Category: 106392-48-7

SDS of cas: 106392-48-7On March 25, 1988, Shiraishi, Tadayoshi; Kameyama, Keiji; Imai, Naohiro; Domoto, Takeshi; Katsumi, Ikuo; Watanabe, Kiyoshi published an article in Chemical & Pharmaceutical Bulletin. The article was 《Specific inhibitors of tyrosine-specific protein kinase. I. Synthesis and inhibitory activities of α-cyanocinnamamides》. The article mentions the following:

A series of α-cyanocinnamamide derivatives was synthesized and evaluated for inhibitory activity against tyrosine-specific protein kinase of intact plasma membrane fractions from an epidermoid carcinoma cell line, A-431. Among these compounds, several novel α-cyano-4-hydroxy-3,5-disubstituted cinnamamide derivatives, e.g., ST 638 (I) showed potent inhibitory activity. The studies on the structure-activity relationship revealed that the presence of the OH group at the 4 position and the double bond in the α-cyano-4-hydroxycinnamamide skeleton were important for potent inhibitory activity, and that the presence of hydrophobic groups at the 3 and 5 positions on the benzene ring also enhanced the inhibitory activity of α-cyano-4-hydroxycinnamamide derivatives In the experimental materials used by the author, we found 2-Cyano-3-(4-hydroxy-3,5-diisopropylphenyl)acrylamide(cas: 106392-48-7SDS of cas: 106392-48-7)

2-Cyano-3-(4-hydroxy-3,5-diisopropylphenyl)acrylamide(cas: 106392-48-7) belongs to amides.SDS of cas: 106392-48-7 The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Martinson, Elizabeth A.; Scheible, Stephan; Presek, Peter published an article in Cellular and Molecular Biology (Paris, France, Printed). The title of the article was 《Inhibition of phospholipase D of human platelets by protein tyrosine kinase inhibitors》.Product Details of 106392-48-7 The author mentioned the following in the article:

Protein tyrosine kinases (PTKs) of the src family are thought to play an important role in platelet signal transduction, but little is known about the targets of these enzymes in platelets. We determined that exposure of human platelets to pervanadate, an inhibitor of protein tyrosine phosphatases, caused an increase in the activity of phospholipase D (PLD), an enzyme that might be involved in signaling events leading to aggregation or secretion. To further investigate whether tyrosine phosphorylation is a step in the pathway of activation of PLD in response to thrombin, we tested the effects of a series of PTK inhibitors on the activity of platelet PLD. PLD was activated in response to 0.3 U/mL thrombin, and this activation was reduced by several of the PTK inhibitors, especially genistein, Me 2,5-dihydroxycinnamate (MDHC), ST271, and the tyrphostins A25 and A47. In saponin-permeabilized platelets, we observed a marked inhibition of GTPγS-stimulated PLD by many of the PTK inhibitors, consistent with the possibility that PTKs are involved in the regulation of PLD activity by a G-protein or small GTP-binding protein. MDHC did not affect PLD activity in permeabilized cells, which suggests that this compound might inhibit PLD in intact platelets via another pathway. The inhibitors were also tested for their effects on the phosphorylation of a peptide substrate of src-family PTKs in a platelet membrane preparation and in permeabilized platelets. Several of the compounds partially inhibited peptide phosphorylation in the membrane preparation and in permeabilized platelets, most notably ST271, ST638, and tyrphostin A25. These results suggest that the activation of PLD by thrombin during platelet stimulation is at least partially controlled by protein tyrosine kinases, possibly pp60c-src or other members of the src family. In the part of experimental materials, we found many familiar compounds, such as 2-Cyano-3-(4-hydroxy-3,5-diisopropylphenyl)acrylamide(cas: 106392-48-7Product Details of 106392-48-7)

2-Cyano-3-(4-hydroxy-3,5-diisopropylphenyl)acrylamide(cas: 106392-48-7) belongs to amides.Product Details of 106392-48-7Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics