Category: 1118-69-0

1118-69-0, name is N-Isopropylacetamide, belongs to amides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 1118-69-0

The compound of formula XIV-1 (31.05 g, 0.15 mol), the compound of formula XIII-1 (30.3 g, 0.30 mmol)Phosphorus oxychloride(20.9 mL, 0.225 mol) were added sequentially to anhydrous toluene. Triethylamine (31.3 mL, 0.225 mol) was added in an ice bathConstant pressure funnel slowly added dropwise to the reaction flask,Maintain the internal temperature is less than 60 .The reaction flask was transferred to an oil bath and heated to reflux.After 2 hours, the reaction flask was cooled to room temperature, slowly poured into 300 g of ice water mixture, 300 ml of ethyl acetate was added, sufficientAfter the mixture was separated, the aqueous layer was extracted with 200 ml of ethyl acetate again. The combined organic layers were washed with saturated brine and dried over anhydrous sulfuric acidSodium dried, concentrated under reduced pressure to give a pale yellow solid, beaten with 100 ml of petroleum ether for 10 minutes, filtered under reduced pressure to give a compound of formulaCompound XV-1 (28.0 g) as an off white solid (yield 92.3%)

Statistics shows that 1118-69-0 is playing an increasingly important role. we look forward to future research findings about N-Isopropylacetamide.

Reference:
Patent; Zhengda Tianqing Pharmaceutical Group Co., Ltd.; Zhang Yinsheng; Liu Yingshuai; Qin Hui; Li Yuan; Zhao Kaidi; Miao Lei; Hu Jie; Liu Haiyan; Wang Xiaojin; (33 pag.)CN107266421; (2017); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Electric Literature of 1118-69-0, A common heterocyclic compound, 1118-69-0, name is N-Isopropylacetamide, molecular formula is C5H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a fashion similar to the preparation of 1, treatment of tetrakis(dimethylamido)hafnium (0.200 g, 0.563 mmol) with N-isopropylacetamide (0.228 g, 2.25 mmol) in refluxing toluene (15 mL) for 3 h afforded 6 as colorless crystals (0.219 g, 67%) upon sublimation at 105 C/0.05 Torr: mp 207-210 C; IR (Nujol, cm-1) 1579 (s), 1404 (s), 1365 (s), 1344 (s), 1319 (m), 1188 (s), 1170 (m), 1127 (m), 1053 (m), 988 (m), 887 (m), 823 (m), 816 (m), 618 (s), 584 (s); 1H NMR (C6D6, 23 C, delta) 3.47 (septet, J = 6.5 Hz, 4H, CH(CH3)2), 1.70 (s, 12H, CH3), 1.23 (d, J = 6.5 Hz, 24H, CH(CH3)2); 13C{1H} NMR (C6D6, 23 C, ppm) 182.44 (s, C=O), 48.67 (s, CH(CH3)2), 23.86 (s, CH(CH3)2), 17.37 (s, CH3). Anal. Calcd for C20H40HfN4O4: C, 41.48; H, 6.96; N, 9.68. Found: C, 41.32; H, 6.85; N, 9.77.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Karunarathne, Mahesh C.; Baumann, Joseph W.; Heeg, Mary Jane; Martin, Philip D.; Winter, Charles H.; Journal of Organometallic Chemistry; vol. 847; (2017); p. 204 – 212;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1118-69-0, name is N-Isopropylacetamide, A new synthetic method of this compound is introduced below., SDS of cas: 1118-69-0

A 100 mL Schlenk flask fitted with a reflux condenser was charged with tetrakis(dimethylamido)zirconium (0.200 g, 0.748 mmol) and toluene (10 mL). A solution of N-isopropylacetamide (0.302 g, 2.99 mmol) in toluene (10 mL) was added slowly and the resultant mixture was refluxed for 3 h. Upon cooling to room temperature, the volatile components were removed under reduced pressure and sublimation of the crude solid at 110 C/0.05 Torr afforded 3 as colorless crystals (0.188 g, 51%): mp 206-209 C; IR (Nujol, cm-1) 1576 (s), 1456 (s), 1403 (s), 1363 (s), 1342 (s), 1319 (m), 1186 (s), 1170 (m), 1126 (m), 1051 (m), 987 (m), 886 (m), 822 (m), 814 (m), 614 (s), 582 (s); 1H NMR (C6D6, 23 C, delta) 3.34 (septet, J = 6.2 Hz, 4H, CH(CH3)2), 1.71 (s, 12H, CH3), 1.24 (d, J = 6.2 Hz, 24H, CH(CH3)2); 13C{1H} NMR (C6D6, 23 C, ppm) 183.00 (s, C=O), 48.94 (s, CH(CH3)2), 23.86 (s, CH(CH3)2), 17.06 (s, CH3). Anal. Calcd for C20H40N4O4Zr: C, 48.85; H, 8.20; N, 11.39. Found: C, 48.69; H, 8.06; N, 11.44.

The synthetic route of 1118-69-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Karunarathne, Mahesh C.; Baumann, Joseph W.; Heeg, Mary Jane; Martin, Philip D.; Winter, Charles H.; Journal of Organometallic Chemistry; vol. 847; (2017); p. 204 – 212;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 1118-69-0, name is N-Isopropylacetamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1118-69-0, Formula: C5H11NO

Preparation example 5: Preparation of (Z)-N’-(4-bromo-2,6-difluorophenyl)-N-isopropyl acetamidine 4-bromo-2,6-difluroaniline (7.87 g, 37.9 mmol)), N-isopropylacetamide (7.65 g, 75.7 mmol) and triethylamine (5.7 g, 56.9 mmol) were dissolved in toluene (150 mL), and phosphorus oxychloride (5.8 g, 37.9 mmol) was added slowly. After the addition, the mixture was heated to reflux for 3 h. Then, the reaction mixture was cooled to room temperature, the solvent was removed by reduced pressure distillation, and dichloromethane (200 mL) was added. The resultant mixture was washed with saturated sodium hydrogen carbonate solution (2×100 mL) twice, dried by anhydrous sodium sulfate, filtrated under suction, and distilled under reduced pressure, to get the solid title compound (7.3 g, yield: 66.2%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Xuanzhu Pharma Co., Ltd.; WU, Frank; CHEN, Bo; (105 pag.)EP3091008; (2016); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1118-69-0, name is N-Isopropylacetamide, A new synthetic method of this compound is introduced below., Safety of N-Isopropylacetamide

Under nitrogen atmosphere, add 1 -(4-amidogen-2, 6-difluoro-phenyl)-3-N,N-dimethylammonium-2-fluoro-2-acrylketone (IV) (2.5 g, 10 mmol), N-isopropyl acetamide (2.0 g, 20 mmol), phosphorus trichloride (2.0 g, 13 mmol) and methylbenzene 50 mE, 0-5 C., and add triethylamine (2.0 g, 20 mmol) while stirring, and then, raise the temperature to 105-115 C. and conduct stirring operations for 3-5 hours. Reduce the pressure and recycle the solvent, and dissolve the leftovers with dichlormethane 100 mE, and wash with saturated sodium bicarbonate and water, and use anhydrous sodium sulfate for drying and concentration, and obtain yellow solid N-[2,6-difluoro-4-(3-N,N-dimethylam- monium-2-fluoro-2-acrylketone- 1 -yl)phenyl] -N?-isopropylethanamidine (V) 2.8 g, the yield rate is 85.6%; mass spectrum (El): mlz 328 (M+H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; SUZHOU MIRACPHARMA TECHNOLOGY CO., LTD.; Xu, Xuenong; (9 pag.)US2017/305884; (2017); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 1118-69-0, name is N-Isopropylacetamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1118-69-0, 1118-69-0

Preparation of Zr(LMeJPr)4 (28). A 100 ml_ Schlenk flask, fitted with a reflux condenser, was charged with tetrakis(dimethylamido)zirconium (0.200 g, 0.748 mmol) and toluene (10 ml_). A solution of LMe iotaPrH (0.302 g, 2.99 mmol) in toluene (10 ml_) was added slowly and the resultant mixture was refluxed for 3 h. Upon cooling to room temperature, the volatile components were removed under reduced pressure and sublimation of the crude solid at 110 C/0.05 Torr afforded 28 as colorless crystals (0.188 g, 51 %): mp 206-209 0C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-Isopropylacetamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; WAYNE STATE UNIVERSITY; WINTER, Charles, H.; KNISLEY, Thomas, Joseph; KARUNARATHNE, Panditha Koralalage, Don Mahesh Chinthaka; WO2010/132871; (2010); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

1118-69-0, name is N-Isopropylacetamide, belongs to amides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 1118-69-0

The compound of formula XIV-1 (31.05 g, 0.15 mol), the compound of formula XIII-1 (30.3 g, 0.30 mmol)Phosphorus oxychloride(20.9 mL, 0.225 mol) were added sequentially to anhydrous toluene. Triethylamine (31.3 mL, 0.225 mol) was added in an ice bathConstant pressure funnel slowly added dropwise to the reaction flask,Maintain the internal temperature is less than 60 .The reaction flask was transferred to an oil bath and heated to reflux.After 2 hours, the reaction flask was cooled to room temperature, slowly poured into 300 g of ice water mixture, 300 ml of ethyl acetate was added, sufficientAfter the mixture was separated, the aqueous layer was extracted with 200 ml of ethyl acetate again. The combined organic layers were washed with saturated brine and dried over anhydrous sulfuric acidSodium dried, concentrated under reduced pressure to give a pale yellow solid, beaten with 100 ml of petroleum ether for 10 minutes, filtered under reduced pressure to give a compound of formulaCompound XV-1 (28.0 g) as an off white solid (yield 92.3%)

Statistics shows that 1118-69-0 is playing an increasingly important role. we look forward to future research findings about N-Isopropylacetamide.

Reference:
Patent; Zhengda Tianqing Pharmaceutical Group Co., Ltd.; Zhang Yinsheng; Liu Yingshuai; Qin Hui; Li Yuan; Zhao Kaidi; Miao Lei; Hu Jie; Liu Haiyan; Wang Xiaojin; (33 pag.)CN107266421; (2017); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics