Category: 102-93-2

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 102-93-2, name is 3-Phenylpropanamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 3-Phenylpropanamide

General procedure: Following the adapted procedure reported by Huang et al. [40], to a round-bottom flaskcharged with a solution of derivatized L-Proline in water (volume to make a 0.8 M solution ofsubstrate) at r.t., CuSO4.5H2O (1 equiv.), AgNO3 (0.15 equiv.) and NH4S2O8 (1.5 equiv.) were addedand the reaction was stirred for 30 min at r.t. Then, the reaction was heated to 60 C and Amberlyst15 (15% weight of substrate) and the corresponding nucleophile (1.1 equiv.) were added and thereaction was stirred for 16-18 h. After that the reaction mixture was diluted with MeOH and filteredunder a celite pad (washed with water and MeOH several times). The filtrate was evaporated untildryness and purified by using RP18 column chromatography. The collected fractions were analyzedby UV-vis and combined according to the obtained UV-spectra to afford the desired product.

The synthetic route of 102-93-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Rippel, Rafael; Pinheiro, Luis; Lopes, Monica; Lourenco, Ana; Ferreira, Luisa M.; Branco, Paula S.; Molecules; vol. 25; 4; (2020);,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

102-93-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 102-93-2, name is 3-Phenylpropanamide, A new synthetic method of this compound is introduced below.

EXAMPLE 13 4-(2,2-dimethyl-1-oxopropyl)-N-(3-phenylpropionyl)-benzamide A slurry of potassium hydride (from 46 grams of 35% potassium hydride in oil washed three times with hexane)in 50 ml of THF is added with stirring under nitrogen to 20 grams of 3-phenylpropionamide in 350ml of THF. After addition of the hydride is complete, the reaction is allowed to warm to room temperature and is stirred for 30 minutes. The thickened reaction mixture is cooled to 0 to 5 C. and is then added dropwise over 30 minutes to a solution of 30 grams of p-pivaloylbenzoyl chloride in 50 ml of dry THF. The resulting solution is stirred for 15 minutes at 0 to 5 C. and is then quenched with 150 ml of saturated ammonium chloride solution. The THF phase is decanted off, and the aqueous phase is extracted with ethyl acetate. The ethyl acetate extract is combined with the THF phase, dried with magnesium sulfate, filtered, and then evaporated almost to dryness. The resulting solids are triturated with ether, and the white crystals obtained are filtered, washed with ether and dried to yield the title product (m.p. 137-138 C.). When the above process is carried out using in place of the 3-phenylpropionamide, an equivalent amount of:

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Sandoz Ltd.; US5378728; (1995); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

102-93-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 102-93-2 name is 3-Phenylpropanamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

DCM (20 mL) was added to a flask containing Lawesson?s reagent (2.022 g, 5.00 mmol). 3-Phenylpropanamide (1 .492 g, 10.00 mmol) was dissolved in DCM (20 mL), added tothe suspension, and stirred at room temperature for 16 hours. The mixture was concentrated under reduced pressure and purified by column chromatography (DCM) to afford the title compound (1 .07 g 1H NMR (500 MHz, ODd3) O 7.30 (t, 2H), 7.24 – 7.21 (m, 3H), 3.12 (t, 2H), 2.95 (t, 2H)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Phenylpropanamide, and friends who are interested can also refer to it.

Reference:
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; BLUM, Francesca; CARR, James Lindsay; SHAH, Pritom; DEL MAR JIMENEZ QUESADA, Maria; FARRE GUTIERREZ, Irene; (213 pag.)WO2016/124938; (2016); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics