Jang, Yoon Kyung published the artcileDesign, synthesis, and biological evaluation of aryl N-methoxyamide derivatives as GPR119 agonists, Computed Properties of 1204742-78-8, the publication is Bioorganic & Medicinal Chemistry Letters (2017), 27(16), 3909-3914, database is CAplus and MEDLINE.
A series of N-methoxyamide derivatives was identified and evaluated as GPR119 agonists. Several N-methoxyamides with thienopyrimidine and pyridine scaffolds showed potent GPR119 agonistic activities. Among them, compound I displayed good in vitro activity and potency. Moreover, compound I lowered glucose excursion in mice in an oral glucose tolerance test and increased GLP-1 secretion in intestinal cells.
Bioorganic & Medicinal Chemistry Letters published new progress about 1204742-78-8. 1204742-78-8 belongs to amides-buliding-blocks, auxiliary class Boronic acid and ester,Amine,Benzene,Amide,Boronate Esters,Boronic Acids,Boronic acid and ester,, name is N-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide, and the molecular formula is C14H20BNO4, Computed Properties of 1204742-78-8.
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