Author: tianli

71510-95-7, Adding a certain compound to certain chemical reactions, such as: 71510-95-7, name is Ethyl 3-(methylamino)-3-oxopropanoate, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 71510-95-7.

General procedure: In a round bottom flask, unsaturated aldehyde 2 (0.25 mmol, 1 equiv), amidomalonate 1 (0.3 mmol, 1.2 equiv), catalyst (0.05 mmol, 20% mol), and KOAc (0.3 mmol, 1.2 equiv) were added sequentially in 1 mL of 2,2,2-trifluoroethanol. The reaction was stirred at room temperature overnight. Then the crude was purified by column chromatography to furnish piperidine adducts 3.

According to the analysis of related databases, 71510-95-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; ?ihalova, Sylva; Valero, Guillem; Schimer, Ji?i; Humpl, Marek; Dra?insky, Martin; Moyano, Albert; Rios, Ramon; Vesely, Jan; Tetrahedron; vol. 67; 46; (2011); p. 8942 – 8950;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

592-35-8, A common heterocyclic compound, 592-35-8, name is Butyl carbamate, molecular formula is C5H11NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 5 The procedure of Comparative Example V was repeated, but the reaction was carried out in the presence of 21.9 mg of zirconium acetylacetonate (0.005 mol %, based on HDA). The reaction system had reached a steady state after 4 hours, with the HDU content of the reaction product (663 g) being 42.6% by weight. This gave a space-time yield of 83 [g/l¡¤h].

The synthetic route of Butyl carbamate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BASF Aktiengesellschaft; US6410778; (2002); B1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

86499-96-9, Adding some certain compound to certain chemical reactions, such as: 86499-96-9, name is 3-Bromo-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 86499-96-9.

3-Bromo-2,3,4,5-tetrahydro-1H-[1]-benzazepin-2-one (300 mg) was added in one portion to a stirred suspension of potassium hydroxide (90 mg) and tetrabutylammonium bromide (40 mg) in tetrahydrofuran (10 ml) maintained at 0¡ã under a nitrogen atmosphere. Stirring was continued for 5 minutes, then ethyl bromoacetate (200 mg) was added in one portion. The reaction mixture was allowed to warm to room temperature while stirring for an additional 3 hours. The tetrahydrofuran was removed under reduced pressure and the residue partitioned between water (5 ml) and ether (25 ml). The organic phase was washed with 2N hydrochloric acid (5 ml), dried over magnesium sulfate, and the solvent removed under reduced pressure to give 3-bromo-1-ethoxycarbonylmethyl-2,3,4,5-tetrahydro-1H-[1]-benzazepin-2-one, m.p. 114¡ã-116¡ã. 3-Chloro-1-ethoxycarbonylmethyl-2,3,4,5-tetrahydro-1H-[1]-benzazepin-2-one was similarly prepared.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 86499-96-9.

Reference:
Patent; Ciba-Geigy Corporation; US4575503; (1986); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

71510-95-7, Adding a certain compound to certain chemical reactions, such as: 71510-95-7, name is Ethyl 3-(methylamino)-3-oxopropanoate, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 71510-95-7.

In the reaction bottle to the drying of, sequentially metal catalyst calls into Yb (OTf)3(0.02mol), chiral ligand L-PiMe2(0.02mol), P-cinnamoyl -3,5 dimethyl pyrazole (0.2mol), replace the nitrogen 3 times, by adding 300 ml of methylene chloride in 35 C activation under 20 min, sequentially adding a single amide (0.2mol) and Et3N (0.2mol), for 30-50 C reaction under 60-80 hours, the reaction solution is washed with dilute hydrochloric acid, concentrated dry, with petroleum ether/ethyl acetate to obtain crystallization 51g of products of catalysis, the yield is 87%, HPLC purity is 94.65%, ee99 . 12%, product HPLC spectrogram as shown in Figure 2.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 3-(methylamino)-3-oxopropanoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Zhejiang Jiuzhou Pharmaceutical Co., Ltd.; Feng, Xiaoming; Zhang, Yu; Liu, Xiaohua; Yao, Gan; Lin, Lili; Zhu, Guoliang; (14 pag.)CN105418502; (2016); A;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

The chemical industry reduces the impact on the environment during synthesis 563-83-7, name is Isobutyramide, I believe this compound will play a more active role in future production and life. 563-83-7

Step A: 2-Methylpropanethioamide; H*C^NH2 CH*A solution of 2-methylpropanamide (6.53 g, 75.0 mmol) and 2,4-bis(4- methoxyphenyl)-1 ,3-dithia-2,4-diphosphetane-2,4-disulfide (15.17 g, 37.51 mmol) in THF (100 ml_) was heated to reflux for 4 h. The reaction mixture was then cooled to rt and poured into saturated aqueous NaHCO3 (200 ml_). The mixture was extracted with ether (4 x 100 ml_). The organic fractions were combined, dried over Na2SO4, filtered, and concentrated. Purification by flash column chromatography (20% EtOAc: hexanes) afforded 4.77 g (62%) of the title compound of Step A. 1H-NMR (400 MHz, CDCI3) delta 7.63 (brs, 1 H), 6.90 (brs, 1 H), 2.88 (m, 1 H), and 1.27 (d, 6H, J = 6.8 Hz).

The chemical industry reduces the impact on the environment during synthesis 563-83-7. I believe this compound will play a more active role in future production and life.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2009/76140; (2009); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

402-46-0, Name is 4-Fluorobenzenesulfonamide, 402-46-0, belongs to amides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

4- fluorobenzene sulfonamide (175mg, 1mmol), catalyst A (8.3mg, 0.01mmol, 1mol%), cesium carbonate (33mg, 0.1mmol, 0.1equiv.), Benzyl alcohol (130mg, 1.2mmol) and water ( 1ml) were successively added to the reaction flask 25mlSchlenk.After the reaction mixture was reacted at 120 15 hours, cooled to room temperature.A large amount of precipitated, water was removed by filtration, the filter cake was washed with water three times to give the title compound, yield: 84%

Statistics shows that 4-Fluorobenzenesulfonamide is playing an increasingly important role. we look forward to future research findings about 402-46-0.

Reference:
Patent; Nanjing University of Science & Technology; Li, Feng; Qu, panpan; Sun, chunlou; Ma, Juan; (17 pag.)CN104418678; (2016); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 402-46-0, name is 4-Fluorobenzenesulfonamide, belongs to amides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 402-46-0, 402-46-0

General procedure: To a round-bottom flask (500 mL) that contained a solution of aryl sulfonamide (6 mmol), 4-dimethyaminopyridine (DMAP, 13 mmol), and 1-[3-(dimethyamino)-propyl]-3-ethylcarbodiimide hydrochloride (EDCI, 13 mmol) in CH2Cl2 (150 mL) was added the synthesized phenylacetic acid (6 mmol) at room temperature. The resulting mixture was stirred at room temperature for 12 h, then cooled to 5 C, and acidified to pH 1 with addition of HCl aqueous solution (10%), which was followed by extraction with CH2Cl2/MeOH (9:1, 3 ¡Á 100 mL). The combined organic layers were washed with H2O and brine, dried over Na2SO4, and concentrated in vacuo. The residue was subjected to silica gel chromatography or crystallization if necessary to afford the compounds (20-44) (Scheme 2).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Fluorobenzenesulfonamide, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Luo, Yin; Li, Yao; Qiu, Ke-Ming; Lu, Xiang; Fu, Jie; Zhu, Hai-Liang; Bioorganic and Medicinal Chemistry; vol. 19; 20; (2011); p. 6069 – 6076;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

53297-70-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 53297-70-4, name is 4-Amino-3-methylbenzenesulfonamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A 100 if L round bottom flask was charged with 4-amino-3-methyl-benzenesulfonamide (0.092 g, 0.495 mmol), dissolved in 2 mL of acetone and NaHCO3 (0.040 g, 0.495 mmol) was added. To the stirred suspension under a nitrogen atmosphere was added dropwise a solution of the acid chloride from step 4 (0.200 g, 0.495 mmol) dissolved in 3 mL acetone and the reaction was stirred for 24 h at RT. The reaction mixture was cooled to 0 C. and quenched with 10% aqueous HCl. The aqueous phase was extracted with EtOAc and the combined extracts were washed with aqueous 10% HCl, water, and brine. The organic phase was dried(Na2SO4), filtered and the solvent was removed in vacuo. The crude product was purified by SiO2 chromatography eluting with DCM/MeOH (93:7) to afford 0.240 g (87%) of I-189: ms (M-H)=551, mp 244.0-245.1; Anal. CHN; calcd C, 47.80; H, 2.92; N, 7.60; found C, 47.51; H, 2.80; N, 7.49.

The synthetic route of 4-Amino-3-methylbenzenesulfonamide has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Roche Palo Alto LLC; US2005/239881; (2005); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 711007-44-2, name is 2,3-Diaminobenzamide, This compound has unique chemical properties. The synthetic route is as follows., 711007-44-2

At room temperature, 2,3-diaminobenzamide (500 mg, 3.30 mmol) and 1-N-Boc-4-piperidinecarboxaldehyde (776 mg, 3.63 mmol) were initially charged in DMA (dimethylamide). With vigorous stirring, sodium bisulfite (585 mg, 5.62 mmol) was added at room temperature, and the reaction solution was then stirred at 130 C. for 5 h. After cooling to room temperature, water was added and the reaction mixture was repeatedly extracted thoroughly with dichloromethane The combined organic phases were then dried over magnesium sulfate, filtered off, concentrated under reduced pressure and then purified by column chromatography (gradient ethyl acetate/heptane). This gave tert-butyl 4-(4-carbamoyl-1H-benzimidazol-2-yl)piperidine-1-carboxylate (1.0 g, 88% of theory) in the form of a colorless solid. 1H-NMR (400 MHz, CDCl3 delta, ppm) 9.70 (br. s, 1H, NH), 8.10 (s, 1H), 7.60 (s, 1H), 7.30 (t, 1H), 5.90 (br. s, 1H, NH), 3.12 (m, 1H), 2.10 (m, 2H), 1.90 (m, 2H), 1.65 (m, 4H), 1.50 (s, 9H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; BAYER CROPSCIENCE AG; Frackenpohl, Jens; Heinemann, Ines; Mueller, Thomas; Dittgen, Jan; Von Koskull-Doering, Pascal; Schmutzler, Dirk; Hills, Martin Jeffrey; US2015/216168; (2015); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1120-16-7, name is Dodecanamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. 1120-16-7

In order to gain a deeper insight into the structure activity relationship, a battery of 15 additional bisphosphonates were synthesized harbouring different functional groups at the alpha-carbon and displaying lipid-tails of different length, respectively (Scheme 1). Scheme 1. Synthesis of bisphosphonates. Reagents and conditions: a) NaH, Toluene, 60 C, 16 h b) HCI, reflux, 16 h c) P(OMe)3, 0 C, 2 h d) HP(OMe)2, nBu2NH, 0 C, 16 h e) H3PO3, MsOH, then PCl3, 90 C, 16 h f) PCl3/H3PO3, 70C, 12 h, then H2O, 2h

The synthetic route of 1120-16-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Humboldt Universitaet zu Berlin; Rheinisch-Westfaelische Technische Hochschule Aachen (RWTH); EP2289900; (2011); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics