Category: 121492-06-6

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 121492-06-6, name is N-Boc-(2-Aminoethyl)-N-methylamine, A new synthetic method of this compound is introduced below., name: N-Boc-(2-Aminoethyl)-N-methylamine

Step 1 [0216] A solution of N-Boc-N-methylethylenediamine (1 g, 5.74 mmol) and sulfamide (1.1 g, 11.48 mmol) in dioxane (20 mL) was stirred at reflux under N2 atmosphere (monitored by TLC). The mixture was then filtered to remove the insoluble material and the filtrate was concentrated under reduced pressure and treated with ethyl acetate. The insoluble material was again removed by filtration and the filtrate concentrated under reduced pressure to give the desired product in 96% yield.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; FOB SYNTHESIS; WO2005/123066; (2005); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 121492-06-6, These common heterocyclic compound, 121492-06-6, name is N-Boc-(2-Aminoethyl)-N-methylamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 95; l,l-dimethylethyl (2-{r8-(2.6-difluorophenvn-4-f5-frf4- fluorophenyl)aminolcarbonyl}-2-methylphenv?-7-oxo-7,8-dihvdropyrido[2.3-^rhoyrimidin-2-yl]amino|ethyl)methylcarbarnateTo a solution of 3-[8-(2,6-difluorophenyl)-2-(methylsulfmyl)-7-oxo-7,8- dihydropyrido[2,3-d]pyrimidin-4-yl]-N-(4-fluorophenyl)-4-methylbenzamide (50 mg, 0.09 mmol) in DCM (5 niL) was added 1,1-dimethylethyl (2-aminoethyl)- methylcarbamate (0.09 mL, 0.5 mmol). The resultant mixture was stirred at room temperature overnight. The mixture was concentrated under vacuo. Flash chromatography (90% CH2Cl2 / 7% MeOH / 3% NH4OH) then provide the title compound (61 mg, 100%). LC-MS (ES) m/z 659 (M+H)+; 1H-NMR(CDCl3) delta 1.39 (s, 9H), 1.70 (br, IH), 2.32 (s, 3H), 2.65 (s, 2H), 2.82 (s, 2H), 3.22 (s, 3H), 3.60 (br, IH), 6.34 (d, IH)5 7.03 (m, 4H)5 7.34 (m, IH), 7.48 (m. 2H), 7.64 (m, IH), 7.84 (m, 2H)5 8.14 (d, IH).

Statistics shows that N-Boc-(2-Aminoethyl)-N-methylamine is playing an increasingly important role. we look forward to future research findings about 121492-06-6.

Reference:
Patent; GLAXO GROUP LIMITED; WO2006/104915; (2006); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 121492-06-6, name is N-Boc-(2-Aminoethyl)-N-methylamine, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 121492-06-6, name: N-Boc-(2-Aminoethyl)-N-methylamine

EXAMPLE H-l 4 Example H-14 N-ethyl-N-(2-((4-(2-hvdroxypropan-2-yl)pyrinudin-2-yl)(methyl)aniino)ethyl)-2- isopropoxynicotinamide Step 1 : tert-butyl (2-(((benzyloxy)carbonyl)amino)ethyl)(methyl)carbamate (H-7) To a solution of tert-butyl (2-aminoethyl) (methyl)carbamate (5.0 g, 28.7 mmol) in THF (100 mL) was added NaHC03 (12.1 g, 143.5 mmol) at 0 C. The resulting mixture was stirred at the same temperature for 15 min. Cbz-Cl (5.9 g, 34.4 mmol) was added dropwise. The mixture was stirred at RT overnight, then filtered and the filtrate was concentrated in vacuo. The residue was purified by combiflash (10% EtOAc in petroleum ether) to give the title compound H-7. LRMS m/z (M+H) 309.1found, 309.4 required.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-Boc-(2-Aminoethyl)-N-methylamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK SHARP & DOHME CORP.; KIM, Ronald; KUDUK, Scott, D.; LIVERTON, Nigel; ZHUO, Gang; (116 pag.)WO2016/100161; (2016); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 121492-06-6, name is N-Boc-(2-Aminoethyl)-N-methylamine, A new synthetic method of this compound is introduced below., COA of Formula: C8H18N2O2

tert-Butyl methyl(2-(3-(5-(trifluoromethyl)-1 ,2,4-oxadiazol -3- yI)benzamido)ethyl)carbamate 3-(5-(Trifluoromethyl)-1 ,2,4-oxadiazol-3-yl)benzoic acid (1 .24 g, 4.8 mmol), EDCI(922 mg, 4.8 mmol), HOBt (648 mg, 4.8 mmol), and DIPEA (774 mg, 6mmol) were added to a solution of crude tert-butyl (2-aminoethyl)(methyl)carbamate in DCM (5OmL). The reaction mixture was stirred at room temperature overnight. Water (20 mL) was added to the mixture and the organic phase was separated. The aqueous phase was extracted with CH2CI2 (40 mL x3). The combined organic solvents was washed with brine (30 mL), driedover Na2SO4. After removal of solvents, the crude compound was purified by flash column (EtOAc: PE = 2:1) to provide tert-butyl methyl(2-(3-(5-(trifluoromethyl)-1,2,4- oxadiazol-3-yl)benzamido)ethyl)carbamate as a white solid (1.1 g, yield 66%). MS (ESI) m/z: Calculated for C18H21F3N404: 414.15; found: 437 (M-f-Na).

The synthetic route of 121492-06-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TEMPERO PHARMACEUTICALS, INC.; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; BALOGLU, Erkan; WO2013/6408; (2013); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application of 121492-06-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 121492-06-6, name is N-Boc-(2-Aminoethyl)-N-methylamine belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a cooled (0 C) solution of NMethylNbocethylendiamine (05 mL, 279 mmol) and NaCNBH3 (140 mg, 223 mmol) in MeOH (10 mL) and acetic acid (05 mL) was added a solution of 2,4,6trimethoxyhenzaldehyde (0 547 mg 279 mmol) in EtOH (10 mL). The mixture was stirrcd at RI for 2 h, acidificd with 2 M HCI (1 mL) and neutralized withsaturated aqueous Na2CO3 (50 mL). Evaporation of all volatiles, DCM extraction of the resulting aqueous slurry and concentration of the organic fractions yielded N MethylNbocN? tmobethy1endiamine (5a) as a crude oil which was purified by RPHPLC.Yield 593 ing (L52 mmol)MS. rn z 377 35 [M+Na], (calculated = 377 14).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-Boc-(2-Aminoethyl)-N-methylamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASCENDIS PHARMA RELAXIN DIVISION A/S; SPROG?E, Kennett; CLEEMANN, Felix; RAU, Harald; HASSEPASS, Nicole; WEGGE, Thomas; ZETTLER, Joachim; BERNHARD, Ana; WO2015/67791; (2015); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Electric Literature of 121492-06-6, These common heterocyclic compound, 121492-06-6, name is N-Boc-(2-Aminoethyl)-N-methylamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 128: N-{5-[3-(4-Bromo-2-fluoro-phenylamino)-pyridin-4-yl]- [1 ,3,4]oxadiazol-2-yl}-N’-methyl-ettiane-1 ,2-diamine; Step 1 : 5-[3-(4-Bromo-2-fluoro-phenylamino)-pyridin-4-yl]-3H-[1 ,3,4]oxadiazol-2-one (example 19, 100mg, 0.277mmol) was dissolved in ethanol (3ml), N-(2-aminoethyl)-N – methylcarbamic acid ^-butylester (96rng, 0.554mmol) was added and the mixture was stirred for20min at 1500C in a microwave oven. The volatiles were removed to give the crude compound, which was used in the next step.Step 2: Dry dichloromethane (5ml) was added to the product derived from step 1 followed by triphenylphosphine (113rng, 0.429mmol), triethylamine (58mul, 0.416mmol) and carbon tetrachloride (107mul, 1.11 mmol). The mixture was heated at 1000C for20min in a microwave oven, the volatiles were removed and the crude material was purified by preparative HPLC to give 87mg (62/yield) of the Boc-protected title compound. The material was treated with 4N HCI in dioxane (4ml) for 1h at ambient temperature and the volatiles were removed to give the pure title compound. LC-MS (method V): rt = 1.94rnin; m/z [M+ H]+ 407/409.

The synthetic route of 121492-06-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.; WO2006/45514; (2006); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 121492-06-6, name is N-Boc-(2-Aminoethyl)-N-methylamine, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C8H18N2O2

Reference Example 61Synthesis of tert-butyl methyl-[2-(2-nitrobenzenesulfonylamino) ethyl]carbamate2-Nitrobenzenesulfonyl chloride (4.9 g, 22 mmol) was added to a dichloromethane solution (100 ml) of tert-butyl (2-aminoethyl)methyl carbamate (3.5 g, 20mmol) and triethylamine (3.3ml, 24 mmol) at 0C, and stirred at room temperature overnight. Waterwas added to the reaction mixture, and extraction with dichloromethanewas performed. The organic layer was dried over anhydrous sodiumsulfate, and concentrated under reduced pressure. The residue waspurified by silica gel column chromatography (n-hexane:ethylacetate=3:2-?2:3) . The purified product was concentrated underreduced pressure to thereby obtain 5.06 g (yield: 70%) of tert-butylmethyl-[2-(2-nitrobenzenesulfonylamino)ethyl]carbamate as a yellowoil.1H-NMR (CDC13) 5ppm:1.45 (9H, s), 2.84 (3H, s), 3.26 – 3.41 (4H, m), 7.68-7.79 (2H, m),7.79-7.90 (1H, m), 8.09-8.19 (1H, m) .

According to the analysis of related databases, 121492-06-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; OTSUKA PHARMACEUTICAL CO., LTD.; WO2009/104819; (2009); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 121492-06-6, name is N-Boc-(2-Aminoethyl)-N-methylamine belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Formula: C8H18N2O2

To a well stirred solution of BoC-NMe-CH2CH2-NH2 (265 mg, 1.52 mmol) in acetone (15 mL) was added a solution of Fmoc-OSu (564 mg, 1.67 mmol in 15 mL acetone). The mixture was then stirred for 2 hours at ambient temperature. TLC analysis of the reaction mixture at this stage showed formation of Boc-NMe-CH2CH2-NH-Fmoc (Rf = 0.35; 3:7 EtOAc: hexanes, UV 254 nm, TLC developed by heating with 3% (w/v) solution of ninhydrin in EtOH).After evaporation of acetone the product was purified by flash-chromatography (40 g Isco-silica column, 40 mL/min, 254 nm, 3:7 EtOAc-hexanes, 18 mL fractions collected, fractions 15-24 had pure product) to give Boc-NMe-CH2CH2-NH-Fmoc as foam (520 mg, yield = 86%). BoC-NMe-CH2CH2-NH-FmOC (520 mg, 1.31 mmol) was treated with TFA-water (15 ml, 95:5, v/v) for 1 hour at ambient temperature, when TLC analysis showed complete Boc- deprotection. TFA-water was removed under reduced pressure and the resulting oil dissolved in DCM (30 mL). To this solution, succinic anhydride (131 mg, 1.31 mmol) was added followed by DIPEA (to pH ~10 by moist pH paper). The mixture was then stirred for 30 min. The reaction mixture was then acidified (pH = 1) with HCI (1 M) and extracted with EtOAc (100 mL x 3). The combined EtOAc layers were washed with brine (100 mL x 2) and dried over Na2SO4. The EtOAc was removed under reduced pressure to give the title compound as a colorless oil. ES-MS (MeOH-direct infusion) Calculated MH+ (C23H26N2O5H+) = 411.10, Observed MH+ 411.09.

The synthetic route of 121492-06-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; APPLERA CORPORATION; WO2007/87534; (2007); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Synthetic Route of 121492-06-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 121492-06-6 as follows.

General procedure: To a solution of acid 7(a-p) (1 equiv) and amine (1.5 equiv) in dichloromethane were added HoBt (1.5 equiv) and EDCI(1.5 equiv). The reaction mixture was stirred at room temperature overnight, then washed with 5% aqueous HCl, 5% aqueous sodium bicarbonate, water, and brine, and dried. Purification by chromatography afforded 8-9(a-c).

According to the analysis of related databases, 121492-06-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Yang, Ying-Rui; Wei, Jin-Lian; Mo, Xiao-Fei; Yuan, Zhen-Wei; Wang, Jia-Lin; Zhang, Chao; Xie, Yi-Yue; You, Qi-Dong; Sun, Hao-Peng; Bioorganic and Medicinal Chemistry Letters; vol. 26; 11; (2016); p. 2713 – 2718;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 121492-06-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 121492-06-6, name is N-Boc-(2-Aminoethyl)-N-methylamine belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 33; 1-{4-[1-(1-Benzyl-piperidin-4-yl)-4-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-phenyl}-3-(2-methylamino-ethyl)-urea (Scheme 32)49 mg (0.2 mmol) 4-isocyanatophenylboronic acid, pinacol ester was dissolved in 2 mL DME. 0.2 mmol (36 uL) N-Me-N-Boc ethylene diamine was added. The mixture was stirred for 30 min at room temperature. 50 mg 1-(1-Benzyl-piperidin-4-yl)-6-chloro-4-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidine was added, followed by 250 uL of a 2M solution of Na2CO3 and 10 mol % Pd(PPh3)4. The mixture was heated under microwave irradiation at 185 C for 6 min. The mixture was cooled to room temperature and 2 mL TFA was added. After stirring at room temperature for 3h the solvents were removed and the mixture was purified by HPLC (TFA buffers) to give 34 mg of the title compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-Boc-(2-Aminoethyl)-N-methylamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Wyeth; US2008/234262; (2008); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics