Electric Literature of 120157-98-4,Some common heterocyclic compound, 120157-98-4, name is tert-Butyl acetylcarbamate, molecular formula is C7H13NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Carbonic acid (1 S,4f?)-4-(6-chloro-purin-9-yl)-cyclopent-2-enyl ester ethyl ester (1 equivalent), acetyl-carbamic acid terf-butyl ester (seeTanaka et al. (1988), supra; 1 .15 equivalents) and triphenyl phosphine (0.15 equivalents) were combined in an oven – dried flask under an atmosphere of argon. Dry deoxygenated THF (to 0.3 M with respect to carbonic acid (1 S,4f?)-4-(6-chloroiDurin-9-yl)-cyclopent-2-enyl ester ethyl ester) was added, followed by Pd2(dba)3 (5 mol%). The reaction mixture was stirred at 500C for 1 hour, and allowed to cool to room temperature, before the volatile components were removed under reduced pressure and the product purified by flash column chromatography/crystallization.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route tert-Butyl acetylcarbamate, its application will become more common.
Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2007/147659; (2007); A1;,
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