Category: 102-07-8

On September 27, 2022, Duss, Michael; Soto, Miguel A.; Patrick, Brian O.; MacLachlan, Mark J. published an article.Safety of 1,3-Diphenylurea The title of the article was A Supramolecular Strategy for the Synthesis of Cyclic Oligomers and Polymers by Ring Expansion. And the article contained the following:

Ring-opening metathesis polymerization (ROMP) of strained macrocycles is a key method to prepare diverse polymers. However, lack of ring strain in most macrocycles is an impediment to polymerization In this paper, the polymerization/oligomerization of unstrained macrocycles was achieved using a supramol. approach, leading selectively to cyclic products. Di-Ph thiourea and other guest mols. were used as additives to the ROMP reaction of unstrained macrocycles. An intermediate host-guest complex leads to the stabilization of the open form of the macrocycle after treatment with Grubbs catalysts, thereby favoring polymerization by inhibiting the ring-closing reaction back to the monomer. This proof-of-concept enables ring-expansion polymerization of unstrained macrocycles leading to cyclic polymers with mol. weights up to 6700 Da. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Safety of 1,3-Diphenylurea

The Article related to supramol cyclic oligomer polymer ring expansion, cyclic polymers, host-guest chemistry, macrocycle, olefin metathesis, supramolecular chemistry, Chemistry of Synthetic High Polymers: Other and other aspects.Safety of 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Szulc, Justyna; Okrasa, Malgorzata; Nowak, Adriana; Niziol, Joanna; Ruman, Tomasz; Kuberski, Slawomir published an article in 2022, the title of the article was Assessment of Physicochemical, Microbiological and Toxicological Hazards at an Illegal Landfill in Central Poland.Name: 1,3-Diphenylurea And the article contains the following content:

This study aimed to assess the physicochem., microbiol. and toxicol. hazards at an illegal landfill in central Poland. The research included the anal. of airborne dust (laser photometer), the number of microorganisms in the air, soil and leachate (culture method) and the microbial diversity in the landfill environment (high-throughput sequencing on the Illumina Miseq); the cytotoxicity (PrestoBlue) and genotoxicity (alk. comet assay) of soil and leachate were tested. Moreover, an anal. of UHPLC-Q-ToF-UHRMS (ultra-high-performance liquid chromatog.-quadrupole-time-of-flight ultrahigh-resolution mass spectrometry) was performed to determine the toxic compounds and microbial metabolites. The PM1 dust fraction constituted 99.89% and 99.99% of total dust and exceeded the threshold of 0.025 mg m-3 at the tested locations. In the air, the total number of bacteria was 9.33 x 101-1.11 x 103 CFU m-3, while fungi ranged from 1.17 x 102 to 4.73 x 102 CFU m-3. Psychrophilic bacteria were detected in the largest number in leachates (3.3 x 104 to 2.69 x 106 CFU mL-1) and in soil samples (8.53 x 105 to 1.28 x 106 CFU g-1). Bacteria belonging to Proteobacteria (42-64.7%), Bacteroidetes (4.2-23.7%), Actinobacteria (3.4-19.8%) and Firmicutes (0.7-6.3%) dominated. In the case of fungi, Basidiomycota (23.3-27.7%), Ascomycota (5.6-46.3%) and Mortierellomycota (3.1%) have the highest abundance. Bacteria (Bacillus, Clostridium, Cellulosimicrobium, Escherichia, Pseudomonas) and fungi (Microascus, Chrysosporium, Candida, Malassezia, Aspergillus, Alternaria, Fusarium, Stachybotrys, Cladosporium, Didymella) that are potentially hazardous to human health were detected in samples collected from the landfill. Tested leachates and soils were characterised by varied cyto/genotoxins. Common pesticides (carbamazepine, prometryn, terbutryn, permethrin, carbanilide, pyrethrin, carbaryl and prallethrin), quaternary ammonium compounds (benzalkonium chlorides), chems. and/or polymer degradation products (melamine, triphenylphosphate, diphenylphtalate, insect repellent diethyltoluamide, and drugs (ketoprofen)) were found in soil and leachate samples. It has been proven that the tested landfill is the source of the emission of particulate matter; microorganisms (including potential pathogens) and cyto/genotoxic compounds The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Name: 1,3-Diphenylurea

The Article related to physicochem microbiol toxicol hazard, uhplc-q-tof-uhrms analysis, bioaerosol, harmful biological agents, illegal landfill, metagenome analysis, toxicological analysis, Placeholder for records without volume info and other aspects.Name: 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chang, Qiaoying; Ge, Lijuan; Li, Jian; Qiu, Guoyu; Wu, Fuxiang; Zhang, Hongyan; Xu, Fenghua; Zhu, Renyuan; Qi, Pengfei; Bai, Ruobin; Ren, Fazheng published an article in 2021, the title of the article was Automated QuEChERS for the determination of 482 pesticide residues in Radix codonopsis by GC-Q-TOF/MS and LC-Q-TOF/MS.COA of Formula: C13H12N2O And the article contains the following content:

A rapid procedure for the determination of 482 pesticide residues in Chinese Materia Medica by GC-Q-TOF/MS and LC-Q-TOF/MS (379 pesticides for LC, 327 pesticides for GC, and 226 pesticides for both) was developed. Radix codonopsis was chosen as the matrix for verification, and a comparative study on the QuEChERS sample preparation was carried out, between a fully automated workstation and manual operation, in terms of limits of quantitation, recovery rate and RSD at 3 spiked levels of 10渭g kg-1, 20渭g kg-1 and 100渭g kg-1. In the linear range of each pesticide in a concentration range of 5-100渭g L-1, the linear correlation coefficients R2 of 85% of the pesticides for GC and 88% for LC were equal to or greater than 0.990. Taking recovery 70-120% and RSD 鈮?20% as the satisfactory standard, the automated workstation performed better at 10渭g kg-1 and 20渭g kg-1 than manual operation, and the numbers of satisfactory pesticides of GC & LC were 401 and 418 for the automated approach, and 378 and 400 for manual, while the two approaches were almost even at 100渭g kg-1, 421 vs. 424. Besides, the automated workstation presented lower RSD (more pesticides 鈮?0%) and better recovery quality (more pesticides within 90-110%). Following the method verification, 50 Radix codonopsis samples purchased from local markets were prepared with the automated workstation and analyzed by GC and LC-Q-TOF/MS. 18 pesticides were detected in 38 samples, one of which was a highly toxic pesticide. The automated QuEChERS workstation can handle 40 samples in one cycle within 6 h, and realize whole-process automation covering from samples after “weighing” to “injection into vials”. The batch-to-batch, day-to-day, and lab-to-lab consistency and 24 x 7 workability of the automated solution have demonstrated a promising and ideal replacement for manual operation in sample preparation The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).COA of Formula: C13H12N2O

The Article related to radix codonopsis pesticide residue gcq lcq tofms, Pharmaceutical Analysis: Inorganic Compounds and other aspects.COA of Formula: C13H12N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On October 16, 2020, Zhao, Yulei; Guo, Xuqiang; Si, Zhiyao; Hu, Yanan; Sun, Ying; Liu, Yunlin; Ji, Zhongyin; You, Jinmao published an article.Electric Literature of 102-07-8 The title of the article was Hydrosilane-Assisted Synthesis of Urea Derivatives from CO2 and Amines. And the article contained the following:

A methodol. employing CO2, amines, and phenylsilane was discussed to access aryl- or alkyl-substituted urea derivatives This procedure was characterized by adopting hydrosilane to promote the formation of ureas directly, without the need to prepare silylamines in advance. Control reactions suggested that FeCl3 was a favorable additive for the generation of ureas, and this 1,5,7-triazabicyclo[4.4.0]dec-5-ene-catalyzed reaction might proceed through nucleophilic addition, silicon migration, and the subsequent formal substitution of silylcarbamate. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Electric Literature of 102-07-8

The Article related to hydrosilane carbon dioxide amine, urea preparation, General Organic Chemistry: Synthetic Methods and other aspects.Electric Literature of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chen, Changpeng; Ling, Liang; Luo, Meiming; Zeng, Xiaoming published an article in 2021, the title of the article was Chromium-Catalyzed Ligand-Free Amidation of Esters with Anilines.Reference of 1,3-Diphenylurea And the article contains the following content:

Amides are important structural motifs in pharmaceutical and agrochem. chem. because of the intriguing biol. active properties. Author’s report here the amidation of com. available esters with anilines that was promoted by low-cost and air-stable chromium(III) pre-catalyst combined with magnesium, providing access to amides. This reaction occurs without the use of external ligands in a simple operation. Mechanistic studies indicate that a reactive aminated Cr species responsible for the amidation can be considered, which may be formed by reaction of low-valent Cr with aniline followed by reduction with hydrogen evolution. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Reference of 1,3-Diphenylurea

The Article related to secondary amide tertiary preparation chromium catalyst, ester aniline amidation, General Organic Chemistry: Synthetic Methods and other aspects.Reference of 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Gu, Zheng-Yang; Chen, Jie; Xia, Ji-Bao published an article in 2020, the title of the article was Pd-catalyzed amidation of 1,3-diketones with CO and azides via a nitrene intermediate.HPLC of Formula: 102-07-8 And the article contains the following content:

An efficient Pd-catalyzed amidation of 1,3-diketones has been developed using carbon monoxide and organic azides. This reaction provides a step-economic approach to produce 尾-ketoamides from readily available compounds under mild ligand-, oxidant-, and base-free conditions. The mechanistic studies showed that the reaction occurred through an in situ generated isocyanate intermediate. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).HPLC of Formula: 102-07-8

The Article related to beta ketoamide preparation, diketone azide carbon monoxide amidation palladium catalyst, General Organic Chemistry: Synthetic Methods and other aspects.HPLC of Formula: 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Chhatwal, A. Rosie; Lomax, Helen V.; Blacker, A. John; Williams, Jonathan M. J.; Marce, Patricia published an article in 2020, the title of the article was Direct synthesis of amides from nonactivated carboxylic acids using urea as nitrogen source and Mg(NO3)2 or imidazole as catalysts.Recommanded Product: 1,3-Diphenylurea And the article contains the following content:

A new method for the direct synthesis of primary and secondary amides from carboxylic acids was described using Mg(NO3)2路6H2O or imidazole as a low-cost and readily available catalyst, and urea as a stable, and easy to manipulate nitrogen source. This methodol. was particularly useful for the direct synthesis of primary and Me amides avoiding the use of ammonia and methylamine gas which can be tedious to manipulate. Furthermore, the transformation does not require the employment of coupling or activating agents which are commonly required. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Recommanded Product: 1,3-Diphenylurea

The Article related to urea carboxylic acid magnesium nitrate imidazole catalyst coupling, primary amide preparation, secondary amide preparation, General Organic Chemistry: Synthetic Methods and other aspects.Recommanded Product: 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On June 5, 2020, Wang, Jiajia; Wen, Yinhang; Zheng, Lu; Dou, Biao; Li, Linrong; Zhao, Kangkang; Wang, Na; Ma, Jing published an article.SDS of cas: 102-07-8 The title of the article was Characterization of chemical profiles of pH-sensitive cleavable D-gluconhydroximo-1, 5-lactam hydrolysates by LC-MS: A potential agent for promoting tumor-targeted drug delivery. And the article contained the following:

Currently, controllable linker cleavage at the target site will facilitate the clin. treatment of cancer. Dual-functional prodrugs in combination of carbohydrate as targeting group and pH-sensitive cleavable linker are desired in clin. development. Here, a qualified structure of N-phenylcarbamate-D-gluconhydroximo-1,5-lactam was employed and proved to be a potential candidate prodrug in the drug design. To proof this concept, the possible mechanism of Beckmann rearrangement and the degraded products were confirmed by HPLC and LC-MS under the acid condition mimic lysosome. Hence, the strategy of D-gluconhydroximo-1,5-lactam as a prodrug carrier fabricated with interested drugs will provide a great potential approach for chemotherapy. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).SDS of cas: 102-07-8

The Article related to gluconhydroximolactam tumor targeting prodrug, beckmann rearrangement, n-phenylcarbamate-d-gluconhydroximo-1,5-lactam, prodrug, ph sensitive, Pharmaceuticals: Formulation and Compounding and other aspects.SDS of cas: 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Liu, Xin; Werner, Thomas published an article in 2021, the title of the article was Indirect reduction of CO2 and recycling of polymers by manganese-catalyzed transfer hydrogenation of amides, carbamates, urea derivatives and polyurethanes.Name: 1,3-Diphenylurea And the article contains the following content:

A manganese pincer complex as a versatile catalyst for the transfer hydrogenation of amides, carbamates, urea derivatives and even polyurethanes leading to the corresponding alcs., amines and methanol as products were reported. Since these compound classes can be prepared using CO2 as a C1 building block the reported reaction represents an approach to the indirect reduction of CO2. Notably, these are the first examples on the reduction of carbamates and urea derivatives as well as on the C-N bond cleavage in amides by transfer hydrogenation. The general applicability of this methodol. is highlighted by the successful reduction of 12 urea derivatives, 26 carbamates and 11 amides. The corresponding amines, alcs. and methanol were obtained in good to excellent yields up to 97%. Furthermore, polyurethanes were successfully converted which represents a viable strategy towards a circular economy. Based on control experiments and the observed intermediates a feasible mechanism was proposed. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Name: 1,3-Diphenylurea

The Article related to carbonyl compound manganese catalyst transfer hydrogenation, polyurethane manganese catalyst transfer hydrogenation, alc amine preparation, General Organic Chemistry: Synthetic Methods and other aspects.Name: 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On February 5, 2021, Wang, Xia; Yang, Peng; Hu, Bo; Zhang, Qian; Li, Dong published an article.SDS of cas: 102-07-8 The title of the article was Hypervalent Iodine Reagent-Promoted Hofmann-Type Rearrangement/Carboxylation of Primary Amides. And the article contained the following:

A novel transformation of primary amides RC(O)NH2 (R = Ph, thiophen-2-yl, Bu, cyclopropyl, etc.) to secondary amides RNHC(O)R1 (R1 = methyltrifluoromethyl, Et, Ph, etc.) promoted by hypervalent iodine reagents Ph(I)(OC(O)R1)2 was developed. The hypervalent iodine reagent-mediated Hofmann-type rearrangement generated an isocyanate intermediate, which was subsequently trapped by an in situ generated carboxylic acid from the hypervalent iodine reagent to provide the corresponding secondary amides. This method provided a facile and efficient route for the synthesis of secondary amides from primary amides and also revealed novel reactivities of hypervalent iodine reagents. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).SDS of cas: 102-07-8

The Article related to secondary amide preparation, primary amide hypervalent iodine reagent hofmann rearrangement carboxylation, General Organic Chemistry: Synthetic Methods and other aspects.SDS of cas: 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics