On July 25, 2013, Popovici-Muller, Janeta; Saunders, Jeffrey O.; Salituro, Francesco G.; Cai, Zhenwei; Yan, Shunqi; Zhou, Ding published a patent.HPLC of Formula: 16230-24-3 The title of the patent was Preparation of heterocycles as isocitrate dehydrogenase 1 inhibitors, therapeutically active compositions and their methods of use. And the patent contained the following:
Provided are compounds of formula I as IDH1 inhibitors; their preparation and use of those compounds for treating cancer. Compounds of formula I wherein R1 is (un)substituted C4-6 carbocyclyl; R2 and R3 are independently (un)substituted aryl and (un)substituted heteroaryl; R4 is (un)substituted saturated heterocyclyl, heteroaralkyl, CH2-heterocyclyl, etc.; and pharmaceutically acceptable salts and hydrates thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). All the invention compounds were evaluated for their IDH1 inhibitory activity. From the assay, it was determined that compound II exhibited IC50 value of ≤ 0.1 μM. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).HPLC of Formula: 16230-24-3
The Article related to heterocycle preparation idh1 inhibitor treatment cancer, Heterocyclic Compounds (One Hetero Atom): Other 5-Membered Rings and other aspects.HPLC of Formula: 16230-24-3
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics