Category: 102-07-8

Bawar, Khirsten Marie; Cruz, Leannie Praise; Ilao, Kristine Bernadette; Justiniano, Julianne Mica; Panganiban, Lara Mae; Fabito, Diane Laine; Amayun, Christine Joy; Nas, John Sylvester published an article in 2021, the title of the article was In silico identification of novel compounds as quorum-sensing inhibitors in selected waterborne pathogens.COA of Formula: C13H12N2O And the article contains the following content:

Quorum sensing (QS) is a process involved in producing, detecting, responding, and releasing signaling mols. to maintain physiol. activities of most utilized by both gram-pos. and gram-neg. bacteria in various environmental conditions. This study aims to identify novel compounds that have potential QS inhibitory mechanisms against the gram-pos. bacteria Staphylococcus aureus (S. aureus) and Streptococcus pneumoniae (S. pneumoniae), and the gram-neg. bacteria Salmonella typhi (S. typhi) and Escherichia coli (E. coli). Compounds that are structurally similar to the known QS inhibitors were identified using ligand-based screening. Candidate compounds with 40 to 80% similarity with the known QS inhibitors were further evaluated through mol. docking with the QS-associated enzymes, namely ComA, ComE, LsrF, LsrK, AgrC, AgrA, LsrB, and Hfq. The binding affinity was visualized to identify the different non-covalent binding interactions. Compounds with <-8.0 kcal/mol docking score were considered for evaluation for their distribution coefficient (LogD) at different optimal growth of the bacteria, such as pH 4, 6, 7.4, 7.8, 8, and 9. Out of the 63 compounds evaluated, only three compounds demonstrated a high binding affinity, namely 1-phenyl-3-[5-(phenylcarbamoylamino)naphthalen-1-yl]urea and 1-naphthalen1-yl-3-[5-(naphthalen-1-ylcarbamoylamino)naphthalen-1-yl]urea with ComE of S. pneumoniae and 3-[(4-Methylphenyl)sulfonyl][1,2,3]triazolo[1,5-a]quinazolin-5(4H)-one to AgrA of S. aureus. Their high binding affinity may be attributed to the numerous hydrogen bonds and hydrophobic interactions. However, only 3-[(4-Methylphenyl)sulfonyl][1,2,3]triazolo[1,5-a]quinazolin-5(4H)-one has comparable LogD value with its QS inhibitor of AgrA, savarin, at the optimal growth pH for S. aureus. These findings suggest that the use of 3-[(4-Methylphenyl)sulfonyl][1,2,3]triazolo[1,5-a] quinazolin-5(4H)-one may be effective in controlling S. aureus growth probably through inhibition of AgrA. However, further studies are needed to confirm these findings. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).COA of Formula: C13H12N2O

The Article related to waterborne pathogen quorum sensing inhibitor, Placeholder for records without volume info and other aspects.COA of Formula: C13H12N2O

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Benkaddour, Rajae; Ben Ali, Naouar; Hamdoun, Ouafaa; Badoc, Alain; Azaroual, Latifa; Martin, Patrick; Lamarti, Ahmed published an article in 2022, the title of the article was Micropropagation and acclimatization of common Oregano (Origanum vulgare L. Subsp. vulgare) by shoot tip culture.SDS of cas: 102-07-8 And the article contains the following content:

Origanum vulgare L. is a com. valued species with remarkable biol. properties. It is subject to over-exploitation practices that seriously threaten its sustainability for future generations. Thus, micropropagation serves as a tool for the protection and domestication of this species. In this study, we established an in vitro vegetative propagation protocol for Origanum vulgare. This is done through the axillary bud technique by carrying out various tests. Six culture media (MS, MSm, N30K, SD, SH and B5) were tested. Therefore, SD was chosen for the following experiments Seven cytokinins (adenine (Ad), N6-(2-isopentenyl) (2i.p.), zeatin (Zeat), kinetin (Kin), benzyladenine (BAP), 1,3-diphenylurea (DPU) and thidiazuron (TDZ) at 5 concentrations (0.44, 1.33, 2.22, 3.11 and 4.44 渭M/L) were evaluated. Thus, Kin at 3.11 渭M allowed high regeneration of vitroplants, optimal elongation, total rooting of explants, maximum bud multiplication, and absence of hyperhydric explants. In fact, the integration of auxins (indole-3-acetic acid (IAA), indole-3-butyric acid (IBA), and 1-naphthaleneacetic acid (NAA)) into the culture medium and their combinations with 3.11 渭M Kinetin contributed to the optimization of the root part. Thus, it was improved in particular in the case of 3.11 渭M Kin and 6.27 渭M IBA. Three polyamines (Putrescine, Spermidine and Spermine) at different concentrations (1.134, 3.402, 5.67, 7.938 and 11.34 渭M/L) combined at 3.11 渭M Kin and 6.27 渭M IBA were tested. In fact, 1.304 渭M putrescine was considered to be the most suitable for in vitro culture of explants, since it allowed optimal propagation of buds and roots, also a high rate of regeneration and rhizogenesis. GA3 at 1.15 渭M combined with 3.11 渭M Kin and 6.27 渭M IBA permitted maximum bud multiplication. The acclimatization was carried out successfully using vitroplants showing good foliar and root development. Thus, three months after acclimatization, the seedlings were transferred into large pots under natural light and temperature conditions. Almost all acclimatized plants developed flowers in the first year between May and July. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).SDS of cas: 102-07-8

The Article related to origanum shoot tip culture micropropagation acclimatization, Placeholder for records without volume info and other aspects.SDS of cas: 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 31, 2020, Piotrowska-Niczyporuk, Alicja; Bajguz, Andrzej; Kotowska, Urszula; Zambrzycka-Szelewa, Elzbieta; Sienkiewicz, Aneta published an article.Related Products of 102-07-8 The title of the article was Auxins and Cytokinins Regulate Phytohormone Homeostasis and Thiol-Mediated Detoxification in the Green Alga Acutodesmus obliquus Exposed to Lead Stress. And the article contained the following:

Abstract: Phytohormones, such as auxins and cytokinins, take part in the integration of growth control and stress response, but their role in algal adaptation to heavy metal remains to be elucidated. The current research indicated that lead (Pb), one of the most toxic metals in nature, causes severe depletion of endogenous cytokinins, auxins, and gibberellin and an increase in abscisic acid content in the green alga Acutodesmus obliquus. Exogenous auxins and cytokinins alleviate Pb toxicity through the regulation of the endogenous phytohormones鈥?levels. Exogenously applied auxins provoked the coordinated activation metal tolerance mechanisms leading to the increase in phytochelatin synthase activity and accumulation of phytochelatins and their precursors, which are essential for Pb sequestration. On the other hand, phytochelatin synthesis decreased in algal cells treated with cytokinins. Significant changes in the levels of low mol. weight metabolites, mainly involved in metal chelation and glutathione synthesis pathway under the influence of phytohormones in algal cells growing in the presence of Pb stress, were observed This is the first report showing that auxins and cytokinins are important regulatory factors in algal adaptation strategies to heavy metal stress based on thiol-mediated compounds and the maintenance of phytohormone homeostasis. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Related Products of 102-07-8

The Article related to acutodesmus auxin cytokinin lead stress thiol detoxifcation, Placeholder for records without volume info and other aspects.Related Products of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On December 16, 2021, Shi, Wei; Tiwari, Surya P.; Thompson, Robert L.; Culp, Jeffrey T.; Hong, Lei; Hopkinson, David P.; Smith, Kathryn; Resnik, Kevin; Steckel, Janice A.; Siefert, Nicholas S. published an article.Recommanded Product: 1,3-Diphenylurea The title of the article was Computational Screening of Physical Solvents for CO2 Pre-combustion Capture. And the article contained the following:

A computational scheme was used to screen phys. solvents for CO2 pre-combustion capture by integrating the com. NIST database, an inhouse computational database, chem-informatics, and mol. modeling. A com. available screened hydrophobic solvent, di-Et sebacate, was identified from the screening with favorable phys. properties and promising absorption performance. The promising performance to use di-Et sebacate in CO2 pre-combustion capture has also been confirmed from experiments Water loading in di-Et sebacate is very low, and therefore, water is kept with H2 in the gas stream. The favorable CO2 interaction with di-Et sebacate and the intermediate solvent free volume fraction leads to both high CO2 solubility and high CO2/H2 solubility selectivity in di-Et sebacate. An inhouse NETL computational database was built to characterize CO2, H2, N2, and H2O interactions with 202 different chem. functional groups. It was found that 13% of the functional groups belong to the strong interaction category with the CO2 interaction energy between -15 and -21 kJ/mol; 62% of the functional groups interact intermediately with CO2 (-8 to -15 kJ/mol). The remaining 25% of functional groups interact weakly with CO2 (below -8 kJ/mol). In addition, calculations show that CO2 interactions with the functional groups are stronger than N2 and H2 interactions but are weaker than H2O interactions. The CO2 and H2O interactions with the same functional groups exhibit a very strong linear pos. correlation coefficient of 0.92. The relationship between CO2 and H2 gas solubilities and solvent fractional free volume (FFV) has been systematically studied for seven solvents at 298.2 K. A skewed bell-shaped relation was obtained between CO2 solubility and solvent FFV. When an organic compound has a d. approx. 10% lower than its d. at 298.2 K and 1 bar, it exhibits the highest CO2 loading at that specific solvent d. and FFV. Note that the solvent densities were varied using simulations, which are difficult to be obtained from the experiment In contrast, H2 solubility results exhibit an almost perfect pos. linear correlation with the solvent FFV. The theor. maximum and min. phys. CO2 solubilities in any organic compound at 298.2 K were estimated to be 11 and 0.4 mol/MPa L, resp. An examination of 182 exptl. CO2 phys. solubility data and 29 simulated CO2 phys. solubilities shows that all the CO2 phys. solubility data are within the maximum and min. with only a few exceptions. Finally, simulations suggest that in order to develop phys. solvents with both high CO2 solubility and high CO2/H2 solubility selectivity, the solvents should contain functional groups which are available to interact strongly with CO2 while minimizing FFV. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Recommanded Product: 1,3-Diphenylurea

The Article related to computational screening solvent carbon dioxide absorption precombustion, Placeholder for records without volume info and other aspects.Recommanded Product: 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On May 31, 2022, Chibwe, Leah; Parrott, Joanne L.; Shires, Kallie; Khan, Hufsa; Clarence, Stacey; Lavalle, Christine; Sullivan, Cheryl; O鈥睟rien, Anna M.; De Silva, Amila O.; Muir, Derek C. G.; Rochman, Chelsea M. published an article.Synthetic Route of 102-07-8 The title of the article was A Deep Dive into the Complex Chemical Mixture and Toxicity of Tire Wear Particle Leachate in Fathead Minnow. And the article contained the following:

The ecol. impact of tire wear particles in aquatic ecosystems is a growing environmental concern. We combined toxicity testing, using fathead minnow (Pimephales promelas) embryos, with nontarget high-resolution liquid chromatog. Orbitrap mass spectrometry to characterize the toxicity and chem. mixture of organic chems. associated with tire particle leachates. We assessed: 1) exposure to tire particle leachates after leaching for 1-, 3-, and 10-d; and 2) the effect of the presence and absence of small tire particulates in the leachates. We observed a decrease in embryonic heart rates, hatching success, and lengths, as well as an increase in the number of embryos with severe deformities and diminished eye and body pigmentation, after exposure to the leachates. Overall, there was a pattern whereby we observed more toxicity in the 10-d leachates, and greater toxicity in unfiltered leachates. Redundancy anal. showed that several benzothiazoles and aryl-amines were correlated with the toxic effects observed in the embryos. These included benzothiazole, 2-aminobenzothiazole, 2-mercaptobenzothiazole, N,N鈥?diphenylguanidine, and N,N鈥?diphenylurea. However, many other chems. characterized as unknowns are likely to also play a key role in the adverse effects observed Our study provides insight into the types of chems. likely to be important toxicol. drivers in tire leachates, and improves our understanding of the ecotoxicol. impacts of tire wear particles. Environ Toxicol Chem 2021;00:1-10. 2021 The Authors. Environmental Toxicol. and Chem. published by Wiley Periodicals LLC on behalf of SETAC. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Synthetic Route of 102-07-8

The Article related to pimephales chem mixture tire wear particle toxicol, complex chemical mixtures, fathead minnow, tire toxicity, tire wear particles, Placeholder for records without volume info and other aspects.Synthetic Route of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 31, 2022, Shinde, Jivan; Bhimrao Patil, Prakash; Kavala, Veerababurao; Yao, Ching-Fa published an article.Related Products of 102-07-8 The title of the article was Synthesis of Unsymmetrical Urea Derivatives via Cu-Catalyzed Reaction of Acylazide and Secondary Amine. And the article contained the following:

The synthesis of unsym. urea generally requires toxic reagent, solvent and harsh reaction condition. Herein, we introduce Cu-catalyzed greener and safer unsym. urea derivatives synthesis in Et acetate. This method minimized utilization of toxic reagent. A variety of indole, amines, and azides with bis-indole successfully employed leading to high yields and gram scale synthesis of isolated urea. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Related Products of 102-07-8

The Article related to urea derivative copper acylazide secondary amine catalysis, curtius rearrangement, copper catalyst, green solvent, unsymmetrical urea, Placeholder for records without volume info and other aspects.Related Products of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On March 2, 2021, Li, Chengwei; Zhong, Jialiang; Liu, Baohu; Yang, Tao; Lv, Binhua; Luo, Youfu published an article.Recommanded Product: 1,3-Diphenylurea The title of the article was Study on Typical Diarylurea Drugs or Derivatives in Cocrystallizing with Strong H-Bond Acceptor DMSO. And the article contained the following:

Diarylureas are widely used in self-assembly and supramol. chem. owing to their outstanding characteristics as both H-bond donors and acceptors. Unfortunately, this bonding property is rarely applied in the development of urea-containing drugs. Herein, seven related DMSO complexes were screened from 12 substrates involving sorafenib and regorafenib, mainly considering the substitution effect following a robust procedure. All complexes were structurally confirmed by spectroscopic means and thermal anal. Specially, five cocrystals with three deuterated, named sorafenib·DMSO, donafenib·DMSO, deuregorafenib·DMSO, 6·DMSO, and 7·DMSO were obtained. The crystal structures revealed that all host mols. consistently bonded with DMSO in intermol. interaction in a 1:1 stoichiometry. However, further comparison with documented DMSO complexes and parent motifs presented some arrangement diversities especially for 6·DMSO which offered a counter-example to previous rules. Major changes in the orientation of meta-substituents and the packing stability for sorafenib·DMSO and deuregorafenib·DMSO were rationalized by theory anal. and computational energy calculation Cumulative data implied that the planarization of two aryl planes in diarylureas may play a crucial role in cocrystn. Also, a polymorph study bridged the transformation between these ureas and their DMSO complexes. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Recommanded Product: 1,3-Diphenylurea

The Article related to diarylurea drug derivative cocrystn dmso, Pharmaceuticals: Pharmaceutics and other aspects.Recommanded Product: 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 19, 2022, York, Edward; McNaughton, Daniel A.; Roseblade, Ariane; Cranfield, Charles G.; Gale, Philip A.; Rawling, Tristan published an article.Application of 102-07-8 The title of the article was Structure-Activity Relationship and Mechanistic Studies of Bisaryl Urea Anticancer Agents Indicate Mitochondrial Uncoupling by a Fatty Acid-Activated Mechanism. And the article contained the following:

Targeting the cancer cell mitochondrion is a promising approach for developing novel anticancer agents. The exptl. anticancer agent N,N’-bis(3,5-dichlorophenyl)urea (SR4) induces apoptotic cell death in several cancer cell lines by uncoupling mitochondrial oxidative phosphorylation (OxPhos) using a protein-free mechanism. However, the precise mechanism by which SR4 depolarizes mitochondria is unclear because SR4 lacks an acidic functional group typically found in protein-independent uncouplers. Recently, it was shown that structurally related thioureas can facilitate proton transport across lipid bilayers by a fatty acid-activated mechanism, in which the fatty acid acts as the site of protonation/deprotonation and the thiourea acts as an anion transporter that shuttles deprotonated fatty acids across the phospholipid bilayer to enable proton leak. In this paper, we show that SR4-mediated proton transport is enhanced by the presence of free fatty acids in the lipid bilayer, indicating that SR4 uncouples mitochondria through the fatty acid-activated mechanism. This mechanistic insight was used to develop a library of substituted bisaryl ureas for structure-activity relationship studies and subsequent cell testing. It was found that lipophilic electron-withdrawing groups on bisaryl ureas enhanced electrogenic proton transport via the fatty acid-activated mechanism and had the capacity to depolarize mitochondria and reduce the viability of MDA-MB-231 breast cancer cells. The most active compound in the series reduced cell viability with greater potency than SR4 and was more effective at inhibiting ATP production The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Application of 102-07-8

The Article related to structure bisaryl urea cancer mitocondrial uncoupling fatty acid, Pharmacology: Structure-Activity and other aspects.Application of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

On August 30, 2020, Sutcharitchan, Chayanis; Miao, Shui; Li, Wenting; Liu, Jiaming; Zhou, Heng; Ma, Yingxian; Ji, Shen; Cui, Yajun published an article.Name: 1,3-Diphenylurea The title of the article was High performance liquid chromatography-tandem mass spectrometry method for residue determination of 39 plant growth regulators in root and rhizome Chinese herbs. And the article contained the following:

A simple, rapid, and effective method based on salting-out extraction and LC-MS/MS techniques was developed for the determination of 39 plant growth regulator (PGR) residues in two of the most common root and rhizome Chinese herbs, Codonopsis Radix (Dangshen) and Notoginseng Radix et Rhizoma (Sanqi). The extraction process was performed with acetonitrile-water (5:1) and citrate buffer extraction salt. The performance of the method was validated in accordance with the anal. quality control criteria of SANTE/11813/2017 guidelines. Analyte recoveries of 79.49-109.41% (Dangshen) and 80.17-102.81% (Sanqi) were achieved. The limit of quantifications (LOQs) were determined with the consideration of accuracy and precision. LOQs were lower than the lowest residue limits in EU pesticide regulation (10μg/kg) for most PGRs. Moreover, the method was successfully applied in the anal. of 35 batches of Dangshen, and 60 batches of Sanqi products. The concentration of eleven PGRs were determined in analyzed samples. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Name: 1,3-Diphenylurea

The Article related to rhizome root hplc dangshen sanqi, chinese medicine, dangshen, determination method, hplc-ms/ms, pesticide residue, plant growth regulator, sanqi, Food and Feed Chemistry: Analysis and other aspects.Name: 1,3-Diphenylurea

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Pan, Jie; Li, Haocong; Sun, Kai; Tang, Shi; Yu, Bing published an article in 2022, the title of the article was Visible-Light-Induced Decarboxylation of Dioxazolones to Phosphinimidic Amides and Ureas.Application of 102-07-8 And the article contains the following content:

A visible-light-induced external catalyst-free decarboxylation of dioxazolones was realized for the bond formation of N = P and N-C bonds to access phosphinimidic amides and ureas. Various phosphinimidic amides and ureas (47 examples) were synthesized with high yields (up to 98%) by this practical strategy in the presence of the system′s ppm Fe. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Application of 102-07-8

The Article related to dioxazolone phosphinimidic amide urea visible light decarboxylation, decarboxylation, dioxazolones, phosphinimidic amides, ureas, visible light, Placeholder for records without volume info and other aspects.Application of 102-07-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics