Sun, Bo; Liu, Xiaowen; Zheng, Xu; Wang, Changyuan; Meng, Qiang; Sun, Huijun; Shu, Xiaohong; Liu, Kexin; Sun, Xiuli; Li, Yanxia; Ma, Xiaodong published an article in 2020, the title of the article was Novel Pyrimidines as Multitarget Protein Tyrosine Kinase Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis (IPF).Recommanded Product: 16230-24-3 And the article contains the following content:
A new class of pyrimidine derivatives were identified as potent protein tyrosine kinase (PTK) inhibitors for the treatment of idiopathic pulmonary fibrosis (IPF). Most of these small-mol. inhibitors displayed strong enzymic activity against BTK and JAK3 kinases at concentrations lower than 10 nM. The representative compound N-(3-((5-chloro-2-(4-((1-morpholino)acetylamino)phenylamino)-4-pyrimidinyl)amino)phenyl)acrylamide (6 a) also exhibited high inhibitory potency toward both BTK and JAK kinase families, as well as ErbB4, at a concentration of 10 nM, achieving rates of inhibition higher than 57%. Addnl., in vivo biol. evaluations showed that 6 a can remarkably decrease the severity of IPF disease. All these investigations suggested that the multi-PTK inhibitor 6 a may serve as a promising agent for the treatment of IPF. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Recommanded Product: 16230-24-3
The Article related to pyrimidine derivative preparation tyrosine kinase inhibitor idiopathic pulmonary fibrosis, ipf, ptk, inhibitors, multitarget, pyrimidine, Pharmacology: Effects Of Inflammation Inhibitors and Immune Agents and other aspects.Recommanded Product: 16230-24-3
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics