5 MPa1/2 at least). A good correlation between the solubility data and the solubility criterion (ΔαΔβ < 0) reveals that hydrogen-bonding interactions are responsible for the solubility Therefore, the excess interaction parameter, χHB (~ΔαΔβ), provides a significant correction in the Flory-Huggins theory. This finding can also serve as a prescreening tool for the solubility of polar polymers besides the ""like dissolves like"" principle. Macromolecules (Washington, DC, United States) published new progress about Acidity. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, SDS of cas: 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mangstl, Martin published the artcileSynthesis and characterization of methylammonium phosphates as crystalline approximants for anhydrous, low melting phosphate glasses, HPLC of Formula: 123-39-7, the main research area is methylammonium phosphate glass crystalline approximant.

Low-melting methylammonium phosphate glasses are synthesized from crystalline starting agents. To this end crystalline tris(methylammonium) cyclotriphosphate [CH3NH3]3P3O9, was synthesized by a novel and simple synthesis route from P4O10 and N-methylformamide. It, undergoes an irreversible phase transition to methylammonium catena-polyphosphate [CH3NH3]PO3. The crystal structure of the catena-polyphosphate was solved and refined from X-ray powder diffraction data by the Rietveld method using constraints obtained by solid-state 31P and 1H NMR spectroscopy. This compound crystallizes in a triclinic space group with a = 13.2236(9), b = 7.8924(6), c = 4.6553(2) Å α = 91.068(4), β = 87.840(5) and γ = 106.550(3)°. Quantum chem. calculations confirm that the obtained structure lies at an energetic min. Finally the reaction of tris(methylammonium) cyclotriphosphate and P4O10 into methylammonium phosphate glass is presented. The synthesized, water-free phosphate glass shows a very low glass transition temperature Tg of 33°C, which was verified by dynamic scanning calorimetry and NMR. The chain-like crystal structure of the high-temperature methylammoniumphosphate [CH3NH3]PO3 serves as an approximation for the short-range order of the glass.

RSC Advances published new progress about Cooling. 123-39-7 belongs to class amides-buliding-blocks, name is N-Methylformamide, and the molecular formula is C2H5NO, HPLC of Formula: 123-39-7.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics