Category: 1122-56-1

Synthetic Route of 1122-56-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1122-56-1, name is Cyclohexanecarboxamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A mixture of cyclohexane carboxamide (1.1 g, 8.56 mmol) and Lawesson’s reagent (2.08 g, 5.14 mmol) in THF (35 mL) was stirred at 50 C. for 5 h. The reaction mixture was cooled, concentrated in vacuo, and purified by silica gel column chromatography (0-50% EtOAc in hexanes) to yield cyclohexane thioamide (938 mg, 77%).

The synthetic route of Cyclohexanecarboxamide has been constantly updated, and we look forward to future research findings.

Reference:
Patent; VICURON PHARMACEUTICALS INC.; US2006/211603; (2006); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Adding some certain compound to certain chemical reactions, such as: 1122-56-1, name is Cyclohexanecarboxamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1122-56-1. 1122-56-1

General procedure: The benzamide (0.2 mmol), NaH (3 equivalents) and dry THF(3 mL) were added to a two-neck flask in turn and stirred atroom temperature for 1 h. Then disulfide (1.5 equivalent) wasadded into the mixture and stirred for another 36 h at roomtemperature. During the whole reaction process, the systemwas kept turbid because of the difficult solubility of NaH inTHF. Then the resulting mixture was filtered and washed withEtOAc to give the solvent, which was concentrated in vacuoand the residue was purified by flash column chromatographyon a silica gel to give the desired product

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Cyclohexanecarboxamide.

Reference:
Article; Zhang, Xing-Song; Zhang, Xiao-Hong; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 191; 1; (2016); p. 89 – 94;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics