Category: 1159977-36-2

Bhise, Nandu Baban published the artcileSynthesis of potential impurities of bicalutamide, Recommanded Product: N-(4-Cyano-3-(trifluoromethyl)phenyl)-3-((2-fluorophenyl)sulfonyl)-2-hydroxy-2-methylpropanamide, the main research area is bicalutamide impurity synthesis.

During the bulk synthesis of bicalutamide (bical), which is an oral nonsteroidal, anti-androgen drug used for prostate cancer, various impurities are formed. The present work details the development of simple processes for the preparation of impurities of bicalutamide, viz bical-sulfoxides, bical-deshydroxy, bical-desfluoro, bical-2-fluoro, and bical-3-fluoro derivatives

Synthetic Communications published new progress about bicalutamide impurity synthesis. 1159977-36-2 belongs to class amides-buliding-blocks, name is N-(4-Cyano-3-(trifluoromethyl)phenyl)-3-((2-fluorophenyl)sulfonyl)-2-hydroxy-2-methylpropanamide, and the molecular formula is C18H14F4N2O4S, Recommanded Product: N-(4-Cyano-3-(trifluoromethyl)phenyl)-3-((2-fluorophenyl)sulfonyl)-2-hydroxy-2-methylpropanamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Nanduri, V. V. S. S. Raman published the artcileDevelopment and Validation of Stability-Indicating HPLC and UPLC Methods for the Determination of Bicalutamide, Product Details of C18H14F4N2O4S, the main research area is bicalutamide impurity determination HPLC UPLC tablet stability.

Six new process related impurities (Imp-08, Imp-09, Imp-10, Imp-12, Imp-13, and Imp-14) of bicalutamide (BCT) were reported in this paper. BCT was subjected to oxidative, acid, alk., hydrolytic, thermal, and photolytic degradation conditions and found to degrade in alk. condition, yielding Imp-11. Stability-indicating high-performance liquid chromatog. and ultra-performance liquid chromatog. methods were developed for the determination of BCT in the presence of its 14 process-related impurities and 1 degradant by Zorbax SB Ph column (150 × 4.6 mm × 3.5 μm) and HSS T3 column (100 × 2.1 mm × 1.8 μm), resp. Both the methods were validated as per International Conference on Harmonization guidelines. Quantitation limits (QL) were found be in the ranges of 0.02-0.03% for both the methods. Precision was evaluated by replicate anal. in which % relative standard deviation (RSD) values for areas were found <2.0. Linearity for the impurities was established in the range of QL to 200% of the specification level and the correlation coefficients derived from of the resp. calibration curves were approx. 0.999. The recoveries obtained for purity (90-100%) and assay (98-102%) ensured the accuracy of the developed methods. Journal of Chromatographic Science published new progress about Decomposition. 1159977-36-2 belongs to class amides-buliding-blocks, name is N-(4-Cyano-3-(trifluoromethyl)phenyl)-3-((2-fluorophenyl)sulfonyl)-2-hydroxy-2-methylpropanamide, and the molecular formula is C18H14F4N2O4S, Product Details of C18H14F4N2O4S.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Sadutto, Daniele published the artcileAnalytical and semipreparative high performance liquid chromatography enantioseparation of bicalutamide and its chiral impurities on an immobilized polysaccharide-based chiral stationary phase, Name: N-(4-Cyano-3-(trifluoromethyl)phenyl)-3-((2-fluorophenyl)sulfonyl)-2-hydroxy-2-methylpropanamide, the main research area is liquid chromatog enantioseparation bicalutamide chiral impurity polysaccharide; Bicalutamide; Chiralpak IA; Enantiomers; Impurities; Semipreparative resolution; Temperature-variable HPLC.

Direct HPLC separation of enantiomers of Bicalutamide (BCT), a non-steroidal antiandrogen used for the treatment of prostate cancer, was performed by using the immobilized amylose-based Chiralpak IA chiral stationary phase (CSP). Enantioselective conditions were achieved using standard normal phase mixtures n-hexane-alc. (ethanol or 2-propanol) and a “”non-standard”” mobile phase containing Et acetate (EA). The chromatog. behavior of the IA CSP under these elution modes was evaluated and compared at different temperatures The eluent mixture n-hexane-EA-ethanol 100-30-5 (volume/volume/v) and the column temperature of 40 °C were identified as the best operational conditions to carry out semipreparative enantioseparations on a 1-cm I. D. IA column. Using this protocol, about 960 mg of (R)-BCT, which is the enantiomer with the almost entire anti-androgenic activity of BCT, per day could be isolated. The anal. and semipreparative HPLC resolution of chiral impurities of BCT, and their empiric absolute configuration assignment by CD correlation method are also presented.

Journal of Chromatography A published new progress about Chiral resolution. 1159977-36-2 belongs to class amides-buliding-blocks, name is N-(4-Cyano-3-(trifluoromethyl)phenyl)-3-((2-fluorophenyl)sulfonyl)-2-hydroxy-2-methylpropanamide, and the molecular formula is C18H14F4N2O4S, Name: N-(4-Cyano-3-(trifluoromethyl)phenyl)-3-((2-fluorophenyl)sulfonyl)-2-hydroxy-2-methylpropanamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics