Category: 121492-06-6

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 121492-06-6, name is N-Boc-(2-Aminoethyl)-N-methylamine, This compound has unique chemical properties. The synthetic route is as follows., 121492-06-6

General procedure: 5-Amino-(30-[N0-methyl-N0-tert-butoxycarbonyl]propyl)-3-(N,N-dimethylcarbox-amide)-6-nitrochromane (9a).[29]A mixture of 5-chloro-3-N,N-dimethyl-carboxamide-6-nitro-chromane (8) (300 mg, 1.10 mmol), primary amine N-Boc-N-methyl-1,3-trimethylenediamine (18) (5.50 mmol),and N-methyl-pyrrolidinone (1.0 mL) was heated in a sealedtube at 758C for 48 h. The reaction mixture was poured into amixture of diethyl ether and water (1 : 1, 80 mL) and the mixturestirred for 30 min. The mixture was transferred to a separationfunnel and the ether layer washed with water (4 25 mL). Theorganic phase was dried over anhydrous sodium sulfate, filtered,and evaporated under reduced pressure. The crude product waspurified by flash chromatography (silica gel, 5 % methanol indichloromethane). The product 9a[29]was isolated as a brightyellow oil (381 mg, 87 %).

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Reference:
Article; Schmit, David; Milewicz, Urszula; Boerneke, Mark A.; Burley, Scott; Walsworth, Kevin; Um, Joann; Hecht, David; Hermann, Thomas; Bergdahl, B. Mikael; Australian Journal of Chemistry; (2020);,
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Adding some certain compound to certain chemical reactions, such as: 121492-06-6, name is N-Boc-(2-Aminoethyl)-N-methylamine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 121492-06-6. 121492-06-6

To a stirred solution of 135 1-fluoro-4-nitrobenzene (1.0 g, 7.09 mmol, 1.0 eq) and 552 tert-butyl (2-aminoethyl)(methyl)carbamate (1.36 g, 7.79 mmol, 1.1 eq) in 47 DMF (20 mL) was added 64 K2CO3 (1.96 g, 14.18 mmol, 2.0 eq) at rt. The resulting mixture was stirred at 90 C. for 12 h. The progress of reaction was monitored by LCMS. The reaction mixture was poured into ice cold 7 water (100 mL), stirred for 5 min, formation of precipitates was observed, which was filtered and dried under vacuum to afford the desired compound, 553 tert-butyl methyl(2-((4-nitrophenyl)amino)ethyl)carbamate (1.72 g, 82.29%) as a yellow solid. (0586) LCMS: 296.1 [M+1]+

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of N-Boc-(2-Aminoethyl)-N-methylamine.

Reference:
Patent; giraFpharma LLC; Chakravarty, Sarvajit; PHAM, Son Minh; Kankanala, Jayakanth; AGARWAL, Anil Kumar; PUJALA, Brahmam; SONI, Sanjeev; ARYA, Satish K.; PALVE, Deepak; KUMAR, Varun; (360 pag.)US2019/106436; (2019); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

121492-06-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 121492-06-6 name is N-Boc-(2-Aminoethyl)-N-methylamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of l-(benzo[d][l,3]dioxol-5-yl)-3-(4-chloro-6-methylpyrimidin-2-yl)urea (280) (82 mg, 0.27 mmol) and 2-propanol (0.5 mL) was treated with N-(2-aminoethyl)-N- methyl carbamic acid tert-butyl ester (0.06 mL, 0.32 mmol), and triethylamine (0.06 mL, 0.40 mmol) and this was heated to 80 C with stirring overnight. Upon cooling the reaction was diluted with MeOH (3mL) and the precipitate formed was filtered to give the title compound (287) (85 mg, 72%). LC/MS: Method 4: Rt = 2.14 min, m/z = 445.3 [MH+].

At the same time, in my other blogs, there are other synthetic methods of this type of compound, N-Boc-(2-Aminoethyl)-N-methylamine, and friends who are interested can also refer to it.

Reference:
Patent; CURTANA PHARMACEUTICALS, INC.; BEATON, Graham; TUCCI, Fabio C.; RAVULA, Satheesh B.; MCHARDY, Stanton F.; RUIZ, Francisco Xavier, III; LOPEZ, Ambrosio, Jr.; CAMPOS, Bismarck; WANG, Hua-Yu Leo; (241 pag.)WO2016/138479; (2016); A1;,
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Amide – an overview | ScienceDirect Topics

The chemical industry reduces the impact on the environment during synthesis 121492-06-6, name is N-Boc-(2-Aminoethyl)-N-methylamine, I believe this compound will play a more active role in future production and life. 121492-06-6

EXAMPLE 365; 5-Bromo-3-[6-(2-methylamino-ethylamino)-2-propyl-2H-pyrazolo[3,4-d]pyrimidin-4-yl]-1,3-dihydro-indol-2-one hydrochloride; salt Example 188 (50 mg, 0.123 mmol) and N-(3-aminoethyl)-N-methyl carbamic acid t-butyl ester (214 mg, 1.23 mmol) were heated in 1 mL EtOH at 130 C. in microwave for 10 min. Upon cooling, the product precipitated in the reaction tube. The resulting solid was filtered and pumped dry before stirring in 5 mL of 4N HCl/dioxane for 1 h at r.t. The reaction mixture was pumped dry, triturated in ether and filtered to afford 38 mg (65%) of a yellow solid. mp 269-271 C.; MS (ES+calculated: 444.34; found: 444.63, 445.75 M+H). HPLC (95%) purity, retention time 3.937 minutes-Method C); 1H NMR (400 MHz, TFA) delta 8.73 (s, 1H), 7.89 (s, 1H), 7.54 (d, J=8 Hz, 1H), 7.17 (d, J=8 Hz, 1H), 4.4 (m, 2H), 4.31 (br s, 2H), 4.07 (m, 1H), 3.85 (m, 3H), 3.10 (br s, 2H), 2.12 (m, 2H), 1.13 (t, J=7 Hz, 3H).

The chemical industry reduces the impact on the environment during synthesis 121492-06-6. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Cephalon, Inc.; US2007/281949; (2007); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 121492-06-6, name is N-Boc-(2-Aminoethyl)-N-methylamine belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. 121492-06-6

To a solution of 3-[8-(2,6-difluorophenyl)-2-(methylsulfinyl)-7-oxo-5, 6,7,8- tetrahydropyrimido[4,5-Patent; GLAXO GROUP LIMITED; WO2007/147109; (2007); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

121492-06-6, The chemical industry reduces the impact on the environment during synthesis 121492-06-6, name is N-Boc-(2-Aminoethyl)-N-methylamine, I believe this compound will play a more active role in future production and life.

A solution of [6-chloro-3-(1’H,3H-spiro[2-benzofuran-1,4′-piperidin]-1′-ylcarbonyl) -1H-indol-1-yl]acetic acid (prepared by treatment of the sodium salt of 1′-[(6-chloro-1H-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-1,4′-piperidine] with bromoacetic acid at room temperature in DMF), 0-(7-azabenzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate (1.05 eq) and Et3N (1.05 eq) were stirred together at room temperature in dry DMF for 15 min. Commercially available N-(2-aminoethyl)-N-methylcarbamic acid tert-butyl ester (1.5 eq) was added and the solution stirred at room temperature for 2 h, then a solution of HCl (15 eq) in dioxane was added and the solution stirred for 2 h. Evaporation and purification by prep. HPLC gave 37% of product. ES-MS m/e (%): 481.3(M+H+).

The chemical industry reduces the impact on the environment during synthesis N-Boc-(2-Aminoethyl)-N-methylamine. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Bissantz, Caterina; Grundschober, Christophe; Ratni, Hasane; Rogers-Evans, Mark; Schnider, Patrick; US2007/27173; (2007); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 121492-06-6 as follows. 121492-06-6

DMF (20 ml), QHL 014 (4.42 g, 9.2 mmol), N-BOC-N-methyl ethylenediamine (2.00 g, 12.5 mmol), HATU (4.20 g, 11 mmol) was added in a 50 ml single-necked flask. After stirring for 5 minutes, DIPEA (5 ml, 27.6 mmol) was added dropwise. Stir at room temperature until QHL014 is completely reacted. DMF was evaporated under reduced pressure, and the crude product was dissolved in ethyl acetate and washed with water. The organic phase was dried and purified by silica gel column chromatography (dichloromethane: methanol = 50:1 to 20:1) to obtain light yellow solid QHL 015 (4.81 g, yield 80%).

According to the analysis of related databases, 121492-06-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Yafei Shanghai Biolog Medicine Science & Technology Co., Ltd.; LIU, Yuan; LIU, Cheng; WANG, Haiyang; (43 pag.)EP3572420; (2019); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

121492-06-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 121492-06-6, name is N-Boc-(2-Aminoethyl)-N-methylamine, This compound has unique chemical properties. The synthetic route is as follows.

Step 3 [0211] To a stirred solution of N-Boc-N-methyl ethylenediamine (1.39 g, 8.0 mmol) and DIEA (1.05 g, 8.1 mmol) in dry DCM (50 mL) at 0C was added a solution ofp- nitrobenzylchloroformate (1.75 g, 8.1 mmol) in dry DCM (10 mL) dropwise over 5- 10 minutes. The reaction mixture was stirred at this temperature for 30 minutes and then allowed to warm to room temperature, and stirred overnight (monitored by TLC). The reaction mixture was then washed with 1M aq. NaHC03 solution, water, and brine. The organic layer was dried over Na2S04, concentrated , and the remaining residue was purified by flash chromatography to give the desired N-Boc-N’-PNB protected intermediate in 73% yield.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; FOB SYNTHESIS; WO2005/123066; (2005); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics