Lemmerer, Miran et al. published their research in Angewandte Chemie, International Edition in 2022 | CAS: 116332-61-7

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.HPLC of Formula: 116332-61-7

HFIP Mediates a Direct C-C Coupling between Michael Acceptors and Eschenmoser’s salt was written by Lemmerer, Miran;Riomet, Margaux;Meyrelles, Ricardo;Maryasin, Boris;Gonzalez, Leticia;Maulide, Nuno. And the article was included in Angewandte Chemie, International Edition in 2022.HPLC of Formula: 116332-61-7 This article mentions the following:

A direct C-C coupling process that merges Michael acceptors and Eschenmoser’s salt was presented. Although reminiscent of the Morita-Baylis-Hillman reaction, this process requires no Lewis base catalyst. The underlying mechanism was unveiled by a combination of kinetic, isotopic labeling experiments as well as computational investigations, which showcased the critical role of HFIP as a superior mediator for proton-transfer events as well as the decisive role of the halide counterion. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7HPLC of Formula: 116332-61-7).

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Thus amides can participate in hydrogen bonding with water and other protic solvents; the oxygen atom can accept hydrogen bonds from water and the N–H hydrogen atoms can donate H-bonds. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.HPLC of Formula: 116332-61-7

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Johansen, Martin B. et al. published their research in Organic & Biomolecular Chemistry in 2020 | CAS: 116332-61-7

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Category: amides-buliding-blocks

Copper-catalyzed and additive free decarboxylative trifluoromethylation of aromatic and heteroaromatic iodides was written by Johansen, Martin B.;Lindhardt, Anders T.. And the article was included in Organic & Biomolecular Chemistry in 2020.Category: amides-buliding-blocks This article mentions the following:

A copper-catalyzed decarboxylative trifluoromethylation of (hetero)aromatic iodides RI (R = 4-cyanophenyl, naphthalen-1-yl, 1-benzyl-1H-pyrazol-4-yl, etc.) has been developed. Importantly, this new copper-catalyzed reaction operates in the absence of any ligands and metal additives. The protocol shows good functional group tolerance and is compatible with heteroaromatic systems. The reaction proved scalable to a 15 mmol scale with increased yield. Finally, late-stage installation of the trifluoromethyl functionality afforded the 2,2,2-trifluoro-N-(3-(4-iodophenoxy)-3-phenylpropyl)-N-methylacetamide variant of the antidepressant agent, Prozac, demonstrating the applicability of the developed method. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7Category: amides-buliding-blocks).

N-Methoxy-N-methyl-4-(trifluoromethyl)benzamide (cas: 116332-61-7) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics