Adding a certain compound to certain chemical reactions, such as: 122734-32-1, name is tert-Butyl (2-(methylamino)ethyl)carbamate, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 122734-32-1, Recommanded Product: tert-Butyl (2-(methylamino)ethyl)carbamate
To a solution of dichlorobenzyl-piperidin-4-one (Example 74, step (i), 4.8 g) and acetic acid (1 ml) in dichloromethane (100 ml) was added (2-methylamino-ethyl)-carbamic acid tert-butyl ester (3.26 g) and the mixture was stirred for 5 minutes before addition of sodium triacetoxyborohydride (7.9 g). The reaction mixture was stirred for 12 hours before addition of sodium bicarbonate solution. The mixture was stirred for 1/2 hour and then partitioned between water and dichloromethane. The organic layer was separated, dried (MgSO4) and solvent removed by evaporation. Purification by Biotage 40S eluding 10%MeOH/2% triethylamine/dichloromethane gave the title compound (1.7 g). MS: ESI 316/318 (+H-(CH3)4COCO) 1H NMR: (CDCl3): delta 1.44 (9H, s), 1.50-1.60 (4H, m), 1.65-1.72 (2H, m), 1.95 (2H, td), 2.23 (3H, s), 2.34 (1H, tt), 2.88 (2H, d), 3.14-3.20 (2H, m), 3.41 (2H, s), 4.95-5.01 (1H, m), 7.13-7.15 (1H, m), 7.37 (1H, d), 7.42 (1H, d).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, tert-Butyl (2-(methylamino)ethyl)carbamate, and friends who are interested can also refer to it.
Reference:
Patent; AstraZeneca, AB; US6903085; (2005); B1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics