Category: 10405-38-6

Li, Xiangjie published the artcilePreparation and characterization of bovine serum albumin surface-imprinted thermosensitive magnetic polymer microsphere and its application for protein recognition, COA of Formula: C10H16N2O2, the main research area is bovine serum albumin thermosensitivity magnetic microsphere; Bovine serum albumin; Magnetic microspheres; Molecular recognition; Thermosensitivity.

A novel bovine serum albumin surface-imprinted thermosensitive magnetic composite microsphere was successfully prepared by the surface grafting copolymerization method in the presence of temperature-sensitive monomer N-isopropylacrylamide (NIPAM), functional monomer methacrylic acid (MAA) and crosslinking agent N,N’-methylenebisacrylamide (MBA). The structure and component of the thermosensitive magnetic molecularly imprinted microsphere were investigated by transmission electron microscopy (TEM), Fourier transform IR (FT-IR), vibrating sample magnetometer (VSM) and thermogravimetric anal. (TGA). The results of thermosensitivity, adsorption capacity, selectivity and reusability showed the formation of a thermosensitivity grafting polymer layer P(NIPAM-MAA-MBA) on the surface of Fe3O4@SiO2 and the good adsorption capacity and specific recognition for template protein. When the adsorption temperature was higher than the lower critical solution temperature (LCST) of poly(N-isopropylacrylamide) (PNIPAM), shape memory effect of imprinted cavities would be more effective. In other words, it was more conducive to capture template mols. under this condition and the imprinting factor would be higher. On the other hand, when the desorption temperature was lower than LCST of PNIPAM, the decrease of shape memory effect between imprinted cavities and template mols. would facilitate the release of template mols. from the imprinted cavities. Based on this property, the adsorption and desorption of template mols. could be regulated by system temperature indirectly which benefited from the existence of thermosensitivity imprinting layer.

Biosensors & Bioelectronics published new progress about Adsorption. 10405-38-6 belongs to class amides-buliding-blocks, name is N,N’-(Butane-1,4-diyl)diacrylamide, and the molecular formula is C10H16N2O2, COA of Formula: C10H16N2O2.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zhou, Shijiao published the artcileThe synthesis of backbone thermo and pH responsive hyperbranched poly(bis(N,N-propyl acryl amide))s by RAFT, HPLC of Formula: 10405-38-6, the main research area is hyperbranched polyacrylamide synthesis RAFT polymerization; RAFT; backbone; hyperbranched; poly(bis(N,N-propyl acrylamide)); thermo-pH response.

Hyperbranched poly(methylene-bisacrylamide), poly(bis(N,N-propylacrylamide)) (HPNPAM) and poly(bis(N,N-butylacrylamide)) were synthesized by reversible addition fragmentation chain transfer polymerization HPNPAMs showed lower critical solution temperature (LCST) due to an appropriate ratio between hydrophilic and hydrophobic groups. The effects of reaction conditions on polymerization were investigated in detail. The structure of HPNPAM was characterized by 1H NMR, FT-IR, Muti detector-size exclusion chromatog. (MDSEC) and UV-visible (UV-Vis). The α value reached 0.20 and DB was 90%, indicating HPNPAMs with compact topol. structure were successfully prepared LCSTs were tuned by Mw and the pH value of the solution The change of mol. size was assayed by dynamic light scattering and scanning electron microscope. These results indicated that the stable uniform nanomicelles were destroyed and macromols. aggregated together, forming large particles as temperature exceeded LCST. In addition, after the cells were incubated for 24 h, the cell viability reached 80%, which confirmed this new dual responsive HPNPAM had low cytotoxicity.

Polymers (Basel, Switzerland) published new progress about Aggregation. 10405-38-6 belongs to class amides-buliding-blocks, name is N,N’-(Butane-1,4-diyl)diacrylamide, and the molecular formula is C10H16N2O2, HPLC of Formula: 10405-38-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Lee, S. K. published the artcileTemperature dependence of the binding of methyl orange by crosslinked poly(4-vinylpyridine), Formula: C10H16N2O2, the main research area is vinylpyridine polymer binding methyl orange; crosslinking vinylpyridine polymer dye binding.

The title polymers with different degrees of crosslinking were prepared by radical copolymerization of 4-vinylpyridine with 3-20% N,N’-tetramethylenebisacrylamide. The binding abilities of these crosslinked polymers with methyl orange were investigated at various temperatures in a buffer solution of pH 7. The first binding constant (K1) and thermodn. parameters were evaluated from the equilibrium amounts of binding. K1 showed bell-shaped curves when plotted against both the binding temperature and the degree of crosslinking. Lower temperature and higher degree of crosslinking at maximum binding in these bell-shaped curves were observed for this binding system when compared with those in a system using N,N’-methylenebisacrylamide as crosslinker. The values of the enthalpy and entropy change increased on increasing the degree of crosslinking and decreasing the binding temperature, whereas the absolute magnitude of the free-energy change was not increased. These results could be accounted for in terms of the temperature dependence of the hole size of the crosslinked polymers in addition to the hydrophobic interactions in the binding process.

Polymer published new progress about Crosslinking. 10405-38-6 belongs to class amides-buliding-blocks, name is N,N’-(Butane-1,4-diyl)diacrylamide, and the molecular formula is C10H16N2O2, Formula: C10H16N2O2.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Boskovic, Zarko V. published the artcileSynthesis of piperlogs and analysis of their effects on cells, Related Products of amides-buliding-blocks, the main research area is piperlog preparation antitumor structure activity; reactive oxygen species level piperlog; piperlongumine analog preparation antitumor structure activity; Michael acceptors; piperlongumine; reactive oxygen species; toxicity.

Piperlongumine (PL) (I) is a naturally occurring small mol. previously shown to induce cell death preferentially in cancer cells relative to non-cancer cells. An initial effort to synthesize analogs highlighted the reactivities of both of piperlongumine’s α,β-unsaturated imide functionalities as key features determining PL’s cellular effects. In this study, a second-generation of analogs, e.g., II, was synthesized and evaluated in cells to gain further insight into how the reactivity, number, and orientation of PL’s reactive olefins contribute to its ability to alter the physiol. of cells.

Tetrahedron published new progress about Antitumor agents. 10405-38-6 belongs to class amides-buliding-blocks, name is N,N’-(Butane-1,4-diyl)diacrylamide, and the molecular formula is C10H16N2O2, Related Products of amides-buliding-blocks.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Moszner, Norbert published the artcileMonomers for adhesive polymers, 4 synthesis and radical polymerization of hydrolytically stable crosslinking monomers, Recommanded Product: N,N’-(Butane-1,4-diyl)diacrylamide, the main research area is dentin adhesive bisacrylamide monomer.

Hydrolytically stable, crosslinking bis(acrylamide)s 1a-1l or bis(methacrylamide)s 2a-2c were synthesized by reaction of acryloyl or methacryloyl chloride using primary or secondary amines. In addition, monomers 3a and 3b were obtained by amidation of 2,6-dimethylene-4-oxaheptane-1,7-dicarboxylic acid (DMOHDA) with propylamine and diethylamine, resp. The structures of the monomers were characterized by IR, 1H, and 13C NMR spectroscopy. All monomers containing N,N’-monosubstituted carbamide groups were solids. Those containing N,N’-disubstituted carbamide groups were water-soluble liquids Water-soluble bis(acrylamide) 1d (N,N’-diethyl-1,3-bis(acrylamido)propane) shows a radical polymerization reactivity in the presence of 2,2′-azobis(2-methylpropionamidine) dihydrochloride (AMPAHC) similar to that of glycerol dimethacrylate, as revealed by gelation experiments in water. 1D is hydrolytically stable in 20 weight-% phosphoric acid and can be used to substitute dimethacrylates in self-etching dentin adhesives. Furthermore, this monomer was also suitable as a reactive diluent in composites.

Macromolecular Materials and Engineering published new progress about Bending strength. 10405-38-6 belongs to class amides-buliding-blocks, name is N,N’-(Butane-1,4-diyl)diacrylamide, and the molecular formula is C10H16N2O2, Recommanded Product: N,N’-(Butane-1,4-diyl)diacrylamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Zayas-Gonzalez, Yashira M. published the artcileDegradable Amine-Reactive Coatings Fabricated by the Covalent Layer-by-Layer Assembly of Poly(2-vinyl-4,4-dimethylazlactone) with Degradable Polyamine Building Blocks, SDS of cas: 10405-38-6, the main research area is amine reactive coating fabricated covalent assembly polyvinyldimethylazlactone polyamine.

We report the fabrication of reactive and degradable crosslinked polymer multilayers by the reactive/covalent layer-by-layer assembly of a non-degradable azlactone-functionalized polymer [poly(2-vinyl-4,4-dimethylazlactone), PVDMA] with hydrolytically or enzymically degradable polyamine building blocks. Fabrication of multilayers using PVDMA and a hydrolytically degradable poly(β-amino ester) (PBAE) containing primary amine side chains yielded multilayers (∼100 nm thick) that degraded over ∼12 days in physiol. relevant media. Physicochem. characterization and studies on stable films fabricated using PVDMA and an analogous non-degradable poly(amidoamine) suggested that erosion occurred by chem. hydrolysis of backbone esters in the PBAE components of these assemblies. These degradable assemblies also contained residual amine-reactive azlactone functionality that could be used to impart new functionality to the coatings post-fabrication. Crosslinked multilayers fabricated using PVDMA and the enzymically degradable polymer poly(L-lysine) were structurally stable for prolonged periods in physiol. media, but degraded over ∼24 h when the enzyme trypsin was added. Past studies demonstrate that multilayers fabricated using PVDMA and non-degradable polyamines [e.g., poly(ethyleneimine)] enable the design and patterning of useful nano/bio-interfaces and other materials that are structurally stable in physiol. media. The introduction of degradable functionality into PVDMA-based multilayers creates opportunities to exploit the reactivity of azlactone groups for the design of reactive materials and functional coatings that degrade or erode in environments that are relevant in biomedical, biotechnol., and environmental contexts. This ‘degradable building block’ strategy should be general; we anticipate that this approach can also be extended to design of amine-reactive multilayers that degrade upon exposure to specific chem. triggers, selective enzymes, or contact with cells by judicious design of the degradable polyamine building blocks used to fabricate the coatings.

Biomacromolecules published new progress about Coating materials. 10405-38-6 belongs to class amides-buliding-blocks, name is N,N’-(Butane-1,4-diyl)diacrylamide, and the molecular formula is C10H16N2O2, SDS of cas: 10405-38-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Hochstrasser, Denis F. published the artcileDevelopment of polyacrylamide gels that improve the separation of proteins and their detection by silver staining, Recommanded Product: N,N’-(Butane-1,4-diyl)diacrylamide, the main research area is protein separation gel electrophoresis crosslinker; silver staining protein detection crosslinker.

Background staining that is associated with Ag detection of proteins and nucleic acids in polyacrylamide gels was due mostly to the amide groups in methylenebisacrylamide, a commonly used gel crosslinker. To reduce this background staining, 8 existing crosslinking agents were tested; all were unsuitable. Six new crosslinking agents were synthesized and tested. Of these, diacrylylpiperazine provided increased phys. strength, improved electrophoretic separation of proteins, and Ag staining detection of proteins with reduced background stain.

Analytical Biochemistry published new progress about Biological staining. 10405-38-6 belongs to class amides-buliding-blocks, name is N,N’-(Butane-1,4-diyl)diacrylamide, and the molecular formula is C10H16N2O2, Recommanded Product: N,N’-(Butane-1,4-diyl)diacrylamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ohkubo, Katsutoshi published the artcileShape- and stereo-selective esterase activities of cross-linked polymers imprinted with a transition-state analogue for the hydrolysis of amino acid esters, Recommanded Product: N,N’-(Butane-1,4-diyl)diacrylamide, the main research area is nitrophenyl leucinate hydrolysis kinetics polymeric catalyst; histidyl polymer preparation catalyst hydrolysis leucinate; isokinetic relationship catalytic hydrolysis nitrophenyl leucinate.

Various cross-linked (with N,N’-ethylene (C2), butylene (C4), hexamethylene (C6), or decamethylene (C10)-bisacrylamide) polymer catalysts containing L-histidine and quaternary trimethylammonium groups were imprinted with a racemic transition-state analog of Ph 1-benzyloxycarbonyl-3-methylpentylphosphonate for the hydrolysis of p-nitrophenyl N-(benzyloxycarbonyl)-L (or D)-leucinate [Z-L (or D)-Leu-PNP]. Among these polymer catalysts, N,N’-C4-bisacrylamide-cross-linked polymer catalyst, which was copolymerized with styrene monomer, exhibited notable substrate-stereospecificity for the Z-L-Leu-PNP hydrolysis in the hydrolysis of enantiomeric L (or D)-N-protected [such as tert-butyloxycarbonyl (Boc-), acetyl (C2-), decanoyl (C10-) or benzyloxycarbonyl (Z-)] amino acid (Leu, Ala, or Phe) p-nitrophenyl esters in 10 volume % MeCN-Tris buffer (pH 7.15) at 30°C.

Journal of Molecular Catalysis A: Chemical published new progress about Amino acid esters Role: RCT (Reactant), RACT (Reactant or Reagent). 10405-38-6 belongs to class amides-buliding-blocks, name is N,N’-(Butane-1,4-diyl)diacrylamide, and the molecular formula is C10H16N2O2, Recommanded Product: N,N’-(Butane-1,4-diyl)diacrylamide.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Ingemann, M. published the artcileStability of enzymes formulated for oral drug delivery, Product Details of C10H16N2O2, the main research area is oral drug delivery enzyme stability.

An oral drug delivery system based on entrapment of an enzyme of interest in acrylic hydrogel is, from a stability point of view, possible for lipase but not for phenylalanine ammonia lyase (PAL). Loss in enzymic activity, when monomers were present, may be caused by conformational changes in the PAL mol. as indicated in CD and fluorescence anal. It was shown that the proteolytic stability of free enzymes has to be improved by the aid of a drug delivery system before oral enzyme substitution therapy by PAL is possible.

Proceedings of the International Symposium on Controlled Release of Bioactive Materials published new progress about Oral drug delivery systems. 10405-38-6 belongs to class amides-buliding-blocks, name is N,N’-(Butane-1,4-diyl)diacrylamide, and the molecular formula is C10H16N2O2, Product Details of C10H16N2O2.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Baek, Kyung-Youl published the artcileCore-Functionalized Star Polymers by Transition Metal-Catalyzed Living Radical Polymerization. 1. Synthesis and Characterization of Star Polymers with PMMA Arms and Amide Cores, SDS of cas: 10405-38-6, the main research area is star PMMA preparation functionalized divinyl core; microgel divinyl core PMMA star; amide microgel core PMMA star.

A series of microgel core-functionalized star-shaped polymers was synthesized by the polymer linking reaction method in RuCl2(PPh3)3-catalyzed living radical polymerization The synthesis was achieved by the polymer linking reaction method; i.e., functionalized divinyl compounds were added in situ to the solution of linear living poly(MMA)s prepared with the Ru(II)-catalyzed living radical polymerization The functionalized microgel cores thus obtained contained acrylamide and methacrylamide. Also, star polymers with varying densities of the microgel cores were prepared from diacrylamides with various lengths and structures of the spacer, and by changing the relative amounts of MMA (arm length) and divinyl compound (core size) to initiator, a variety of core-functionalized star polymers could be obtained in high yield. These core-functionalized star-shaped polymers have f of 20-640, Mw of 3.3 × 105-1.3 × 107, and Rz of 5-42 nm. These results indicated that the cores carry as many as 440-51,000 amide groups in microgel networks.

Macromolecules published new progress about Radius of gyration. 10405-38-6 belongs to class amides-buliding-blocks, name is N,N’-(Butane-1,4-diyl)diacrylamide, and the molecular formula is C10H16N2O2, SDS of cas: 10405-38-6.

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics