Category: 112101-81-2

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Recommanded Product: R-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide, 112101-81-2, Name is R-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide, SMILES is N[C@@H](CC1=CC(=C(C=C1)OC)[S](=O)(=O)N)C, in an article , author is Ioannou, Aristos, once mentioned of 112101-81-2.

Opposing Effects of Side-Chain Flexibility and Hydrogen Bonding on the Thermal, Mechanical, and Rheological Properties of Supramolecularly Cross-Linked Polyesters

We report the design of a series of polyesters containing pendant secondary amide groups to probe the cumulative effects of hydrogen bonding and chain flexibility on their thermal, mechanical, and rheological properties. Reported studies on polymers with secondary amide groups have usually focused on the effect of hydrogen bonding interactions on the mechanical, self-assembly, or self-healing properties, whereas the effect of chain flexibility has often been overlooked. In an effort to probe the cumulative effects of hydrogen bonding and chain flexibility, in this work polyesters were designed with either one or two pendant secondary amide-propyl groups and compared to a control polyester with one pendant ester-propyl group. The results show that hydrogen bonding increases glass transition temperature (T-g), Youngs modulus, and polymer brittleness. But at higher temperature (T-g + 50 degrees C), rheometry shows that the polyester containing two amide groups has the shortest chain relaxation time and the lowest zero-shear rate viscosity (eta(0)). These results are counterintuitive, since the polymer with two hydrogen bonding amide groups was expected to relax more slowly and have higher viscosity. Our results demonstrate the opposing effects of side-chain flexibility and hydrogen bonding interactions can be used as a strategy to design materials with desired rheological properties.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 112101-81-2, you can contact me at any time and look forward to more communication. Recommanded Product: R-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide.

In an article, author is Lin, Miaoman, once mentioned the application of 112101-81-2, Recommanded Product: R-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide, Name is R-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide, molecular formula is C10H16N2O3S, molecular weight is 244.3106, MDL number is MFCD07782137, category is amides-buliding-blocks. Now introduce a scientific discovery about this category.

HIGHLY SENSITIVE CHEMOSENSOR FOR Cu2+ AND Hg2+ BASED ON ANTHRACENE ANCHORED CALIX[4]ARENE PYRIDINE AMIDE RECEPTOR

In this study, anthracene anchored calix[4]arene pyridine amide (ant-CLX4) receptor was synthesized for the detection of Hg2+ and Cu2+ metal ions and fully characterized by spectroscopic methods. The ion binding properties of ant-CLX4 towards some selected metal ions such as Cu2+, Hg2+, Cr3+, CO2+, Ag+, Tb3+, Zn2+, Cd2+, Ni2+, Ga3+, Mn2+, Yb3+ and Gd3+ were studied by absorption and emission spectra. The ant-CLX4 demonstrated excellent fluorescence response with quenching mechanism (turn-off) in the presence of trace amount of Hg2+ and Cu2+ ions. This quenching response of ant-CLX4 receptor showing the possible binding interaction between ant-CLX4 receptor and metal ions was also observed by a fluorescence color change from bright blue to colorless in presence of metal ions as Hg2+ and Cu2+. Furthermore, the binding stoichiometry of ant-CLX4 with metal ions was confirmed a 1:1 (ant-CLX4-Hg2+ and ant-CLX4-Cu2+) binding model by Job’s Plot method. The detection limits of copper and mercury ions were calculated to be 3.8 x10(-7) M and 3.3 x10(-7) M with a satisfying level for the detection of such ions in the micromolar scale, respectively. This work showed that anthracene anchored calix[4]arene pyridine amide (ant-CLX4) receptor could be used as a member of family of highly sensitive synthetic chemosensor towards toxic ions as Hg2+ and Cu2+.

If you are interested in 112101-81-2, you can contact me at any time and look forward to more communication. Recommanded Product: R-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide.

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 112101-81-2, Name is R-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide, molecular formula is C10H16N2O3S, belongs to amides-buliding-blocks compound. In a document, author is Sarwar, Zahid, introduce the new discover, Recommanded Product: 112101-81-2.

Liquid Phase Peptide Synthesis via One-Pot Nanostar Sieving (PEPSTAR)

Herein, a one-pot liquid phase peptide synthesis featuring iterative addition of amino acids to a nanostar support, with organic solvent nanofiltration (OSN) for isolation of the growing peptide after each synthesis cycle is reported. A cycle consists of coupling, Fmoc removal, then sieving out of the reaction by-products via nanofiltration in a reactor-separator, or synthesizer apparatus where no phase or material transfers are required between cycles. The three-armed and monodisperse nanostar facilitates both efficient nanofiltration and real-time reaction monitoring of each process cycle. This enabled the synthesis of peptides more efficiently while retaining the full benefits of liquid phase synthesis. PEPSTAR was validated initially with the synthesis of enkephalin-like model penta- and decapeptides, then octreotate amide and finally octreotate. The crude purities compared favorably to vendor produced samples from solid phase synthesis.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 112101-81-2. Recommanded Product: 112101-81-2.

Application of 112101-81-2, A common heterocyclic compound, 112101-81-2, name is R-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide, molecular formula is C10H16N2O3S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 4:Preparation of By-Product (5-((R)-2-{Bis-[2-(2-ethoxy phenoxy)ethyI]amino}-propyl)-2-methoxy benzene sulfonamide)This example demonstrates how by-product 5-((R)-2-{Bis-[2-(2-ethoxyphenoxy) ethyl]amino}-propyl)-2-methoxybenzenesulfonamide is prepared by reacting the (R)- enantiomer of reactant-V according to prior processes. A round-bottomed flask is charged with 4.0 g (16.37 mmol) of (R)-reactant-V, 3.47 g (32.74 mmol) OfNa2CO4, 8.01 g (32.65 mmol) of the bromide form of reactant-VI, and 24 mL of N,N-dimethylformamide. Notably, alkyl phosphite solvent was not used in this example. The mixture is heated up to 80 C, and is stirred overnight at 80 C, and then the mixture is cooled down to about 20-25 C. EPO At this point, 40 mL of water and 40 mL of AcOEt are charged into the flask and the resulting mixture is then stirred for 30 minutes and left to decant. The organic phase is separated and then charged again into the flask, is reintroduced in the flask and washed with slightly acidic water (pH 5). The mixture is let to decant and the organic phase is dried with Na2SO4 and the solvent evaporated to obtain 8.96 g of crude 5-((R)-2-{Bis-[2-(2- ethoxyphenoxy)ethyl]amino}-propyl)-2-methoxybenzene sulfonamide. The crude product was purified by silica gel column chromatography (AcOEt as eluent) to obtain 6.29 g of 5- ((R)-2- {Bis-2-(2-ethoxyphenoxy)ethyl]amino } -propyl)-2-methoxybenzenesulfonamide, which still was unpurified and contained unused reactant-VI. A second silica gel column chromatography (CHCI3 as eluent) was performed to obtain 6.00 g of purified 5-((R)-2-{Bis- [2-(2-ethoxyphenoxy)ethyl]amino}-propyl)-2-methoxybenzenesulfonamide (yield 64%).Prior to purification by gel column chromotography, the crude product has approximately 9% (area) tamsulosin free base and approximately 73.3% (area) of the byproduct. Following purification by gel column chromotography, tamsulosin free base is not detected according to HPLC method 1 analysis.The 1H-NMR pMSO-d6, 300 MHz), delta (ppm) of the byproduct is characterized as follows: 0.94 (d, 3H, NCHCH3); 1.24 (t, 6H, OCH2CH3); 2.49 (m (overlapped with DMSO-d5), IH, Ar- CHA); 2.84 (dd, IH, Ar-CHB); 2.89-3.05 (complex signal , 5H, N(CH2-)2 and NH-CHCH3); 3.83 (s, 3H, OCH3); 3.78-4.01 (complex signal, 8H52 OCH2CH3 and 2 NHCH2CH2O); 6.79-6.94 (complex signal, 8H, Ar-H of Ar-OEt); 6.97 (broad s, 2H SO2NH2); 7.00, (d, IH, 3-H (Ar- SO2NH2)); 7.41 (dd, IH, 4-H (Ar-SO2NH2); 7.57 (d, IH, 6-H (Ar-SO2NH2));The 13C NMR (DMSO-d6, 300 MHz), delta (ppm) of the byproduct is characterized as follows: 14.9 (2CH3, 2 OCH2CH3); 15.3 (CH3, CHCH3); 38.3 (CH2 , ArCH2); 50.1 (2 CH2, 2 OCH2CH2N); 56.1 (CH3, OCH3); 59.2 (CH, CHCH3); 63.9 (2 CH2, 2OCH2CH3); 68.6 (2 CH2, 2 OCH2CH2N); 112.4 (CH, C3 (Ar-SO2NH2)); 113.6 , 113.7 and 120.9 (2 x 4CH (Ar-OEt)); 128.1 (CH, C6 (Ar-SO2NH2); 130.9 and 132.3 (2 x C, Ci and C5 (Ar-SO2NH2)); 134.3 (CH, C4 (Ar-SO2NH2); 148.4 and 148.5 2 X 2C (Ar-OEt); 154.2 (C, C2 (Ar-SO2NH2).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; MEDICHEM, S.A.; WO2007/4077; (2007); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Reference of 112101-81-2,Some common heterocyclic compound, 112101-81-2, name is R-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide, molecular formula is C10H16N2O3S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 1: Preparation of 5-[(2R)-2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2- methoxybenzene-sulfonamide (Tamsulosin base)(R)-5-(2-arriinopropyl)-2-methoxybenzenesurfonarnide (60 g; 245.59 mmol) and l-(2- bromoethoxy)-2-ethoxybenzene (57.25 g; 233 mmol) were dissolved in 240 mL of N5N- dimethylformamide and 50.5 mL of diisopropylethylamine. The reaction mixture was heated to 100 C and stirred for 90 minutes. The mixture was then cooled to 20 C and 720 mL of ethyl acetate and 300 mL of water added to the vessel. The mixture was then stirred for 20 minutes at atmospheric condition, and then was allowed to settle. The aqueous layer was separated and re-extracted twice with 300 mL of ethyl acetate. The organic layers were combined and washed with 600 mL of water.The organic phase (1120 mL of ethyl acetate) was then concentrated by distillation at atmospheric pressure during which a white solid was precipitated. The mixture was then cooled to 2 C and stirred for 1 hour. The resulting crystals were isolated by filtration and washed with ethyl acetate to yield 133.59 g of wet tamsulosin base (Loss on Drying: 55.08% (corresponding to 60.01 g of dry material); HPLC Purity: 95.025%).EXAMPLE 3: Preparation of 5-[(2R)-2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2- methoxybenzene-sulfonamide (Tamsulosin base)(R)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide (100 g; 409.31 mmol) and 1- (2-bromoethoxy)-2-ethoxybenzene (95.4 g; 388 mmol) were dissolved in 400 mL of N,N- dimethylformamide and 84 mL of diisopropylethylamine. The reaction mixture was heated to 100 C and stirred for 90 minutes. The mixture was then cooled to 20 C, and 1200 mL of ethyl acetate and 500 mL of water were added. The mixture was then stirred for 20 minutes at atmospheric conditions and was allowed to settle. The aqueous layer was then separated and re-extracted twice with 500 mL of ethyl acetate. Next, the organic layers were combined and washed with 1000 mL of water.The organic phase (~1570 mL of ethyl acetate) was then concentrated by distillation at atmospheric pressure during which a white solid was precipitated. The mixture was then cooled to 2 C, and stirred for 1 hour. The resulting crystals were isolated by filtration and washed with ethyl acetate to yield 125.93 g of wet tamsulosin base (Loss on Drying: 24.09% (corresponding to 95.59 g of dry material); HPLC Purity: 97.62%). EXAMPLE 4: Preparation of 5-[(2R)~2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyI]-2- methoxybenzene-sulfonamide (Tamsulosin base)(R)-5-(2-arninopropyl)-2-methoxybenzenesulfonamide (3 g; 12.27 mmol) and l-(2- bromoethoxy)-2-ethoxybenzene (2.86 g ; 11.63 mmol) were dissolved in 12 mL of N5N- dimethylformamide and 2.55 mL of diisopropylemylamine. The reaction mixture was heated to 100 C and stirred for 90 minutes. The mixture was then cooled to 20 C, and 36 mL of ethyl acetate and 15 mL of water were added. The mixture was then stirred for 20 minutes at atmospheric conditions and was allowed to settle. The aqueous layer was then separated and re-extracted twice with 15 mL of ethyl acetate. Next, the organic layers were combined and washed with 75 mL of water.The organic phase (~80 mL of ethyl acetate) was concentrated by distillation at atmospheric pressure during which a white solid was precipitated. The mixture was then cooled to 2 C and stirred for 1 hour. The resulting crystals were isolated by filtration and washed with ethyl acetate to yield 5.14 g of wet tamsulosin base (Loss on Drying: 39.68% (corresponding to 3.1 g of dry material); HPLC Purity: 96.65%).The solid obtained in the previous step was then combined with 31 mL of ethanol. The reaction mixture was then heated to 78 C and stirred for 40 minutes, cooled to 0 C and stirred for 150 minutes. The resulting crystals were isolated by filtration to yield 4.92 g of wet tamsulosin base (Loss on Drying: 40.59% (corresponding to 2.81 g of dry material); HPLC Purity: 98.70%).

The synthetic route of 112101-81-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MEDICHEM, S.A.; WO2007/119110; (2007); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Some common heterocyclic compound, 112101-81-2, name is R-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide, molecular formula is C10H16N2O3S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of R-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide

EXAMPLES Example 1 Preparation of (R)-2-bromo-N- [2- (4-methoxy-3-aminosulfonyl-phenyl)-1-methyl-ethyl] – acetamide) 1.0 g of (R)-2- (4-methoxyphenyl-3-aminosulfonyl-phenyl)-1-methylethylamine was dissolved in 50 ml of methylene chloride. 0.72 g (2.0 eq) of triethyamine was added to the resultant solution and cooled to 0 to 5C. Then, 1.44 g (2.0 eq) of bromoacetyl bromide was added dropwise to the resultant solution and stirred at 0 to 5C. After it was confirmed by HPLC that the starting materials were completely consumed, 100 ml of ethyl acetate and then 50 ml of 10% HCI were added to the resultant solution and stirred. The ethyl acetate layer was separated and washed with 50 ml of a 10% K2CO3 solution and dried over MgS04, and then, filtered and concentrated. The obtained concentrate was dissolved in ethyl acetate and recrystallized with hexane to obtain the title compound (1.2 g). Yield : 80.0% NMR (DMSO-d6) : 1.15 (3H, d), 2. 6-2. 8 (2H, m), 3.8 (2H, s), 3.90 (4H, s), 7.0 (2H, s), 7.1 (1H, d), 7.4 (1H, d), 7.6 (1H, d), 8.21 (2H, d). [a] 24D = + 5.0 (C=1, MeOH)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 112101-81-2, its application will become more common.

Reference:
Patent; CJ CORPORATION; WO2005/56521; (2005); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Electric Literature of 112101-81-2,Some common heterocyclic compound, 112101-81-2, name is R-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide, molecular formula is C10H16N2O3S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2.6. Tamsulosin; I IV yield 50% 11 220 g (0.88 mol) of intermediate IV and 84 g (0.79 mol) of sodium carbonate and N, N- dimethylformamide (1500 ml) are added to 208 g (0.85 mol) of intermediate I. The reaction mixture is stirred at 70 C for 5 hours. Water is added to the reaction mixture and product II is extracted with ethylacetate. The evaporation residue is stirred in ethanol and after sucking off, the yield is 173.9 g (50 %) of crude base II. The method according to CZ 291802. The yield is, for comparison, also calculated on the crude base. The reaction takes place at 60 to 70 C for 5 hours and the product is not purified with the demanding column chromatography.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route R-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide, its application will become more common.

Reference:
Patent; ZENTIVA, A.S.; WO2005/75415; (2005); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Some common heterocyclic compound, 112101-81-2, name is R-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide, molecular formula is C10H16N2O3S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: R-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide

EXAMPLE 34 R-(-)-5-[2-[2-(5-Fluoro-2-methoxyphenoxy)-ethylamino]propyl]-2-methoxybenzenesulfonamide hydrochloride A suspension of 1.00 g of R-(-)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide [[alpha]D25 -13.8 (C=1,MeOH), m.p.156.5-160.5 C. (H2 O) ] 11.00 g of 2-(2-bromoethoxy)-4-fluoroanisole and 0.20 g of potassium iodide in 40 ml of N,N-dimethylformamide was heated for 10 hours at 85 C. After cooling, the reaction mixture was poured into water, made alkaline with 10% sodium hydroxide aqueous solution and extracted with ethyl acetate. The extract was washed with water, dried and evaporated. The residue was chromatographed on silica gel using chloroform-methanol (9:1) as an eluant to give 0.81 g of the free base as colorless crystals which were recrystallized from methanol as colorless needles, m.p.144-145 C. Analysis for C19 H25 FN2 O5 S: Calculated %: C, 55.33; H, 6.11; N, 6.79. Found %: C, 55.20; H, 5.93; N, 6.54.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 112101-81-2, its application will become more common.

Reference:
Patent; Hokuriku Pharmaceutical Co., Ltd.; US4971990; (1990); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

112101-81-2, name is R-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide, belongs to amides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 112101-81-2

EXAMPLE 32 (b) By following the same procedure as in Example 32 (a), (S)(+)-5-[(2-amino-2-methyl)ethyl]-2-methoxybenzenesulfonamide was obtained by using (S)(-)-N-acetyl-5-[(2-amino-2-methyl)ethyl]-2-methoxybenzenesulfonamide as the starting material. Melting point: 273-276 C. (decomposition). Elemental analysis for C10 H17 ClN2 O3 S: [alpha]D24: 6.0 (c=1.01, methanol). cl EXAMPLE 33 (a) In 120 ml of ethanol were dissolved 2.4 g of (R)(-)-5-[(2-amino-2-methyl)ethyl]-2-methoxybenzenesulfonamide and 1.2 g of 2-(o-ethoxyphenoxy)ethyl bromide, and the mixture was refluxed for 16 hours under heating. The solvent was distilled away, and after rendering alkaline the residue by the addition of 10% sodium hydroxide, and the oily material precipitated was extracted with ethyl acetate. The extract solution was washed with a saturated aqueous sodium chloride, and dried over anhydrous magnesium sulfate. The solvent was distilled away, and the residue was subjected to silica-gel column chromatography. The product was eluted with CHCl3 -methanol (9:5) to provide 1.5 g of the crude crystals of (R)(-)-5-[2-[[2-(o-ethoxyphenoxy)ethyl]amino]-2-methylethyl]-2-methoxybenzenesulfonamide, which was treated with HCl-ethanol to give a hydrochloric acid salt of (R)(-)-5-[2-[[2-(o-ethoxyphenoxy)ethyl]amino]-2-methylethyl]-2-methoxybenzenesulfonamide. Melting point: 228-230 C. Elemental analysis for C20 H29 ClN2 O5 S: [alpha]D-24: -4.0 (c=0.35, methanol).

Statistics shows that 112101-81-2 is playing an increasingly important role. we look forward to future research findings about R-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide.

Reference:
Patent; Yamanouchi Pharmaceutical Co., Ltd.; US4731478; (1988); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 112101-81-2 name is R-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 112101-81-2

EXAMPLE 2: Formation of tamsulosin amide (4) A 500 ml three-necked, round bottom flask was charged with 15.12g of amine 3 and 76 mi of THF. With moderate stirring under nitrogen, a heavy white suspension was formed. The suspension was then cooled in an ice-water bath to 0- 5C. With moderate stirring, 65 ml of a 1 M solution of diisobutylaluminum hydride in THF was added to the suspension at a rate such that the batch temperature was maintained at 5-10C. After the addition was completed, the mixture was stirred at 5-10C for 5 minutes to give a light white suspension. The cooling bath was removed and the mixture was allowed to warm to 20-25C and agitated for 1 hour at this temperature. With moderate agitation, 13.02 g of 2 in toluene was charged into the mixture via a syringe. The resulting reaction mixture was stirred at 20-25C for 16 hours and then cooled in an ice-water bath to 0-5C. With vigorous agitation, HCI was charged in slowly such that the reaction temperature was maintained at 20- 25C. A heavy white suspension was formed. The above suspension was transferred to a 1 L Erlenmeyer flask equipped with a magnetic stirring bar with the aid of CH2CI2. This mixture was stirred vigorously for 30 minutes at 20-25C to give a biphasic solution. The layers were separated and the lower organic layer was collected and washed with water. The cloudy solution was filtered and concentrated via distillation under atmospheric pressure. The solution was cooled to 40-50C and ethanol was added. The resultant solution was again concentrated via distillation under atmospheric pressure to generate a heavy white suspension. The heavy white suspension obtained above was cooled to 20-25C. With moderate stirring, MTBE was charged. The resultant mixture was stirred for 5 minutes and then cooled in an ice-water bath to 0-5C. Agitation continued for another 30 minutes. The white solid in the suspension was collected by suction filtration while cold. The cake was collected and dried under vacuum at 45C for 16 hours to give 20.2 g of the amide 4 with a yield of 77%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, R-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide, and friends who are interested can also refer to it.

Reference:
Patent; TORCAN CHEMICAL LTD.; WO2005/51897; (2005); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics