Category: 1192620-83-9

Hall, Thomas H.; Adams, Hannah; Vyas, Vijyesh K.; Michael Chu, K. L.; Wills, Martin published the artcile< Asymmetric transfer hydrogenation of unsaturated ketones; factors influencing 1,4- vs 1,2- regio- and enantioselectivity, and alkene vs alkyne directing effects>, HPLC of Formula: 1192620-83-9, the main research area is unsaturated ketone enantioselective regioselective transfer hydrogenation chemoselectivity.

A detailed study has been completed on the asym. transfer hydrogenation (ATH) of a series of enones using Ru(II) catalysts. Electron-rich rings adjacent to the C=O group reduce the level of C=O reduction compared to C=C. The ATH reaction can readily discriminate between double and triple bonds adjacent to ketones, reducing the double bond but leaving a triple bond intact in the major product.

Tetrahedron published new progress about Allylic alcohols Role: BYP (Byproduct), PREP (Preparation) (chiral). 1192620-83-9 belongs to class amides-buliding-blocks, and the molecular formula is C30H31ClN2O2RuS, HPLC of Formula: 1192620-83-9.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zheng, Ye; Martinez-Acosta, Jaime A.; Khimji, Mohammed; Barbosa, Luiz C. A.; Clarkson, Guy J.; Wills., Martin published the artcile< Asymmetric Transfer Hydrogenation of Aryl Heteroaryl Ketones using Noyori-Ikariya Catalysts>, Computed Properties of 1192620-83-9, the main research area is aryl heteroaryl alc preparation enantioselective; heteroaryl aryl ketone asym transfer hydrogenation Noyori Ikariya catalyst.

A range of ketones ArC(O)R (Ar = Ph, 2-bromophenyl, naphthalen-1-yl, etc.; R = furan-2-yl, thiophen-2-yl, 1-methyl-1H-imidazol-2-yl) flanked by a combination of an aromatic and a heterocyclic ring were reduced under asym. transfer hydrogenation (ATH) conditions. Using a range of [(arene)Ru(TsDPEN)Cl] precatalysts, including tethered derivatives, I, the reduction enantioselectivity was high (up to 99% ee) in cases where the aromatic ring contained an ortho-substituent. The enantioselectivity is influenced by a combination of steric and electronic factors which for the furan and thiophene series, follow literature precedents. In the case of the N-methylimidazole-containing ketones ArC(O)R (R = 1-methyl-1H-imidazol-2-yl), an unexpected switch in enantioselectivity took place upon variation of the opposing aromatic group. Pyrrole- containing ketones II (R1 = Me, tert-butoxycarbonyl) were resistant to reduction This study demonstrates the asym. transfer hydrogenation (ATH) of a range of hindered heterocyclic ketones, in high conversion and ee, using Noyori-Ikariya catalysts I.

ChemCatChem published new progress about Aromatic alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 1192620-83-9 belongs to class amides-buliding-blocks, and the molecular formula is C30H31ClN2O2RuS, Computed Properties of 1192620-83-9.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Shende, Vaishali S.; Raut, Amol B.; Raghav, Prathamesh; Kelkar, Ashutosh A.; Bhanage, Bhalchandra M. published the artcile< Room-Temperature Asymmetric Transfer Hydrogenation of Biomass-Derived Levulinic Acid to Optically Pure γ-Valerolactone Using a Ruthenium Catalyst>, Product Details of C30H31ClN2O2RuS, the main research area is asym transfer hydrogenation biomass levulinic acid valerolactone ruthenium catalyst.

This study presents a first report on ruthenium-catalyzed asym. transfer hydrogenation (ATH) of levulinic acid (LA) to chiral γ-valerolactone (GVL). ATH of LA has been explored with Noyori’s chiral catalyst (Ru-TsDPEN) in methanol solvent. Efficacy of ATH reaction of LA was investigated under different reactions conditions such as temperature, catalyst, and hydrogen donor concentration The effect of various organic tertiary bases along with formic acid (FA) as a hydrogen donor was studied, and N-methylpiperidine with FA (1:1 molar ratio) was revealed as an efficient hydrogen donor for ATH of LA to GVL furnishing chiral GVL with complete conversion and 93% enantiomeric excess (ee). This operationally simple and mild ATH protocol was tested for practical applicability of ATH of LA obtained from biomass waste (rice husk and wheat straw) and furnished chiral GVL with 82% ee.

ACS Omega published new progress about Biomass. 1192620-83-9 belongs to class amides-buliding-blocks, and the molecular formula is C30H31ClN2O2RuS, Product Details of C30H31ClN2O2RuS.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Mishra, Ashish A.; Bhanage, Bhalchandra M. published the artcile< Electronic And Steric Effect Favored Selective Synthesis Of Asymmetric (-) N-Aryl Mandelamides>, SDS of cas: 1192620-83-9, the main research area is asym aryl mandelamide preparation enantioselective; aryl benzoyl formamide asym transfer hydrogenation ruthenium catalyst.

This work reports selective synthesis of asym. (-) α-Hydroxyl Amides like N-aryl mandelamides (S)-4-RC6H4NHC(O)CH(OH)R1 [R = H, Me; R1 = Ph, 2-fluorophenyl, 2,4,6-tris(propan-2-yl)phenyl, etc.] via asym. transfer hydrogenation (ATH) of α-keto Amides like N-aryl benzoyl formamides 4-RC6H4NH(C(O))2R1 using Ru-Tethered TsDPEN catalyst I. The electronic and steric effect at ortho position leading to high enantioselectivity for ATH of carbonyl, sandwiched between two sp2 carbon is studied. A wide range of mono and di ortho substituted α-hydroxyl amide is synthesized using this protocol with good enantioselectivity.

ChemistrySelect published new progress about Amides, hydroxy Role: SPN (Synthetic Preparation), PREP (Preparation). 1192620-83-9 belongs to class amides-buliding-blocks, and the molecular formula is C30H31ClN2O2RuS, SDS of cas: 1192620-83-9.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhang, Yi-Ming; Wang, Dong-Chao; Xie, Ming-Sheng; Qu, Gui-Rong; Guo, Hai-Ming published the artcile< Asymmetric Transfer Hydrogenation of rac-α-(Purin-9-yl)cyclopentones via Dynamic Kinetic Resolution for the Construction of Carbocyclic Nucleosides>, Category: amides-buliding-blocks, the main research area is asym transfer hydrogenation dynamic kinetic resolution purinylcyclopentone; crystal structure hydrogenation kinetic resolution purinylcyclopentone purinylcyclopentanol carbocyclic nucleoside.

An asym. transfer hydrogenation via dynamic kinetic resolution of a broad range of rac-α-(purin-9-yl)cyclopentones was first developed. A series of cis-β-(purin-9-yl)cyclopentanols were obtained with up to 97% yield, >20/1 dr, and >99% ee. This also provides an efficient synthetic route to a variety of chiral carbocyclic nucleosides.

Organic Letters published new progress about Carbocyclic nucleosides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1192620-83-9 belongs to class amides-buliding-blocks, and the molecular formula is C30H31ClN2O2RuS, Category: amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Vyas, Vijyesh K.; Bhanage, Bhalchandra M. published the artcile< Kinetic Resolution Driven Diastereo- and Enantioselective Synthesis of cis-β-Heteroaryl Amino Cycloalkanols by Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation>, Reference of 1192620-83-9, the main research area is azolyl cycloalkanol diastereoselective enantioselective preparation; tethered ruthenium catalyst asym transfer hydrogenation azolyl ketone; dynamic kinetic resolution azolyl ketone tethered ruthenium catalyst; phenyltriazolyl bromoindanol crystal structure absolute configuration.

In the presence of a tethered Ru-TsDPEN complex, ketones with α-nitrogen heterocycle substituents such as I underwent diastereoselective and enantioselective dynamic kinetic resolution and transfer hydrogenation reactions with triethylamine and formic acid in dichloromethane for 6 h at 27° to yield cis-azolyl cycloalkanols such as II. Using the method, a nonracemic antileishmanial agent and a nonracemic ionic liquid were prepared The structure and absolute configuration of a (phenyltriazolyl)bromoindanol were determined by X-ray crystallog.

Organic Letters published new progress about Azoles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (β-hydroxycycloalkyl, β-ketocycloalkyl). 1192620-83-9 belongs to class amides-buliding-blocks, and the molecular formula is C30H31ClN2O2RuS, Reference of 1192620-83-9.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Soni, Rina; Cheung, Fung Kei; Clarkson, Guy C.; Martins, Jose E. D.; Graham, Mark A.; Wills, Martin published the artcile< The importance of the N-H bond in Ru/TsDPEN complexes for asymmetric transfer hydrogenation of ketones and imines>, Quality Control of 1192620-83-9, the main research area is nitrogen hydrogen bond ruthenium TsDPEN complex; asym transfer hydrogenation ketone imine crystallog.

Ru(II) complexes of TsDPEN containing two alkyl groups on the nontosylated nitrogen atom are poor catalysts for asym. transfer hydrogenation of ketones and imines; this observation provides direct evidence for the importance of the N-H interaction in the transition state for ketone reduction

Organic & Biomolecular Chemistry published new progress about Crystal structure. 1192620-83-9 belongs to class amides-buliding-blocks, and the molecular formula is C30H31ClN2O2RuS, Quality Control of 1192620-83-9.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Parekh, Vimal; Ramsden, James A.; Wills, Martin published the artcile< Asymmetric transfer hydrogenation of quinolines using tethered Ru(II) catalysts>, Recommanded Product: Chloro[N-[(1R,2R)-1,2-diphenyl-2-[[3-(η6-phenyl)propyl]amino-κN]ethyl]-4-methylbenzenesulfonamidato-κN]ruthenium, the main research area is asym transfer hydrogenation quinoline ruthenium catalyst.

The first report of an asym. transfer hydrogenation, in formic acid/triethylamine, of quinolines is described. Using a Ru(II) catalyst containing a 4-carbon tether, products of up to 73% ee were formed, while a Rh(III)-tethered catalyst gave products of up to 94% ee.

Tetrahedron: Asymmetry published new progress about Enantioselective synthesis. 1192620-83-9 belongs to class amides-buliding-blocks, and the molecular formula is C30H31ClN2O2RuS, Recommanded Product: Chloro[N-[(1R,2R)-1,2-diphenyl-2-[[3-(η6-phenyl)propyl]amino-κN]ethyl]-4-methylbenzenesulfonamidato-κN]ruthenium.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics