105-60-2 Archives - Amides-buliding-blocks

Ogurtsov, Vladimir A. et al. published their research in Molbank in 2021 |CAS: 105-60-2

The Article related to dihydroindolyl methyl amine preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Category: amides-buliding-blocks

On September 30, 2021, Ogurtsov, Vladimir A.; Rakitin, Oleg A. published an article.Category: amides-buliding-blocks The title of the article was (2,3-Dihydro-1H-indol-5-ylmethyl)amine. And the article contained the following:

New (2,3-dihydro-1H-indol-5-ylmethyl)amine was synthesized from 2-((1-acetylindolin-5-yl)methyl)isoindoline-1,3-dione by simultaneous deprotection of phthalimide and acetyl groups. The structure of the newly synthesized compounds was established by elemental anal., high resolution mass-spectrometry, 1H, 13C NMR and IR spectroscopy and mass-spectrometry. The resulting compound is a convenient intermediate for various disubstituted 1-(indolin-5-yl)methanamines, which may be of interest as substances with useful pharmacol. properties. The experimental process involved the reaction of Azepan-2-one(cas: 105-60-2).Category: amides-buliding-blocks

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wang, Zhiguo et al. published their patent in 2021 |CAS: 105-60-2

The Article related to indole formic acid formylation reduction, formylindoline preparation hydroxymethyl phthalimide compound friedel crafts reaction, dioxyisoindolinyl methylindole formaldehyde preparation amination, aminomethyl dihydro indole carboxaldehyde preparation deprotection, indoline methylamine dihydrochloride preparation and other aspects.Formula: C6H11NO

On October 15, 2021, Wang, Zhiguo; Li, Shijiang; Li, Ronghao; Luo, Chunyan published a patent.Formula: C6H11NO The title of the patent was Preparation of indoline-5-methylamine dihydrochloride from indole. And the patent contained the following:

The present invention relates to the preparation of indoline-5-methylamine dihydrochloride from indole. In particular, the preparation method comprises of following steps: (1) using indole as a raw material, and reacting with an acid to obtain a formyl-protected indoline; (2) carrying out Friedel-Crafts reaction of the formyl protected indoline with an amination reagent to obtain 5-[(1,3-dioxoisoindolin-2-yl)methyl]indole-1-carbaldehyde; (3) the obtained intermediate compound is treated with hydrazine hydrate to obtain 5-(aminomethyl)indole-1-aminoaldehyde; and (4) carrying out the deprotection reaction of 5-(aminomethyl)indole-1-aminoaldehyde to obtain the target product indoline-5-methylamine dihydrochloride. The inventive method has a short process route, low cost, easy availability of raw materials and auxiliary materials, high reactivity, simple operation, easy control, and has high yield of the target product, which is convenient for industrial scale-up. The experimental process involved the reaction of Azepan-2-one(cas: 105-60-2).Formula: C6H11NO

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Brief introduction of 105-60-2

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 105-60-2.

These common heterocyclic compound, 105-60-2, name is epsilon-Caprolactam, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 105-60-2

A. Preparation of 3,3-Dibromoazacycloheptan-2-one To a cold solution of 45.2 g (0.4 mol) of caprolactam in CHCl3 was added 166.0 g (0.8 mol) of PCl5, keeping the temperature less than 5 C. The mixture was brought to room temperature, 2.0 g of ZnCl2 was added, and finally 128 g (0.8 mol) of bromine was added dropwise. After stirring the mixture for 5 hours at room temperature, the solvent and excess bromine was removed by vacuum distillation. The residue was poured into ice water and extracted with CH2 Cl2. The combined organic extracts were washed with sat. Na2 S2 O5, dried over MgSO4, and concentrated in vacuo to give a crude solid. Washing the solid with CH2 Cl2 /toluene yielded the product as a white powder; mp 156-159 C.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 105-60-2.

Reference:
Patent; Nelson Research & Development Co.; US4755535; (1988); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics