Category: 102-07-8

On November 8, 2021, Karimi, Farzaneh; Shariatipour, Monire; Heydari, Akbar published an article.Safety of 1,3-Diphenylurea The title of the article was Deep Eutectic Solvent Mediated Carbonylation of Amines and Alcohols by Using Dimethyl Carbonate: Selective Symmetrical Urea and Organic Carbonate Synthesis. And the article contained the following:

This work presented one-pot synthesis of sym. organic carbonates and ureas by employing cheap and biodegradable deep eutectic solvent as the catalyst and reaction media. The effect of different reaction parameters such as temperature, DMC/amines and alcs. ratio and reaction time were investigated on the reaction efficiency. This new protocol provided a simple, fast, and sustainable approach and proceeded with high efficiency with aliphatic and aromatic amines and alcs. as well. Finally, applicability of this methodol. was also examined for reaction of nucleophiles such as Ph hydrazine and Ph glycine with di-Me carbonate. Interestingly, it was found that this reaction system obtained good yields of product for both of them. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Safety of 1,3-Diphenylurea

The Article related to sym urea preparation, amine dimethyl carbonate carbonylation deep eutectic solvent mediated, carbonate preparation, alc dimethyl carbonate carbonylation deep eutectic solvent mediated and other aspects.Safety of 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Wan, Yameng; Wu, Hao; Ma, Nana; Zhao, Jie; Zhang, Zhiguo; Gao, Wenjing; Zhang, Guisheng published an article in 2021, the title of the article was De novo design and synthesis of dipyridopurinone derivatives as visible-light photocatalysts in productive guanylation reactions.Related Products of 102-07-8 And the article contains the following content:

De novo design and synthesis of a series of 6H-dipyrido[1,2-e:2′,1′-i]purin-6-ones (DPs), e.g., I as a new class of visible-light photoredox catalysts (PCs) was described. The synthesized DPs showed their λAbs(max) values in 433-477 nm, excited state redox potentials E*1/2 red and E*1/2 ox in 1.15-0.69 eV and -1.41 to -1.77 eV (vs. SCE), resp. As a representative, DP I enabled productive guanylation of amines, including 1°, 2°, and 3°-alkyl primary amines, secondary amines, aryl and heteroaryl amines, amino-nitrile, amino acids and peptides as well as propynylamines and α-amino esters giving diversities in biol. important guanidines and cyclic guanidines. The photocatalytic efficacy of DP I in guanylation overmatched commonly used Ir and Ru polypyridyl complexes, and some organic PCs. Other salient merits of this method included broad substrate scope and functional group tolerance, gram-scale synthesis, and versatile late-stage derivatizations that led to a derivative 81 exhibiting 60-fold better anticancer activity against Ramos cells with IC50 of 0.086μM than that of clin. drug ibrutinib (5.1μM). The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Related Products of 102-07-8

The Article related to dipyridopurinone photocatalyst preparation dft, guanidine photochem preparation antiproliferative, amine thiourea guanylation dipyridopurinone photocatalyst visible light induced and other aspects.Related Products of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 5, 2021, Nanda, Tanmayee; Biswal, Pragati; Pati, Bedadyuti Vedvyas; Banjare, Shyam Kumar; Ravikumar, Ponneri Chandrababu published an article.Formula: C13H12N2O The title of the article was Palladium-Catalyzed C-C Bond Activation of Cyclopropenone: Modular Access to Trisubstituted α,β-Unsaturated Esters and Amides. And the article contained the following:

Strain-driven palladium/N-heterocyclic carbene-catalyzed C-C bond activation of diphenylcyclopropenone (DPC) was explored for one-step access to trisubstituted α,β-unsaturated esters and amides. The designed transformation worked under mild conditions providing exclusively a single stereoisomer. Mechanistic studies support the oxidative addition of the C-C bond of cyclopropenone to in-situ-generated Pd(0) intermediate. Vinylic hydrogen in the product was proved that it is coming from phenol/aniline through deuterium-labeling studies. Late-stage functionalization of bioactive mols. such as procaine, estrone, and hymecromone demonstrated the robustness of this protocol. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Formula: C13H12N2O

The Article related to trisubstituted unsaturated ester preparation, phenol cyclopropenone bond activation palladium catalyst, amide trisubstituted unsaturated preparation, amine cyclopropenone bond activation palladium catalyst and other aspects.Formula: C13H12N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Cai, Bao-Gui; Li, Qian; Zhang, Qiong; Li, Lei; Xuan, Jun published an article in 2021, the title of the article was Synthesis of trisubstituted hydroxylamines by a visible light-promoted multicomponent reaction.Related Products of 102-07-8 And the article contains the following content:

A green and efficient method for the synthesis of trisubstituted hydroxylamines I [R1 = H, Me, F, etc.; R2 = Me, iPr, tBu, admantyl; R3 = Me, cyclopentyl, methylallyl, etc.; Ar = Ph, 2-naphthyl, 4-MeC6H4, etc.] via three component reaction of β-keto esters, 2-nitrosopyridine and aryldiazoacetates was developed. Also, trisubstituted hydroxylamines II [R4 = H, Me, Br, etc.; R5 = Me, iPr, tBu, admantyl; R6 = Me, cyclopentyl, methylallyl, etc.; Ar1 = Ph, 4-MeOC6H4, 4-ClC6H4, etc.] were developed via multicomponent reaction of β-keto esters, 2-nitrosopyridine, cyclic ethers and aryldiazoacetates. Both reactions were occurred under sole blue LED irradiation in the absence of addnl. catalysts and additives. Two different kinds of trisubstituted hydroxylamines I and II could be easily obtained by simply changing the reaction media used. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Related Products of 102-07-8

The Article related to trisubstituted hydroxylamine green preparation, keto ester nitrosopyridine diazoacetate three component visible light promoted, hydroxylamine trisubstituted green preparation, ester nitrosopyridine diazoacetate cyclic ether multicomponent visible light promoted and other aspects.Related Products of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 25, 2022, Qaroush, Abdussalam K.; Alsayyed, Ahed W.; Eftaiha, Ala’a F.; Al-Qaisi, Feda’a M.; Salameh, Bader A. published an article.Recommanded Product: 102-07-8 The title of the article was Green Microwave-Assisted Synthesis of Cyclic/Acyclic Ureas from Propylene Carbonate. And the article contained the following:

Herein, an organocatalyzed synthetic pathway for the preparation of acyclic ureas RHNC(O)NHR (R = Bu, sec-Bu, Ph, cyclohexyl, cyclohexylmethyl, benzyl)/cyclic ureas I (n = 1, 2) from their parent primary aliphatic or aromatic monoamines NH2(CH2)nCH2NH2/diamines RNH2 with propylene carbonate as a carbonylating agent obtaining reasonable to very good yields with high selectivity has been described. This method is considered green as nine out of twelve green chem. principles (GCPs) are fulfilled. Most importantly, the absence of solvent and, energy-efficient pathway, in addition to the ease of synthesis and separation, under fast reaction times down to a few minutes together with the straightforward workup with min. use of organic solvents are described. This method was successful in preparing 1,3-diphenylurea from aniline giving 8% yield in 10 min, which was not previously reported using aromatic amines with carbonate esters. The method is applicable for primary rather than secondary amines, which implies high chemoselectivity of the former for the synthesis of urea compounds The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Recommanded Product: 102-07-8

The Article related to acyclic urea preparation green chem microwave chemoselective, primary amine propylene carbonate carbonylation diazabicycloundecene catalyst, cyclic urea preparation green chem microwave chemoselective, diamine primary propylene carbonate carbonylation diazabicycloundecene catalyst and other aspects.Recommanded Product: 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 15, 2021, Pinilla Pena, Diana C.; Ruiz Pereyra, Elba N.; Firpo, Guadalupe; Ceballos, Noelia M.; Fueloep, Ferenc; Szakonyi, Zsolt; Iriarte, Ana G.; Pelaez, Walter J. published an article.Electric Literature of 102-07-8 The title of the article was Flash Vacuum Pyrolysis (FVP) of cis-N-phenyl-hexahydro-2H-benzo[d][1,3]oxazin-2-imine and Thiazin-2-imine Derivatives. And the article contained the following:

Cis-N-phenyl-hexahydro-2H-benzo[d][1,3]oxazin-2-imines and cis-N-phenyl-hexahydro-2H-benzo[d][1,3]thiazin-2-imines I (R = H, Me, PhC2; X = O, S) were prepared and subjected to flash vacuum pyrolysis (FVP). N-H- and N-Me tetrahydrobenzoxazines reacted at lower temperatures than N-H and N-Me tetrahydrobenzothiazines, showing lower thermal stabilities, while the N-benzyl tetrahydrobenzothiazine was less stable than the N-benzyl tetrahydrobenzoxazine. Oxazines and thiazines yielded different products through homolytic fragmentations of the heterocycle moiety, the stability of which increased with the N- substitution. Based on the anal. of the reaction temperatures and the unraveling of the obtained products, it is proposed that any heterocyclic ring-opening reactions (initiated by X3-C4, C8a-N1, or C2-X3 bond rupture) require less energy than the retro-Diels-Alder process (RDA) that yields butadiene. This concerted reaction path is only achieved at temperatures higher than 470°C. Kinetic measurements reveal neg. entropies of activation, which suggest a partially concerted way of reaction or slightly asynchronous fragmentation processes, with higher energy of activation (Ea) values for the N-substituted derivatives compared to the unsubstituted ones. Exptl. results agree with calculations at the DFT level (B3LYP/6-311+G(d,p)) and M06-2X (6-311+G(d,p)) from Gaussian09 software. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Electric Literature of 102-07-8

The Article related to hydrobenzoxazinimine hydrobenzothiazinimine preparation flash vacuum photolysis fragmentation, thermal fragmentation mechanism hydrobenzoxazinimine hydrobenzothiazinimine, calculated transition state structure energy thermal fragmentation hydrobenzoxazinimine hydrobenzothiazinimine, dft method difference calculation transition state structure energy fragmentation and other aspects.Electric Literature of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 1, 2021, Pereira, Kelly L.; Ward, Martyn W.; Wilkinson, John L.; Sallach, Jonathan Brett; Bryant, Daniel J.; Dixon, William J.; Hamilton, Jacqueline F.; Lewis, Alastair C. published an article.Application In Synthesis of 1,3-Diphenylurea The title of the article was An automated methodology for non-targeted compositional analysis of small molecules in high complexity environmental matrices using coupled ultra performance liquid chromatography orbitrap mass spectrometry. And the article contained the following:

The life-critical matrixes of air and water are among the most complex chem. mixtures that are ever encountered. Ultrahigh-resolution mass spectrometers, such as the Orbitrap, provide unprecedented anal. capabilities to probe the mol. composition of such matrixes, but the extraction of non-targeted chem. information is impractical to perform via manual data processing. Automated non-targeted tools rapidly extract the chem. information of all detected compounds within a sample dataset. However, these methods have not been exploited in the environmental sciences. Here, we provide an automated and (for the first time) rigorously tested methodol. for the non-targeted compositional anal. of environmental matrixes using coupled liquid chromatog.-mass spectrometric data. First, the robustness and reproducibility was tested using authentic standards, evaluating performance as a function of concentration, ionization potential, and sample complexity. The method was then used for the compositional anal. of particulate matter and surface waters collected from worldwide locations. The method detected >9600 compounds in the individual environmental samples, arising from critical pollutant sources, including carcinogenic industrial chems., pesticides, and pharmaceuticals among others. This methodol. offers considerable advances in the environmental sciences, providing a more complete assessment of sample compositions while significantly increasing throughput. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Application In Synthesis of 1,3-Diphenylurea

The Article related to automated methodol nontargeted compositional analysis small mol environmental matrixes, coupled ultra performance liquid chromatog orbitrap mass spectrometry, compound discoverer, liquid chromatography−mass spectrometry, non-targeted analysis, ultrahigh-resolution mass spectrometry and other aspects.Application In Synthesis of 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 28, 2020, Wu, Qiumin; Chen, Jinzhu; Liu, Zhen; Xu, Yisheng published an article.Name: 1,3-Diphenylurea The title of the article was CO Activation Using Nitrogen-Doped Carbon Nanotubes for Reductive Carbonylation of Nitroaromatics to Benzimidazolinone and Phenyl Urea. And the article contained the following:

Carbonylation of nitroaroms. with CO is extensively investigated with efficient but precious group 8-10 metal-based catalysts for the productions of both industrially and academically important chems. such as isocyanates, formamides, carbamates, ureas and several types of heterocyclic compounds Herein, we report that rationally designed nitrogen-doped carbon nanotubes (N-CNTs) exhibit catalytic activity toward CO activation for carbonylation of nitroaroms. to benzimidazolinones and ureas. Under the optimal conditions, N-CNT-promoted intramol. carbonylation of 2-nitroaniline (1a) with CO leads to formation of 1,3-dihydro-2H-benzo[d]imidazol-2-one in 90% yield. Moreover, an intermol. carbonylation of nitrobenzene and aniline with CO in the presence of the N-CNT gives 70% yield of N,N’-diphenylurea. The N-CNT is also applicable to various benzimidazolinones and Ph ureas; moreover, it can be readily reused at least 9 times for the carbonylation. The theor. investigation based on d. functional theory calculations indicates that the graphitic N of the N-CNT plays a crucial step in the 1a reduction with CO. The correlation between the structural defect and catalytic performance of the N-CNT reveals an enhanced catalytic activity of the N-CNT with its increased structural defects. This research thus represents a major breakthrough in CO activation for nitroarom. carbonylation with environmental-friendly, low-cost, and carbon-based catalysts as a potential alternative to expensive and scarce noble-metal-based catalysts. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Name: 1,3-Diphenylurea

The Article related to nitrogen doped carbon nanotube catalyst reductive carbonylation nitroarom aniline, carbon monoxide activation nitrogen doped carbon nanotube, benzimidazolinone ph urea preparation green chem mol modeling, carbon catalysis, carbon monoxide, carbonylation, defect, nitrogen-doped carbon nanotubes and other aspects.Name: 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 2, 2022, Franchino, Allegra; Marti, Alex; Echavarren, Antonio M. published an article.Electric Literature of 102-07-8 The title of the article was H-Bonded Counterion-Directed Enantioselective Au(I) Catalysis. And the article contained the following:

A new strategy for enantioselective transition-metal catalysis is presented, wherein a H-bond donor placed on the ligand of a cationic complex allows precise positioning of the chiral counteranion responsible for asym. induction. The successful implementation of this paradigm is demonstrated in 5-exo-dig and 6-endo-dig cyclizations of 1,6-enynes, combining an achiral phosphinourea Au(I) chloride complex with a BINOL-derived phosphoramidate Ag(I) salt and thus allowing the 1st general use of chiral anions in Au(I)-catalyzed reactions of challenging alkyne substrates. Experiments with modified complexes and anions, 1H NMR titrations, kinetic data, and studies of solvent and nonlinear effects substantiate the key H-bonding interaction at the heart of the catalytic system. This conceptually novel approach, which lies at the intersection of metal catalysis, H-bond organocatalysis, and asym. counterion-directed catalysis, provides a blueprint for the development of supramolecularly assembled chiral ligands for metal complexes. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Electric Literature of 102-07-8

The Article related to silver binaphtholphosphinate preparation catalyst enyne cyclization crystal structure, crystal structure silver binaphtholphosphinate gold phosphinothiourea complex, mol structure silver binaphtholphosphinate gold phosphinothiourea complex, gold phosphinothiourea complex preparation catalyst enyne cyclization crystal structure and other aspects.Electric Literature of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics