Category: 10238-21-8

Compensation mechanism for membrane potential against hypoosmotic stress in the Onchidium neuron was written by Nishi, Takako;Sakamoto, Katsuhiko;Matsuo, Ryota. And the article was included in Comparative Biochemistry and Physiology, Part A: Molecular & Integrative Physiology in 2022.Name: 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide This article mentions the following:

The effect of acute hypoosmotic stress on the neural response was investigated using the neurons identified in the abdominal ganglion of the amphibious mollusk Onchidium. The membrane potential of an identified neuron (Ip-1/2) was not significantly altered in 50% hypoosmotic artificial sea water. In isotonic 50% artificial seawater (ASW) with osmolarity that was compensated for using glycerol or urea, the membrane potentials of Ip-1/2 were also not altered compared to those in 50% hypoosmotic ASW. However, hyperpolarization was induced in isotonic 50% ASW when osmolarity was compensated for using sucrose or mannose. In the presence of volume-regulated anion channel (VRAC) inhibitors (niflumic acid and glibenclamide), the Ip-1/2 membrane potentials were hyperpolarized in 50% hypoosmotic ASW. These results suggest that there is a compensatory mechanism involving aquaglyceroporin and VRAC-like channels that maintains membrane potential under hypoosmotic conditions. Here, we detected the expression of aquaglyceroporin mRNA in neural tissues of Onchidium. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8Name: 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide).

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, such as in the amino acids asparagine and glutamine. Amides can be recrystallised from large quantities of water, ethanol, ethanol/ether, aqueous ethanol, chloroform/toluene, chloroform or acetic acid. The likely impurities are the parent acids or the alkyl esters from which they have been made. The former can be removed by thorough washing with aqueous ammonia followed by recrystallisation, whereas elimination of the latter is by trituration or recrystallisation from an organic solvent.Name: 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Production of copper-graphene nanocomposite as a voltammetric sensor for determination of anti-diabetic metformin using response surface methodology was written by Hassasi, Shima;Hassaninejad-Darzi, Seyed Karim;Vahid, Amir. And the article was included in Microchemical Journal in 2022.Application In Synthesis of 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide This article mentions the following:

In this paper, application of a sensitive electrochem. technique assisted with multivariate optimization methods is presented for measurement of anti-diabetic metformin (MET) drug in pharmaceutical and serum samples. The sensitive electrochem. sensor was modified carbon paste electrode by copper-graphene nanocomposite (Cu-G/CPE). Firstly, synthesis of graphene (G) and copper-graphene (Cu-G) were performed and X-ray diffraction, field emission SEM, transmission electron microscopy, Fourier transform IR spectroscopy, Raman spectroscopy and N₂ adsorption-desorption isotherm were applied to specify the structure of them. Field emission SEM of Cu-G shows carbon sheets were decorated with some dense layer of well-dispersed uniform CuNPs with a type size around 50 nm. Also, the X-ray diffraction pattern of Cu-G displays several peaks for Cu, which approves the formation of Cu-G nanocomposite. Next, the G and Cu-G are used for modification of a carbon paste electrode (CPE) surface. Results from response surface methodol. indicated that solution pH of 12, 11% of Cu-G nanocomposite in the modified CPE, accumulation potential (0.2 V) and accumulation time (80 s) outcomes in the maximal c.d. The electrochem. behavior of MET at the Cu-G/CPE surface are investigated by differential pulse voltammetry (DPV), cyclic voltammetry (CV), and chronoamperometry techniques. The electron-transfer coefficient, catalytic rate constant and diffusion coefficient are found to be 0.84, 6.27 x 10⁶ cm³ mol^-1 s^-1 and 1.07 x 10^-8 cm² s^-1, resp. Under the optimum conditions, the detection limit and linear dynamic range were found to be 3.4μM and 10.4-1125.0μM by DPV technique, resp. The Cu-G/CPE exhibited good reproducibility, stability and high recovery and it has low cost, low background current, ease of surface renewal. The Cu-G/CPE has better poisoning tolerance ability than bare CPE for electro-oxidation of MET and is a superior sensor for the long-term action. Furthermore, the proposed method can be applied as a valorous anal. method in the quality control of the pharmaceutical industry. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8Application In Synthesis of 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide).

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Application In Synthesis of 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The Influence of Intravenous Transplantation of Mesenchymal Stem Cells on the Functional Activity of KATP Channels of Pial Arteries after Ischemia/Reperfusion of the Brain was written by Sokolova, I. B.;Gorshkova, O. P.;Pavlichenko, N. N.. And the article was included in Cell and Tissue Biology in 2022.Product Details of 10238-21-8 This article mentions the following:

The aim of this work was to study the effect of i.v. transplantation of human mesenchymal stem cells (hMSCs) on the functional state of KATP channels of smooth-muscle cells of cerebral arteries at different times of the postischemic period. Using a device for intravital visualization of pial vessels, the reaction of arteries to the KATP-channel blocker glibenclamide (GC), the activator of the same channels of pinacidil (PI), acetylcholine (ACh), and ACh against a background of GC action (ACh/GC) 7, 14, and 21 days after cerebral ischemia/reperfusion (I/R) and i.v. hMSC transplantation. On exposure to GC 7 days after I/R, two to five times fewer arteries narrowed than in the SO group and 1.5 times fewer expanded after PI. The introduction of hMSCs on the day of I/R of the brain after 7 days had no effect on the functioning of KATP channels: the constrictor reaction to GC and the dilator reaction to PI in this group were the same as in animals that underwent I/R. Fourteen days after I/R, the number of narrowed pial arteries on GC was 1.5-2 times less than in SO rats; the number of arteries that responded with dilatation to PI was 2-2.5 times less. In the cell-therapy group, for 14 days after I/R, the number of pial arteries that narrowed under the influence of GC and expanded under that of PI almost completely corresponded to those in SO rats. On day 21 after I/R, complete recovery of pial-artery responses to GC to the level in LO rats was observed In the cell-therapy group, the reactivity of the pial arteries fully corresponded to the indicators in the SO group of animals. The functional state of KATP channels after I/R of the brain was assessed by comparing the dilator reactions of the pial arteries when exposed to pure ACh and ACh against a background of KATP channels being blocked with glibenclamide (ACh/GC). In SO animals, GC blocked the dilator reaction to ACh. The application of ACh against the background of GC increased the number of dilatations 7-14 days after I/R. After 21 days, the number of dilated vessels on exposure to ACh and ACh/GC was the same. In animals with transplanted hMSCs, excluding the first 7 days, GC blocked the dilator reaction of the pial arteries to ACh in the same way as in the SO group. It can be concluded that I/R of the rat cerebral cortex reduces the contribution of KATP channels to maintaining the basal tone of the pial arterial vessels. Changes persist for 14 days after ischemic exposure. At the same time, in the period from 7 to 21 days after I/R, the role of KATP channels in the dilatation of pial arteries on ACh decreased and by day 21 channels practically did not participate in the dilator response. I.v. transplantation of hMSCs on the day of brain I/R results in earlier (as early as after 14 days) restoration of participation of SMC KATP channels in maintaining the basal tone and ACh-mediated dilatation of pial arteries. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8Product Details of 10238-21-8).

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Product Details of 10238-21-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Gastroprotective action of the ethanol extract of Leonurus sibiricus L. (Lamiaceae) in mice was written by Biano, Laiza S.;Oliveira, Alan S.;Palmeira, David N.;Silva, Luis Andre;de Albuquerque-Junior, Ricardo L. C.;Duarte, Marcelo C.;Correa, Cristiane B.;Grespan, Renata;Batista, Josemar S.;Camargo, Enilton A.. And the article was included in Journal of Ethnopharmacology in 2022.Quality Control of 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide This article mentions the following:

Leonurus sibiricus L. (Lamiaceae) is a medicinal plant known in Brazil as “rubim” or “erva de macae”. It is used for various purposes, including stomach disorders. To evaluate the effect of the ethanol extract of the aerial parts of L. sibiricus (EELs) in models of gastric damage in mice. The effect of EELs (50, 100 and 300 mg/kg, p.o., 1 h before induction) was tested on acidified ethanol (ACEt)-induced gastric ulcers. Addnl., we tested the effect of EELs (by intraduodenal administration) in the pylorus ligation (PL) model. Pretreatment with EELs, at 300 mg/kg, but not 50 and 100 mg/kg, reduced the relative area of gastric ulcers induced by ACEt (p < 0.01) and lipoperoxidation (p < 0.001), and increased the sulfhydryl content (p < 0.01) in the stomach in comparison with the vehicle group. Pretreatment with N-ethylmaleimide (a blocker of non-protein sulfhydryl groups, 10 mg/kg, i.p.) or glibenclamide (a KATP channel blocker, 10 mg/kg, i.p.) inhibited the gastroprotective response caused by EELs (300 mg/kg; p < 0.001), but there were no alterations due to pretreatments with inhibitors of the synthesis of prostaglandins (indomethacin, 10 mg/kg), nitric oxide (L-NAME, 70 mg/kg) or hydrogen sulfide (DL-propargylglycine, 10 mg/kg). Treatment with EELs (300 mg/kg) reduced mucus production (p < 0.001) and the volume of gastric secretion (p < 0.001) after PL without affecting gastric acidity or pH. These results provide evidence that EELs exerts gastroprotective action in mice, with the participation of oxidative stress and mediation of NP-SH, KATP channels and mucus production In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8Quality Control of 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide).

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis. As a result of interactions such as these, the water solubility of amides is greater than that of corresponding hydrocarbons. These hydrogen bonds are also have an important role in the secondary structure of proteins.Quality Control of 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Continuous degradation of micropollutants in real world treated wastewaters by photooxidation in dynamic conditions was written by Brice, Reoyo-Prats;Anastasia, Sellier;Somar, Khaska;Corinne, Le Gal Lassalle;Karine, Weiss;Vincent, Goetz;Gael, Plantard. And the article was included in Water Research in 2022.Recommanded Product: 10238-21-8 This article mentions the following:

Wastewater is a major issue for the ecosystem because of its considerable quantities, the treatment methods adopted in the large majority of WWTPs, and its level of contamination by various types of pollutants, especially emerging ones. One of the solutions considered to reduce this pressure on water is the reuse of wastewater after treatment for watering green areas, road cleaning, industry, groundwater recharge but also for crop irrigation. This paper proposes to study the capabilities of a photoreactor for the removal of micropollutants contained in wastewater from wastewater treatment plants. The experiments are carried out under dynamic artificial irradiation conditions which can be controlled in order to apply irradiation representative of the sunshine conditions. The experiments aim at treating a real effluent from urban wastewater. On the basis of these data, the photo-oxidation mass capacities expressed per unit of irradiated surface and per day were evaluated. Our results show that the oxidation process acts in a selective and differentiated manner according to the categories of substances and within each category. Some mols. are not or only partially oxidized. Note that the photo-reactor fed continuously with wastewater from wastewater treatment plants containing about 80 substances, is subjected to a typical irradiation setpoint of a sunny day in Apr. This allows to define the instantaneous and daily capacities of the system with respect to the target mols. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8Recommanded Product: 10238-21-8).

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. Ionic, or saltlike, amides are strongly alkaline compounds ordinarily made by treating ammonia, an amine, or a covalent amide with a reactive metal such as sodium.Recommanded Product: 10238-21-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Human health and ecological risk assessment of 98 pharmaceuticals and personal care products (PPCPs) detected in Indian surface and wastewaters was written by Sengar, Ashish;Vijayanandan, Arya. And the article was included in Science of the Total Environment in 2022.Formula: C23H28ClN3O5S This article mentions the following:

The release of pharmaceuticals and personal care products (PPCPs) in environmental waters has become an urgent issue due to their pseudo-persistent traits. The present study was undertaken to conduct a screening-level risk assessment of 98 PPCPs, detected in different water matrixes (treated wastewater, surface water, and groundwater) of India, for evaluating ecol. risk (risk to fish, daphnia, and algae), human health risk, and antimicrobial resistance (AMR) selection risk by following risk quotient (RQ) based methodol. In the present study, 47% of the detected PPCPs in Indian waters were found to exert a possible risk (RQ > 1) to either aquatic species and human health, or cause AMR selection risk. 17 out of 25 antibiotics detected in the environmental waters were found to pose a threat of AMR selection. 11 out of 49 pharmaceuticals were found to exert human health risk from ingesting contaminated surface water, whereas only 2 pharmaceuticals out of 25 were found to exert risk from the intake of groundwater. Very high RQs (>1000) for few pharmaceuticals were obtained, signifying a great potential of the detected PPCPs in causing severe health concern, aquatic toxicity, and AMR spread. Within India, special attention needs to be given to the pharmaceutical hubs, as the environmental waters in these regions were found to be severely contaminated with drug residues resulting in extremely high RQs. The present study will be helpful in prioritizing the detected PPCPs in the environmental waters of India, for which immediate attention and enforceable guidelines are required. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8Formula: C23H28ClN3O5S).

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. Compared to amines, amides are very weak bases and do not have clearly defined acid–base properties in water. On the other hand, amides are much stronger bases than esters, aldehydes, and ketones. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Formula: C23H28ClN3O5S

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Advancing Base-Metal Catalysis: Development of a Screening Method for Nickel-Catalyzed Suzuki-Miyaura Reactions of Pharmaceutically Relevant Heterocycles was written by Goldfogel, Matthew J.;Guo, Xuelei;Melendez Matos, Jeishla L.;Gurak, John A. Jr.;Joannou, Matthew V.;Moffat, William B.;Simmons, Eric M.;Wisniewski, Steven R.. And the article was included in Organic Process Research & Development in 2022.Related Products of 10238-21-8 This article mentions the following:

Interest in replacing palladium catalysts with base metals resulted in the development of a 24-reaction screening platform for identifying nickel-catalyzed Suzuki-Miyaura reaction conditions. This method was designed to be directly applicable to process scale-up by employing homogeneous reaction conditions alongside stable and inexpensive nickel(II) precatalysts and has proven to be broadly suitable for complex heterocyclic substrates relevant to bioactive mols. These advances were enabled by the key discovery that a methanol additive greatly improves the reaction performance and enables the use of organic-soluble amine bases. The screening platform and scale-up workflow were applied to a representative cross-coupling using the antipsychotic perphenazine and enabled the rapid development of a gram-scale synthesis that highlighted the utility of this method and the advantages of nickel catalysis for metal remediation. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8Related Products of 10238-21-8).

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Related Products of 10238-21-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Predicting impact of food and feeding time on oral absorption of drugs with a novel rat continuous intestinal absorption model was written by Radice, Casey;Korzekwa, Ken;Nagar, Swati. And the article was included in Drug Metabolism & Disposition in 2022.Application of 10238-21-8 This article mentions the following:

Intricacies in intestinal physiol., drug properties, and food effects should be incorporated into models to predict complex oral drug absorption. A previously published human continuous intestinal absorption model based on the convection-diffusion equation was modified specifically for the male Sprague-Dawley rat in this report. Species-specific physiol. conditions along intestinal length – exptl. velocity and pH under fasted and fed conditions, were measured and incorporated into the intestinal absorption model. Concentration-time (C-t) profiles were measured upon a single i.v. and peroral (PO) dose for three drugs: amlodipine (AML), digoxin (DIG), and glyburide (GLY). Absorption profiles were predicted and compared with exptl. collected data under three feeding conditions: 12-h fasted rats were provided food at two specific times after oral drug dose (1 h and 2 h for AML and GLY; 0.5 h and 1 h for DIG), or they were provided food for the entire study. I.v. vs. PO C-t profiles suggested absorption even at later times and informed design of appropriate math. input functions based on exptl. feeding times. With this model, AML, DIG, and GLY oral C-t profiles for all feeding groups were generally well predicted, with exposure overlap coefficients in the range of 0.80-0.97. Efflux transport for DIG and uptake and efflux transport for GLY were included, modeling uptake transporter inhibition in the presence of food. Results indicate that the continuous intestinal rat model incorporates complex physiol. processes and feeding times relative to drug dose into a simple framework to provide accurate prediction of oral absorption. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8Application of 10238-21-8).

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents. The presence of the amide group –C(=O)N– is generally easily established, at least in small molecules. It can be distinguished from nitro and cyano groups in IR spectra. Amides exhibit a moderately intense νCO band near 1650 cm−1. By 1H NMR spectroscopy, CONHR signals occur at low fields. In X-ray crystallography, the C(=O)N center together with the three immediately adjacent atoms characteristically define a plane.Application of 10238-21-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

ATP-sensitive inward rectifier potassium channels reveal functional linkage between salivary gland function and blood feeding in the mosquito, Aedes aegypti was written by Li, Zhilin;Soohoo-Hui, Alexander;O’Hara, Flinn M.;Swale, Daniel R.. And the article was included in Communications Biology in 2022.Reference of 10238-21-8 This article mentions the following:

Reducing saliva secretions into the vertebrate host reduces feeding efficacy by most hematophagous arthropods. However, seminal studies suggested saliva is not a prerequisite for blood feeding in Aedes aegypti. To test this paradigm, author manually transected the salivary duct of female A. aegypti and an inability to salivate was correlated to an inability to imbibe blood. These data justified testing the relevance of inwardly rectifying potassium (Kir) channels in the A. aegypti salivary gland as an antifeedant target site. Pharmacol. activation of ATP-gated Kir (K_ATP) channels reduced the secretory activity of the salivary gland by 15-fold that led to near elimination of blood ingestion during feeding. The reduced salivation and feeding success nearly eliminated horizontal transmission and acquisition of Dengue virus-2 (DENV2). These data suggest mosquito salivation is a prerequisite for blood feeding and provide evidence that K^ATP channels are critical for salivation, feeding, and vector competency. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8Reference of 10238-21-8).

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. Amides can be viewed as a derivative of a carboxylic acid RC(=O)OH with the hydroxyl group –OH replaced by an amine group −NR′R″; or, equivalently, an acyl (alkanoyl) group RC(=O)− joined to an amine group. Amides are stable compounds. The lower-melting members (such as acetamide) can be readily purified by fractional distillation. Most amides are solids which have low solubilities in water.Reference of 10238-21-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The role of potassium channels in the proliferation and migration of endometrial adenocarcinoma HEC1-A cells was written by Erdem Kis, Emel;Tiftik, R. Nalan;Al Hennawi, Khairat;Un, Ismail. And the article was included in Molecular Biology Reports in 2022.HPLC of Formula: 10238-21-8 This article mentions the following:

Endometrial cancer is the most common gynecol. cancer in developed countries. Potassium channels, which have many types, are suggested to play a major role in cancer progression. However, their role in endometrial cancer has not been fully investigated. We aimed to demonstrate whether the ATP-sensitive potassium channel blocker glibenclamide, voltage-sensitive potassium channel blocker 4-aminopyridine, non-selective (voltage-sensitive and calcium-activated) potassium channels blocker tetraethylammonium and potassium chloride (KCl) have any effect on the proliferation and migration of HEC1-A cells. Methods and results: Proliferation and migration were evaluated by real-time cell anal. (xCELLigence system) and wound healing assays, resp. Proliferation was reduced by glibenclamide (0.1 and 0.2 mM, P < 0.05 and P < 0.01, resp.), 4-aminopyridine (10 and 20 mM, P < 0.001) and tetraethylammonium (10 and 20 mM, P < 0.01 and P < 0.001, resp.). However, KCl did not change the proliferation. Migration was reduced by glibenclamide (0.01, 0.1 and 0.2 mM, P < 0.001, P < 0.001 and P < 0.01, resp.) and 4-aminopyridine (10 and 20 mM, P < 0.05 and P < 0.01, resp.). Tetraethylammonium did not change migration. However, KCl reduced it (10, 25 and 50 mM, P < 0.05, P < 0.01 and P < 0.01, resp.). Both proliferation and migration were reduced by glibenclamide and 4-aminopyridine. However, tetraethylammonium only reduced proliferation and KCl only reduced migration. Potassium channels have an important role in HEC1-A cell proliferation and migration and potassium channel blockers needs to be further investigated for their therapeutic effect in endometrial cancer. In the experiment, the researchers used many compounds, for example, 5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8HPLC of Formula: 10238-21-8).

5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide (cas: 10238-21-8) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds. Tertiary amides, with the important exception of N,N-dimethylformamide, exhibit low solubility in water. In simple aromatic amides, fragmentation occurs on both sides of the carbonyl group. If a hydrogen is available in N-substituted aromatic amides, it tends to migrate and form an aromatic amine and the loss of a ketene.HPLC of Formula: 10238-21-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics