Category: 122848-57-1

Reference of 122848-57-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 122848-57-1, name is tert-Butyl 3,6-diazabicyclo[3.2.0]heptane-6-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.

In a sealed tube, 7-fluoro-2-(2-methyl-[l,2,4]triazolo[l,5-a]pyrimidin-6-yl)-4H-pyrido[l,2- a]pyrimidin-4-one (Intermediate (VI-1), 25.4 mg, 0.169 mmol, 1 eq.), and tert-butyl 3,6- diazabicyclo[3.2.0]heptane-6-carboxylate (100 mg, 0.506 mmol, 3 eq.) were stirred in DMSO (2 ml) at 120C for 48 hours. The crude was purifed by preparative HPLC. (0364) The isolated solid was then treated following the General Procedure 1 for Boc deprotection to afford the product 7-(3,6-diazabicyclo[3.2.0]heptan-3-yl)-2-(2-methyl-[l,2,4]triazolo[l,5- a]pyrimidin-6-yl)-4H-pyrido[l,2-a]pyrimidin-4-one 2,2,2-trifluoroacetate (12.4 mg, 0.025 mmol, 73.9 % yield) as a yellow solid.

The chemical industry reduces the impact on the environment during synthesis tert-Butyl 3,6-diazabicyclo[3.2.0]heptane-6-carboxylate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GILLESPIE, Robert Jack; HASANE, Ratni; SARIE, Jerome Charles; (89 pag.)WO2016/184832; (2016); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 122848-57-1,Some common heterocyclic compound, 122848-57-1, name is tert-Butyl 3,6-diazabicyclo[3.2.0]heptane-6-carboxylate, molecular formula is C10H18N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a 10 mL microwave reaction vessel compound 5-chloro-6-ethyl-2- (pyrido[3,2-b]pyrazin-7-ylthio)-7H-pyrrolo[2,3-d]pyrimidin-4-yl 4-methylbenzenesulfonate (Example 19) (0.02 g, 0.039 mmol) and tert-butyl 3,6-diazabicyclo[3.2.0]heptane-6- carboxylate (7.7 mg, 0.039 mmol) was dissolved in ethanol (0.1 mL). The reaction was sealed and heated to 100C for 0.5 h after which the solvent was removed and the crude was used for the next step without further purification

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route tert-Butyl 3,6-diazabicyclo[3.2.0]heptane-6-carboxylate, its application will become more common.

Reference:
Patent; TRIUS THERAPEUTICS, INC.; CREIGHTON, Chris; TARI, Les; CHEN, Zhiyong; HILGERS, Mark; LAM, Thanh; LI, Xiaoming; TRZOSS, Michael; ZHANG, Junhu; FINN, John; WO2011/32050; (2011); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics